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SANMESLFDGLTILELGHVIAAPFAASLIGDFGAQVIKIEDPGSGDMLRRSGPRKDGVPLWWKSAARNKS SVAVDLRLAEGQALVRKMVERADVVIENFRPGTLERWGLGWEELHAANPRLIMLRISGYGQIGPESAKPG YGRVGEAMSGAVHITGHPDRPPTHFGFSLGDVTTGIMGAFAVAGALFKREAIGDRFDGECIDLALYESLF RGIDWQVILYDQLNFVAERQGNQFQVSPSPVSDTYLSGDGVWYTVATGTVRSVQSLLELLGGTTLRNDPK YATQELQMLHREELGEMVRQWFAENNSDIVEKACASSGVVAARIFTPAEMFSSPTFAARQSLVEVADQEL GPVRVTGVVPRLTNFPGSVRSTGPGLGIHGQEVLTEWLGMADSEYEALVSSGVVGAVDVDGEVPGH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0555 | - | - | 100% (417) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. gilvum PYR-GCK | Mflv_0637 | - | 0.0 | 100.00% (417) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. gilvum PYR-GCK | Mflv_4465 | - | 7e-69 | 36.00% (400) | Formyl-CoA transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1897 | - | 3e-34 | 27.07% (410) | hypothetical protein Mb1897 |
| M. tuberculosis H37Rv | Rv1866 | - | 3e-34 | 27.07% (410) | hypothetical protein Rv1866 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 2e-71 | 37.78% (405) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 5e-71 | 38.00% (400) | hypothetical protein MMAR_1494 |
| M. avium 104 | MAV_0341 | - | 1e-79 | 39.95% (398) | caib/baif family protein |
| M. smegmatis MC2 155 | MSMEG_6294 | - | 2e-72 | 37.44% (398) | caib/baif family protein |
| M. thermoresistible (build 8) | TH_3339 | - | 3e-79 | 39.29% (397) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_2446 | - | 2e-70 | 38.07% (394) | hypothetical protein MUL_2446 |
| M. vanbaalenii PYR-1 | Mvan_0528 | - | 0.0 | 100.00% (417) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0555|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1897|M.bovis_AF2122/97 MVTRLLADLGADVLKVQPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
Rv1866|M.tuberculosis_H37Rv MVTRLLADLGADVLKVEPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
Mflv_0555|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1897|M.bovis_AF2122/97 NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
Rv1866|M.tuberculosis_H37Rv NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
Mflv_0555|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1897|M.bovis_AF2122/97 SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
Rv1866|M.tuberculosis_H37Rv SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
Mflv_0555|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1897|M.bovis_AF2122/97 AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
Rv1866|M.tuberculosis_H37Rv AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
Mflv_0555|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1897|M.bovis_AF2122/97 RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
Rv1866|M.tuberculosis_H37Rv RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
Mflv_0555|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1897|M.bovis_AF2122/97 DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
Rv1866|M.tuberculosis_H37Rv DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
Mflv_0555|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0528|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
MSMEG_6294|M.smegmatis_MC2_155 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1897|M.bovis_AF2122/97 SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
Rv1866|M.tuberculosis_H37Rv SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
