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VCDDHGSSTVPHDEPERIRSLREDLGLDAIVDVHTHFMPKRVMDKVWAYFDSAGPLTGRPWPISYRQDEQ TRVAGLREFGVSAFTSLVYPHKPDMAAWLNEWATGFARATPDCLHTATFYPERGAAGYVQRAIDAGARVF KAHIQVGDYSPADPLLGEVWDILEHHRVPTVIHAGSGPAPGRFTGPAPVAEILRSRPHLPLIVAHMGMPE YRDFLDLAHRFDGVYLDTTMAFTDFSERTHPFPQSARADLLALGDKVLFGSDYPNIPYSYQHAVESITRL GLGPEWCRKVLRDNAVRLFAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1007 | - | - | 100% (301) | amidohydrolase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3540c | - | 2e-08 | 32.12% (137) | hypothetical protein Mb3540c |
| M. tuberculosis H37Rv | Rv3510c | - | 2e-08 | 32.12% (137) | hypothetical protein Rv3510c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4667 | - | 1e-108 | 62.63% (289) | putative amidohydrolase |
| M. marinum M | MMAR_4998 | - | 6e-07 | 29.93% (137) | hypothetical protein MMAR_4998 |
| M. avium 104 | MAV_0646 | - | 1e-07 | 33.33% (138) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_0628 | - | 1e-110 | 65.17% (290) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_1451 | - | 1e-109 | 65.37% (283) | amidohydrolase family protein |
| M. ulcerans Agy99 | MUL_4959 | - | 2e-05 | 36.92% (65) | hypothetical protein MUL_4959 |
| M. vanbaalenii PYR-1 | Mvan_0424 | - | 1e-109 | 62.85% (288) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3540c|M.bovis_AF2122/97 --------------------------------MTIDVWMQHP--------
Rv3510c|M.tuberculosis_H37Rv --------------------------------MTIDVWMQHP--------
MMAR_4998|M.marinum_M --------------------------------MTIDAWMQHP--------
MAV_0646|M.avium_104 --------------------------------MTIDVWMQHP--------
MSMEG_0628|M.smegmatis_MC2_155 --------------------MMDE----IAAVRSIWSDLGLPG-----LI
TH_1451|M.thermoresistible__bu -------------------------------VRELWRGLGLPG-----LI
Mvan_0424|M.vanbaalenii_PYR-1 ---------------------MDE----PESARRIWQALELPG-----IV
MAB_4667|M.abscessus_ATCC_1997 ---------------------MSESAFDPAPVRQIWQELGIPG-----IV
Mflv_1007|M.gilvum_PYR-GCK --------------MCDDHGSSTVPHDEPERIRSLREDLGLDA-----IV
MUL_4959|M.ulcerans_Agy99 MKTELGFTFFDCGNHYYEAVDAFTRHIEREYKKRAIQWAQLDGRARLIIG
Mb3540c|M.bovis_AF2122/97 --TQRFLHGDMFASLRR------WTGGSIP-------ETDIPIEATVSSM
Rv3510c|M.tuberculosis_H37Rv --TQRFLHGDMFASLRR------WTGGSIP-------ETDIPIEATVSSM
MMAR_4998|M.marinum_M --TQRFLRSDMLASLRR------WTDSSIP-------EAQIPIEATIASM
MAV_0646|M.avium_104 --TVRFLRSDMLASLRR------WTGGSIP-------DTDIPIEATLASM
MSMEG_0628|M.smegmatis_MC2_155 DVHTHFMPKNVMDKVWQ------YFDSQGP-------LIGREWPITYRAD
TH_1451|M.thermoresistible__bu DVHTHFMPKRVMDKVWR------YFDSAGP-------LVGREWPISYRLA
Mvan_0424|M.vanbaalenii_PYR-1 DVHTHFMPKNVMDKVWR------YFDDAGP-------LVGRPWPITYRSD
MAB_4667|M.abscessus_ATCC_1997 DVHTHFMPKSVMDKVWA------YFDSAGP-------LVGRPWPITYRAD
