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SRLALSRPALGVLAGWASLSVVLALTTVGPTANWGLLDGGGDLDVYRRGAWHVLSGLPLYDFPVDKKLFY TYTPFSALVFAPLELLPAEPDRHIWLALNLAVLIAVVVQSWRLLGYRVDRALVGVSVLMALGCVFVEPVR TTLFFGQINLILMLLILSDTVGATRSRLAGIGTGLAAGIKLTPLYFVLYFLTLRQRRVAVTAVAVFAATV VVGLILLPRDSLTYWAGTFLRSERIGDRLGHPSNQSLRGMLARLLDDEPPVWLWLALAVLIGVASLTLAV WLHRTGERLLSVTVVGLSSAVVSPFSWTHHWVWVVPLMVWFVHRALTCWRWWLAPAALFVALGAWPFWFR NLADPRIGFYLFPYTHVPEVLLRNAYLWLFAVLLIWLGVRAARSVAGAKAAGEEPVRAEE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0993 | - | - | 100% (411) | hypothetical protein Mflv_0993 |
| M. gilvum PYR-GCK | Mflv_2153 | pimE | 1e-40 | 34.49% (374) | mannosyltransferase |
| M. gilvum PYR-GCK | Mflv_2968 | - | 9e-37 | 31.93% (404) | putative integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2203 | - | 5e-40 | 35.14% (296) | integral membrane protein |
| M. tuberculosis H37Rv | Rv2181 | - | 5e-40 | 35.14% (296) | integral membrane protein |
| M. leprae Br4923 | MLBr_00893 | - | 1e-42 | 33.14% (350) | hypothetical protein MLBr_00893 |
| M. abscessus ATCC 19977 | MAB_0281 | - | 8e-64 | 40.06% (322) | hypothetical protein MAB_0281 |
| M. marinum M | MMAR_3225 | - | 4e-39 | 35.79% (299) | hypothetical protein MMAR_3225 |
| M. avium 104 | MAV_2312 | - | 2e-38 | 34.56% (298) | hypothetical protein MAV_2312 |
| M. smegmatis MC2 155 | MSMEG_5149 | pimE | 2e-43 | 38.44% (333) | mannosyltransferase |
| M. thermoresistible (build 8) | TH_0647 | - | 3e-42 | 36.99% (319) | CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_3536 | - | 1e-38 | 35.79% (299) | hypothetical protein MUL_3536 |
| M. vanbaalenii PYR-1 | Mvan_4550 | pimE | 3e-39 | 31.05% (409) | mannosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2203|M.bovis_AF2122/97 MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIY
Rv2181|M.tuberculosis_H37Rv MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIY
MMAR_3225|M.marinum_M MSTWRSPDVGSRLGRFSVWYLLWLVAAAALGYVVWRLFGHIPYRIDIDIY
MUL_3536|M.ulcerans_Agy99 MSTLRSPDVGSRLGRVSVWYLLWLVAAAALGYVAWRLFGHIPYRIDIDIY
MLBr_00893|M.leprae_Br4923 MSRQQTPEVGNKHRQIGRCCLLWLLAVTALGQVAWQLLGHTPYRIDIDIY
MAV_2312|M.avium_104 ------------------------------------MFGHTPYRIDIDVY
MSMEG_5149|M.smegmatis_MC2_155 ---------------------MLLVVSILARLAWTYLVPNGANFVDLHVY
Mvan_4550|M.vanbaalenii_PYR-1 ---MPARRAARLVAHLSAAAPALLILSIAARLAWTYLVPNGANFVDLHVY
TH_0647|M.thermoresistible__bu -----VSTTVRRSNRLLIAAPVLLVVSIAARLAWAYLLPNGANFVDLHVY
