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MSALPQSLPGLPAASAKLRFQSAAASVTSRYPSRVRPLSRPPAGSGLKPVLGNYGFPVLGHHLSTFVEPL EFARERYERFGPVSWAGGIGFRVVQLMGPEALETAWINRDKAFSSTRGWAPVIGPFFHRGIMLLDFEEHR DHRRIMQQAFTRSALDGYLTLMRPGISRTVTSWPTAAGFPFYTAIKKLLLDQAAEVFVGAVLGAEADRLS SDFHDTVCGGQAMIRADVPGGTWARGLRARERLERYFAAQIPDRRAGTGADLFSMMCRSRSEDGDSFSDA DIVNHMIFLLMAAHDTSAIAISMLVYELGRNLRWQDALRDEADAGDGLGLADLDGAYPLLDAAFKEILRM YAPAGTLFRQTVTDTEVCGHYIPRRTQVAINVYASLRLADWWPDPDRFDPGRFLGGGDAAAVHRYAFAPF GGGVHKCIGQQFADMNVKLVMHQLLRQFRWRVAPGYRPLMTWGTGPTPADGLPISLQRLSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1527 | - | - | 100% (482) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4315 | - | e-100 | 43.78% (450) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4604 | - | 4e-34 | 43.68% (174) | cytochrome P450-like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3085 | cyp136 | 1e-103 | 44.23% (459) | cytochrome P450 136 |
| M. tuberculosis H37Rv | Rv3059 | cyp136 | 1e-103 | 44.23% (459) | cytochrome P450 136 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-06 | 24.10% (332) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3423 | - | 1e-102 | 44.57% (451) | cytochrome P450 |
| M. marinum M | MMAR_1634 | cyp136A2 | 1e-101 | 44.57% (451) | cytochrome P450 136A2 Cyp136A2 |
| M. avium 104 | MAV_3927 | - | 1e-105 | 45.25% (453) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_1167 | - | 0.0 | 78.51% (470) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_2954 | - | 1e-103 | 44.79% (451) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 1e-101 | 44.57% (451) | cytochrome P450 136A2 Cyp136A2 |
| M. vanbaalenii PYR-1 | Mvan_2031 | - | 1e-102 | 42.44% (483) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1527|M.gilvum_PYR-GCK MSALPQSLPGLPAASAKLRFQSAAAS------VTSRYPSR---VRPLSRP
MSMEG_1167|M.smegmatis_MC2_155 -MTIPAAEA---AADAKVRLQTAVAG------ITARYPSR---EHALAAP
TH_2954|M.thermoresistible__bu --MATINTRDYLLDQAKRRLIPTVNNIPGMGIVEKKLREREWKQFKLADP
Mvan_2031|M.vanbaalenii_PYR-1 --MPSISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEP
MAV_3927|M.avium_104 -MTATISTPQYLLDQARRRFTPTLNTIPGMGAIEKRLLAHEWQTKVLAEP
Mb3085|M.bovis_AF2122/97 --MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEP
Rv3059|M.tuberculosis_H37Rv --MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEP
MMAR_1634|M.marinum_M --MATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADP
MUL_3402|M.ulcerans_Agy99 --MATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADP
MAB_3423|M.abscessus_ATCC_1997 --MATISSTDYLIDQAKRRL-PTMNTLPGMGYIENYLNNREWPMTELAAP
MLBr_02088|M.leprae_Br4923 ------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDP
. : * *
Mflv_1527|M.gilvum_PYR-GCK PAGSGLKPVLGNYGFPVLGHHLSTFVEPLEFARERYERFGPVSWAGGIGF
MSMEG_1167|M.smegmatis_MC2_155 PPGSGLKPVMGNYGFPILGHVMSTLVEPLAFARERYERYGPVSWAGGVGF
TH_2954|M.thermoresistible__bu PPGSGLKPVMGDAGLPILGHMIEAFRGGPDYVLEVYRKYGPVHYAYSPAL
Mvan_2031|M.vanbaalenii_PYR-1 PAGSDLKPILGDAGLPIIGHMIEIFRGGPDFILEIYRKHGPVYFAESPAL
MAV_3927|M.avium_104 PAGSGLKPVLGDAGLPILGHIIELFRGGPDYALFLYRNHGPLIYLDSPIM
Mb3085|M.bovis_AF2122/97 PPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVL
Rv3059|M.tuberculosis_H37Rv PPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVL
MMAR_1634|M.marinum_M PPGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVL
MUL_3402|M.ulcerans_Agy99 PPGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVL
MAB_3423|M.abscessus_ATCC_1997 PPGSGLKPVMGDQGLPMLGHMVEMFRGGIDWVLNMYQERGPVSWTQTPIG
MLBr_02088|M.leprae_Br4923 GTRADPFPVYR----ALIDYGPMQLPG---MPLTVFSSFSDCDEALRHPL
. :. *: .::.: : : .
Mflv_1527|M.gilvum_PYR-GCK RVVQLMGPEALETAWINRDKAFSSTRGWAPVIGPFFHRGIMLLDFEEHRD
MSMEG_1167|M.smegmatis_MC2_155 RVALLMGPEALETVWINKDKAFSSTLGWAPVIGPFFHRGIMLLDFEEHRD
TH_2954|M.thermoresistible__bu ASVSALGPDATQEIFSNKNKDYS-QKGWHPVIGPFFNRGLMMLDFEEHMY
Mvan_2031|M.vanbaalenii_PYR-1 SSVMALGPDATQAVFSNRNKDFS-QRAWDPVIGPFFEGGLMLLDFDEHMF
MAV_3927|M.avium_104 PAVTALGPDATQAVFSNRNKDYS-QKGWHPVIGPFFNRGLMMLDFDEHMY
Mb3085|M.bovis_AF2122/97 PGVAALGPDAAQVIYSNRNKDYS-QQGWVPVIGPFFHRGLMLLDFEEHMF
Rv3059|M.tuberculosis_H37Rv PGVAALGPDAAQVIYSNRNKDYS-QQGWVPVIGPFFHRGLMLLDFEEHMF
MMAR_1634|M.marinum_M PAVVALGPDAAQVIYSNRNKDYS-QQGWVPVIGPFFRRGLMLLDFEEHMF
MUL_3402|M.ulcerans_Agy99 SAVVALGPDAAQVIYSNRNKDYS-QQGWVPVIGPFFRRGLMLLDFEEHMF
MAB_3423|M.abscessus_ATCC_1997 KIVAALGPDATQAVFSNANKDFS-QQGWVPVIGPFFNRGLMLLDFQEHRE
MLBr_02088|M.leprae_Br4923 SASDRLKATLAQQAIAAG-----------AEPRPFYASSFMFLDPPDHTR
: . : . **: .:*:** :*
Mflv_1527|M.gilvum_PYR-GCK HRRIMQQAFTRSALDGYLTLMRPGISRTVT-SWPT-AAGFPFYTAIKKLL
MSMEG_1167|M.smegmatis_MC2_155 HRRIMQQAFTRSALNGYLDLMRPGIDRTVR-SWPA-AQRFPFYTSVKHLL
TH_2954|M.thermoresistible__bu HRRIMQEAFTRPRLAGYVEHIDRVASEVVVRDWATDDPRFLFHPSVKKLT
Mvan_2031|M.vanbaalenii_PYR-1 HRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELT
MAV_3927|M.avium_104 HRRIMQEAFTRSRLTGYVEHIDRVATDIVA-DWPTNDARFLFHPAMKELT
Mb3085|M.bovis_AF2122/97 HRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALT
Rv3059|M.tuberculosis_H37Rv HRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALT
MMAR_1634|M.marinum_M HRRIMQEAFVRSRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLT
MUL_3402|M.ulcerans_Agy99 HRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLT
MAB_3423|M.abscessus_ATCC_1997 HRLIMQQAFLRSRLAGYVEQIDAVASEIVA-QWPTNDNRFLFYPAIKELT
MLBr_02088|M.leprae_Br4923 LRKLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAGQFDVIADLAFPLAV
* ::.:** : . : : . . :.
Mflv_1527|M.gilvum_PYR-GCK LDQAAEVFVGAVLGAEADRLS---SDFHDTVCGGQAMIRADVPGGTWARG
MSMEG_1167|M.smegmatis_MC2_155 LDQAAEVFIGAELGPEADQLS---RDFHDTVCGGQAVIRADVPGGVWSRG
TH_2954|M.thermoresistible__bu LDIASVVFMGHEPGSDKELVTKVNDAFTITTRAGGAIIRTSVPPFKWWRG
Mvan_2031|M.vanbaalenii_PYR-1 LDIASEVFMGVPAGTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRG
MAV_3927|M.avium_104 LDIASLVFMGHEPGTDHDLVTKVNQAFTTTTRAGGAIIRQPIPPFKWWRG
Mb3085|M.bovis_AF2122/97 LDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRG
Rv3059|M.tuberculosis_H37Rv LDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRG
MMAR_1634|M.marinum_M LDIASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRG
MUL_3402|M.ulcerans_Agy99 LDIASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRG
MAB_3423|M.abscessus_ATCC_1997 LDVASVVFMGNEPHAQHERLEKVNKAFVATTRAGGAIFRFGLPPFKWWQG
MLBr_02088|M.leprae_Br4923 AVICRLLGVPYEDAPEFGRVS-----ALLVQSVDPFITITGEPPEATEER
. : : .: : . . : * .
Mflv_1527|M.gilvum_PYR-GCK LRARERLERYFAAQIP-DRRAGTGADLFSMMCRSRSEDGDSFSDADIVNH
MSMEG_1167|M.smegmatis_MC2_155 LRARRRLERYFAGQLP-ARRSGEGTDLFSMLCRSRSDEGERFSDTDIVNH
TH_2954|M.thermoresistible__bu LQARKVLEDYFVQRVK-ERRDSGGTDMLSVLCHATDEDGNTFTDEDIVNH
Mvan_2031|M.vanbaalenii_PYR-1 IKARKTLEDYFSSRIG-EKRRSESTDMFSVLCHSADEDGQSFTDDQIVSH
MAV_3927|M.avium_104 LRARQLLEDYFSERVK-ERRNATGNDMLTVLCHTEDDDGNSFTDDDIVNH
Mb3085|M.bovis_AF2122/97 LRARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVNH
Rv3059|M.tuberculosis_H37Rv LRARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVNH
MMAR_1634|M.marinum_M IRARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNH
MUL_3402|M.ulcerans_Agy99 IRARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNH
MAB_3423|M.abscessus_ATCC_1997 LQGRKLLEEYFAERVGIARQKTEGADMLTALCHAETDEGDAFTDTDIVNH
MLBr_02088|M.leprae_Br4923 LRAGVWLRDYLEQLVK-CRRGTPGEDLISRLIELD-ESGDQLTEEEIIAT
::. *. *: : :: . *::: : . :.*: ::: :*:
Mflv_1527|M.gilvum_PYR-GCK MIFLLMAAHDTSAIAISMLVYELGRNLRWQDALRDEADAG-DG-LGLADL
MSMEG_1167|M.smegmatis_MC2_155 MIFLLMAAHDTSAIAISMLVYELGRNLRWQNTLRDEALSGPQGEITMEDL
TH_2954|M.thermoresistible__bu MIFLMMAAHDTSTSTMTTMAYYLAANQDWQQRCRDESDRLGDGPLDIEAL
Mvan_2031|M.vanbaalenii_PYR-1 MIFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEAL
MAV_3927|M.avium_104 MIFLMMAAHDTSTSTTTTMVYNMAAHPEWQERAREESTRLGDGPLDIEAL
Mb3085|M.bovis_AF2122/97 MIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESL
Rv3059|M.tuberculosis_H37Rv MIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESL
MMAR_1634|M.marinum_M MIFLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEAL
MUL_3402|M.ulcerans_Agy99 MIFLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEAL
MAB_3423|M.abscessus_ATCC_1997 MIFLMMAAHDTTTSTTTTMAYYLAANPEWQERVRDESDRLGDGPLDIDSL
MLBr_02088|M.leprae_Br4923 CGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSN--------------
:*::*.*:*:. : . : : . .:
