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ADGTGARRISPGWWAMLLVTGIVAAVVLSLAMFNRTFTPTVPVTLTADRSGLMLEPNSRVKMRGVQIGRV SAVTGGDAPRIQLAIDPDQIRHIPANVEARIQSISLFGAKYVDLVYPPDPSPQRLSAGAVLTSQNTATEV NTVFQNVVQLIKTIDPLKLNAVLSALAEGVRGQGDRIGEAITASNQVLLELNPRTDTVREDFRALKGVSD TYSAAAKDIIDTVAAATTTSATVTTHAQQLDTLLLNVVGLSRSGIDLLGASKDNLVKAVNLLEPTTNLLM KYNPMLTCLFVGAKTTLDTGYADMLGGNGKSLIMDAALLLGDDPYRYPDHRPINAAKGGEGGKPSCGSLP DVAQNFPVRQLIANTGFGTGLDWRPNPGIGFPGYANYFPVTRAVPEPPSIRYPGGPAPGPMPYPGAPPYG APQYGPDGTPLYPGVPVPPPPSAGPTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0652 | - | - | 100% (448) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2101 | - | e-159 | 61.16% (448) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_0711 | - | 8e-58 | 37.40% (361) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3529c | mce4A | 6e-59 | 35.04% (351) | MCE-family protein MCE4A |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-135 | 57.65% (425) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 2e-51 | 31.44% (388) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 5e-57 | 35.01% (337) | MCE-family protein |
| M. marinum M | MMAR_4051 | mce3A_1 | 1e-162 | 62.28% (448) | MCE-family protein Mce3A_1 |
| M. avium 104 | MAV_2532 | - | 1e-152 | 62.44% (410) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-158 | 60.63% (442) | virulence factor |
| M. thermoresistible (build 8) | TH_3624 | - | 1e-168 | 69.90% (412) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-162 | 62.05% (448) | MCE-family protein Mce3A_1 |
| M. vanbaalenii PYR-1 | Mvan_0500 | - | 0.0 | 100.00% (448) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3529c|M.bovis_AF2122/97 ----MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTVS
MAB_4153c|M.abscessus_ATCC_199 ----MSDTSTRR-AVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
Mflv_0652|M.gilvum_PYR-GCK ---MADGTGARRISPGWWAMLLVTGIVAAVVLSLAMFNRTFTPTVPVTLT
Mvan_0500|M.vanbaalenii_PYR-1 ---MADGTGARRISPGWWAMLLVTGIVAAVVLSLAMFNRTFTPTVPVTLT
TH_3624|M.thermoresistible__bu ---MAARRKTPRIASEWFATMLVVALSGAAALCVAAFNQSFTPSVPVTLT
MMAR_4051|M.marinum_M -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MUL_3918|M.ulcerans_Agy99 -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MAV_2532|M.avium_104 ----------------------------------------------MTLT
MSMEG_0346|M.smegmatis_MC2_155 ---MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRSFVPVTLV
Rv1966|M.tuberculosis_H37Rv ---MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLA
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
:*:
Mb3529c|M.bovis_AF2122/97 SPRAGLVMEKGAKVKYRGIQVGKVTDISYS----GNQARLKLAIDSGEMG
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYA----NDQAKLELAVNAKDLR
Mflv_0652|M.gilvum_PYR-GCK ADRSGLMLEPNSRVKMRGVQIGRVSAVTGG----DAPR-IQLAIDPDQIR
Mvan_0500|M.vanbaalenii_PYR-1 ADRSGLMLEPNSRVKMRGVQIGRVSAVTGG----DAPR-IQLAIDPDQIR
TH_3624|M.thermoresistible__bu AERSGLVMEPYAKVKMRGVEVGRVAGVSGG----SGRVGLRLEIDPKQIE
MMAR_4051|M.marinum_M SERSGLVMETNAKVKLRGVQVGRVASIVGGGK-GATPVALTLEIDSDQIR