Mflv_0993|M.gilvum_PYR-GCK ---MSRLALSRPALGVLAGWASLSVVLALTTVGPTANWGLLDGGGDLDVY
MAB_0281|M.abscessus_ATCC_1997 -MTVRIMSWRTAGFWLAAGLVAVLLQHWLIPLNAPNSFGLFSNGGDLMTY
*: *
Mb2203|M.bovis_AF2122/97 QMGARAWLDGRPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPA
Rv2181|M.tuberculosis_H37Rv QMGARAWLDGRPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPA
MMAR_3225|M.marinum_M QMGGQAWLDGRPLYSGDVKFHTPIGLDLPFTYPPLSAVVFSPFAWLHMPA
MUL_3536|M.ulcerans_Agy99 QMGGQAWLDGRPLYSGDVKFHTPIGLDLPFTYPPLSAVVFSPFAWLHMPA
MLBr_00893|M.leprae_Br4923 QMGGQAWLDGRPLYSGDVLFHTPIGLNLPFTYPPLAAIAFCPFAWLHMPA
MAV_2312|M.avium_104 QMGARAWMDGRPLYRGDVLFHTPI-VDLPFTYPPLAAIVFCPFAWMHMPT
MSMEG_5149|M.smegmatis_MC2_155 -VGGADALDGPGALYDYVYADQTPDFPLPFTYPPFAAIVFYPLHLLPFGV
Mvan_4550|M.vanbaalenii_PYR-1 -VGGAAELDGPGTLYEYVYADQTPDFPLPFTYPPFAAVVFYPLHLLPFGF
TH_0647|M.thermoresistible__bu -VGGAERVDGPGALYDYVYADQTPDFPLPFTYPPFAALIFYPMHLLPFGV
Mflv_0993|M.gilvum_PYR-GCK RRGAWHVLSG------LPLYDFPVDKKLFYTYTPFSALVFAPLELLPAEP
MAB_0281|M.abscessus_ATCC_1997 RFGGLRVLHR------ELLYATEIPDAGWFTYTPFAAMLFAPLGFVTLGA
*. : :**.*::*: * *: :
Mb2203|M.bovis_AF2122/97 ASVAITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVA
Rv2181|M.tuberculosis_H37Rv ASVAITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVA
MMAR_3225|M.marinum_M ASVAITFLTLVVLIASTVVVLTALDVWPDSEQLPGPAWLRRLWLAVIIVA
MUL_3536|M.ulcerans_Agy99 ASVAITFLTLVVLTASTVVVLTALDVWPNSEQLPGPAWLRRLWLAVIIVA
MLBr_00893|M.leprae_Br4923 ASVAITLTTLMLLIVSTIIVLTRLDVWAMSRAVPGPAWLRRLWLAVIIVS
MAV_2312|M.avium_104 ASVAITALTLVLLVVSTVIVLARLDVWSTSALLPGPAWLRRWWLAVVVAA
MSMEG_5149|M.smegmatis_MC2_155 VAFIWQIGIIAALYGVVRVSQRLMGLQSQ-------------RRVAMLWT
Mvan_4550|M.vanbaalenii_PYR-1 VAFAWQVGIIAALYGVVRLSQRLLSPTAVGS-----------RRVAMLWT
TH_0647|M.thermoresistible__bu LGFLWQLGTIAALYGVVRLSQRLLAGPQD-------------RRVAMLWT
Mflv_0993|M.gilvum_PYR-GCK DRHIWLALNLAVLIAVVVQSWRLLGYRVDRA----------LVGVSVLMA
MAB_0281|M.abscessus_ATCC_1997 AKVIWFLVNLGALFIIIWRCWRVLGFSANAP----------LAIACVGMN
: * : . :
Mb2203|M.bovis_AF2122/97 PATIWLEPISSNFAFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALK
Rv2181|M.tuberculosis_H37Rv PATIWLEPISSNFAFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALK
MMAR_3225|M.marinum_M PASLWLEPISSNFAFGQINAVLMTLVILDCFPRRTPWPRGLLLGLGIALK
MUL_3536|M.ulcerans_Agy99 PASLWLEPISSNFAFGQINAVLMTLVILDCFPRRTPWPRGLLLGLGIALK
MLBr_00893|M.leprae_Br4923 PAAIWLEPISSNFAFGQINVVLMTLVIADCVPRRTPWPRGLMLGLGIALK
MAV_2312|M.avium_104 AATIWLEPISSNFAFGQINVVLMTLVIADCLPRRTPWPRGLLLGLGMALK