Mflv_1527|M.gilvum_PYR-GCK DGAYPLLDAAFKEILRMYAPAGTLFRQTVTDTEVCGHYIPRRTQVAINVY
MSMEG_1167|M.smegmatis_MC2_155 DSAYPLLDAAFKESLRMYAPAGTLFRQTLTATAVAGHFIPRKTQVAIGVY
TH_2954|M.thermoresistible__bu E-KLESLDLVMNESLRLVTPLPFNVRQTVRDTDLLGYYIPAGTNVVTWPG
Mvan_2031|M.vanbaalenii_PYR-1 E-KLETYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPS
MAV_3927|M.avium_104 E-KLETLELIMNESLRMVTPLPFNMRQAVRDTELLGHYIPAGTNITIWPG
Mb3085|M.bovis_AF2122/97 E-QLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPG
Rv3059|M.tuberculosis_H37Rv E-QLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPG
MMAR_1634|M.marinum_M E-KLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPG
MUL_3402|M.ulcerans_Agy99 E-KLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPG
MAB_3423|M.abscessus_ATCC_1997 E-KLESLDLVMNEALRLVTPLPFNIRSTVRDTDLLGFHIPAGTMINIWPG
MLBr_02088|M.leprae_Br4923 ---PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLA
.:* :* .. * : : :. :
Mflv_1527|M.gilvum_PYR-GCK ASLRLADWWPDPDRFDPGRFLGGGDAAAVHRYAFAPFGGGVHKCIGQQFA
MSMEG_1167|M.smegmatis_MC2_155 ASMRLADWWPEPDEFDPARFLTGSDATAVQRYAFAPFGGGAHKCIGQQFA
TH_2954|M.thermoresistible__bu MNHRLPELWTEPEKFDPERFAEPRSEHKRHRYAFAPFGGGAHKCIGMVFG
Mvan_2031|M.vanbaalenii_PYR-1 INHRLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFG
MAV_3927|M.avium_104 MNHRLPELWTDPDKFDPERFAEPRAEHKKHRYAFAPFGGGAHKCIGMVFG
Mb3085|M.bovis_AF2122/97 MNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFG
Rv3059|M.tuberculosis_H37Rv MNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFD
MMAR_1634|M.marinum_M MNHRLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFG
MUL_3402|M.ulcerans_Agy99 MNHRLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFG
MAB_3423|M.abscessus_ATCC_1997 MNHRLPELWTEPDKFDPDRFSEPRNEHKRHRYAFSPFGGGAHKCIGMVFG
MLBr_02088|M.leprae_Br4923 AANRDPAVYSRPDEFDPDRPSS----------RHLAFAVGSHFCLGAALA
* . :. * *** * . .*. * * *:* :
Mflv_1527|M.gilvum_PYR-GCK DMNVKLVMHQLLRQFRWRVA-PGYRPLMTWGTGPTPADGLPISLQRLSGG
MSMEG_1167|M.smegmatis_MC2_155 NMNVKAIMLHLLRHFRWHVP-AGYQPRMTWGTGPTPADGLPITLERLSA-
TH_2954|M.thermoresistible__bu QLEIKTVMHRLLREYRLELPRPGYTPRYDYGGMPIPMDGMPIVLRRLR--
Mvan_2031|M.vanbaalenii_PYR-1 QLEIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLRPLH--
MAV_3927|M.avium_104 QLEVKTVVHRLLRRYRLELARPGYQPRWDYGGMPIPMDGMPIVLRPL---
Mb3085|M.bovis_AF2122/97 QLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR---
Rv3059|M.tuberculosis_H37Rv QLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR---
MMAR_1634|M.marinum_M QLEIKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL---
MUL_3402|M.ulcerans_Agy99 QLEIKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL---
MAB_3423|M.abscessus_ATCC_1997 QLEIKAVMHRLLRRYRFELAHPHYQPKWDYAGMPLPIDGMPIILRPLH--
MLBr_02088|M.leprae_Br4923 RLEATVTLSAIS--ARFPQVQLAGELVYKPNVAMRGMSALPVQV------
:: . : : * ..:*: :