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TIPAAEAAADAKVRLQTAVAGITARYPSREHALAAPPPGSGLKPVMGNYGFPILGHVMSTLVEPLAFARE RYERYGPVSWAGGVGFRVALLMGPEALETVWINKDKAFSSTLGWAPVIGPFFHRGIMLLDFEEHRDHRRI MQQAFTRSALNGYLDLMRPGIDRTVRSWPAAQRFPFYTSVKHLLLDQAAEVFIGAELGPEADQLSRDFHD TVCGGQAVIRADVPGGVWSRGLRARRRLERYFAGQLPARRSGEGTDLFSMLCRSRSDEGERFSDTDIVNH MIFLLMAAHDTSAIAISMLVYELGRNLRWQNTLRDEALSGPQGEITMEDLDSAYPLLDAAFKESLRMYAP AGTLFRQTLTATAVAGHFIPRKTQVAIGVYASMRLADWWPEPDEFDPARFLTGSDATAVQRYAFAPFGGG AHKCIGQQFANMNVKAIMLHLLRHFRWHVPAGYQPRMTWGTGPTPADGLPITLERLSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1167 | - | - | 100% (479) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_2289 | - | e-100 | 42.45% (457) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_1009 | - | e-100 | 42.45% (457) | cytochrome p450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3085 | cyp136 | 1e-100 | 42.79% (458) | cytochrome P450 136 |
| M. gilvum PYR-GCK | Mflv_1527 | - | 0.0 | 78.51% (470) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3059 | cyp136 | 1e-99 | 42.79% (458) | cytochrome P450 136 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-07 | 23.71% (329) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3423 | - | 1e-100 | 43.33% (450) | cytochrome P450 |
| M. marinum M | MMAR_3135 | cyp136B2 | 1e-99 | 42.25% (445) | cytochrome P450 136B2 Cyp136B2 |
| M. avium 104 | MAV_3927 | - | 1e-100 | 42.98% (449) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_2954 | - | 1e-104 | 44.93% (454) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 2e-96 | 42.38% (453) | cytochrome P450 136A2 Cyp136A2 |
| M. vanbaalenii PYR-1 | Mvan_2031 | - | 6e-98 | 41.28% (453) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1167|M.smegmatis_MC2_155 -MTIPAAEA---AADAKVRLQTAVAG-------ITARYPSR---EHALAA
Mflv_1527|M.gilvum_PYR-GCK MSALPQSLPGLPAASAKLRFQSAAAS-------VTSRYPSR---VRPLSR
TH_2954|M.thermoresistible__bu --MATINTRDYLLDQAKRRLIPTVNN-IPGMGIVEKKLREREWKQFKLAD
Mvan_2031|M.vanbaalenii_PYR-1 --MPSISTTDYVLDQAKRRLKPTPVT-IPGMGAVEKRLKDKHWDQFVLAE
MAV_3927|M.avium_104 -MTATISTPQYLLDQARRRFTPTLNT-IPGMGAIEKRLLAHEWQTKVLAE
Mb3085|M.bovis_AF2122/97 --MATIHPPAYLLDQAKRRFTPSFNN-FPGMSLVEHMLLNTKFPEKKLAE
Rv3059|M.tuberculosis_H37Rv --MATIHPPAYLLDQAKRRFTPSFNN-FPGMSLVEHMLLNTKFPEKKLAE
MUL_3402|M.ulcerans_Agy99 --MATISTPAYLLDQAQRRLTPSFNN-FPGMGMVERWLLKTQFPETTLAD
MAB_3423|M.abscessus_ATCC_1997 --MATISSTDYLIDQAKRRL-PTMNT-LPGMGYIENYLNNREWPMTELAA
MMAR_3135|M.marinum_M ----MANQLLAITRHPKERLTSVLLAPAPRVVDDKWRQWSRDWRVRELAP
MLBr_02088|M.leprae_Br4923 -MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRAD
. :
MSMEG_1167|M.smegmatis_MC2_155 PPPGSGLKPVMGNYGFPILGHVMSTLVEPLAFARERYERYGPVSWAGGVG
Mflv_1527|M.gilvum_PYR-GCK PPAGSGLKPVLGNYGFPVLGHHLSTFVEPLEFARERYERFGPVSWAGGIG
TH_2954|M.thermoresistible__bu PPPGSGLKPVMGDAGLPILGHMIEAFRGGPDYVLEVYRKYGPVHYAYSPA
Mvan_2031|M.vanbaalenii_PYR-1 PPAGSDLKPILGDAGLPIIGHMIEIFRGGPDFILEIYRKHGPVYFAESPA
MAV_3927|M.avium_104 PPAGSGLKPVLGDAGLPILGHIIELFRGGPDYALFLYRNHGPLIYLDSPI
Mb3085|M.bovis_AF2122/97 PPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAV
Rv3059|M.tuberculosis_H37Rv PPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAV
MUL_3402|M.ulcerans_Agy99 PPPGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPV
MAB_3423|M.abscessus_ATCC_1997 PPPGSGLKPVMGDQGLPMLGHMVEMFRGGIDWVLNMYQERGPVSWTQTPI
MMAR_3135|M.marinum_M APAGSGLRAVLGDAGLPLLGHTVDYIRFGSEFSRERYERLGSVSWMGAFG
MLBr_02088|M.leprae_Br4923 PFP--VYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATL
. . :.::. : : * : : . ..
