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MKTELGFTFFDCGNHYYEAVDAFTRHIEREYKKRAIQWAQLDGRARLIIGGRVNRFIPNPTFDPVGKPGA LDEYFRGRNPRGADLNALFGDLEPIRPEYRDRDARLAAMDEQGMQGCIMLPTLGVGMEQALLPDLEATAA TFRAFNRWMQEDWGFAYQERIFAAPYITLCIPDNAVRELEWALRHDARFIVMVPGPVTTEVGMRAPGDPL FDPFWQLANDSGITVCYHSGETYYSKFMPAWGEADYMMSFQALLGFRSLFSGDPLQDTFANHLHKGLFHR FPNLRMACIESGSAWVFHLFEKLAKSYGQIPFIYQEDPRETFKRHVWVSPFYEDELADLLKLLGADRIIM GSDYPHVEGLAEPASYIKDLQNFDYAPDQCRAVMRDNGLELALRRPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4959 | - | - | 100% (397) | hypothetical protein MUL_4959 |
| M. ulcerans Agy99 | MUL_3878 | - | 3e-84 | 41.28% (390) | metal-dependent hydrolase |
| M. ulcerans Agy99 | MUL_0308 | - | 1e-77 | 38.76% (387) | hypothetical protein MUL_0308 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4350 | - | 3e-84 | 39.64% (391) | amidohydrolase 2 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0299 | - | 2e-07 | 25.25% (305) | putative amidohydrolase (aminocarboxymuconate-semialdehyde |
| M. marinum M | MMAR_0138 | - | 0.0 | 98.99% (397) | hypothetical protein MMAR_0138 |
| M. avium 104 | MAV_1591 | - | 7e-86 | 41.22% (393) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2230 | - | 2e-84 | 40.66% (391) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_4037 | - | 2e-83 | 39.69% (393) | PUTATIVE amidohydrolase 2 |
| M. vanbaalenii PYR-1 | Mvan_1994 | - | 5e-87 | 41.43% (391) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4959|M.ulcerans_Agy99 MKT-------------ELGFTFFDCGNHYYEAVDAFTRHIEREYKKRAIQ
MMAR_0138|M.marinum_M MKT-------------ELGFTFFDCDNHYYEAVDAFTRHIEREYKKRAIQ
Mflv_4350|M.gilvum_PYR-GCK MTIQQEERV----AAQRLDYRAIDVDNHYYEPIDSFTRHLPKEFRSRGVQ
MSMEG_2230|M.smegmatis_MC2_155 MTTDPE----------RLPYLAVDVDNHYYEPLDAFTRHLPKEFRSRGVQ
Mvan_1994|M.vanbaalenii_PYR-1 MTATQQEAQRTAPAPKPLGYRAIDVDNHYYEPIDSFTRYLPKEFSRRGVQ
TH_4037|M.thermoresistible__bu -VIMTE-----------LDYRAIDVDNHYYEPLDAFTRYLPKEFTRRGVQ
MAV_1591|M.avium_104 MT--------------ALNYRVIDVDNHYYEPLDSFTRHLDKKFKRRGVQ
MAB_0299|M.abscessus_ATCC_1997 -----------------MTSVRIDIHAHLWS-------------------
: .* * :.
MUL_4959|M.ulcerans_Agy99 WAQLDGRARLIIGGRVNRFIPNPTFDPVGKPGALDEYFRGRNPRGADLNA
MMAR_0138|M.marinum_M WAQLDGRARLIVGGRVNRFIPNPTFDPVGKPGALDEYFRGRNPRGADLNA
Mflv_4350|M.gilvum_PYR-GCK MLNDGKRTYAVFGGVINHFIPNPTFDPIIEPGCLDLLFRGEIPEGVDPAS
MSMEG_2230|M.smegmatis_MC2_155 MLTDGKRTYAVFGGVVNHFIPNPSFDPIIEPGCLDLLFRGEVPEGVDPAS
Mvan_1994|M.vanbaalenii_PYR-1 MYQDGKRTWAVMGGRVNTFIPNPTFDPIIEPGCLDLLFRGEIPEGVDPAS
TH_4037|M.thermoresistible__bu MLTDGKRTFALMGEKVNHFIPNPTFDPIIEPGCLDLLFRGEIPEGVDPGS
MAV_1591|M.avium_104 MLSDGKRTWAVIGDRVNHFIPNPTFDPIIVPGCLDLLFRGEIPDGVDPAS
MAB_0299|M.abscessus_ATCC_1997 ----------------DEYLS--LLDGYGRP-------ATDVHRGLGAG-
: ::. :* * * .
