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PSISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPPAGSDLKPILGDAGLPIIGHMIE IFRGGPDFILEIYRKHGPVYFAESPALSSVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLLD FDEHMFHRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLDIASEVFMGVPAG TDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIKARKTLEDYFSSRIGEKRRSESTDMFSVLCHSA DEDGQSFTDDQIVSHMIFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEKLET YDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINHRLPELWTDPEKFDPERFAEPRSE HKKHRYAFAPFGGGAHKCIGMVFGQLEIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLRP LH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2031 | - | - | 100% (493) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5161 | - | 9e-33 | 26.70% (427) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0675 | - | 1e-30 | 25.88% (456) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3085 | cyp136 | 0.0 | 65.38% (491) | cytochrome P450 136 |
| M. gilvum PYR-GCK | Mflv_4315 | - | 0.0 | 82.96% (493) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3059 | cyp136 | 0.0 | 65.17% (491) | cytochrome P450 136 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-14 | 22.94% (327) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3423 | - | 0.0 | 64.37% (494) | cytochrome P450 |
| M. marinum M | MMAR_1634 | cyp136A2 | 0.0 | 68.16% (490) | cytochrome P450 136A2 Cyp136A2 |
| M. avium 104 | MAV_3927 | - | 0.0 | 74.69% (490) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_2289 | - | 0.0 | 88.37% (490) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_2954 | - | 0.0 | 75.00% (492) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 0.0 | 67.96% (490) | cytochrome P450 136A2 Cyp136A2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3085|M.bovis_AF2122/97 MA-TIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPP
Rv3059|M.tuberculosis_H37Rv MA-TIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPP
MMAR_1634|M.marinum_M MA-TISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPP
MUL_3402|M.ulcerans_Agy99 MA-TISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPP
Mvan_2031|M.vanbaalenii_PYR-1 MP-SISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPP
MSMEG_2289|M.smegmatis_MC2_155 MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLKRKQWDQFVFSTPP
Mflv_4315|M.gilvum_PYR-GCK MT-AISTPEYLLDQAKRRLKPTPVTIPGMGAIEKRLLEKQWDEIILAEPP
TH_2954|M.thermoresistible__bu MA-TINTRDYLLDQAKRRLIPTVNNIPGMGIVEKKLREREWKQFKLADPP
MAV_3927|M.avium_104 MTATISTPQYLLDQARRRFTPTLNTIPGMGAIEKRLLAHEWQTKVLAEPP
MAB_3423|M.abscessus_ATCC_1997 MA-TISSTDYLIDQAKRRL-PTMNTLPGMGYIENYLNNREWPMTELAAPP
MLBr_02088|M.leprae_Br4923 -----MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPG
. : *. * . : *
Mb3085|M.bovis_AF2122/97 PGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLP
Rv3059|M.tuberculosis_H37Rv PGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLP
MMAR_1634|M.marinum_M PGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLP
MUL_3402|M.ulcerans_Agy99 PGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLS
Mvan_2031|M.vanbaalenii_PYR-1 AGSDLKPILGDAGLPIIGHMIEIFRGGPDFILEIYRKHGPVYFAESPALS
MSMEG_2289|M.smegmatis_MC2_155 AGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPALS
Mflv_4315|M.gilvum_PYR-GCK AGSGLKAVRGDNGLPIVAHMIEMFRGGPDFILHQYRKYGPVYYSGSQVLP
TH_2954|M.thermoresistible__bu PGSGLKPVMGDAGLPILGHMIEAFRGGPDYVLEVYRKYGPVHYAYSPALA
MAV_3927|M.avium_104 AGSGLKPVLGDAGLPILGHIIELFRGGPDYALFLYRNHGPLIYLDSPIMP
MAB_3423|M.abscessus_ATCC_1997 PGSGLKPVMGDQGLPMLGHMVEMFRGGIDWVLNMYQERGPVSWTQTPIGK
MLBr_02088|M.leprae_Br4923 TRADPFPVYR----ALIDYGPMQLPGMP---LTVFSSFSDCDEALRHPLS
. :. .: .:: : : * : : .