Mflv_1007|M.gilvum_PYR-GCK DVHTHFMPKRVMDKVWA------YFDSAGP-------LTGRPWPISYRQD
MUL_4959|M.ulcerans_Agy99 GRVNRFIPNPTFDPVGKPGALDEYFRGRNPRGADLNALFGDLEPIRPEYR
:*: : : : . *
Mb3540c|M.bovis_AF2122/97 D-AGGVTLGLLSAWR----------GPNGQDLISNDAVAEWVRLYPNRFA
Rv3510c|M.tuberculosis_H37Rv D-AGGVTLGLLSAWR----------GPNGQDLISNDAVAEWVRLYPNRFA
MMAR_4998|M.marinum_M D-AADVEFGLLSAWR----------GPNGQDLVSNDEVAGWVDLHPQRFA
MAV_0646|M.avium_104 D-AAGVGYGLLSAWR----------GPNGQDLVSNDEVAQWVAAHPNRFA
MSMEG_0628|M.smegmatis_MC2_155 E-QQRLATLREFGVR----------RFSSLVYPHKPDMAAWLNQWAREFA
TH_1451|M.thermoresistible__bu E-TERVEVLRGFGVT----------RFTSLVYPHKPDMAAWLNQWAAEFA
Mvan_0424|M.vanbaalenii_PYR-1 E-NARLHTLRSFGVL----------AFTSLIYAHKPDMAAWLNQWAAGFA
MAB_4667|M.abscessus_ATCC_1997 E-SQRVTTLRDFGVL----------RFTSLVYPHKPQMAAWLNQWAAQFA
Mflv_1007|M.gilvum_PYR-GCK E-QTRVAGLREFGVS----------AFTSLVYPHKPDMAAWLNEWATGFA
MUL_4959|M.ulcerans_Agy99 DRDARLAAMDEQGMQGCIMLPTLGVGMEQALLPDLEATAATFRAFNRWMQ
: : . * . :
Mb3540c|M.bovis_AF2122/97 G-----LAAVDLDR-------PMAAVRELRRRVGEG-----FVGLRVVPW
Rv3510c|M.tuberculosis_H37Rv G-----LAAVDLDR-------PMAAVRELRRRVGEG-----FVGLRVVPW
MMAR_4998|M.marinum_M G-----LAAVDLDR-------PMVAVRELRSRIASG-----FVGLRVVPW
MAV_0646|M.avium_104 G-----LAAVDLDR-------PMEAVRELRCRIADGG----FVGLRVVPW
MSMEG_0628|M.smegmatis_MC2_155 RNTPDCLSTATFYP-------EEQAGRYVAEAIDAG-----TQIFKAHIQ
TH_1451|M.thermoresistible__bu RTTPDCLATATFYP-------EPGVAEYVTRAIDDG-----VRVFKVHVQ
Mvan_0424|M.vanbaalenii_PYR-1 ADTPDCMATATFYP-------EPGAAGYVSAAIESG-----TRVFKAHVQ
MAB_4667|M.abscessus_ATCC_1997 AQTPDCIHTATFFP-------EPGAADYVREAIDAG-----VGVFKVHVQ
Mflv_1007|M.gilvum_PYR-GCK RATPDCLHTATFYP-------ERGAAGYVQRAIDAG-----ARVFKAHIQ
MUL_4959|M.ulcerans_Agy99 EDWGFAYQERIFAAPYITLCIPDNAVRELEWALRHDARFIVMVPGPVTTE
: . : : . .
Mb3540c|M.bovis_AF2122/97 LWGAPPTDRRYYPLFAECVQSAVPFCTQVGHTGPLRPS------------
Rv3510c|M.tuberculosis_H37Rv LWGAPPTDRRYYPLFAECVQSAVPFCTQVGHTGPLRPS------------
MMAR_4998|M.marinum_M LWEAPPTDRRYYPLFAECVESGVPFCTQVGHTGPLRPS------------
MAV_0646|M.avium_104 LWNAPPTDRRYYPLFAACVEAGVPFCTQVGHTGPLRPS------------
MSMEG_0628|M.smegmatis_MC2_155 VGAYDPNDPLLDEVWGMVEDAAVPVVIHCG-SGPAPGE------------
TH_1451|M.thermoresistible__bu VGGYDPTDPLLDDVWGVIEDAGVPVVIHCG-SGPAPGE------------
Mvan_0424|M.vanbaalenii_PYR-1 VGDYDPTDPLLDDVWGLIEDAGTPVVIHCG-SGPAPGR------------
MAB_4667|M.abscessus_ATCC_1997 VGAFSPTDPLLVPVWGLIEDAGVPVVIHCG-SGPAPGE------------
Mflv_1007|M.gilvum_PYR-GCK VGDYSPADPLLGEVWDILEHHRVPTVIHAG-SGPAPGR------------
MUL_4959|M.ulcerans_Agy99 VGMRAPGDPLFDPFWQLANDSGITVCYHSGETYYSKFMPAWGEADYMMSF
: * * .: . . : * :
Mb3540c|M.bovis_AF2122/97 ---------ETGRPIPY------IDQVALDFPELVIVCGHVG----YPWT
Rv3510c|M.tuberculosis_H37Rv ---------ETGRPIPY------IDQVALDFPELVIVCGHVG----YPWT
