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M. marinum M MMAR_1634 (cyp136A2)

annotation: cytochrome P450 136A2 Cyp136A2
coordinates: 1972493 - 1973971
length: 492

ATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPPPGSDLKPVVGDAGLPILGHLIE
MLRGGPDYLMFLYRTKGPVVFGDSPVLPAVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLLD
FEEHMFHRRIMQEAFVRSRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLTLDIASMVFMGHEPG
TDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRGIRARQLLENYFAARVTERRGQEGNDLLTVLCHTA
DEDGNRFSDQDIVNHMIFLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEKLES
LDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEFWTDPMTFDPDRFAEPRNE
HKRHRYAFTPFGGGAHKCLGMVFGQLEIKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRP
L*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_1634cyp136A2-100% (492)cytochrome P450 136A2 Cyp136A2
M. marinum MMMAR_3135cyp136B2e-11445.96% (446) cytochrome P450 136B2 Cyp136B2
M. marinum MMMAR_0283cyp274A15e-3428.14% (430) cytochrome P450 274A1 Cyp274A1

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3085cyp1360.086.76% (491) cytochrome P450 136
M. gilvum PYR-GCKMflv_4315-0.068.50% (492) cytochrome P450
M. tuberculosis H37RvRv3059cyp1360.086.56% (491) cytochrome P450 136
M. leprae Br4923MLBr_02088-5e-1322.89% (332) putative cytochrome p450
M. abscessus ATCC 19977MAB_3423-0.066.33% (493) cytochrome P450
M. avium 104MAV_3927-0.074.34% (491) cytochrome p450
M. smegmatis MC2 155MSMEG_2289-0.067.76% (490) cytochrome p450
M. thermoresistible (build 8)TH_2954-0.073.58% (492) PUTATIVE cytochrome P450
M. ulcerans Agy99MUL_3402cyp136A20.099.39% (492) cytochrome P450 136A2 Cyp136A2
M. vanbaalenii PYR-1Mvan_2031-0.068.16% (490) cytochrome P450

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_1634|M.marinum_M               MA-TISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPP
MUL_3402|M.ulcerans_Agy99           MA-TISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPP
Mb3085|M.bovis_AF2122/97            MA-TIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPP
Rv3059|M.tuberculosis_H37Rv         MA-TIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPP
MSMEG_2289|M.smegmatis_MC2_155      MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLKRKQWDQFVFSTPP
Mvan_2031|M.vanbaalenii_PYR-1       MP-SISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPP
Mflv_4315|M.gilvum_PYR-GCK          MT-AISTPEYLLDQAKRRLKPTPVTIPGMGAIEKRLLEKQWDEIILAEPP
TH_2954|M.thermoresistible__bu      MA-TINTRDYLLDQAKRRLIPTVNNIPGMGIVEKKLREREWKQFKLADPP
MAV_3927|M.avium_104                MTATISTPQYLLDQARRRFTPTLNTIPGMGAIEKRLLAHEWQTKVLAEPP
MAB_3423|M.abscessus_ATCC_1997      MA-TISSTDYLIDQAKRRL-PTMNTLPGMGYIENYLNNREWPMTELAAPP
MLBr_02088|M.leprae_Br4923          -----MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPG
                                                  .   :         *.     *   .     :  * 

MMAR_1634|M.marinum_M               PGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLP
MUL_3402|M.ulcerans_Agy99           PGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLS
Mb3085|M.bovis_AF2122/97            PGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLP
Rv3059|M.tuberculosis_H37Rv         PGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLP
MSMEG_2289|M.smegmatis_MC2_155      AGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPALS
Mvan_2031|M.vanbaalenii_PYR-1       AGSDLKPILGDAGLPIIGHMIEIFRGGPDFILEIYRKHGPVYFAESPALS
Mflv_4315|M.gilvum_PYR-GCK          AGSGLKAVRGDNGLPIVAHMIEMFRGGPDFILHQYRKYGPVYYSGSQVLP
TH_2954|M.thermoresistible__bu      PGSGLKPVMGDAGLPILGHMIEAFRGGPDYVLEVYRKYGPVHYAYSPALA
MAV_3927|M.avium_104                AGSGLKPVLGDAGLPILGHIIELFRGGPDYALFLYRNHGPLIYLDSPIMP
MAB_3423|M.abscessus_ATCC_1997      PGSGLKPVMGDQGLPMLGHMVEMFRGGIDWVLNMYQERGPVSWTQTPIGK
MLBr_02088|M.leprae_Br4923          TRADPFPVYR----ALIDYGPMQLPGMP---LTVFSSFSDCDEALRHPLS
                                    . :.  .:      .:: :    : *     :  :   .           