MUL_3918|M.ulcerans_Agy99 SERSGLVMETNAKVKLRGVQVGRVASIVGGGK-GATPVALTLEIDSDQIR
MAV_2532|M.avium_104 ADRSGLIMEPGAKVKLRGVQVGRVTSIHSG-----DPVTLRLELYPEQLQ
MSMEG_0346|M.smegmatis_MC2_155 SDRSGLVMETGAKVKLNGVEVGRVSEIRGG----ASGVSLQLEIEPDQIR
Rv1966|M.tuberculosis_H37Rv ADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEW-AQNGASLRLEIDPDQIR
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
: *:**::: .:: .*:::*:*: : : * : . :
Mb3529c|M.bovis_AF2122/97 FIPSNATVRIAGNTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
Mflv_0652|M.gilvum_PYR-GCK HIPANVEARIQSISLFGAKYVDLVYPPDPSPQRLSAGAVLTSQNTATEVN
Mvan_0500|M.vanbaalenii_PYR-1 HIPANVEARIQSISLFGAKYVDLVYPPDPSPQRLSAGAVLTSQNTATEVN
TH_3624|M.thermoresistible__bu HIPANVEARIDATSLFGTKFVELVYPRQPSPQRLSAGAVLRSQNVAVEVN
MMAR_4051|M.marinum_M YIPANVQAEIRATTVFGAKFVDLVYPQDPSPQRLKAGQVLMSRNVTSEAN
MUL_3918|M.ulcerans_Agy99 YIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSRNVTSEAN
MAV_2532|M.avium_104 YIPANVTAQITATTAFGGKYVDLQIPESPSPRRLAAGAVVRSRNVTTEVN
MSMEG_0346|M.smegmatis_MC2_155 FIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSRNVSTEVN
Rv1966|M.tuberculosis_H37Rv YIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEIN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
**:*. . * . : ** * *.: * *: * . : : . * *
Mb3529c|M.bovis_AF2122/97 TLFQSLIDLLHKIDPLETNATLSALSEGLRGHGDDLGALLSGLNTLTRQA
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
Mflv_0652|M.gilvum_PYR-GCK TVFQNVVQLIKTIDPLKLNAVLSALAEGVRGQGDRIGEAITASNQVLLEL
Mvan_0500|M.vanbaalenii_PYR-1 TVFQNVVQLIKTIDPLKLNAVLSALAEGVRGQGDRIGEAITASNQVLLEL
TH_3624|M.thermoresistible__bu TVFQNLVDLIAQIEPAKLNAVLSALSEAVRGQGDRIGVATTDADELLLEL
MMAR_4051|M.marinum_M TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MUL_3918|M.ulcerans_Agy99 TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MAV_2532|M.avium_104 TVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATTDLNEVLGAI
MSMEG_0346|M.smegmatis_MC2_155 TVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDANEVLMAI
Rv1966|M.tuberculosis_H37Rv TVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEAL
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
*:*:.: : ::. : * .*:* .:.. * * :* :
Mb3529c|M.bovis_AF2122/97 NPKLPALQEDFRKAAVVANVYADAAGDLNTVFDNLPTINKTIVDQKDNLN
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
Mflv_0652|M.gilvum_PYR-GCK NPRTDTVREDFRALKGVSDTYSAAAKDIIDTVAAATTTSATVTTHAQQLD
Mvan_0500|M.vanbaalenii_PYR-1 NPRTDTVREDFRALKGVSDTYSAAAKDIIDTVAAATTTSATVTTHAQQLD
TH_3624|M.thermoresistible__bu NSRTDTMRETWRSLAGVSDTYAVAAQDLLDTLNAASTTSETVTSHAQQLD
MMAR_4051|M.marinum_M NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITSHSTQLD
MUL_3918|M.ulcerans_Agy99 NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITGHSTQLD
MAV_2532|M.avium_104 NPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALD
MSMEG_0346|M.smegmatis_MC2_155 NPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVTSHRSELD
Rv1966|M.tuberculosis_H37Rv NARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLD
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
*.: : . : :* *: . . *: : *.