MMAR_4998|M.marinum_M ---------ETGRPIPY------IDQVALDFPELVIVCGHVG----YPWT
MAV_0646|M.avium_104 ---------ETGRPIPY------IDQVALDFPELVIVCGHVG----YPWT
MSMEG_0628|M.smegmatis_MC2_155 ---------YTG-PER-------VEKLLARHPRLVLIIAHMG----MPEY
TH_1451|M.thermoresistible__bu ---------FTG-PEP-------VRSLLGRHPRLRLIIAHMG----MPEY
Mvan_0424|M.vanbaalenii_PYR-1 ---------YTG-PAP-------IRAVLAEHPRLRLVIAHMG----GPEY
MAB_4667|M.abscessus_ATCC_1997 ---------FTG-PDP-------VTALLKQFPHLRLIVAHMG----MPEY
Mflv_1007|M.gilvum_PYR-GCK ---------FTG-PAP-------VAEILRSRPHLPLIVAHMG----MPEY
MUL_4959|M.ulcerans_Agy99 QALLGFRSLFSGDPLQDTFANHLHKGLFHRFPNLRMACIESGSAWVFHLF
:* * : *.* : . *
Mb3540c|M.bovis_AF2122/97 EEMVAVARKHENVYIDT----SAYTIKRLPGKLVRFMKTDTGQ--RKVLF
Rv3510c|M.tuberculosis_H37Rv EEMVAVARKHENVYIDT----SAYTIKRLPGKLVRFMKTDTGQ--RKVLF
MMAR_4998|M.marinum_M EEMVAVARKHENVYIDT----SAYTIKRLPHELIRFMKTGTGR--RKVMF
MAV_0646|M.avium_104 EEMVAVARKHENVYIDT----SAYTIERLPDELVRFIKTGTGQ--RKVLF
MSMEG_0628|M.smegmatis_MC2_155 SEFLDLAERFDGVRLDTTMAFTPFSEAMMPFPPADRARLYDLG--ERILF
TH_1451|M.thermoresistible__bu VDFIDLAERFDGVRLDTTMAFTDFAEKVMPFPADQYPRLAGLG--ERIVF
Mvan_0424|M.vanbaalenii_PYR-1 SEFLDLCRDFEQLHLDTTMAFTGFTEKNMPFPAGEYGRLRDMG--DRILF
MAB_4667|M.abscessus_ATCC_1997 SEFLDLCEQHDEVRLDTTMAFTAFSNEKAPFPESDYPRLVEMG--HKIYF
Mflv_1007|M.gilvum_PYR-GCK RDFLDLAHRFDGVYLDTTMAFTDFSERTHPFPQSARADLLALG--DKVLF
MUL_4959|M.ulcerans_Agy99 EKLAKSYGQIPFIYQEDPRETFKRHVWVSPFYEDELADLLKLLGADRIIM
.: : : * :: :
Mb3540c|M.bovis_AF2122/97 GTNYPMIAH--THALTGLDEL---GLSDEARRDFLHGNAVRVFKLDPRGK
Rv3510c|M.tuberculosis_H37Rv GTNYPMIAH--THALTGLDEL---GLSDEARRDFLHGNAVRVFKLDPRGK
MMAR_4998|M.marinum_M GTNFPMIAH--AHALAGLDEL---GLEDEARRDFLHGNAERVFGLAQRPP
MAV_0646|M.avium_104 GTNYPMITA--EHALAGLDGL---GLSDEARRDFLHGNAERVFRLEAAT-
MSMEG_0628|M.smegmatis_MC2_155 GSDFPNIPYGYADALRHTVDLP--GIDDTWRRNVLHDNAARLFGVASR--
TH_1451|M.thermoresistible__bu GSDFPNIPYPYPHALQVLTELP--GIDDDWLCNVLYRNAAELFRV-----
Mvan_0424|M.vanbaalenii_PYR-1 GSDFPNIPYGYTHAMSVLTELP--CVDDTWLRNVFHDNAVRLFGATGSCP
MAB_4667|M.abscessus_ATCC_1997 GSDFPNIPYGYAEAITALRRMP--GIDDAWMRDVLYHNGARLFGVDTSAS
Mflv_1007|M.gilvum_PYR-GCK GSDYPNIPYSYQHAVESITRL---GLGPEWCRKVLRDNAVRLFAL-----
MUL_4959|M.ulcerans_Agy99 GSDYPHVEG-LAEPASYIKDLQNFDYAPDQCRAVMRDNGLELALRRPV--
*:::* : .. : .: *. .:
Mb3540c|M.bovis_AF2122/97 VQT------------
Rv3510c|M.tuberculosis_H37Rv VQT------------
MMAR_4998|M.marinum_M R--------------
MAV_0646|M.avium_104 ---------------
MSMEG_0628|M.smegmatis_MC2_155 ---------------
TH_1451|M.thermoresistible__bu ---------------
Mvan_0424|M.vanbaalenii_PYR-1 GLPSAEPHRVRKAAP
MAB_4667|M.abscessus_ATCC_1997 GR-------------
Mflv_1007|M.gilvum_PYR-GCK ---------------
MUL_4959|M.ulcerans_Agy99 ---------------