MUL_4959|M.ulcerans_Agy99 LFG-DLEPIRPEYRDRDARLAAMDEQGMQGCIMLPTLGVGMEQALLPDLE
MMAR_0138|M.marinum_M LFG-DLEPIRPEYRDRDARLAAMDEQGMQGCIMLPTLGVGMEQALLPDLE
Mflv_4350|M.gilvum_PYR-GCK LMKVDRLSEHPEYQNRDARVKILDKQNLETVFMLPTFACGVEEGLKHDIP
MSMEG_2230|M.smegmatis_MC2_155 LMKVDRLTDHPEYQNRDARVAVLDRQRLETVFMLPTFACGVEEGLKHDIG
Mvan_1994|M.vanbaalenii_PYR-1 LMKVDRISDHPEYRNRDARVKILDKQNLETVFMLPTFACGVEEALKHDVE
TH_4037|M.thermoresistible__bu LMKVDRLANHPEYQNRDERVKILDKQNLETVFMLPTFACGVEEGLKHDIE
MAV_1591|M.avium_104 LMKVERLADHPEYQNRDARIAVMDEQDIETAFMLPTFGCGVEEALKHDIE
MAB_0299|M.abscessus_ATCC_1997 ----------ATRDDLDGRFELMDEAGVDLQILTATPASPHFEDQAAAVA
. : * *. :*. :: :: .* . : :
MUL_4959|M.ulcerans_Agy99 ATAATFRAFNRWMQEDWGFAY-QERIFAAPYITLCIPDNAVRELEWALRH
MMAR_0138|M.marinum_M ATAATFRAFNRWMQEDWGFAY-QERIFAAPYITLCIPDNAVRELEWALRH
Mflv_4350|M.gilvum_PYR-GCK ATMASVHAFNLWLDEDWGFNRPDGRILSAPIISLADVQKAVEEVEFVLSR
MSMEG_2230|M.smegmatis_MC2_155 ATMASIHAFNLWLDEDWGFDRPDGRIIAAPIISLADPEKAVGEVEFVLGR
Mvan_1994|M.vanbaalenii_PYR-1 ATMVSVHAFNLWLDEDWGFNRPDHRILAAPIISLADPDKAVEEAEFVLSR
TH_4037|M.thermoresistible__bu ATMVSLHAFNLWLDEDWGFDRPDGRILSAPMISLADPEKAVEEVEFVLNR
MAV_1591|M.avium_104 ATMASVHAFNLWLDEDWGFDRPDHRIIAAPIVSLADPTRAVEEVDFVLAR
MAB_0299|M.abscessus_ATCC_1997 SARFINDEYAKLSSEYP------GRFGALASLPLPHVPAALEELARAIDE
:: : .* *: : . :.* *: * .: .
MUL_4959|M.ulcerans_Agy99 DARFIVMVPGPVTTEVGMRAPGDPLFDPFWQLANDSGITVCYHSGETYYS
MMAR_0138|M.marinum_M GARFIVMVPGPVTTEVGMRAPGDPLFDPFWQLANDSGITVCYHSGETYYS
Mflv_4350|M.gilvum_PYR-GCK GAKIVCVRPAPVPGEVRPRSLGDPVHDPVWARLAEAGVPVVFHLSDSGYT
MSMEG_2230|M.smegmatis_MC2_155 GAKLVCVRPAPVPGLVRPRSLGDPVHDPVWARLAEAGVPVVFHLSDSGYM
Mvan_1994|M.vanbaalenii_PYR-1 GAKVVCVRPAPVPGVVKPRSLGDPVHDPVWARLAEAGVPVVFHLSDSGYM
TH_4037|M.thermoresistible__bu GARIVCVRPAPVPGVVKPRSLGDPVHDPVWARLAEAGVPVIFHLSDSGYL
MAV_1591|M.avium_104 GAKLVLVRPAPVPGLVKPRSLGDRSHDPVWARLAEAGVPVGFHLSDSGYL
MAB_0299|M.abscessus_ATCC_1997 LG----MYGASITTSVLGRSIADPIFDPLYAELNRRRAVLFVHP------
. : ..:. * *: .* .**.: : *
MUL_4959|M.ulcerans_Agy99 KFMPAWGEADYMMSFQALLGFRSLFSGD-PLQDTFANHLHKGLFHRFPNL
MMAR_0138|M.marinum_M KFMPAWGEADYMMSFQALLGFRSLFSGD-PLQDTFANHLHKGLFHRFPNL
Mflv_4350|M.gilvum_PYR-GCK AIPALWGGSGVFKGFGKRDPLDMVIMDDRAIHDTIASMIVHQVFTRHPKL
MSMEG_2230|M.smegmatis_MC2_155 AIPALWGGSGVFKGFGKRDPLDMVIMDDRAIHDTIASMIVHQVFTRHPKL
Mvan_1994|M.vanbaalenii_PYR-1 AIPALWGGKDTFEGFGKRDPLDMVVMDDRAIHDSIASMIVHQVFTRHPTL
TH_4037|M.thermoresistible__bu AISALWGGTGTFEGFGKRDPLDNVLLDDRAIHDTMASMIVHQVFTRHPNL
MAV_1591|M.avium_104 HIAAAWGGKSTFEGFGAKDPLDQVLLDDRAIHDTMASMIVHGVFTRHPKL
MAB_0299|M.abscessus_ATCC_1997 ------AGCGAESSLITDHSLTWSIGAPIEDTVAIMHLIVAGVPSRYPDM
. . .: : . :: : : *.* :
MUL_4959|M.ulcerans_Agy99 RMACIESGSAWVFHLFEKLAKSYGQIPFIYQEDPRETFKRHVWVSP--FY
MMAR_0138|M.marinum_M RMACIESGSAWVFHLFEKLAKSYGQIPFIYQEDPRETFKRHVWVSP--FY
Mflv_4350|M.gilvum_PYR-GCK KVASIENGSYFVYRLIKRLKKSANNAPYHYKEDPVEQLRNNVWIAP--YY
MSMEG_2230|M.smegmatis_MC2_155 KVVSIENGSYFVYRLIKRLKKSANNAPYHYKEDPVEQLKNHVWIAP--YY
Mvan_1994|M.vanbaalenii_PYR-1 KVASIENGSYFVYRLIKRLKKSANNAPYHYKEDPVEQLRNNVWIAP--YY
TH_4037|M.thermoresistible__bu KVASIENGSYFVYRLIKRLKKAANTAPSHFKEDPVEQLKNNVWIAP--YY
MAV_1591|M.avium_104 KAVSIENGSYFVHRLIKRLKKAANTQPQYFPEDPVEQLRNNVWIAP--YY
MAB_0299|M.abscessus_ATCC_1997 KIVTCHLGGALPMVLERAHRQVTEWEATQCPEAPRDAARRLWYDTVGHDH
: . . *. * . : . * * : :. : : :
MUL_4959|M.ulcerans_Agy99 EDELADLLKLLGADRIIMGSDYPHVEGLAEPASYIKDLQNFDYAP-DQCR
MMAR_0138|M.marinum_M EDELADLLKLLGADRIIMGSDYPHVEGLAEPASYIKDLQNFDYTP-DQCR
Mflv_4350|M.gilvum_PYR-GCK EDDVKLLAETIGVDKILFGSDWPHGEGLADPTSFTADIPQFPEFSHEDTR
MSMEG_2230|M.smegmatis_MC2_155 EDDVKLLADTIGVDKILFGSDWPHGEGLADPTSFTADIPQFPEFSHEDTR
Mvan_1994|M.vanbaalenii_PYR-1 EDDVKLLADTIGVDKILFGSDWPHGEGLADPTSFTADIPQFPEFSHEDTR
TH_4037|M.thermoresistible__bu EDDVKLLAETIGVDRILFGSDWPHGEGLADPMTFTADIPQFPEFSHEDTR
MAV_1591|M.avium_104 EDDLPELARVIGVDKILFGSDWPHGEGLASPVSFTAELKGFSES---DIR
MAB_0299|M.abscessus_ATCC_1997 TPALRAAVASLGVDRLIFGSDFPYQAG---PRYVSSATYIEEGLSAEDAS
: :*.*::::***:*: * * :
MUL_4959|M.ulcerans_Agy99 AVMRDNGLELALRRPV------------
MMAR_0138|M.marinum_M AVMRDNGLELALRRPV------------
Mflv_4350|M.gilvum_PYR-GCK KVMRDNALTLVHGA--------------
MSMEG_2230|M.smegmatis_MC2_155 RVMRHNALELLGDPDRTAPGARHLAASV
Mvan_1994|M.vanbaalenii_PYR-1 KVMRDNALTLVGTHVSA-----------
TH_4037|M.thermoresistible__bu KVMRGNALTLLGANVPATA---------
MAV_1591|M.avium_104 KIMRDNALDLLGVQVGSAA---------
MAB_0299|M.abscessus_ATCC_1997 AILDHNGAELLGLTGV------------
:: *. *