Mb3529c|M.bovis_AF2122/97 DTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTSDYSPVFGCLFK
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
Mflv_0652|M.gilvum_PYR-GCK TLLLNVVGLSRSGIDLLGASKDNLVKAVNLLEPTTNLLMKYNPMLTCLFV
Mvan_0500|M.vanbaalenii_PYR-1 TLLLNVVGLSRSGIDLLGASKDNLVKAVNLLEPTTNLLMKYNPMLTCLFV
TH_3624|M.thermoresistible__bu ALLVGLAGFSNSGTKVLSPSKDELVNAINRLEPTTNLLMKYNPGLTCLLL
MMAR_4051|M.marinum_M ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MUL_3918|M.ulcerans_Agy99 ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MAV_2532|M.avium_104 SLLLNVIGLSHSGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLL
MSMEG_0346|M.smegmatis_MC2_155 TLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQPEYTCLLD
Rv1966|M.tuberculosis_H37Rv ALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNPEYTCFLQ
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
*: *:.. . :. : . : .. : *.* * :
Mb3529c|M.bovis_AF2122/97 GIARGVKEFAPLIGV--RKAGLFTSSSFVLGAPSYTYP-ESLPIVNASGG
MAB_4153c|M.abscessus_ATCC_199 AISKALVTFTPLIGG--VRPGLFLTNSFPLGAPVYTYP-DSLPIVNASGG
Mflv_0652|M.gilvum_PYR-GCK GAKTTLDTGYADMLG-GNGKSLIMDAALLLGDDPYRYP-DHRPINAAKGG
Mvan_0500|M.vanbaalenii_PYR-1 GAKTTLDTGYADMLG-GNGKSLIMDAALLLGDDPYRYP-DHRPINAAKGG
TH_3624|M.thermoresistible__bu GAKTALDKGAMDYIG-GNGKSAVLDAALLLGDDPYRYP-DHLPINAAKGG
MMAR_4051|M.marinum_M GAKYLLDHGGYEAPG-GNGRSLVLDAALALGDDPYRFP-DNLPIIGAKGG
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPG-GNGRSLVLDAALALGDDPYRFP-DNLPIIGAKGG
MAV_2532|M.avium_104 GSKYDAEFFGDVAGG-HNGYSVTLDVALLLGDEAYRYP-DNLPINGAKGG
MSMEG_0346|M.smegmatis_MC2_155 GSVSLLQNGHVDAFG-GNGRSAIFDIGLLLGNDPYHYP-DDLPIVGAKGG
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGGADGRTLQLDVALLFGNDPYVYP-DNLPVVAAKGG
MLBr_02589|M.leprae_Br4923 NYHDIEPKVTSFLGG--NGYSINDHVELLSGLGFLLNPTSAISIIGAGVL
: * * . .: *
Mb3529c|M.bovis_AF2122/97 ----PNCRGLPDIPTKQTGGSFYRAPFLVTDNALIP-----------YQP
MAB_4153c|M.abscessus_ATCC_199 ----PNCRGLPNIPTKMQNGSWFRSPFLVTDNAYIP-----------YKP
Mflv_0652|M.gilvum_PYR-GCK EGGKPSCGSLPDVAQNFPVRQLIANTGFGTGLDWRPNPGIGFPGYANYFP
Mvan_0500|M.vanbaalenii_PYR-1 EGGKPSCGSLPDVAQNFPVRQLIANTGFGTGLDWRPNPGIGFPGYANYFP
TH_3624|M.thermoresistible__bu PGGKPGCGSLPDVADNWPVRYLVTNTGFGTGLDVRPNPGIGFPGWANYFP
MMAR_4051|M.marinum_M PGGKPGCGSLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFP
MUL_3918|M.ulcerans_Agy99 PGGKPGCGSLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFP
MAV_2532|M.avium_104 PGGQPGCGSLPDVSKNFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLP
MSMEG_0346|M.smegmatis_MC2_155 PGGKPGCGSLPDVAKNFPVRQLVTNTGWGTGLDIRPNPGIGFPGWANYFP
Rv1966|M.tuberculosis_H37Rv PGGRPGCGPLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFP
MLBr_02589|M.leprae_Br4923 SQGLLAPLGLAGVVNGAANPYIYPENLPRVNARGGPGGAPG-----CWQH
*. . * :
Mb3529c|M.bovis_AF2122/97 FTELQVDAPSTLQFLFNGAFAERDDF------------------------
MAB_4153c|M.abscessus_ATCC_199 LEELQVNAPDTLQYLYNGAFAKRSEF------------------------
Mflv_0652|M.gilvum_PYR-GCK VTRAVPEPPSIR-YPGGPAPGPMPYPGAPPYGAPQYGPDGTPLYPGVPVP
Mvan_0500|M.vanbaalenii_PYR-1 VTRAVPEPPSIR-YPGGPAPGPMPYPGAPPYGAPQYGPDGTPLYPGVPVP
TH_3624|M.thermoresistible__bu VTRAVPEPPSIR-YPGGPAPGPVTSPGTP--------------------P
MMAR_4051|M.marinum_M VTRGTPEPPSIRNLFGGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPA
MUL_3918|M.ulcerans_Agy99 VTRGTPEPPSIRNLFGGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPA
MAV_2532|M.avium_104 VTRGTPQPPSLR-HPGGTAPGPMPYPGAPPYGAPQYAPDGTPLYPGLPPA
MSMEG_0346|M.smegmatis_MC2_155 VTRGIPQPPIIRNLGGGPAPGPIPYPGAPPYGADLYADDGTPLWPGLPPA
Rv1966|M.tuberculosis_H37Rv VTRAVPEPPSIRQCIPGPAIGPNPAAGEQP--------------------
MLBr_02589|M.leprae_Br4923 ITRDLWPTPELVMDTGNSIAPYNHLDSGSPYAIEYVWGRQVGDNTINP--
. . .* .
Mb3529c|M.bovis_AF2122/97 --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0652|M.gilvum_PYR-GCK PPPS------AGPTP-----------------------------------
Mvan_0500|M.vanbaalenii_PYR-1 PPPS------AGPTP-----------------------------------
TH_3624|M.thermoresistible__bu PP------------------------------------------------
MMAR_4051|M.marinum_M PPPG--APRESGPTP-GSEPFVVPAPAQAQPTP----LPPAPLP-QEVAP
MUL_3918|M.ulcerans_Agy99 PPPG--APRESGPTP-GSEPFVVPASAQAQPTP----LPPAPLP-QEVAP
MAV_2532|M.avium_104 PPPG--RPRDAGPPPAGSEPFTPPVPGAIQPTCGVLNQVCEPLPPPPNVP
MSMEG_0346|M.smegmatis_MC2_155 PPPSDQPPPDPNNPPPGAEPFVPPAPAAMTPTQ-----------------
Rv1966|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02589|M.leprae_Br4923 --------------------------------------------------
Mb3529c|M.bovis_AF2122/97 --
MAB_4153c|M.abscessus_ATCC_199 --
Mflv_0652|M.gilvum_PYR-GCK --
Mvan_0500|M.vanbaalenii_PYR-1 --
TH_3624|M.thermoresistible__bu --
MMAR_4051|M.marinum_M SP
MUL_3918|M.ulcerans_Agy99 SP
MAV_2532|M.avium_104 GP
MSMEG_0346|M.smegmatis_MC2_155 --
Rv1966|M.tuberculosis_H37Rv --
MLBr_02589|M.leprae_Br4923 --