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MDEIAAVRSIWSDLGLPGLIDVHTHFMPKNVMDKVWQYFDSQGPLIGREWPITYRADEQQRLATLREFGV RRFSSLVYPHKPDMAAWLNQWAREFARNTPDCLSTATFYPEEQAGRYVAEAIDAGTQIFKAHIQVGAYDP NDPLLDEVWGMVEDAAVPVVIHCGSGPAPGEYTGPERVEKLLARHPRLVLIIAHMGMPEYSEFLDLAERF DGVRLDTTMAFTPFSEAMMPFPPADRARLYDLGERILFGSDFPNIPYGYADALRHTVDLPGIDDTWRRNV LHDNAARLFGVASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0628 | - | - | 100% (295) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2232 | - | 4e-06 | 25.95% (158) | amidohydrolase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3540c | - | 5e-08 | 28.57% (161) | hypothetical protein Mb3540c |
| M. gilvum PYR-GCK | Mflv_1007 | - | 1e-110 | 65.17% (290) | amidohydrolase 2 |
| M. tuberculosis H37Rv | Rv3510c | - | 5e-08 | 28.57% (161) | hypothetical protein Rv3510c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4667 | - | 1e-123 | 69.34% (287) | putative amidohydrolase |
| M. marinum M | MMAR_4998 | - | 3e-10 | 28.57% (161) | hypothetical protein MMAR_4998 |
| M. avium 104 | MAV_0646 | - | 7e-08 | 28.21% (156) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_1451 | - | 1e-126 | 72.98% (285) | amidohydrolase family protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0424 | - | 1e-123 | 68.28% (290) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0628|M.smegmatis_MC2_155 ----------MMDEIAAVRSIWSDLGLPGLIDVHTHFMPKNVMDKVWQYF
TH_1451|M.thermoresistible__bu -----------------VRELWRGLGLPGLIDVHTHFMPKRVMDKVWRYF
Mflv_1007|M.gilvum_PYR-GCK MCDDHGSSTVPHDEPERIRSLREDLGLDAIVDVHTHFMPKRVMDKVWAYF
Mvan_0424|M.vanbaalenii_PYR-1 -----------MDEPESARRIWQALELPGIVDVHTHFMPKNVMDKVWRYF
MAB_4667|M.abscessus_ATCC_1997 -------MSESAFDPAPVRQIWQELGIPGIVDVHTHFMPKSVMDKVWAYF
Mb3540c|M.bovis_AF2122/97 ------------------MTIDVWMQHP-----TQRFLHGDMFASLRRWT
Rv3510c|M.tuberculosis_H37Rv ------------------MTIDVWMQHP-----TQRFLHGDMFASLRRWT
MAV_0646|M.avium_104 ------------------MTIDVWMQHP-----TVRFLRSDMLASLRRWT
MMAR_4998|M.marinum_M ------------------MTIDAWMQHP-----TQRFLRSDMLASLRRWT
: : :*: :: .: :