MSMEG_1167|M.smegmatis_MC2_155 FRVALLMGPEALETVWINKDKAFSSTLGWAPVIGPFFHRGIMLLDFEEHR
Mflv_1527|M.gilvum_PYR-GCK FRVVQLMGPEALETAWINRDKAFSSTRGWAPVIGPFFHRGIMLLDFEEHR
TH_2954|M.thermoresistible__bu LASVSALGPDATQEIFSNKNKDYS-QKGWHPVIGPFFNRGLMMLDFEEHM
Mvan_2031|M.vanbaalenii_PYR-1 LSSVMALGPDATQAVFSNRNKDFS-QRAWDPVIGPFFEGGLMLLDFDEHM
MAV_3927|M.avium_104 MPAVTALGPDATQAVFSNRNKDYS-QKGWHPVIGPFFNRGLMMLDFDEHM
Mb3085|M.bovis_AF2122/97 LPGVAALGPDAAQVIYSNRNKDYS-QQGWVPVIGPFFHRGLMLLDFEEHM
Rv3059|M.tuberculosis_H37Rv LPGVAALGPDAAQVIYSNRNKDYS-QQGWVPVIGPFFHRGLMLLDFEEHM
MUL_3402|M.ulcerans_Agy99 LSAVVALGPDAAQVIYSNRNKDYS-QQGWVPVIGPFFRRGLMLLDFEEHM
MAB_3423|M.abscessus_ATCC_1997 GKIVAALGPDATQAVFSNANKDFS-QQGWVPVIGPFFNRGLMLLDFQEHR
MMAR_3135|M.marinum_M TKMVVIAGPDATREAFTSEAKAFS-QDGWSFLIDAFFHRGLMLMSFDEHL
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEP----------------------RPFYASSFMFLDPPDHT
. *.:. .*: .:*::. :*
MSMEG_1167|M.smegmatis_MC2_155 DHRRIMQQAFTRSALNGYLDLMRPGIDRTVR-SWPAA-QRFPFYTSVKHL
Mflv_1527|M.gilvum_PYR-GCK DHRRIMQQAFTRSALDGYLTLMRPGISRTVT-SWPTA-AGFPFYTAIKKL
TH_2954|M.thermoresistible__bu YHRRIMQEAFTRPRLAGYVEHIDRVASEVVVRDWATDDPRFLFHPSVKKL
Mvan_2031|M.vanbaalenii_PYR-1 FHRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKEL
MAV_3927|M.avium_104 YHRRIMQEAFTRSRLTGYVEHIDRVATDIVA-DWPTNDARFLFHPAMKEL
Mb3085|M.bovis_AF2122/97 FHRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKAL
Rv3059|M.tuberculosis_H37Rv FHRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKAL
MUL_3402|M.ulcerans_Agy99 FHRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKL
MAB_3423|M.abscessus_ATCC_1997 EHRLIMQQAFLRSRLAGYVEQIDAVASEIVA-QWPTNDNRFLFYPAIKEL
MMAR_3135|M.marinum_M MHRRIMQEAFTRPRLTGYVGQVAPCVRAAVP-AWPTG-PSVRIYPLLKNL
MLBr_02088|M.leprae_Br4923 RLRKLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAG-----QFDVIADL
* ::.:** : . : : . . : *
MSMEG_1167|M.smegmatis_MC2_155 LLDQAAEVFIGAELGPEAD---QLSRDFHDTVCGGQAVIRADVPGGVWSR
Mflv_1527|M.gilvum_PYR-GCK LLDQAAEVFVGAVLGAEAD---RLSSDFHDTVCGGQAMIRADVPGGTWAR
TH_2954|M.thermoresistible__bu TLDIASVVFMGHEPGSDKELVTKVNDAFTITTRAGGAIIRTSVPPFKWWR
Mvan_2031|M.vanbaalenii_PYR-1 TLDIASEVFMGVPAGTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWR
MAV_3927|M.avium_104 TLDIASLVFMGHEPGTDHDLVTKVNQAFTTTTRAGGAIIRQPIPPFKWWR
Mb3085|M.bovis_AF2122/97 TLDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWR
Rv3059|M.tuberculosis_H37Rv TLDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWR
MUL_3402|M.ulcerans_Agy99 TLDIASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWR
MAB_3423|M.abscessus_ATCC_1997 TLDVASVVFMGNEPHAQHERLEKVNKAFVATTRAGGAIFRFGLPPFKWWQ
MMAR_3135|M.marinum_M TLDIATDVFMG---GRGKDESAAVNEAFVSTVRAASSFVRVPLPGTRFRA
MLBr_02088|M.leprae_Br4923 AFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEE
: * *: . . *
