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RELKVVGLDVDGTRIICETGDSGEKFVLRADDRLKAAVRGDRAASNQTTIDVEVPNMLRPREIQSKIRAG ASVEQIASAAGVDIARVERFAHPVLLERSRAAELATAAHPVLADGPSVLTLLETVSTALIARGLDPEATT WDAWRNEDSRWTVQLAWKAGLSDNVAHFRYAPGAHGGTVTAFDDAASELIDPTFARPLRPLAPVAQLALG EPEPAPAPTPAPAPAPAPAPESIPEPQAEAPEDTPAAKTSRPRKSRPAVPAWEDVLLGVRSSGGQR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1717 | - | - | 100% (277) | hypothetical protein Mflv_1717 |
| M. gilvum PYR-GCK | Mflv_4889 | - | 5e-06 | 38.89% (72) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_1703 | - | 2e-05 | 38.24% (102) | transglycosylase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0907c | - | 4e-96 | 63.50% (274) | hypothetical protein Mb0907c |
| M. tuberculosis H37Rv | Rv0883c | - | 4e-96 | 63.50% (274) | hypothetical protein Rv0883c |
| M. leprae Br4923 | MLBr_02137 | - | 1e-92 | 63.50% (274) | hypothetical protein MLBr_02137 |
| M. abscessus ATCC 19977 | MAB_0883c | - | 9e-92 | 62.04% (274) | hypothetical protein MAB_0883c |
| M. marinum M | MMAR_4649 | - | 2e-98 | 65.82% (275) | hypothetical protein MMAR_4649 |
| M. avium 104 | MAV_1010 | - | 4e-90 | 61.37% (277) | hypothetical protein MAV_1010 |
| M. smegmatis MC2 155 | MSMEG_5685 | - | 1e-113 | 73.74% (278) | DNA-binding protein |
| M. thermoresistible (build 8) | TH_2833 | - | 2e-06 | 36.36% (88) | PUTATIVE 2-oxoglutarate dehydrogenase, E2 component, |
| M. ulcerans Agy99 | MUL_0267 | - | 5e-99 | 65.33% (274) | hypothetical protein MUL_0267 |
| M. vanbaalenii PYR-1 | Mvan_5034 | - | 1e-132 | 84.48% (277) | hypothetical protein Mvan_5034 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1717|M.gilvum_PYR-GCK ---------------MRELKVVG-----------LDVDGTRIICETGDSG
Mvan_5034|M.vanbaalenii_PYR-1 ---------------MRELRVVG-----------LDVDGRRIICETGDSG
MSMEG_5685|M.smegmatis_MC2_155 ---------------MRELRVVG-----------LDVDGKRIICETADSA
MMAR_4649|M.marinum_M ---------------MRELRVVG-----------LDADGKYILCEGVDSS
MUL_0267|M.ulcerans_Agy99 ---------------MRELRVVG-----------LDADGKYILCEGVDST
Mb0907c|M.bovis_AF2122/97 ---------------MRELKVVG-----------LDADGKNIICQGAIPS
Rv0883c|M.tuberculosis_H37Rv ---------------MRELKVVG-----------LDADGKNIICQGAIPS
MLBr_02137|M.leprae_Br4923 ---------------MRELKVVG-----------LDPDSKTILCEGDIPG
MAV_1010|M.avium_104 ---------------MRELKVVG-----------LDADSKYLICESDDPA
MAB_0883c|M.abscessus_ATCC_199 ---------------MRELKVIG-----------LSADGKRVICQDANGT
TH_2833|M.thermoresistible__bu VLMPELGESVTEGTVTRWLKKVGDTVEVDEPLLEVSTDKVDTEIPSPVAG
* *: :* :. *
Mflv_1717|M.gilvum_PYR-GCK EKFVLRADDRLKAAVRGDRAAS----------------------------