MSMEG_5149|M.smegmatis_MC2_155 ALGIWTEPLRSTFDYGQVNVVLVLAVLCAVSTTR-WWLSGLLVGLAAGIK
Mvan_4550|M.vanbaalenii_PYR-1 AVGIWTEPLRSTFDYGQVNVLLVLGVLYAVYTSK-WWLSGLVVGLAAGVK
TH_0647|M.thermoresistible__bu AVGIWTEPLRSTFDYGQINVVLVFAALWAVYSTR-WWLSGLLVGLAAGVK
Mflv_0993|M.gilvum_PYR-GCK LGCVFVEPVRTTLFFGQINLILMLLILSDTVGATRSRLAGIGTGLAAGIK
MAB_0281|M.abscessus_ATCC_1997 LVAWDIQPIHGTLWQGQVNLVLAALIIWDLTRPEGARWRGWSVGLASGVK
:*: .: **:* :* : * **. .:*
Mb2203|M.bovis_AF2122/97 LTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRDSWEYWTHTLH
Rv2181|M.tuberculosis_H37Rv LTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRDSWEYWTHTLH
MMAR_3225|M.marinum_M LTPAVFLLYFLLRRDNRAALTAVASFVVATLAGFALAWRDSWEYWTDTLL
MUL_3536|M.ulcerans_Agy99 LTPAVFLLYFLLRRDNRAALTAVASFVVATLAGFALAWHDSWEYWTDTLL
MLBr_00893|M.leprae_Br4923 LTPAVFLLYFVLRRDNRAALTSWASFAGATLVGFVLAWRDSWEYWTHTVH
MAV_2312|M.avium_104 LTPAVFLLYFLLRRDHRAVLTALASFAGATLLGFVLAYTDSWEYWTHTVH
MSMEG_5149|M.smegmatis_MC2_155 LTPAVAGLYFLGARRWAAVACSAAVFFATVGVSWLVVGAQARRYFTELLG
Mvan_4550|M.vanbaalenii_PYR-1 LTPAVAGLYFVGARRWATVLFSAAVFALTIGVSALIVGDQTRMYFTELLG
TH_0647|M.thermoresistible__bu LTPAITGLYFLGARRWGAAIFSAVVFFATVGLSILVVDQQARYYFTDLLG
Mflv_0993|M.gilvum_PYR-GCK LTPLYFVLYFLTLRQRRVAVTAVAVFAATVVVGLILLPRDSLTYWAGTFL
MAB_0281|M.abscessus_ATCC_1997 LTAVIFVPYLLITRQWRAVAAAAVTAIGTVVLGWIVLPSDSSDYWLGAVR
**. *:: * .. : . : . : :: *: .
Mb2203|M.bovis_AF2122/97 HTDRIGA-AALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAM
Rv2181|M.tuberculosis_H37Rv HTDRIGA-AALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAM
MMAR_3225|M.marinum_M HTDRIGS-AALNTDQNIAGALARLPIGEHASHLMWVLLSLGVLAVTVWAM
MUL_3536|M.ulcerans_Agy99 HTDRIGS-AALNTDQNIAGALARLPIGEHASHLLWVLLSLGVLAVTVWAM
MLBr_00893|M.leprae_Br4923 NTERIGA-AALNTDQNIAGALARLGLGEHERFLLWAAGCLLVLAATAWAM
MAV_2312|M.avium_104 HTDRIGS-ASLNTDQNIAGALARLGLAQQPRSLLWVAASLLVLAVTVWAM
MSMEG_5149|M.smegmatis_MC2_155 DADRIGP-IGTSFNQSWRGGISRILGHDAGFGPLVLIGIGITAVLALLAW
Mvan_4550|M.vanbaalenii_PYR-1 DADRVGP-VGTSFNQSWRGGISRILGHDAGYGALVLVGVAVTAVLALLAW
TH_0647|M.thermoresistible__bu DADRVGP-IGTSFNQSWRGGLSRVLGYDAGYGPLVLTALALTAVLAVLAW
Mflv_0993|M.gilvum_PYR-GCK RSERIGDRLGHPSNQSLRGMLARLLDDEP-PVWLWLALAVLIGVASLTLA
MAB_0281|M.abscessus_ATCC_1997 TTGHIGS-LDHPANSSIGGALANVYTPQPMPTWLWVLLAGGAALLGMAAA
: ::* :.. * ::.: : :
Mb2203|M.bovis_AF2122/97 RRVLRAG----EPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLVIG---
Rv2181|M.tuberculosis_H37Rv RRVLRAG----EPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLVIG---
