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MRIGLTGGGSSVDKIVAQAQQAEADGFAALWYASAVAGDPLVAMAFAGRATSTIELGTAVLQTYPCHPLL QANRVAAAANAMGRPGLTLGLGPSHEPIVRNVLGLNYDHPVRNTREYVQIVTGLLAGADIDLDGTDWTAH SAGRMTALDHPVPVLLSALSPRMLRVATKFTDGVVLWLATATAIAERIAPAVAGGRIVAGLPVAVHDDIR EAREAIAATAGGYERMSNYQNIIRAGGGASAADVGIVGDEAAVTRQLVELIEAGATDVWAQPVAVGADRA QRSASVKRTRALLAALAREG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1261 | - | - | 100% (300) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_2389 | - | 2e-42 | 34.38% (317) | luciferase family protein |
| M. gilvum PYR-GCK | Mflv_2453 | - | 6e-38 | 33.33% (318) | luciferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3550c | - | 4e-09 | 28.09% (178) | coenzyme F420-dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3520c | - | 4e-09 | 28.09% (178) | coenzyme F420-dependent oxidoreductase |
| M. leprae Br4923 | MLBr_00348 | - | 4e-10 | 27.27% (198) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1339 | - | 5e-27 | 27.91% (301) | putative monooxygenase (luciferase-like) |
| M. marinum M | MMAR_4796 | - | 2e-40 | 34.21% (304) | oxidoreductase |
| M. avium 104 | MAV_0923 | - | 2e-44 | 38.17% (317) | hypothetical protein MAV_0923 |
| M. smegmatis MC2 155 | MSMEG_0528 | - | 1e-114 | 67.43% (307) | hypothetical protein MSMEG_0528 |
| M. thermoresistible (build 8) | TH_4355 | - | 2e-42 | 33.33% (318) | PUTATIVE luciferase family protein |
| M. ulcerans Agy99 | MUL_0365 | - | 1e-40 | 34.21% (304) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4198 | - | 8e-44 | 35.94% (320) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1261|M.gilvum_PYR-GCK -------MRIGLTGG--------GSSVDKIVAQAQQAEADGFAALWYASA
MSMEG_0528|M.smegmatis_MC2_155 -------MRIGLSGG--------AANVDDIVRQAQRAEEDGFSSLWYASG
MMAR_4796|M.marinum_M -------MRVGVMIGPERGDS--GRKVGRMLADIDWAETAGLDSAWIPQI
MUL_0365|M.ulcerans_Agy99 -------MRVGVMIGPERGDS--GRKVGRMLADIDWAETAGLDSAWIPQI
TH_4355|M.thermoresistible__bu -------MRVGVMIGAERGDM--ARKVRKFLEDIEWAESAGFDTAWMPQV
MAV_0923|M.avium_104 -------MRIGLMVGSDKERSR-AERLAGLVDDAAAAERGGFTAFWMPQV
Mvan_4198|M.vanbaalenii_PYR-1 -------MRIGLMVGSDRDRPR-PDRLDGVITDGTAAEALGFSSFWFPQV
MAB_1339|M.abscessus_ATCC_1997 -------MKLGVAIGRPLSVQNSTNLVDTFIAHARRVAEAGVRTLWLGQM
Mb3550c|M.bovis_AF2122/97 -MEAG--MKLGLQLG-----YWGAQPPQNHAELVAAAEDAGFDTVFTAEA
Rv3520c|M.tuberculosis_H37Rv -MEAG--MKLGLQLG-----YWGAQPPQNHAELVAAAEDAGFDTVFTAEA
MLBr_00348|M.leprae_Br4923 MVERANAMKLGLQLG-----YWAAQPPGNAAELVAAAEGAGFDAVFTGEA
*::*: * . *. : : .
Mflv_1261|M.gilvum_PYR-GCK VAG-DPLVAMAFAGRATSTIELGTAVLQTYPCHPLLQANRVAAAANAMGR
MSMEG_0528|M.smegmatis_MC2_155 VAG-DPLTAMAIAGRATTSIELGTAVLQTYPCHPLLQANRVAAAANAMGR
MMAR_4796|M.marinum_M PNDFDALVAVTLMGTRSSRIELGTAVVPLQTQHPIALARQALSVHAATGG
MUL_0365|M.ulcerans_Agy99 PNDFDALVAVTLMGTRSSRIELGTAVVPLQTQHPIALARQALSVHAATGG
TH_4355|M.thermoresistible__bu PNDFDALTMVALMATRTDRIELGTAVVPLQAQHPIALARQALSVHAGSGG
MAV_0923|M.avium_104 PGYLDALTAVALIGQATERIEIGTAVVPIQTRHPMALAQQALTTQVACGG
Mvan_4198|M.vanbaalenii_PYR-1 PGYLDAMTALALLGASTTTIELGTAVVPIQTRHPMILAQQGLTTNAACGG
MAB_1339|M.abscessus_ATCC_1997 YHY-DSITMAAVVGQTVPDVTVGVSVIPINPRHPIEVSAAAQTAQAATHG
Mb3550c|M.bovis_AF2122/97 WGS-DAYTPLAWWGSSTQRVRLGTSVIQLSARTPTACAMAALTLDHLSGG
Rv3520c|M.tuberculosis_H37Rv WGS-DAYTPLAWWGSSTQRVRLGTSVIQLSARTPTACAMAALTLDHLSGG
MLBr_00348|M.leprae_Br4923 WGS-DAYTPLAWWGSSTQRVRLGTSVVQLSARTPTACAMAALTLDHLSGG
*. . : . : :*.:*: . * : :
Mflv_1261|M.gilvum_PYR-GCK PGLTLGLGPSHEPIVRNVLGLNYDHPVRNTREYVQIVTGLLAG-ADIDLD
MSMEG_0528|M.smegmatis_MC2_155 PGLTLGLGPSHEPVVRGVLGLSYDRPGTNAEEYLRIVSALLRG-ETVDHD
MMAR_4796|M.marinum_M -RLVLGVGPSHHWIVDDMLGLPYQRPAAYTRDYLEVLAAALANPGPVDVE
MUL_0365|M.ulcerans_Agy99 -RLVLGVGPSHHWIVDDMLGLPYQRPAAYTRDYLEVLAAALANPGPVDVE
TH_4355|M.thermoresistible__bu -RLALGVGPSHHWIIRDMLGIPYERPAAYTRDYLEVLNAAIAGPGPVDVE
MAV_0923|M.avium_104 -RFTLGIGPSHHWIVNGQLGLPYERPARLTRNYLQVLGAAFAGPGSVDVD
Mvan_4198|M.vanbaalenii_PYR-1 -RFTLGLGLSHDWIINGQLGIPYQRPVRELRDHLEVLTAAFDGPGQVDVD
MAB_1339|M.abscessus_ATCC_1997 -RFQLGLGLGAPVIEGPSYGLHVDKPIRRLREYLITLRQLLDAGTADFHG
Mb3550c|M.bovis_AF2122/97 -RHILGLGVSGPQVVEGWYGQRFPKPLARTREYIDIVRQVWARESPVTSA
Rv3520c|M.tuberculosis_H37Rv -RHILGLGVSGPQVVEGWYGQRFPKPLARTREYIDIVRQVWARESPVTSA
MLBr_00348|M.leprae_Br4923 -RHILGLGVSGPQVVEGWYGQPFPKPLSRTREYIDIVRQVWAREAPVVSD
**:* . : * :* .::: :
Mflv_1261|M.gilvum_PYR-GCK GTDWTAHSA------------GRMTALDHPVPVLLSALSPRMLRVATKFT
MSMEG_0528|M.smegmatis_MC2_155 GREWTAHSD------------GRMVAVDHRVPILLSALSPRMLRIAGTFA
MMAR_4796|M.marinum_M NDSFRVHNP------------LDL-AAVAPLPVLVAALGPVMLTLAGERA
MUL_0365|M.ulcerans_Agy99 NDSFRVHNP------------LDL-AAVAPLPVLVAALGPVMLTLAGERA
TH_4355|M.thermoresistible__bu NDSFTVHNP------------TVLGTDDTPMPVLVAALGPVMLQIAGELA
MAV_0923|M.avium_104 NESYCVHSP------------VDVTDSFGVS-ILLSALGPTMLQLAGERA
Mvan_4198|M.vanbaalenii_PYR-1 NDSFRVHSP------------VDVSD-LSPP-VLLAALGPTMLRIAGERT
MAB_1339|M.abscessus_ATCC_1997 QTLTVAPQF------------TTSQPGGENIPVLVAAMAPQALRATGELA
Mb3550c|M.bovis_AF2122/97 GPHYRLPLTGEGTTGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEIC
Rv3520c|M.tuberculosis_H37Rv GPHYRLPLTGEGTTGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEIC
MLBr_00348|M.leprae_Br4923 GQHYPLPLTGAGATGLGKALKPITHPLRADIPIMLGAEGPKNVALAAEIC
:::.* .* : :
Mflv_1261|M.gilvum_PYR-GCK DGVVLWLATATAIAERIAP-----AVAGG----RIVAGLPVAVH--DDIR
MSMEG_0528|M.smegmatis_MC2_155 DGVVLWMASAEAIRSHIVPKLTVAATAAGRPAPRVVAGLPVVVH--DDPV
MMAR_4796|M.marinum_M DGTVLWMADERAVAEHVVPRISKAADNAGRPAPRIVAGIPVCLCGSSEVE
MUL_0365|M.ulcerans_Agy99 DGTVLWMADERAVAEHVVPRISKAADNAGRPVPRIVAGIPVCLCGSSEVE
TH_4355|M.thermoresistible__bu DGTVLWMADERAIGEHIAPRITKAADNAGRPAPRIIAGIPVCLCANSEIE
MAV_0923|M.avium_104 DGTILWMADERAIGEHVVPRITAAAGGAGRPAPRVVAGVPVAVCSNSEID
Mvan_4198|M.vanbaalenii_PYR-1 DGTILWMADERAIAEHVAPRITAAAHAAGRPAPRVVAGVPVAVCAPGDVD
MAB_1339|M.abscessus_ATCC_1997 DGTIPLHAGPRALGQEVVPVISAAAERAGRPRPRVIAGVAVVVT--SEPE
Mb3550c|M.bovis_AF2122/97 DGWLPIFYSPRMAGMYNEWLDEGFARPGAR-----RSREDFEICATAQVV
Rv3520c|M.tuberculosis_H37Rv DGWLPIFYSPRMAGMYNEWLDEGFARPGAR-----RSREDFEICATAQVV
MLBr_00348|M.leprae_Br4923 DGWLPIFFSPRMADMYNEWLDEGFARTGAR-----RSREDFEICASAQIV
** : * .. : . : :
Mflv_1261|M.gilvum_PYR-GCK EAREAIAATAGGYERMSNYQNIIRAGGGASAADVGIVGDEAAVTRQLVEL
MSMEG_0528|M.smegmatis_MC2_155 AARAAVDAASTSYASMTNYRRIIEAGGGSAAGDVAVSGDETAVQTKLREL
MMAR_4796|M.marinum_M VARDRANRILGEAEVSPNYQRLLGYGDAKDVGDICAAGDEDAILARFRRF
MUL_0365|M.ulcerans_Agy99 VARDRANRILGEAEVSPNYQRLLGHGDAKDVGDICAAGDEDAILARFRRF
TH_4355|M.thermoresistible__bu VAKERANRILGEAEVSPNYQRLLERGDARDVGDLCAAGDEEAIMARFRRF
MAV_0923|M.avium_104 DARAYAGEMLGHAEFSPNYVRLLQHGDAEDVGDTMAAGDESAVLRRLRRY
Mvan_4198|M.vanbaalenii_PYR-1 AAQRYASELLGHAHFSPNYVALLEHGDAADVGDTMAAGDESCVLNRLRAY
MAB_1339|M.abscessus_ATCC_1997 RVRALAIEDMAFYENIPSYRKVLDAEGVQHTGELAIIGDEQHVATELQRY
Mb3550c|M.bovis_AF2122/97 ITDDRAAAFAGIKPFLALYMGGMGAEETNFHADVYRRMGYTQVVDEVTKL
Rv3520c|M.tuberculosis_H37Rv ITDDRAAAFAGIKPFLALYMGGMGAEETNFHADVYRRMGYTQVVDEVTKL
MLBr_00348|M.leprae_Br4923 VTEDRAAAFAGIKPFLALYMGGMGAEGTNFHADVYRRMGYAEVVDEVTAL
. . * : .: . : ..
Mflv_1261|M.gilvum_PYR-GCK IEAGATDVWAQPVA------------VGADRAQRSASVKRTRALLAALAR
MSMEG_0528|M.smegmatis_MC2_155 LDAGATDIWAQPVA------------VGTDRAERVASLRRTRALLRELAR
MMAR_4796|M.marinum_M AEAGVTDLSVRLLP------------IGDNREELVASKRRTRDMIATLAT
MUL_0365|M.ulcerans_Agy99 AEAGVTDLSVRLLP------------IGDNREELVASKRRTRDMIATLAT
TH_4355|M.thermoresistible__bu ADAGVTDLSVRLLP------------IGETRDELVASKYRTREVIAQLAA
MAV_0923|M.avium_104 RDAGATDLAARIVP------------LGNDARERAESRRRTHEFLSAVCP
Mvan_4198|M.vanbaalenii_PYR-1 RDAGVTDLAARIVP------------LGDDPASRRRSRERTAEFLASVVS
MAB_1339|M.abscessus_ATCC_1997 FDAGATEVFASHTE------------LGGPQDE-----ARTLALLGELSR
Mb3550c|M.bovis_AF2122/97 FRSGRKDEAAEIIPDELVDDAVIVGDIDHVRKQMAVWEAAGVTMMVVTAG
Rv3520c|M.tuberculosis_H37Rv FRSGRKDEAAEIIPDELVDDAVIVGDIDHVRKQMAVWEAAGVTMMVVTAG
MLBr_00348|M.leprae_Br4923 FRSNQKDKAAEIIPNELVDSTMIVGDVDYVCKQIAAWSAAGVTMMMVSAS
:. .: . :. . .:
Mflv_1261|M.gilvum_PYR-GCK EG----------
MSMEG_0528|M.smegmatis_MC2_155 A-----------
MMAR_4796|M.marinum_M EVR---------
MUL_0365|M.ulcerans_Agy99 EVR---------
TH_4355|M.thermoresistible__bu DLR---------
MAV_0923|M.avium_104 AL----------
Mvan_4198|M.vanbaalenii_PYR-1 EF----------
MAB_1339|M.abscessus_ATCC_1997 GN----------
Mb3550c|M.bovis_AF2122/97 SAEQVRDLAALV
Rv3520c|M.tuberculosis_H37Rv SAEQVRDLAALV
MLBr_00348|M.leprae_Br4923 SVEQVRDLAGLF