MSMEG_0628|M.smegmatis_MC2_155 DSQGPLIGREWPITYRADEQQRLATLREFGVRRFSSLVYPHKPDMAAWLN
TH_1451|M.thermoresistible__bu DSAGPLVGREWPISYRLAETERVEVLRGFGVTRFTSLVYPHKPDMAAWLN
Mflv_1007|M.gilvum_PYR-GCK DSAGPLTGRPWPISYRQDEQTRVAGLREFGVSAFTSLVYPHKPDMAAWLN
Mvan_0424|M.vanbaalenii_PYR-1 DDAGPLVGRPWPITYRSDENARLHTLRSFGVLAFTSLIYAHKPDMAAWLN
MAB_4667|M.abscessus_ATCC_1997 DSAGPLVGRPWPITYRADESQRVTTLRDFGVLRFTSLVYPHKPQMAAWLN
Mb3540c|M.bovis_AF2122/97 GGSIPETDIPIEATVSSMDAGGVTLGLLSAWRGPNGQDLISNDAVAEWVR
Rv3510c|M.tuberculosis_H37Rv GGSIPETDIPIEATVSSMDAGGVTLGLLSAWRGPNGQDLISNDAVAEWVR
MAV_0646|M.avium_104 GGSIPDTDIPIEATLASMDAAGVGYGLLSAWRGPNGQDLVSNDEVAQWVA
MMAR_4998|M.marinum_M DSSIPEAQIPIEATIASMDAADVEFGLLSAWRGPNGQDLVSNDEVAGWVD
.. * : : : . .. : :* *:
MSMEG_0628|M.smegmatis_MC2_155 QWAREFARNTPDCLSTATFYPEEQAGRYVAEAIDAG-TQIFKAHIQVGAY
TH_1451|M.thermoresistible__bu QWAAEFARTTPDCLATATFYPEPGVAEYVTRAIDDG-VRVFKVHVQVGGY
Mflv_1007|M.gilvum_PYR-GCK EWATGFARATPDCLHTATFYPERGAAGYVQRAIDAG-ARVFKAHIQVGDY
Mvan_0424|M.vanbaalenii_PYR-1 QWAAGFAADTPDCMATATFYPEPGAAGYVSAAIESG-TRVFKAHVQVGDY
MAB_4667|M.abscessus_ATCC_1997 QWAAQFAAQTPDCIHTATFFPEPGAADYVREAIDAG-VGVFKVHVQVGAF
Mb3540c|M.bovis_AF2122/97 LYPNRFAG-----LAAVDLDRPMAAVRELRRRVGEG-FVGLRVVPWLWGA
Rv3510c|M.tuberculosis_H37Rv LYPNRFAG-----LAAVDLDRPMAAVRELRRRVGEG-FVGLRVVPWLWGA
MAV_0646|M.avium_104 AHPNRFAG-----LAAVDLDRPMEAVRELRCRIADGGFVGLRVVPWLWNA
MMAR_4998|M.marinum_M LHPQRFAG-----LAAVDLDRPMVAVRELRSRIASG-FVGLRVVPWLWEA
. ** : :. : . : : * ::. :
MSMEG_0628|M.smegmatis_MC2_155 DPNDPLLDEVWGMVEDAAVPVVIHCG-SGPAPGEYTG-PER-VEKLLARH
TH_1451|M.thermoresistible__bu DPTDPLLDDVWGVIEDAGVPVVIHCG-SGPAPGEFTG-PEP-VRSLLGRH
Mflv_1007|M.gilvum_PYR-GCK SPADPLLGEVWDILEHHRVPTVIHAG-SGPAPGRFTG-PAP-VAEILRSR
Mvan_0424|M.vanbaalenii_PYR-1 DPTDPLLDDVWGLIEDAGTPVVIHCG-SGPAPGRYTG-PAP-IRAVLAEH
MAB_4667|M.abscessus_ATCC_1997 SPTDPLLVPVWGLIEDAGVPVVIHCG-SGPAPGEFTG-PDP-VTALLKQF
Mb3540c|M.bovis_AF2122/97 PPTDRRYYPLFAECVQSAVPFCTQVGHTGPLRPSETGRPIPYIDQVALDF
Rv3510c|M.tuberculosis_H37Rv PPTDRRYYPLFAECVQSAVPFCTQVGHTGPLRPSETGRPIPYIDQVALDF
MAV_0646|M.avium_104 PPTDRRYYPLFAACVEAGVPFCTQVGHTGPLRPSETGRPIPYIDQVALDF