MMAR_1634|M.marinum_M               AVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLLDFEEHMFHR
MUL_3402|M.ulcerans_Agy99           AVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLLDFEEHMFHR
Mb3085|M.bovis_AF2122/97            GVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHR
Rv3059|M.tuberculosis_H37Rv         GVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHR
MSMEG_2289|M.smegmatis_MC2_155      SVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMYHR
Mvan_2031|M.vanbaalenii_PYR-1       SVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLLDFDEHMFHR
Mflv_4315|M.gilvum_PYR-GCK          AVGALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLRDFEDHMYHR
TH_2954|M.thermoresistible__bu      SVSALGPDATQEIFSNKNKDYSQKGWHPVIGPFFNRGLMMLDFEEHMYHR
MAV_3927|M.avium_104                AVTALGPDATQAVFSNRNKDYSQKGWHPVIGPFFNRGLMMLDFDEHMYHR
MAB_3423|M.abscessus_ATCC_1997      IVAALGPDATQAVFSNANKDFSQQGWVPVIGPFFNRGLMLLDFQEHREHR
MLBr_02088|M.leprae_Br4923          ASDRLKATLAQQAIAAGAEPR----------PFYASSFMFLDPPDHTRLR
                                        * .  :*   :   :            **:  .:*: *  :*   *

MMAR_1634|M.marinum_M               RIMQEAFVRSRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLTLD
MUL_3402|M.ulcerans_Agy99           RIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLTLD
Mb3085|M.bovis_AF2122/97            RIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLD
Rv3059|M.tuberculosis_H37Rv         RIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLD
MSMEG_2289|M.smegmatis_MC2_155      RIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELTLD
Mvan_2031|M.vanbaalenii_PYR-1       RIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLD
Mflv_4315|M.gilvum_PYR-GCK          RIMQEAFTRSRLTGYVEHIDQVASAVIANDWVADDRRFLFYPAVKELTLD
TH_2954|M.thermoresistible__bu      RIMQEAFTRPRLAGYVEHIDRVASEVVVRDWATDDPRFLFHPSVKKLTLD
MAV_3927|M.avium_104                RIMQEAFTRSRLTGYVEHIDRVATDIVA-DWPTNDARFLFHPAMKELTLD
MAB_3423|M.abscessus_ATCC_1997      LIMQQAFLRSRLAGYVEQIDAVASEIVA-QWPTNDNRFLFYPAIKELTLD
MLBr_02088|M.leprae_Br4923          KLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAG-----QFDVIADLAFP
                                     ::..**    : .   .:  :.   :      .      .  :  *:: 

MMAR_1634|M.marinum_M               IASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRGIR
MUL_3402|M.ulcerans_Agy99           IASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRGIR
Mb3085|M.bovis_AF2122/97            IASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLR
Rv3059|M.tuberculosis_H37Rv         IASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLR
MSMEG_2289|M.smegmatis_MC2_155      IASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRGIQ
Mvan_2031|M.vanbaalenii_PYR-1       IASEVFMGVPAGTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIK
Mflv_4315|M.gilvum_PYR-GCK          IASVVFMGHKAGTDKQLVTTVNEAFTTTTRAGNAIVRKPVPPLSWWRGIR
TH_2954|M.thermoresistible__bu      IASVVFMGHEPGSDKELVTKVNDAFTITTRAGGAIIRTSVPPFKWWRGLQ
MAV_3927|M.avium_104                IASLVFMGHEPGTDHDLVTKVNQAFTTTTRAGGAIIRQPIPPFKWWRGLR
MAB_3423|M.abscessus_ATCC_1997      VASVVFMGNEPHAQHERLEKVNKAFVATTRAGGAIFRFGLPPFKWWQGLQ
MLBr_02088|M.leprae_Br4923          LAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLR
                                    :*  *:      . .      . :   .  ..  :     **    . ::

MMAR_1634|M.marinum_M               ARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHMI
MUL_3402|M.ulcerans_Agy99           ARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHMI
Mb3085|M.bovis_AF2122/97            ARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMI
Rv3059|M.tuberculosis_H37Rv         ARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMI
MSMEG_2289|M.smegmatis_MC2_155      ARKTLEDYFLSRID-EKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHMI
Mvan_2031|M.vanbaalenii_PYR-1       ARKTLEDYFSSRIG-EKRRSESTDMFSVLCHSADEDGQSFTDDQIVSHMI
Mflv_4315|M.gilvum_PYR-GCK          ARKTLEDYFNAGIA-EKRRSESTDMFSVLCHAQDEDGQSFTDQDVVSHMI
TH_2954|M.thermoresistible__bu      ARKVLEDYFVQRVK-ERRDSGGTDMLSVLCHATDEDGNTFTDEDIVNHMI
MAV_3927|M.avium_104                ARQLLEDYFSERVK-ERRNATGNDMLTVLCHTEDDDGNSFTDDDIVNHMI
MAB_3423|M.abscessus_ATCC_1997      GRKLLEEYFAERVGIARQKTEGADMLTALCHAETDEGDAFTDTDIVNHMI
MLBr_02088|M.leprae_Br4923          AGVWLRDYLEQLVK-CRRGTPGEDLISRLIELD-ESGDQLTEEEIIATCG
                                    .   *.:*:   :   ::   . *::: * .   :.*: ::: :::    

MMAR_1634|M.marinum_M               FLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEK
MUL_3402|M.ulcerans_Agy99           FLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEK
Mb3085|M.bovis_AF2122/97            FLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQ
Rv3059|M.tuberculosis_H37Rv         FLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQ
MSMEG_2289|M.smegmatis_MC2_155      FLMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALEK
Mvan_2031|M.vanbaalenii_PYR-1       FLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEK
Mflv_4315|M.gilvum_PYR-GCK          FLMMAAHDTSTSTLTTMAYHLAANPEWQDRCREESERIGDGPLDIEALEK
TH_2954|M.thermoresistible__bu      FLMMAAHDTSTSTMTTMAYYLAANQDWQQRCRDESDRLGDGPLDIEALEK
MAV_3927|M.avium_104                FLMMAAHDTSTSTTTTMVYNMAAHPEWQERAREESTRLGDGPLDIEALEK
MAB_3423|M.abscessus_ATCC_1997      FLMMAAHDTTTSTTTTMAYYLAANPEWQERVRDESDRLGDGPLDIDSLEK
MLBr_02088|M.leprae_Br4923          LLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQRAP-----------
                                    :*::*.*:*:..  :. .  :  : .  .   .:. *             

MMAR_1634|M.marinum_M               LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
MUL_3402|M.ulcerans_Agy99           LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
Mb3085|M.bovis_AF2122/97            LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
Rv3059|M.tuberculosis_H37Rv         LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
MSMEG_2289|M.smegmatis_MC2_155      LETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSINH
Mvan_2031|M.vanbaalenii_PYR-1       LETYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINH
Mflv_4315|M.gilvum_PYR-GCK          LETYDLVINEALRMVTPLPFNFREAVRDTELLGYYIPAGTAIMTWPALNH
TH_2954|M.thermoresistible__bu      LESLDLVMNESLRLVTPLPFNVRQTVRDTDLLGYYIPAGTNVVTWPGMNH
MAV_3927|M.avium_104                LETLELIMNESLRMVTPLPFNMRQAVRDTELLGHYIPAGTNITIWPGMNH
MAB_3423|M.abscessus_ATCC_1997      LESLDLVMNEALRLVTPLPFNIRSTVRDTDLLGFHIPAGTMINIWPGMNH
MLBr_02088|M.leprae_Br4923          -----LVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAAN
                                         *:::*::*  ..:    * : :*  :    :. *  :    .  :

MMAR_1634|M.marinum_M               RLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFGQLE
MUL_3402|M.ulcerans_Agy99           RLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFGQLE
Mb3085|M.bovis_AF2122/97            RLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFGQLE
Rv3059|M.tuberculosis_H37Rv         RLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLE
MSMEG_2289|M.smegmatis_MC2_155      RLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLE
Mvan_2031|M.vanbaalenii_PYR-1       RLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLE
Mflv_4315|M.gilvum_PYR-GCK          RLPELWTDPEKFDPARFAEPRNEHKKHRYAFAPFGGGAHKCIGMVFGQLE
TH_2954|M.thermoresistible__bu      RLPELWTEPEKFDPERFAEPRSEHKRHRYAFAPFGGGAHKCIGMVFGQLE
MAV_3927|M.avium_104                RLPELWTDPDKFDPERFAEPRAEHKKHRYAFAPFGGGAHKCIGMVFGQLE
MAB_3423|M.abscessus_ATCC_1997      RLPELWTEPDKFDPDRFSEPRNEHKRHRYAFSPFGGGAHKCIGMVFGQLE
MLBr_02088|M.leprae_Br4923          RDPAVYSRPDEFDPDRPSS----------RHLAFAVGSHFCLGAALARLE
                                    * * .:: *  *** * :.           . .*. * * *:* .: :**

MMAR_1634|M.marinum_M               IKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL-
MUL_3402|M.ulcerans_Agy99           IKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL-
Mb3085|M.bovis_AF2122/97            IKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR-
Rv3059|M.tuberculosis_H37Rv         IKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR-
MSMEG_2289|M.smegmatis_MC2_155      IKTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR
Mvan_2031|M.vanbaalenii_PYR-1       IKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLRPLH
Mflv_4315|M.gilvum_PYR-GCK          IKTVMHRLLRKYRLEPVSPNYRPRYDHGGMAVPIDGMPIVLRPLH
TH_2954|M.thermoresistible__bu      IKTVMHRLLREYRLELPRPGYTPRYDYGGMPIPMDGMPIVLRRLR
MAV_3927|M.avium_104                VKTVVHRLLRRYRLELARPGYQPRWDYGGMPIPMDGMPIVLRPL-
MAB_3423|M.abscessus_ATCC_1997      IKAVMHRLLRRYRFELAHPHYQPKWDYAGMPLPIDGMPIILRPLH
MLBr_02088|M.leprae_Br4923          ATVTLSAISARFPQVQLAGELVYKPN-----VAMRGMSALPVQV-
                                     .. :  :  .:             :     :.  **. :