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EAVLKALSDANRRTLLARLGDRDGQTLKELCADLAMARQSVAKHLEVLEAAGLVTVQWEGRQKLHHLDTG PITELAGELTARWGAPRRHGARLEAGAGNDGDVFVYVIYIRTTPERLWHAITNPGTSLGYLGHAIESDWL KGSTYVWIERGIRFERPQQVVLESDPYQRLAFTYPMPRTPDLDDPGAEHDTTRVSFDIEPGEHQVKLTLV HDGLRPDSITHTLVSGEWPLKLSDLKSGLEQLTAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3497 | - | - | 100% (246) | transcriptional regulator, ArsR family protein |
| M. smegmatis MC2 155 | MSMEG_5679 | - | 1e-16 | 43.69% (103) | putative DNA-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0591 | - | 4e-11 | 24.42% (217) | ArsR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2031 | - | 4e-54 | 45.59% (261) | activator of Hsp90 ATPase 1 family protein |
| M. tuberculosis H37Rv | Rv0576 | - | 4e-11 | 24.42% (217) | ArsR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0986 | - | 5e-38 | 39.68% (247) | ArsR family transcriptional regulator |
| M. marinum M | MMAR_5343 | - | 2e-15 | 47.13% (87) | transcriptional regulator |
| M. avium 104 | MAV_2783 | - | 4e-07 | 39.47% (76) | ArsR family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3423 | - | 7e-07 | 32.14% (84) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0086 | - | 1e-16 | 48.28% (87) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4686 | - | 4e-56 | 46.27% (255) | regulatory protein, ArsR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2031|M.gilvum_PYR-GCK ---------MDEVFRALADPSRRRLLDNLNARNGQSLRELCAGLD-----
Mvan_4686|M.vanbaalenii_PYR-1 ---------MDEVFRALADPSRRRLLDSLNARNGQSLRELCAGLD-----
MSMEG_3497|M.smegmatis_MC2_155 ---------MEAVLKALSDANRRTLLARLGDRDGQTLKELCADLA-----
MMAR_5343|M.marinum_M ---MHIVREVGDVFKALADPTRRVILDELTDRNGQTLFEICARLTTKHGI
MUL_0086|M.ulcerans_Agy99 ------MREVGDVFKALADPTRRVILGELTDRNGQTLFEICARLTTKHGI
MAB_0986|M.abscessus_ATCC_1997 MQSAPGHSHWDVVFKALADPTRRELLDRLHERNGQTLSQLCEGVA-----
TH_3423|M.thermoresistible__bu ---MTATDQLHPVFHALGDPNRMRLITRLCDAGPGSTSQVAQAVS-----
MAV_2783|M.avium_104 ---MVVVTGVDRVFLALANPVRRELLQLLA-RHPLSAGELSERFE-----
Mb0591|M.bovis_AF2122/97 ------------MLEVAAEPTRRRLLQLLAPGERT-VTQLASQFT-----
Rv0576|M.tuberculosis_H37Rv ------------MLEVAAEPTRRRLLQLLAPGERT-VTQLASQFT-----
:: . .:. * :: * ::. .
Mflv_2031|M.gilvum_PYR-GCK -MARQSVSKHLKVLEDANLVSIVWQGREKLHYLNAEPINAIADRWINHYD
Mvan_4686|M.vanbaalenii_PYR-1 -MARQSVSKHLKVLEDANLVSTVWRGREKLHYLNAEPINAIADRWINHYD
MSMEG_3497|M.smegmatis_MC2_155 -MARQSVAKHLEVLEAAGLVTVQWEGRQKLHHLDTGPITELAGELTARWG
MMAR_5343|M.marinum_M CSTRQAISQHLDVLEAAELIETQRGGRQKFHYLNTAPLGQIAKRWR----
MUL_0086|M.ulcerans_Agy99 CSTRQAISQHLDVLEAAGLIETQRGGRQKFHYLNTAPLGQIAKRWR----
MAB_0986|M.abscessus_ATCC_1997 -MARQSATQHLGVLESANLISTVRHGREKLHYLNPVPLHEIQERWIDKFE
TH_3423|M.thermoresistible__bu -VSRQAATKHLLILEEAGLVRSDRRGRERIWRMQPEALDDASEYLDRLAR
MAV_2783|M.avium_104 -LSRPAVAEHLKVLREAALVADERRGRQRIYHLTAEPLAELGEWLHP---
Mb0591|M.bovis_AF2122/97 -VTRSAISQHLGMLAEAGLVTARKQGRERYYRLDERGVLRLRALMESFWS
Rv0576|M.tuberculosis_H37Rv -VTRSAISQHLGMLAEAGLVTARKQGRERYYRLDERGVLRLRALMESFWS
:* : ::** :* * *: **:: : :
Mflv_2031|M.gilvum_PYR-GCK RMRAQTLADLKTALERNPMADNTHSAAADFVYTTYIRTTPERLWQAVTDP
Mvan_4686|M.vanbaalenii_PYR-1 RLRAQTLADLKTALEQDTMEHDN-----DFVYTTYIRTTPERLWQAVTDP
MSMEG_3497|M.smegmatis_MC2_155 APRRHG-----ARLEAGAGNDGD-----VFVYVIYIRTTPERLWHAITNP
MMAR_5343|M.marinum_M ---------------IDT--------------------------------
MUL_0086|M.ulcerans_Agy99 ---------------IDT--------------------------------
MAB_0986|M.abscessus_ATCC_1997 RPRLRALSAIKQRAEERDMSQPT------FVYTTYINSTPEKVWQAITDP
TH_3423|M.thermoresistible__bu R-------------------------------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 DELDRLVADAAHYPPSQGDCAMP------FEKAVVVPLDPTSTFALITQP
Rv0576|M.tuberculosis_H37Rv DELDRLVADAAHYPPSQGDCAMP------FEKAVVVPLDPTSTFALITQP
Mflv_2031|M.gilvum_PYR-GCK AFSERYMGHGLVSDWQVGSTFAWRDGDLS-ITSPEQVILECEPYRRLAFT
Mvan_4686|M.vanbaalenii_PYR-1 AFSERYMGHGLVTDWKVGSTFDWRDGDLN-ISNPEQVVLEADPYRRLAFT
MSMEG_3497|M.smegmatis_MC2_155 GTSLGYLGHAIESDWLKGSTYVWIERGIR-FERPQQVVLESDPYQRLAFT
MMAR_5343|M.marinum_M ------------ADSGRGTT------------------------------
MUL_0086|M.ulcerans_Agy99 ------------ADSGRGTT------------------------------
MAB_0986|M.abscessus_ATCC_1997 ELSGQYWGHANVSDWQEGSRWEHRRTDGSGIADVVGTVVESDPPRKLVTT
TH_3423|M.thermoresistible__bu ------------WDRALGRLRAFVEAPEQ---------------------
MAV_2783|M.avium_104 -----------FEKFWRTRLRRLAEVAEELE-------------------
Mb0591|M.bovis_AF2122/97 DRLRRWMAVAARIELRTGGAYRWTVTPGH---SAAGTVIDVDPGKRVVFT
Rv0576|M.tuberculosis_H37Rv DRLRRWMAVAARIELRTGGAYRWTVTPGH---SAAGTVIDVDPGKRVVFT
.