MMAR_4998|M.marinum_M PPTDRRYYPLFAECVESGVPFCTQVGHTGPLRPSETGRPIPYIDQVALDF
* * :: . .* : * :** ** * : :
MSMEG_0628|M.smegmatis_MC2_155 PRLVLIIAHMGMPEYSEFLDLAERFDGVRLDTTMAFTPFSEAMMPFPPAD
TH_1451|M.thermoresistible__bu PRLRLIIAHMGMPEYVDFIDLAERFDGVRLDTTMAFTDFAEKVMPFPADQ
Mflv_1007|M.gilvum_PYR-GCK PHLPLIVAHMGMPEYRDFLDLAHRFDGVYLDTTMAFTDFSERTHPFPQSA
Mvan_0424|M.vanbaalenii_PYR-1 PRLRLVIAHMGGPEYSEFLDLCRDFEQLHLDTTMAFTGFTEKNMPFPAGE
MAB_4667|M.abscessus_ATCC_1997 PHLRLIVAHMGMPEYSEFLDLCEQHDEVRLDTTMAFTAFSNEKAPFPESD
Mb3540c|M.bovis_AF2122/97 PELVIVCGHVGYPWTEEMVAVARKHENVYIDT----SAYTIKRLPGKLVR
Rv3510c|M.tuberculosis_H37Rv PELVIVCGHVGYPWTEEMVAVARKHENVYIDT----SAYTIKRLPGKLVR
MAV_0646|M.avium_104 PELVIVCGHVGYPWTEEMVAVARKHENVYIDT----SAYTIERLPDELVR
MMAR_4998|M.marinum_M PELVIVCGHVGYPWTEEMVAVARKHENVYIDT----SAYTIKRLPHELIR
*.* :: .*:* * ::: :.. .: : :** : :: *
MSMEG_0628|M.smegmatis_MC2_155 RARLYDLGERILFGSDFPNIPYGYADALRHTVDLPGIDDTWRRNVLHDNA
TH_1451|M.thermoresistible__bu YPRLAGLGERIVFGSDFPNIPYPYPHALQVLTELPGIDDDWLCNVLYRNA
Mflv_1007|M.gilvum_PYR-GCK RADLLALGDKVLFGSDYPNIPYSYQHAVESITRL-GLGPEWCRKVLRDNA
Mvan_0424|M.vanbaalenii_PYR-1 YGRLRDMGDRILFGSDFPNIPYGYTHAMSVLTELPCVDDTWLRNVFHDNA
MAB_4667|M.abscessus_ATCC_1997 YPRLVEMGHKIYFGSDFPNIPYGYAEAITALRRMPGIDDAWMRDVLYHNG
Mb3540c|M.bovis_AF2122/97 FMKTDTGQRKVLFGTNYPMIAH--THALTGLDEL-GLSDEARRDFLHGNA
Rv3510c|M.tuberculosis_H37Rv FMKTDTGQRKVLFGTNYPMIAH--THALTGLDEL-GLSDEARRDFLHGNA
MAV_0646|M.avium_104 FIKTGTGQRKVLFGTNYPMITA--EHALAGLDGL-GLSDEARRDFLHGNA
MMAR_4998|M.marinum_M FMKTGTGRRKVMFGTNFPMIAH--AHALAGLDEL-GLEDEARRDFLHGNA
:: **:::* *. .*: : : ..: *.
MSMEG_0628|M.smegmatis_MC2_155 ARLFGVASR-----------------
TH_1451|M.thermoresistible__bu AELFRV--------------------
Mflv_1007|M.gilvum_PYR-GCK VRLFAL--------------------
Mvan_0424|M.vanbaalenii_PYR-1 VRLFGATGSCPGLPSAEPHRVRKAAP
MAB_4667|M.abscessus_ATCC_1997 ARLFGVDTSASGR-------------
Mb3540c|M.bovis_AF2122/97 VRVFKLDPRGKVQT------------
Rv3510c|M.tuberculosis_H37Rv VRVFKLDPRGKVQT------------
MAV_0646|M.avium_104 ERVFRLEAAT----------------
MMAR_4998|M.marinum_M ERVFGLAQRPPR--------------
.:*