Mvan_5034|M.vanbaalenii_PYR-1 EKFVLRSDDRLKAAVRGDRAGS----------------------------
MSMEG_5685|M.smegmatis_MC2_155 EMFTLRVDDRLRAALRGDKVAS----------------------------
MMAR_4649|M.marinum_M EKYKLPADDRLRAALKRQSIPP----------------------------
MUL_0267|M.ulcerans_Agy99 EKYKLPADDRLRAALKRQPIPP----------------------------
Mb0907c|M.bovis_AF2122/97 EQFKLPVDDRLRAALRDDSVQP----------------------------
Rv0883c|M.tuberculosis_H37Rv EQFKLPVDDRLRAALRDDSVQP----------------------------
MLBr_02137|M.leprae_Br4923 ERFKLPADDRLRAAVRGDTTLL----------------------------
MAV_1010|M.avium_104 EQFKLPADDHLRAVLRHEAEPP----------------------------
MAB_0883c|M.abscessus_ATCC_199 DKFAIDADDRLRAAARGDLSRL----------------------------
TH_2833|M.thermoresistible__bu TLVSITAEEDATVEVGGELAVIGEAGAQAGAQPEPEPEPRPEPEPAPQPE
: :: . :
Mflv_1717|M.gilvum_PYR-GCK --------NQTTIDVEVPNMLRPREIQSKIRAG----ASVEQIASAAGVD
Mvan_5034|M.vanbaalenii_PYR-1 --------NQTTIDVEVPTLLRPREIQSKIRAG----ASVEQVAASAGVD
MSMEG_5685|M.smegmatis_MC2_155 --------NQTEIDLEVQSVLRPKEIQAKIRAG----ASVEQLAAAAGVP
MMAR_4649|M.marinum_M --------EQPQLDIEVTNMLSPKEIQARIRAG----ASVEQVATASGSD
MUL_0267|M.ulcerans_Agy99 --------EQPQLDIEVTNMLSPKEIQARIRAG----ASVEQVATASGSD
Mb0907c|M.bovis_AF2122/97 --------EQAQLDIEVTNVLSPKEIQARIRAG----ASVEQVAAASGSD
Rv0883c|M.tuberculosis_H37Rv --------EQAQLDIEVTNVLSPKEIQARIRAG----ASVEQVAAASGSD
MLBr_02137|M.leprae_Br4923 --------DQPQLDIQVTNMLSPKEIQARIRAG----ASVEQVAMASGSD
MAV_1010|M.avium_104 --------EQPQLEIEVTNMLSPKEIQAKIRAG----ASVEQVAAASGSD
MAB_0883c|M.abscessus_ATCC_199 --------GQIQIEMESS--LRPREIQARIRAG----ATVQQVATAAGVD
TH_2833|M.thermoresistible__bu PEPEQKAAPQPQPESRPEPQPQPARQAPQRESGPYVTPLVRKLAAEHGVD
* : . * . .: .:* . *.::* *
Mflv_1717|M.gilvum_PYR-GCK IA---------RVERFAHPVLLERSRAAELATAAHPVLADGPSVLTLLET
Mvan_5034|M.vanbaalenii_PYR-1 IA---------RVERFAHPVLLERARAAELASAAHPVLADGPSVLTLLET
MSMEG_5685|M.smegmatis_MC2_155 VE---------RVERFAHPVLLERARAAELATAAHPVLADGPSVLTLLET
MMAR_4649|M.marinum_M IA---------RIQRFAHPVLLERSRAAELATAAHPMLADGPAVLTLLET
MUL_0267|M.ulcerans_Agy99 IA---------RIQRFAHPVLLERSRAAELATAAHPMLADGPAVLTLLET
Mb0907c|M.bovis_AF2122/97 IA---------RIRRFAHPVLLERSRAAELATAAHPVLADGPAVLTMQET
Rv0883c|M.tuberculosis_H37Rv IA---------RIRRFAHPVLLERSRAAELATAAHPVLADGPAVLTMQET
MLBr_02137|M.leprae_Br4923 IA---------RIRRFAHPVLLERSRAAELATAAHPVLADGPAVLTLLET
MAV_1010|M.avium_104 VS---------RVRRFAHPVLLERYRAAELATAAHPMLADGPAVLTLLET
MAB_0883c|M.abscessus_ATCC_199 VS---------RIERFAHPVLLERQRAAEMASAAHPVRNDGPAVSTLADT
TH_2833|M.thermoresistible__bu LSTVKGTGVGGRIRKQDVLAAAEAAKKAAEAPAAEPAETAKPAAAAASAA
: *:.: . * : * *.**.* *:. : :