MSMEG_1167|M.smegmatis_MC2_155 GLRARRRLERYFAGQLP-ARRSGEGTDLFSMLCRSRSDEGERFSDTDIVN
Mflv_1527|M.gilvum_PYR-GCK GLRARERLERYFAAQIP-DRRAGTGADLFSMMCRSRSEDGDSFSDADIVN
TH_2954|M.thermoresistible__bu GLQARKVLEDYFVQRVK-ERRDSGGTDMLSVLCHATDEDGNTFTDEDIVN
Mvan_2031|M.vanbaalenii_PYR-1 GIKARKTLEDYFSSRIG-EKRRSESTDMFSVLCHSADEDGQSFTDDQIVS
MAV_3927|M.avium_104 GLRARQLLEDYFSERVK-ERRNATGNDMLTVLCHTEDDDGNSFTDDDIVN
Mb3085|M.bovis_AF2122/97 GLRARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVN
Rv3059|M.tuberculosis_H37Rv GLRARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVN
MUL_3402|M.ulcerans_Agy99 GIRARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVN
MAB_3423|M.abscessus_ATCC_1997 GLQGRKLLEEYFAERVGIARQKTEGADMLTALCHAETDEGDAFTDTDIVN
MMAR_3135|M.marinum_M GVHGRRVLEDYFSRHLP-AARAGETDDLFAALCQATTEDGERFSDEDVIN
MLBr_02088|M.leprae_Br4923 RLRAGVWLRDYLEQLVK-CRRGTPGEDLISRLIELD-ESGDQLTEEEIIA
::. *. *: : : *::: : . :.*: ::: :::
MSMEG_1167|M.smegmatis_MC2_155 HMIFLLMAAHDTSAIAISMLVYELGRNLRWQNTLRDEALSGPQGEITMED
Mflv_1527|M.gilvum_PYR-GCK HMIFLLMAAHDTSAIAISMLVYELGRNLRWQDALRDEADAG-DG-LGLAD
TH_2954|M.thermoresistible__bu HMIFLMMAAHDTSTSTMTTMAYYLAANQDWQQRCRDESDRLGDGPLDIEA
Mvan_2031|M.vanbaalenii_PYR-1 HMIFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEA
MAV_3927|M.avium_104 HMIFLMMAAHDTSTSTTTTMVYNMAAHPEWQERAREESTRLGDGPLDIEA
Mb3085|M.bovis_AF2122/97 HMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIES
Rv3059|M.tuberculosis_H37Rv HMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIES
MUL_3402|M.ulcerans_Agy99 HMIFLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEA
MAB_3423|M.abscessus_ATCC_1997 HMIFLMMAAHDTTTSTTTTMAYYLAANPEWQERVRDESDRLGDGPLDIDS
MMAR_3135|M.marinum_M HMIFLMMAAHDTSTITTTAVTYFLAKHPEWQEKAAAEARSFGHDSPDIDE
MLBr_02088|M.leprae_Br4923 TCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSN-------------
:*::*.*:*:. : . : : . :
MSMEG_1167|M.smegmatis_MC2_155 LDSAYPLLDAAFKESLRMYAPAGTLFRQTLTATAVAGHFIPRKTQVAIGV
Mflv_1527|M.gilvum_PYR-GCK LDGAYPLLDAAFKEILRMYAPAGTLFRQTVTDTEVCGHYIPRRTQVAINV
TH_2954|M.thermoresistible__bu LE-KLESLDLVMNESLRLVTPLPFNVRQTVRDTDLLGYYIPAGTNVVTWP
Mvan_2031|M.vanbaalenii_PYR-1 LE-KLETYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWP
MAV_3927|M.avium_104 LE-KLETLELIMNESLRMVTPLPFNMRQAVRDTELLGHYIPAGTNITIWP
Mb3085|M.bovis_AF2122/97 LE-QLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYP
Rv3059|M.tuberculosis_H37Rv LE-QLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYP
MUL_3402|M.ulcerans_Agy99 LE-KLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYP
MAB_3423|M.abscessus_ATCC_1997 LE-KLESLDLVMNEALRLVTPLPFNIRSTVRDTDLLGFHIPAGTMINIWP
MMAR_3135|M.marinum_M LE-RMTVLDLILKEALRLLAPVPLVMRKTVRDVAIDGYHIPRETLCAITP
MLBr_02088|M.leprae_Br4923 ----PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLL
.:* :* .. * : : :.