Mb3085|M.bovis_AF2122/97 GVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHR
Rv3059|M.tuberculosis_H37Rv GVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHR
MMAR_1634|M.marinum_M AVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLLDFEEHMFHR
MUL_3402|M.ulcerans_Agy99 AVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLLDFEEHMFHR
Mvan_2031|M.vanbaalenii_PYR-1 SVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLLDFDEHMFHR
MSMEG_2289|M.smegmatis_MC2_155 SVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMYHR
Mflv_4315|M.gilvum_PYR-GCK AVGALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLRDFEDHMYHR
TH_2954|M.thermoresistible__bu SVSALGPDATQEIFSNKNKDYSQKGWHPVIGPFFNRGLMMLDFEEHMYHR
MAV_3927|M.avium_104 AVTALGPDATQAVFSNRNKDYSQKGWHPVIGPFFNRGLMMLDFDEHMYHR
MAB_3423|M.abscessus_ATCC_1997 IVAALGPDATQAVFSNANKDFSQQGWVPVIGPFFNRGLMLLDFQEHREHR
MLBr_02088|M.leprae_Br4923 ASDRLKATLAQQAIAAGAEPR----------PFYASSFMFLDPPDHTRLR
* . :* : : **: .:*: * :* *
Mb3085|M.bovis_AF2122/97 RIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLD
Rv3059|M.tuberculosis_H37Rv RIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLD
MMAR_1634|M.marinum_M RIMQEAFVRSRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLTLD
MUL_3402|M.ulcerans_Agy99 RIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLTLD
Mvan_2031|M.vanbaalenii_PYR-1 RIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLD
MSMEG_2289|M.smegmatis_MC2_155 RIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELTLD
Mflv_4315|M.gilvum_PYR-GCK RIMQEAFTRSRLTGYVEHIDQVASAVIANDWVADDRRFLFYPAVKELTLD
TH_2954|M.thermoresistible__bu RIMQEAFTRPRLAGYVEHIDRVASEVVVRDWATDDPRFLFHPSVKKLTLD
MAV_3927|M.avium_104 RIMQEAFTRSRLTGYVEHIDRVATDIVA-DWPTNDARFLFHPAMKELTLD
MAB_3423|M.abscessus_ATCC_1997 LIMQQAFLRSRLAGYVEQIDAVASEIVA-QWPTNDNRFLFYPAIKELTLD
MLBr_02088|M.leprae_Br4923 KLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAG-----QFDVIADLAFP
::..** : . .: :. : . . : *::
Mb3085|M.bovis_AF2122/97 IASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLR
Rv3059|M.tuberculosis_H37Rv IASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLR
MMAR_1634|M.marinum_M IASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRGIR
MUL_3402|M.ulcerans_Agy99 IASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRGIR
Mvan_2031|M.vanbaalenii_PYR-1 IASEVFMGVPAGTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIK
MSMEG_2289|M.smegmatis_MC2_155 IASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRGIQ
Mflv_4315|M.gilvum_PYR-GCK IASVVFMGHKAGTDKQLVTTVNEAFTTTTRAGNAIVRKPVPPLSWWRGIR
TH_2954|M.thermoresistible__bu IASVVFMGHEPGSDKELVTKVNDAFTITTRAGGAIIRTSVPPFKWWRGLQ
MAV_3927|M.avium_104 IASLVFMGHEPGTDHDLVTKVNQAFTTTTRAGGAIIRQPIPPFKWWRGLR
MAB_3423|M.abscessus_ATCC_1997 VASVVFMGNEPHAQHERLEKVNKAFVATTRAGGAIFRFGLPPFKWWQGLQ
MLBr_02088|M.leprae_Br4923 LAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLR
:* *: . . . : . .. : ** . ::
Mb3085|M.bovis_AF2122/97 ARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMI
Rv3059|M.tuberculosis_H37Rv ARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMI
MMAR_1634|M.marinum_M ARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHMI
MUL_3402|M.ulcerans_Agy99 ARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHMI
Mvan_2031|M.vanbaalenii_PYR-1 ARKTLEDYFSSRIG-EKRRSESTDMFSVLCHSADEDGQSFTDDQIVSHMI
MSMEG_2289|M.smegmatis_MC2_155 ARKTLEDYFLSRID-EKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHMI
Mflv_4315|M.gilvum_PYR-GCK ARKTLEDYFNAGIA-EKRRSESTDMFSVLCHAQDEDGQSFTDQDVVSHMI
TH_2954|M.thermoresistible__bu ARKVLEDYFVQRVK-ERRDSGGTDMLSVLCHATDEDGNTFTDEDIVNHMI
MAV_3927|M.avium_104 ARQLLEDYFSERVK-ERRNATGNDMLTVLCHTEDDDGNSFTDDDIVNHMI
MAB_3423|M.abscessus_ATCC_1997 GRKLLEEYFAERVGIARQKTEGADMLTALCHAETDEGDAFTDTDIVNHMI
MLBr_02088|M.leprae_Br4923 AGVWLRDYLEQLVK-CRRGTPGEDLISRLIELD-ESGDQLTEEEIIATCG
. *.:*: : :: . *::: * . :.*: ::: :::
Mb3085|M.bovis_AF2122/97 FLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQ
Rv3059|M.tuberculosis_H37Rv FLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQ
MMAR_1634|M.marinum_M FLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEK
MUL_3402|M.ulcerans_Agy99 FLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEK
Mvan_2031|M.vanbaalenii_PYR-1 FLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEK
MSMEG_2289|M.smegmatis_MC2_155 FLMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALEK
Mflv_4315|M.gilvum_PYR-GCK FLMMAAHDTSTSTLTTMAYHLAANPEWQDRCREESERIGDGPLDIEALEK
TH_2954|M.thermoresistible__bu FLMMAAHDTSTSTMTTMAYYLAANQDWQQRCRDESDRLGDGPLDIEALEK
MAV_3927|M.avium_104 FLMMAAHDTSTSTTTTMVYNMAAHPEWQERAREESTRLGDGPLDIEALEK
MAB_3423|M.abscessus_ATCC_1997 FLMMAAHDTTTSTTTTMAYYLAANPEWQERVRDESDRLGDGPLDIDSLEK
MLBr_02088|M.leprae_Br4923 LLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQRAP-----------
:*::*.*:*:.. :. . : : . . .:. *
Mb3085|M.bovis_AF2122/97 LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
Rv3059|M.tuberculosis_H37Rv LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
MMAR_1634|M.marinum_M LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
MUL_3402|M.ulcerans_Agy99 LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
Mvan_2031|M.vanbaalenii_PYR-1 LETYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINH
MSMEG_2289|M.smegmatis_MC2_155 LETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSINH
Mflv_4315|M.gilvum_PYR-GCK LETYDLVINEALRMVTPLPFNFREAVRDTELLGYYIPAGTAIMTWPALNH
TH_2954|M.thermoresistible__bu LESLDLVMNESLRLVTPLPFNVRQTVRDTDLLGYYIPAGTNVVTWPGMNH
MAV_3927|M.avium_104 LETLELIMNESLRMVTPLPFNMRQAVRDTELLGHYIPAGTNITIWPGMNH
MAB_3423|M.abscessus_ATCC_1997 LESLDLVMNEALRLVTPLPFNIRSTVRDTDLLGFHIPAGTMINIWPGMNH
MLBr_02088|M.leprae_Br4923 -----LVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAAN
*:::*::* ..: * : :* : :. * : . :
Mb3085|M.bovis_AF2122/97 RLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFGQLE
Rv3059|M.tuberculosis_H37Rv RLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLE
MMAR_1634|M.marinum_M RLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFGQLE
MUL_3402|M.ulcerans_Agy99 RLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFGQLE
Mvan_2031|M.vanbaalenii_PYR-1 RLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLE
MSMEG_2289|M.smegmatis_MC2_155 RLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLE
Mflv_4315|M.gilvum_PYR-GCK RLPELWTDPEKFDPARFAEPRNEHKKHRYAFAPFGGGAHKCIGMVFGQLE
TH_2954|M.thermoresistible__bu RLPELWTEPEKFDPERFAEPRSEHKRHRYAFAPFGGGAHKCIGMVFGQLE
MAV_3927|M.avium_104 RLPELWTDPDKFDPERFAEPRAEHKKHRYAFAPFGGGAHKCIGMVFGQLE
MAB_3423|M.abscessus_ATCC_1997 RLPELWTEPDKFDPDRFSEPRNEHKRHRYAFSPFGGGAHKCIGMVFGQLE
MLBr_02088|M.leprae_Br4923 RDPAVYSRPDEFDPDRPSS----------RHLAFAVGSHFCLGAALARLE
* * .:: * *** * :. . .*. * * *:* .: :**
Mb3085|M.bovis_AF2122/97 IKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR-
Rv3059|M.tuberculosis_H37Rv IKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR-
MMAR_1634|M.marinum_M IKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL-
MUL_3402|M.ulcerans_Agy99 IKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL-
Mvan_2031|M.vanbaalenii_PYR-1 IKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLRPLH
MSMEG_2289|M.smegmatis_MC2_155 IKTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR
Mflv_4315|M.gilvum_PYR-GCK IKTVMHRLLRKYRLEPVSPNYRPRYDHGGMAVPIDGMPIVLRPLH
TH_2954|M.thermoresistible__bu IKTVMHRLLREYRLELPRPGYTPRYDYGGMPIPMDGMPIVLRRLR
MAV_3927|M.avium_104 VKTVVHRLLRRYRLELARPGYQPRWDYGGMPIPMDGMPIVLRPL-
MAB_3423|M.abscessus_ATCC_1997 IKAVMHRLLRRYRFELAHPHYQPKWDYAGMPLPIDGMPIILRPLH
MLBr_02088|M.leprae_Br4923 ATVTLSAISARFPQVQLAGELVYKPN-----VAMRGMSALPVQV-
.. : : .: : :. **. :