Mflv_1717|M.gilvum_PYR-GCK -------------------------VSTALIARGLDPEATTWDAWRNEDS
Mvan_5034|M.vanbaalenii_PYR-1 -------------------------VTSALIARGLDPDGANWDAWRNEDS
MSMEG_5685|M.smegmatis_MC2_155 -------------------------VTKALVARGLDPDAVAWDAWRNEDS
MMAR_4649|M.marinum_M -------------------------ITAALVTRGLNPERLDWDAWRNEDG
MUL_0267|M.ulcerans_Agy99 -------------------------ITAALVTRGLNPERLDWDAWRNEDG
Mb0907c|M.bovis_AF2122/97 -------------------------VAAALVARGLNPDSLTWDAWRNEDS
Rv0883c|M.tuberculosis_H37Rv -------------------------VAAALVARGLNPDSLTWDAWRNEDS
MLBr_02137|M.leprae_Br4923 -------------------------VSAALVKRGLEPDKLSWDAWRNEDS
MAV_1010|M.avium_104 -------------------------VTAAFVTRGLRHDKLSWDAWRNEDN
MAB_0883c|M.abscessus_ATCC_199 -------------------------VAGAMFARGGDPDAIEWDAWKVEDG
TH_2833|M.thermoresistible__bu PESPLAHLRGTTKKASRIRQITAQRTRESLQTTAQLTQVHEVDMTKIVAL
:: . : * :
Mflv_1717|M.gilvum_PYR-GCK RWTVQLAWKAGLSDNVAHFRYAPGAHGGTVTAFD----------------
Mvan_5034|M.vanbaalenii_PYR-1 RWTVQLAWKAGLSDNVAHFRYAPGAHGGTVTAFD----------------
MSMEG_5685|M.smegmatis_MC2_155 RWTVQLAWKAGRSDNVAHFRFTPGSHGGLVTASD----------------
MMAR_4649|M.marinum_M RWTVQLAWKAGRSDNLAHFRFAPGAHGGTVTAID----------------
MUL_0267|M.ulcerans_Agy99 RWTVQLAWKAGRSDNLAHFRFAPGAHGGTVTAID----------------
Mb0907c|M.bovis_AF2122/97 RWTVQLAWKAGRSDNLAHFRFTPGAHGGTATAID----------------
Rv0883c|M.tuberculosis_H37Rv RWTVQLAWKAGRSDNLAHFRFTPGAHGGTATAID----------------
MLBr_02137|M.leprae_Br4923 RWTVQLMWHAGRSDNLAHFCFTPGAHGGTVTASD----------------
MAV_1010|M.avium_104 RWTVQLAWKVGRSDNVAHFCFTPGAHGGTVTAID----------------
MAB_0883c|M.abscessus_ATCC_199 RWTVQLQWRTGRSDNKAHFRYTPGAHGGTVTALD----------------
TH_2833|M.thermoresistible__bu RARAKAEFREREGVNLTYLPFIARAVIDALKAHPNVNASYNEETKEITYY
* .: :: . * ::: : . : . .*
Mflv_1717|M.gilvum_PYR-GCK ---------DAASELIDPTFARP--------LRPLAPVAQLALG-EPEPA
Mvan_5034|M.vanbaalenii_PYR-1 ---------DAAAELIDPNFARP--------LRPVAAVAQLALG-EPEDP
MSMEG_5685|M.smegmatis_MC2_155 ---------DAAHQLINPDFARP--------LRPVAAVPQLEFE-APQPA
MMAR_4649|M.marinum_M ---------DAASELIDPEYKAP--------LRPLAPVSHLAFD-EPAKP
MUL_0267|M.ulcerans_Agy99 ---------DAASELIDPEYKAP--------LRPLAPVSHLAFD-EPAKP
Mb0907c|M.bovis_AF2122/97 ---------DTAHELINPTFNRP--------LRPLAPVAHLDFD-EPE--
Rv0883c|M.tuberculosis_H37Rv ---------DTAHELINPTFNRP--------LRPLAPVAHLDFD-EPE--
MLBr_02137|M.leprae_Br4923 ---------DAANELIDPDFNRP--------LRPLARVAHLDFV-EPA--
MAV_1010|M.avium_104 ---------DAATALIDPNFELP--------LRPLARVAHVDFD-EPAKP
MAB_0883c|M.abscessus_ATCC_199 ---------DSARELIDPTFTRS--------LRPVAAVSPLLPEPEPELF
TH_2833|M.thermoresistible__bu DAEHLGIAVDTEKGLLSPVIHNAGDLSLGGLARAIADIAARARSGDLKPD
*: *:.* . *.:* :.