Mflv_2031|M.gilvum_PYR-GCK FHTFTKDLTTVGLSEDVIERAAAEPRSQVVFDIESVEDGRVKLTVTHTGF
Mvan_4686|M.vanbaalenii_PYR-1 FHTFTRQLTTVGLSEDVIDRAAAEPRSKVSFDIEQVDGGRVKLTVIHTGF
MSMEG_3497|M.smegmatis_MC2_155 YP--------MPRTPDLDDPGAEHDTTRVSFDIEPGE-HQVKLTLVHDGL
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 WAD--------------PADGADAAVSTVTFLIQPYQ-NIVRLTVSHADL
TH_3423|M.thermoresistible__bu -----------------PDPGMSE--------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 WGWEDHGDPPPGGSTVTITLTPVDGGTEVRLVHDGLTAQQAARHAKGWNH
Rv0576|M.tuberculosis_H37Rv WGWEDHGDPPPGGSTVTITLTPVDGGTEVRLVHDGLTAQQAARHAKGWNH
Mflv_2031|M.gilvum_PYR-GCK PSESIVRELVSG-----GWPSKLSDLKTHLELDRVAVGA-----------
Mvan_4686|M.vanbaalenii_PYR-1 PSGSIVRELVSG-----GWPSKLSDLKSNLELASVTADA-----------
MSMEG_3497|M.smegmatis_MC2_155 RPDSITHTLVSG-----EWPLKLSDLKSGLEQLTAP--------------
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 -ADPAEYAQASG-----GWAAVLSNLKSFLETGAPLPTEPWTQPG-----
TH_3423|M.thermoresistible__bu --------------------------------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 FLDRLVVAGQHGDAGPDEWAAAPDPLDELSCAEATLAVLQHVLRGIGASD
Rv0576|M.tuberculosis_H37Rv FLDRLVVAGQRGDAGPDEWAAAPDPLDELSCAEATLAVLQHVLRGIGASD
Mflv_2031|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4686|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3497|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3423|M.thermoresistible__bu --------------------------------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 LTRQTPCTEYDVSQLADHLLRSLAIIGAAAGAQLAPRDVDAPLETQVADA
Rv0576|M.tuberculosis_H37Rv LTRQTPCTEYDVSQLADHLLRSLAIIGAAAGAQLAPRDVDAPLETQVADA
Mflv_2031|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4686|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3497|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3423|M.thermoresistible__bu --------------------------------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 AQAVMEAWRRRGLAGTVELNSNQVPATVPVGILCLEFLVHAWDFAIATGS
Rv0576|M.tuberculosis_H37Rv AQAVMEAWRRRGLAGTVELNSNQVPATVPVGILCLEFLVHAWDFAIATGS
Mflv_2031|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4686|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3497|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5343|M.marinum_M --------------------------------------------------
MUL_0086|M.ulcerans_Agy99 --------------------------------------------------
MAB_0986|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3423|M.thermoresistible__bu --------------------------------------------------
MAV_2783|M.avium_104 --------------------------------------------------
Mb0591|M.bovis_AF2122/97 QVIASEPVSEYVLAVAGKVITPATRNSAGFAAPAAVGSFAPVLDRLIAFT
Rv0576|M.tuberculosis_H37Rv QVIASEPVSEYVLAVAGKVITPATRNSAGFAAPAAVGSFAPVLDRLIAFT
Mflv_2031|M.gilvum_PYR-GCK ------------
Mvan_4686|M.vanbaalenii_PYR-1 ------------
MSMEG_3497|M.smegmatis_MC2_155 ------------
MMAR_5343|M.marinum_M ------------
MUL_0086|M.ulcerans_Agy99 ------------
MAB_0986|M.abscessus_ATCC_1997 ------------
TH_3423|M.thermoresistible__bu ------------
MAV_2783|M.avium_104 ------------
Mb0591|M.bovis_AF2122/97 GRQPTAGHVSAT
Rv0576|M.tuberculosis_H37Rv GRQPTAGHVSAT