MSMEG_1167|M.smegmatis_MC2_155 YASMRLADWWPEPDEFDPARFLTGSDATAVQRYAFAPFGGGAHKCIGQQF
Mflv_1527|M.gilvum_PYR-GCK YASLRLADWWPDPDRFDPGRFLGGGDAAAVHRYAFAPFGGGVHKCIGQQF
TH_2954|M.thermoresistible__bu GMNHRLPELWTEPEKFDPERFAEPRSEHKRHRYAFAPFGGGAHKCIGMVF
Mvan_2031|M.vanbaalenii_PYR-1 SINHRLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVF
MAV_3927|M.avium_104 GMNHRLPELWTDPDKFDPERFAEPRAEHKKHRYAFAPFGGGAHKCIGMVF
Mb3085|M.bovis_AF2122/97 GMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVF
Rv3059|M.tuberculosis_H37Rv GMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVF
MUL_3402|M.ulcerans_Agy99 GMNHRLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVF
MAB_3423|M.abscessus_ATCC_1997 GMNHRLPELWTEPDKFDPDRFSEPRNEHKRHRYAFSPFGGGAHKCIGMVF
MMAR_3135|M.marinum_M AVNHFDRRIWSDPDRFDPSRFDEPRREDQQHRFAWVPFGGGAHKCIGMQF
MLBr_02088|M.leprae_Br4923 AAANRDPAVYSRPDEFDPDRPSS----------RHLAFAVGSHFCLGAAL
:. * *** * .*. * * *:* :
MSMEG_1167|M.smegmatis_MC2_155 ANMNVKAIMLHLLRHFRWHVPA-GYQPRMTWGTGPTPADGLPITLERLSA
Mflv_1527|M.gilvum_PYR-GCK ADMNVKLVMHQLLRQFRWRVAP-GYRPLMTWGTGPTPADGLPISLQRLSG
TH_2954|M.thermoresistible__bu GQLEIKTVMHRLLREYRLELPRPGYTPRYDYGGMPIPMDGMPIVLRRLR-
Mvan_2031|M.vanbaalenii_PYR-1 GQLEIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLRPLH-
MAV_3927|M.avium_104 GQLEVKTVVHRLLRRYRLELARPGYQPRWDYGGMPIPMDGMPIVLRPL--
Mb3085|M.bovis_AF2122/97 GQLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR--
Rv3059|M.tuberculosis_H37Rv DQLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR--
MUL_3402|M.ulcerans_Agy99 GQLEIKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL--
MAB_3423|M.abscessus_ATCC_1997 GQLEIKAVMHRLLRRYRFELAHPHYQPKWDYAGMPLPIDGMPIILRPLH-
MMAR_3135|M.marinum_M GTLEVKAILHQMLRTYTWTVPN-DYHVRWDNTSLPIPVDGLPVTLRHR--
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAGELVYKPNVAMR--GMSALPVQV-----
:: . : : : ..:*: :
MSMEG_1167|M.smegmatis_MC2_155 -
Mflv_1527|M.gilvum_PYR-GCK G
TH_2954|M.thermoresistible__bu -
Mvan_2031|M.vanbaalenii_PYR-1 -
MAV_3927|M.avium_104 -
Mb3085|M.bovis_AF2122/97 -
Rv3059|M.tuberculosis_H37Rv -
MUL_3402|M.ulcerans_Agy99 -
MAB_3423|M.abscessus_ATCC_1997 -
MMAR_3135|M.marinum_M -
MLBr_02088|M.leprae_Br4923 -