Mflv_1717|M.gilvum_PYR-GCK PAPTP------APAPAPAPAPESIPEPQAEAPEDTPAAKTSRPRKSRPAV
Mvan_5034|M.vanbaalenii_PYR-1 HAPVQ------AATPAPEPAPVETPEP-------APTVKTPRPRKSRPAV
MSMEG_5685|M.smegmatis_MC2_155 QPAAPPQPAQAVPTPEPAPAPEQEPEP-------APAPAPKRSRKARATV
MMAR_4649|M.marinum_M AKQAK----------PAKPAKQTPPAP---------AEQPASSRRGKPAI
MUL_0267|M.ulcerans_Agy99 AKQAK----------PAKPPKQTPPAP---------AEQPASSRRGKPAI
Mb0907c|M.bovis_AF2122/97 ---------------PAQP---TLTVP---------SAQPVSNRRGKPAI
Rv0883c|M.tuberculosis_H37Rv ---------------PAQP---TLTVP---------SAQPVSNRRGKPAI
MLBr_02137|M.leprae_Br4923 -----------------TP---ATVTP---------DNQLVSSRRGKPTI
MAV_1010|M.avium_104 P--------------TAEAPAAEPAEP---------EEKPVHTRRGKPVI
MAB_0883c|M.abscessus_ATCC_199 TESPAP-------LPEPEPAVAEEHTET----ETTQAPAPRRSRRSKPAV
TH_2833|M.thermoresistible__bu ELSGG-----TFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVIE
. :: :
Mflv_1717|M.gilvum_PYR-GCK PAWEDVLLGVRSSGGQR---------------------------------
Mvan_5034|M.vanbaalenii_PYR-1 PAWEDVLLGVRSSGGQR---------------------------------
MSMEG_5685|M.smegmatis_MC2_155 PAWEDVLLGVRSSGTQR---------------------------------
MMAR_4649|M.marinum_M PAWEDVLLGVRSSG-QR---------------------------------
MUL_0267|M.ulcerans_Agy99 PAWEDVLLGVRSSG-QR---------------------------------
Mb0907c|M.bovis_AF2122/97 PAWEDVLLGVRSGG-RR---------------------------------
Rv0883c|M.tuberculosis_H37Rv PAWEDVLLGVRSGG-RR---------------------------------
MLBr_02137|M.leprae_Br4923 PAWEDVLLGVRSAG-QR---------------------------------
MAV_1010|M.avium_104 PAWEDVLLGVRSGG-QR---------------------------------
MAB_0883c|M.abscessus_ATCC_199 PTWEDVLLGVRSSG-QN---------------------------------
TH_2833|M.thermoresistible__bu DEFGNESIGIRSVCYLPLTYDHRLIDGADAGRFLTTIKKRLEEGAFEAEL
: : :*:**
Mflv_1717|M.gilvum_PYR-GCK --
Mvan_5034|M.vanbaalenii_PYR-1 --
MSMEG_5685|M.smegmatis_MC2_155 --
MMAR_4649|M.marinum_M --
MUL_0267|M.ulcerans_Agy99 --
Mb0907c|M.bovis_AF2122/97 --
Rv0883c|M.tuberculosis_H37Rv --
MLBr_02137|M.leprae_Br4923 --
MAV_1010|M.avium_104 --
MAB_0883c|M.abscessus_ATCC_199 --
TH_2833|M.thermoresistible__bu GL