MMAR_3225|M.marinum_M RRVLRAE----EPSLAVICVALFGLVVSPVSWSHHWVWMLPAVVVTG---
MUL_3536|M.ulcerans_Agy99 RRVLRAE----EPSLAVICVALFGLVVSPVSWSHHWVWMLPAVVVTG---
MLBr_00893|M.leprae_Br4923 LRVLRAG----EPMLAVICVALFGLVVSPVSWSHHWVWMLPAVLVTG---
MAV_2312|M.avium_104 RRVLRAD----EPTLALVCVALFGLVVSPVSWSHHWVWVLPTVLVTG---
MSMEG_5149|M.smegmatis_MC2_155 RAIGGAQ----DRLGGILVVSLFGLVLSPISWTHHWVWLIPLMMWLL---
Mvan_4550|M.vanbaalenii_PYR-1 RAIGGAD----DRLGAIVIVELFGLLLSPISWTHHWVWLIPLMIWLL---
TH_0647|M.thermoresistible__bu RAIGGARGENGDRLGALVIVQLFGLLLSPISWTHHWVWLIPLMIWLI---
Mflv_0993|M.gilvum_PYR-GCK VWLHRTG----ERLLSVTVVGLSSAVVSPFSWTHHWVWVVPLMVWFVHRA
MAB_0281|M.abscessus_ATCC_1997 WRAHRTG----RELLAITVVGMVGCVVSPLAWTHHWVWTVPLMVLLVNQI
: .: * : . ::**.:*:***** :* ::
Mb2203|M.bovis_AF2122/97 -----LLGWRRRNVALAMLS---LAGVVLMRWTPIDLLPQHRETTAVWWR
Rv2181|M.tuberculosis_H37Rv -----LLGWRRRNVALAMLS---LAGVVLMRWTPIDLLPQHRETTAVWWR
MMAR_3225|M.marinum_M -----VLAWRRRNVALAVVT---IAGLALMRWSPIDLLPKHREATAAWWR
MUL_3536|M.ulcerans_Agy99 -----VLAWRRRNVALAVVT---IAGLALMRWSPIDLLPKHREATAAWWR
MLBr_00893|M.leprae_Br4923 -----ILSWRRQNVAVAVIS---AAGVALMRWTPIGLLPQHQETTAVWWR
MAV_2312|M.avium_104 -----VLGWRRRNAALLVLS---VVGVALMRWTPIDLLPKHHEASAVWWR
MSMEG_5149|M.smegmatis_MC2_155 -----HGPLSALRGARILGWGWLALTLLGVPWLLSFAQPTIWEIGRPWYL
Mvan_4550|M.vanbaalenii_PYR-1 -----HGPLRAQLGARVLGWGWLALTLVGVPWLLSFAQPTIWVIPRPWYL
TH_0647|M.thermoresistible__bu -----HGPLRDRVGAKVLGWGWLALTLIGVPWLLSFAQPSIWEIGRPWYL
Mflv_0993|M.gilvum_PYR-GCK LT-----CWRWWLAPAALFVALGAWPFWFRNLADPRIGFYLFPYTH---V
MAB_0281|M.abscessus_ATCC_1997 MTTQGGARWRWAAATTVIAVLVSMWWYWGLYVRAMRLNPDFESYITGWGA
. :
Mb2203|M.bovis_AF2122/97 QLAGMSYVWWALAVIVVAGLTVTARMTPQRSLTRGL-TPAPTAS
Rv2181|M.tuberculosis_H37Rv QLAGMSYVWWALAVIVVAGLTVTARMTPQRSLTRGL-TPAPTAS
MMAR_3225|M.marinum_M QLAGMSYVWWALAVIVVAGLTVTTRMTMQRPAEPGR-TPVPAAR
MUL_3536|M.ulcerans_Agy99 QLAGMSYVWWALAVIVVAGLTVTTRMTMQRPAEPDR-TPAPAAR
MLBr_00893|M.leprae_Br4923 QLAGMSYVWWALAVIVATGLTVTTRVTSQDSATQTLLTPVSTAS
MAV_2312|M.avium_104 QLAGMSYVWWALAVIVAAGVTVTARAASRDAAPQQL-TPVTAIG
MSMEG_5149|M.smegmatis_MC2_155 AWAGLVYIVATLATLGWIAFS----------RKGSG--------
Mvan_4550|M.vanbaalenii_PYR-1 AWAGLVYIVATLATLAWVATRGSRRY-----RAPSA-HPCL---
TH_0647|M.thermoresistible__bu AWAGLCYVVATIATLAWIAGTRPAVTGRSVRRSPLP-VPSPSR-
Mflv_0993|M.gilvum_PYR-GCK PEVLLRNAYLWLFAVLLIWLGVRAARSVAGAKAAGEEPVRAEE-
MAB_0281|M.abscessus_ATCC_1997 VIAHMSRAERVFDTALYPLLFLTVATWVLATKSLRAGTVQE---
. : : .