Mflv_0555|M.gilvum_PYR-GCK -------------MSAN---MESLFDGLTILELGHVIAAPFAASLIGDFG
Mvan_0528|M.vanbaalenii_PYR-1 -------------MSAN---MESLFDGLTILELGHVIAAPFAASLIGDFG
MAV_0341|M.avium_104 -------------MLD----------GLRVLDLATLAAAPLVATYLGEFG
MSMEG_6294|M.smegmatis_MC2_155 -------------MFDTTSAQPPPLRGVRVVDGATIYAGPMIATLLGDFG
TH_3339|M.thermoresistible__bu --------MTTEVETTATQPTTGPLHGIRVVEMGSLLAGPIVGQMMGDLG
MMAR_1494|M.marinum_M ------------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMG
MUL_2446|M.ulcerans_Agy99 ------------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMG
MAB_4651c|M.abscessus_ATCC_199 --------------------MTGALDGIRVLELGTLIAGPFAGRLLGDMG
Mb1897|M.bovis_AF2122/97 QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
Rv1866|M.tuberculosis_H37Rv QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
*: ::: . : *. . :*::*
Mflv_0555|M.gilvum_PYR-GCK AQVIKIEDPGSGDMLRRSG-PRKDGVPLWWKSAARNKSSVAVDLRLAEGQ
Mvan_0528|M.vanbaalenii_PYR-1 AQVIKIEDPGSGDMLRRSG-PRKDGVPLWWKSAARNKSSVAVDLRLAEGQ
MAV_0341|M.avium_104 ADVIKVEEPRHGDPIRGWG-NQRDGVGLMWKSISRNKKSITLDLRSADGQ
MSMEG_6294|M.smegmatis_MC2_155 ADVIKVEHP-HGDGLRQWE-WRKDGESLWWALVGRNKRDISLSLSDPRGA
TH_3339|M.thermoresistible__bu ADVVKIEDPGKGDPLRQWGQNRPKGQSLWFSIVGRNKRSVTINLREPRGQ
MMAR_1494|M.marinum_M ADVIKVEAPGAPDPLRTWGQAEVDGHHVFWTVHARNKRAITLDLRRPQGR
MUL_2446|M.ulcerans_Agy99 ADVIKVEAPGAPDPLRTWGQAEVDGHHVFWTVHARNKRAITLDLRRPQGR
MAB_4651c|M.abscessus_ATCC_199 AEVLKIEPPGAPDPLRTWGQAEVDGHHVFWTVHARNKKAITLDLRTEAGR
Mb1897|M.bovis_AF2122/97 AEVIKVESADHPDGLRQTR--VGDAMSESFAWTHRNHLALGLDLRNSEGK
Rv1866|M.tuberculosis_H37Rv AEVIKVESADHPDGLRQTR--VGDAMSESFAWTHRNHLALGLDLRNSEGK
*:*:*:* . * :* .. : **: : :.* *
Mflv_0555|M.gilvum_PYR-GCK ALVRKMVERADVVIENFRPGTLERWGLGWEELHAANPRLIMLRISGYGQI
Mvan_0528|M.vanbaalenii_PYR-1 ALVRKMVERADVVIENFRPGTLERWGLGWEELHAANPRLIMLRISGYGQI
MAV_0341|M.avium_104 QLVRRLVEHADVAIFNTRPQTLRKWGLDYESLRAVNERLVMLHITGYGLS
MSMEG_6294|M.smegmatis_MC2_155 DVMRRLLADADVFIENFRPGTLEKWGLDPEDLIAANPKLVVVRVSGFGQT
TH_3339|M.thermoresistible__bu ELVRQLVAEADVLVENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQD
MMAR_1494|M.marinum_M ELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQT
MUL_2446|M.ulcerans_Agy99 ELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQT
MAB_4651c|M.abscessus_ATCC_199 ALFLDLVDKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQT
Mb1897|M.bovis_AF2122/97 AIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNR
Rv1866|M.tuberculosis_H37Rv AIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNR
:. :: :* . * :* *: .:. . * * ::: :.:*
Mflv_0555|M.gilvum_PYR-GCK GPESAKPGYGRVGEAMSGAVHITGHPDRPPTH-------FGFSLGDVTTG
Mvan_0528|M.vanbaalenii_PYR-1 GPESAKPGYGRVGEAMSGAVHITGHPDRPPTH-------FGFSLGDVTTG
MAV_0341|M.avium_104 GPKSERPGFGTLGEAMSGFAHITGQAGAPPTL-------PPFMLADGVAS
MSMEG_6294|M.smegmatis_MC2_155 GPYRSRPGFGTIAEAMSGFADTNGAADGPPVL-------PQWPLADGVAA
TH_3339|M.thermoresistible__bu GPYASRPGYGAIGEAMGGLRYVVGDPSTPPSR-------VGISIGDTLAA
MMAR_1494|M.marinum_M GPDAHKAGYASVAEAASGLRHLNGFPGGPPPR-------LALSLGDSLAG
MUL_2446|M.ulcerans_Agy99 GPDAHKAGYASVAEAASGLRHLNGFPGGPPPR-------LALSLGDSLAG
MAB_4651c|M.abscessus_ATCC_199 GPDAHKAGYASVAEAASGLRHLNGFPGGPPPR-------MALSIGDTLAG
Mb1897|M.bovis_AF2122/97 GPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVG
Rv1866|M.tuberculosis_H37Rv GPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVG
** : *:. : .* * * : * ..
Mflv_0555|M.gilvum_PYR-GCK IMGAFAVAGALFKREAIGDRFDGECIDLALYESLFRGIDWQVILYDQLNF
Mvan_0528|M.vanbaalenii_PYR-1 IMGAFAVAGALFKREAIGDRFDGECIDLALYESLFRGIDWQVILYDQLNF
MAV_0341|M.avium_104 LNAAYAVMMALYHRDVHGG--PGQLIDVNLIDPLARLLEQTLLGYDQLGL
MSMEG_6294|M.smegmatis_MC2_155 LAGAFATMIALRHAEATG---HGQVVDLSIYEPLFWILGAQTSAYDQLGT
TH_3339|M.thermoresistible__bu LFATIGALAALREREISG---RGQMVDSAIYEAVLGVMESLVPEWTVSGY
MMAR_1494|M.marinum_M MFGAQGALAALYRRSVTG---TGQVVDVALTESCLALQESTISDYDVGGV
MUL_2446|M.ulcerans_Agy99 MFGPQGALAALYRRSVTG---TGQVVDVALTESCLALQESTISDYDVGGV
MAB_4651c|M.abscessus_ATCC_199 MFAAQGALAALYRRTVTG---RGQVVDAALTESCLAVQESTIPDYDVGRV
Mb1897|M.bovis_AF2122/97 RVGALLALAALIHRDRTG---GGAHVHISQAEVVVNQLDTMFVAEAARAT
Rv1866|M.tuberculosis_H37Rv RVGALLALAALIHRDRTG---GGAHVHISQAEVVVNQLDTMFVAEAARAT
.. . ** . * * :. :
Mflv_0555|M.gilvum_PYR-GCK VAERQGNQFQVSPSPVSDTYLSGDGVWYTVATGTVRSVQSLLELLGGTTL
Mvan_0528|M.vanbaalenii_PYR-1 VAERQGNQFQVSPSPVSDTYLSGDGVWYTVATGTVRSVQSLLELLGGTTL
MAV_0341|M.avium_104 VPERSGNRWDISAP--RNTYQTADGRWLAMSGSSPALALRVFRAIGRDDL
MSMEG_6294|M.smegmatis_MC2_155 LPTRQGSRTGFNVP--RECYRTRDGRWIALSGATTATAQRIMRAVGRPDL
TH_3339|M.thermoresistible__bu QRERTGAILPKIAP--SNVYPTSDDTWILIAANQDTVFRRLAEAMGRPEL
MMAR_1494|M.marinum_M VRGPSGTRLEGIAP--SNIYRSADESWVVIAANQDTVFTRLCQAMGCPEL
MUL_2446|M.ulcerans_Agy99 VRGPSGTRLKGIAP--SNIYRSADESWVVIAANQDTVFTRLCQAMGCPEL
MAB_4651c|M.abscessus_ATCC_199 VRGPSGTRLEGIAP--SNIYQSADGSWVVIAANQDTVFRRLCEAMGRPEL
Mb1897|M.bovis_AF2122/97 DVAEIHPDTSVHAVY----PCAGDDEWCVISIRSDDEWRRATSVFGQPEL
Rv1866|M.tuberculosis_H37Rv DVAEIHPDTSVHAVY----PCAGDDEWCVISIRSDDEWRRATSVFGQPEL
: * * :: .* *
Mflv_0555|M.gilvum_PYR-GCK RNDPKYATQELQMLHREELGEMVRQWFAENNSDIVEKACASSGVVAARIF
Mvan_0528|M.vanbaalenii_PYR-1 RNDPKYATQELQMLHREELGEMVRQWFAENNSDIVEKACASSGVVAARIF
MAV_0341|M.avium_104 LGDPDFSDPQRRLARAREVDTLVADWVAGKTLSEAMAVFEAHEVAAAPVY
MSMEG_6294|M.smegmatis_MC2_155 ADAEWFSDISGRIEHRETIDEAIASWVGQRDNADVLAMFESVGATAGPVY
TH_3339|M.thermoresistible__bu AEDERYATHVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHNVPVGKIY
MMAR_1494|M.marinum_M ATDDRFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPIN
MUL_2446|M.ulcerans_Agy99 ATDDRFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPIN
MAB_4651c|M.abscessus_ATCC_199 SSDARFANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPIN
Mb1897|M.bovis_AF2122/97 ANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMN
Rv1866|M.tuberculosis_H37Rv ANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAGVAAGPMN
:. : . : : : . . .. :
Mflv_0555|M.gilvum_PYR-GCK TPAEMFSSPTFAARQSLVEVADQELG-PVRVTGVVPRLTNFPGSVRSTGP
Mvan_0528|M.vanbaalenii_PYR-1 TPAEMFSSPTFAARQSLVEVADQELG-PVRVTGVVPRLTNFPGSVRSTGP
MAV_0341|M.avium_104 DISDLVADEQLAHRGVFVSVDDQQLG-PMTVQAPVPRFSSASGTVEHLGP
MSMEG_6294|M.smegmatis_MC2_155 TAADIVADPHFTERGSIVTVDHPTLG-AVRMQGLIAQLSRTPGQIRHPGP
TH_3339|M.thermoresistible__bu RPKEMLADPQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRGSIRWPGP
MMAR_1494|M.marinum_M TVAEVVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGP
MUL_2446|M.ulcerans_Agy99 TVAEVVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGP
MAB_4651c|M.abscessus_ATCC_199 TVADVVQDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGP
Mb1897|M.bovis_AF2122/97 RPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAP
Rv1866|M.tuberculosis_H37Rv RPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPAP
::. . : * : . :. : . : . .*
Mflv_0555|M.gilvum_PYR-GCK G-LGIHGQEVLTEWLGMADSEYEALVSSGVVGAVDVDGEVPGH--
Mvan_0528|M.vanbaalenii_PYR-1 G-LGIHGQEVLTEWLGMADSEYEALVSSGVVGAVDVDGEVPGH--
MAV_0341|M.avium_104 R-LGEHNAEVYGELLGLTPDEIDQLRARGVV--------------
MSMEG_6294|M.smegmatis_MC2_155 A-VGEHNDEILRTELAYPDDVVDALAEAGVIGRTLQPTSTKRVSS
TH_3339|M.thermoresistible__bu G-LGEHTDEVLR-QLGLSDEELQKLHDAGVV--------------
MMAR_1494|M.marinum_M ARPGQHNDDVYIGLLGKSIEELEQLRAEEVL--------------
MUL_2446|M.ulcerans_Agy99 ARPGQHNDDVYIGLLGKSIEELEQLRAVEVL--------------
MAB_4651c|M.abscessus_ATCC_199 ARPGQDNDDVYVGLLGKSAQDIERLRAEGVL--------------
Mb1897|M.bovis_AF2122/97 L-PGQDSVQICRKLLGMTADETERLINERVMFGPAVTA-------
Rv1866|M.tuberculosis_H37Rv L-PGQDSVQICRKLLGMTADETERLINERVMFGPAVTA-------
* . :: *. . . : * *: