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MSRRWLALGVLTLAVLLIGVDGTVLALATPFISADLGATGTELLWIGDIYSFVLAALLVTMGSLGDRVGH RKLLLCGATAFSAVSALTAYSTSPEMLIGTRALLGMAGATLAPATLALIRGLFPDSRERSIAVGIWASAF SAGAALGPVVGGVLLEHFWWGSVFLINIPVMVILLVGGLVLLPEHRDPDPGPWDLPSVALSMVGMLGIVY AIKEGFTGLVHGLGAEVVIAAAVGVAALTLFVRRQLRLPHPLIDVRLFANPRFSGVVGANLFSVLGLSGL VFFLSQYFQLVHGYGPLKAGLAELPAAVTATVFGVLAGVAVRYFSHRSVLTTGLALVGTAMAALMASLLI FRPLTPYLPLGISLFVVGVGLGLAFTVASDVILASVPKERAGAAAAVSETAYELGMALGIAVLGSILTAV YRTVTIPAGVPADAAAQARDSLPKAIDAARGLPDAAQSALLESAKESFTLGLSVSAGVGAALLLTSAVAV WWLLRSPGPAEVGVLPDPGVHHDARGDGGVDTAGGAELGNRHS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0241 | - | - | 100% (533) | major facilitator transporter |
M. gilvum PYR-GCK | Mflv_0642 | - | 1e-59 | 31.21% (439) | EmrB/QacA family drug resistance transporter |
M. gilvum PYR-GCK | Mflv_5055 | - | 1e-57 | 35.36% (509) | major facilitator transporter |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2486 | - | 4e-46 | 29.21% (517) | integral membrane transport protein |
M. tuberculosis H37Rv | Rv2459 | - | 4e-46 | 29.21% (517) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01562 | - | 4e-28 | 26.03% (411) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_2958 | - | 1e-102 | 42.60% (493) | putative transmembrane-transport protein |
M. marinum M | MMAR_1146 | - | 4e-85 | 35.91% (504) | integral membrane transport protein |
M. avium 104 | MAV_1387 | - | 2e-48 | 29.71% (515) | drug transporter |
M. smegmatis MC2 155 | MSMEG_6225 | - | 1e-120 | 48.16% (490) | proton antiporter efflux pump |
M. thermoresistible (build 8) | TH_3412 | - | 7e-99 | 39.56% (503) | PUTATIVE putative major facilitator superfamily MFS_1 |
M. ulcerans Agy99 | MUL_0911 | - | 2e-85 | 35.84% (505) | integral membrane transport protein |
M. vanbaalenii PYR-1 | Mvan_0664 | - | 0.0 | 81.87% (535) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0241|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0664|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6225|M.smegmatis_MC2_155 -------------------------------------MSTCIEGTPSTTR TH_3412|M.thermoresistible__bu -------------------------------------------MTQCAVR MAB_2958|M.abscessus_ATCC_1997 -------------------------------MTSCKSTAPENATAPEGAR MMAR_1146|M.marinum_M --------------------------------------------MRIQPV MUL_0911|M.ulcerans_Agy99 --------------------------------------------MRIQPV Mb2486|M.bovis_AF2122/97 -------------------------------------------------- Rv2459|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1387|M.avium_104 -------------------------------------------------- MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF Mflv_0241|M.gilvum_PYR-GCK -MSRRWLALGVLTLAVLLIGVDGTVLALATPFISADLGATGTELLWIGDI Mvan_0664|M.vanbaalenii_PYR-1 -MTRRWSALAVLTLAVLLIGIDGTVLALATPFISADLGATGTQILWIGDI MSMEG_6225|M.smegmatis_MC2_155 TPTRAWVALAVLALPVLLIAIDNTVLAFALPLIAEDFRPSATTQLWIVDV TH_3412|M.thermoresistible__bu AGAREWAGLGVLAVPTVLLGLDVTVLYLVLPAVAADLAPSPVQTLWIMDA MAB_2958|M.abscessus_ATCC_1997 VGRRTWFGLASLLLPVFLVSMDVSVLFLAMPRLSESLNPSAAEQLWILDV MMAR_1146|M.marinum_M FRDHPIPALAVICLSVFVISVDATIVNVALPTLSRQLGADTAQLQWIVDA MUL_0911|M.ulcerans_Agy99 FRDHPILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA Mb2486|M.bovis_AF2122/97 MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAG Rv2459|M.tuberculosis_H37Rv MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAG MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA .: :* .: .. * : : * Mflv_0241|M.gilvum_PYR-GCK YSFVLAALLVTMGSLGDRVGHRKLLLCGATAFSAVSALTAYSTSPEMLIG Mvan_0664|M.vanbaalenii_PYR-1 YSFVLAALLISMGSLGDRIGHRKLLLCGATAFAVISAVTAYSTSPQMLIL MSMEG_6225|M.smegmatis_MC2_155 YSLVLAALLVAMGSLGDRLGRRRLLLIGGAGFAVVSALAAFAPSAELLVG TH_3412|M.thermoresistible__bu YGFFIAGFLITMGTLGDRIGRRRLLTIGVTAFAGASVLAALAPSAELLIV MAB_2958|M.abscessus_ATCC_1997 YGFLLAGLLITMGNLGDRWGRRRLMLWGATLFAAASVLAAFAPTPLALIG MMAR_1146|M.marinum_M YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLIA MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA Mb2486|M.bovis_AF2122/97 YSLGIAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTV Rv2459|M.tuberculosis_H37Rv YSLGMAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTV MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI * : . .:: . *.* * : * * * : Mflv_0241|M.gilvum_PYR-GCK TRALLGMAGATLAPATLALIRGLFPDSRERSIAVGIWASAFSAGAALGPV Mvan_0664|M.vanbaalenii_PYR-1 TRALLGMAGATLTPATLALIRGLFPDQRERSIAVGIWASAFSAGAALGPV MSMEG_6225|M.smegmatis_MC2_155 ARALLGVFGAMLMPSTLSLIRNIFTDASARRLAIAIWASCFTAGSALGPI TH_3412|M.thermoresistible__bu ARALLGVAGATLMPSTLSLISNMFVDAAQRALAIGVWATMFAVGMAAGPV MAB_2958|M.abscessus_ATCC_1997 ARALMGVGGATLLPASLALIGVMFPNPRQKALAIGIWSAAFSFGAAVGPV MMAR_1146|M.marinum_M ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI Mb2486|M.bovis_AF2122/97 ARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPA Rv2459|M.tuberculosis_H37Rv ARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPA MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFPAER-RGVAVSVWSATAGAASLAGPL MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV :* *: .. *. : * : * . : : . . Mflv_0241|M.gilvum_PYR-GCK VGGVLLEHFWWGSVFLINIPVMVILLVGGLVLLPEHRDPDPGPWDLPSVA Mvan_0664|M.vanbaalenii_PYR-1 VGGVLLEHFWWGSVFLINIPVMVILLVGGVLLLPEHRNPDPGPWDLPSVA MSMEG_6225|M.smegmatis_MC2_155 VGGALLEHFHWGAVFLVAVPILLPLLVLGPRLVPESRDPNPGPFDPVSIV TH_3412|M.thermoresistible__bu VGGALVDRFWWGAAFLLAVPVAAAVLLG-ARLLPEYADPQAGRLDLRSVA MAB_2958|M.abscessus_ATCC_1997 IGGVLLHHFWWGSVFLINVPVLIVLLLTADALIPEYRNPIRAPFDLVGVA MMAR_1146|M.marinum_M TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM Mb2486|M.bovis_AF2122/97 LGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQL Rv2459|M.tuberculosis_H37Rv LGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQL MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLP-TQSHRFDLVGVG MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI ** : . * *:: :*: : * . Mflv_0241|M.gilvum_PYR-GCK LSMVGMLGIVYAIKEGFTGLVHGLGAEVVIAAAVGVAALTLFVRRQ-LRL Mvan_0664|M.vanbaalenii_PYR-1 LSMVGMLAVVYAVKEGFAGLAHGVGPDVAVAGLVGAAALTMFVRRQ-LRL MSMEG_6225|M.smegmatis_MC2_155 LSFTTMLPIVWAVKT---AAHDGLSAAAAAAFAVGIVSGALFVRRQ-NRS TH_3412|M.thermoresistible__bu LSLLAILAAIYAVKH---VAVHGVDGVAVAACALAAAAATVFVHRQ-RRL MAB_2958|M.abscessus_ATCC_1997 LSMVGIMTLVYSVKA---MATHGFSAAVAITGAVGVLTLALFVRQQ-VRN MMAR_1146|M.marinum_M LSAVGITALVYTIIEAP--NWGWTSTRASGGFIAAAIVLVGFALWE-RRS MUL_0911|M.ulcerans_Agy99 LSAVGITALVYTIIEAP--NWGWTSTRASGGFIAAAIVLVGFALWE-RRS Mb2486|M.bovis_AF2122/97 TLIPAVALIAYTIIEAP-RFDRQSAGFVAALLLAAGVLLWLFVRHE-HRA Rv2459|M.tuberculosis_H37Rv TLIPAVALIAYTIIEAP-RFDRQSAGFVAALLLAAGVLLWLFVRHE-HRA MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQ---AAHWQPWIWALIVAGVGFVTVFVFWQSVNV MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGP--EKGWISLTTIGSGLVALVAAIAFAVVE-RTA : . . *. : Mflv_0241|M.gilvum_PYR-GCK PHPLIDVRLFANPRFSGVVGANLFSVLGLSGLVFFLSQYFQLVHGYGPLK Mvan_0664|M.vanbaalenii_PYR-1 PAPLIDVRLFANPRFSGVVAANLLSVLGLSGLVFFLSQYFQLVHGYGPLK MSMEG_6225|M.smegmatis_MC2_155 ATPMLDIGLFKVMPFTSSILANFLSIIGLIGFIFFISQHLQLVLGLSPLT TH_3412|M.thermoresistible__bu DAPLLDVTLFADRAFTAALTVLLIGLIGVGGTMYLVTQFLQLVEGLTPVR MAB_2958|M.abscessus_ATCC_1997 PHPLLALDLFRNRTFTVAIVGTVGAMATFGATTYLTGLYVQSVLGFDVLA MMAR_1146|M.marinum_M SHPMLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQ MUL_0911|M.ulcerans_Agy99 SHPMLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQ Mb2486|M.bovis_AF2122/97 AFPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLH Rv2459|M.tuberculosis_H37Rv AFPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLH MAV_1387|M.avium_104 REPLIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTR MLBr_01562|M.leprae_Br4923 ENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALR *:: . :* . . * : . Mflv_0241|M.gilvum_PYR-GCK AGLAELPAAVTATVFGVLAGVAVRYFSHRSVLTTGLALVGTAMAALMASL Mvan_0664|M.vanbaalenii_PYR-1 AGLAELPAAVTATVFGVLAGVAVRYVSHRAVLATGLALVGVAMAAMTTSL MSMEG_6225|M.smegmatis_MC2_155 AGLVTLPGAVVSMIAGLAVVKAAKRFAPDTLMVTGLVFVAVG----FLMI TH_3412|M.thermoresistible__bu AGWWMGPPALAMFVAAIGAPLIARRVRPGVVMAATLGVSVLG-----YAV MAB_2958|M.abscessus_ATCC_1997 AAFLGLPMAVVVAYFSMDAPRIERVLGERWTFVTSLLAMALG----NAVL MMAR_1146|M.marinum_M TGVRLLPVALSIALAAILGPRLVERVGTTAVVAAGLAVFAAA----LAWA MUL_0911|M.ulcerans_Agy99 TGVRLLPVAFSIALAAILGPRLVERVGTTAVVAAGLAVFAAA----LAWA Mb2486|M.bovis_AF2122/97 AGLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIG-----LAI Rv2459|M.tuberculosis_H37Rv AGLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIG-----LAI MAV_1387|M.avium_104 SALLIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALT---WLT MLBr_01562|M.leprae_Br4923 AGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLY--GWA :. * . Mflv_0241|M.gilvum_PYR-GCK LIFRPLTPYLPLGISLFVVGVGLGLAFTVASDVILASVPKERAGAAAAVS Mvan_0664|M.vanbaalenii_PYR-1 LVFTPVAPYLPLGVALFVVGVGLGLAFTVASDVILASVPRERAGAAAAVS MSMEG_6225|M.smegmatis_MC2_155 LLFRHNLTVAAIIASFVVLELGVGVSQTVSNDTIVASVPAAKSGAASAVS TH_3412|M.thermoresistible__bu LASAGRGDGPAVVVAFAFVYLGLGAIAALGTDIVVGAAPAAKSGSAAAMS MAB_2958|M.abscessus_ATCC_1997 LALGPHGPVAVYIAATVIVGAGAGVMFTFVSAVALGAAPTERAGQATGIS MMAR_1146|M.marinum_M STADATTPYTQIALQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVN MUL_0911|M.ulcerans_Agy99 STADATTPYTQITLQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVN Mb2486|M.bovis_AF2122/97 FAISMDHAHPVALVGLTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGML Rv2459|M.tuberculosis_H37Rv FAISMDHAHPVALVGLTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGML MAV_1387|M.avium_104 FEMSPATPIWRLVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSAVY MLBr_01562|M.leprae_Br4923 FMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIA * . * :.: Mflv_0241|M.gilvum_PYR-GCK ETAYELGMALGIAVLGSILTAVYRT-VTIPAGVP---------------- Mvan_0664|M.vanbaalenii_PYR-1 ETAYELGMALGIAMLGSIVTAVYRT-VVIAPEIP---------------- MSMEG_6225|M.smegmatis_MC2_155 ETAYELGAVVGTATLGTIFTAFYRSNVDVPAGLT---------------- TH_3412|M.thermoresistible__bu ETVQELGIAVGVALLGSVTAAVYRSRMTGPEGVA---------------- MAB_2958|M.abscessus_ATCC_1997 EMSFELGTAFGLALFGALASAVFAARTHVH-------------------- MMAR_1146|M.marinum_M DTTRELGGTLGVAIAGSVFASVYSGQLGSASTLAT--------------- MUL_0911|M.ulcerans_Agy99 DTTRELGGTLGVAIAGSVFASVYSGQLGSASALAT--------------- Mb2486|M.bovis_AF2122/97 NLQRSLGGIFGVAFLGTIVAAWLGAALPNTMADEIPDPI----------- Rv2459|M.tuberculosis_H37Rv NLQRSLGGIFGVAFLGTIVAAWLGAALPNTMADEIPDPI----------- MAV_1387|M.avium_104 NSVRQLGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGP MLBr_01562|M.leprae_Br4923 LMLQSLGGPLVLAVIQAVITSRTLYLGGTTG------------------- .** . * :. : Mflv_0241|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0664|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_6225|M.smegmatis_MC2_155 -------------------------------------------------- TH_3412|M.thermoresistible__bu -------------------------------------------------- MAB_2958|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_1146|M.marinum_M -------------------------------------------------- MUL_0911|M.ulcerans_Agy99 -------------------------------------------------- Mb2486|M.bovis_AF2122/97 -------------------------------------------------- Rv2459|M.tuberculosis_H37Rv -------------------------------------------------- MAV_1387|M.avium_104 FAAAMSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGD MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_0241|M.gilvum_PYR-GCK -------------------ADAAAQARDSLPKAIDAARGLPDAAQSALLE Mvan_0664|M.vanbaalenii_PYR-1 -------------------SAAADLARDSLPGAIHAAHSLPADQQSTLLD MSMEG_6225|M.smegmatis_MC2_155 -------------------PEQTGAAAESIGGAAAVAADLPAATATQLLD TH_3412|M.thermoresistible__bu -------------------EGVGGPDAERLAESLPAAVSVADRVPGEAVR MAB_2958|M.abscessus_ATCC_1997 ---------------------------ETLGQAMANAKELGGDAGAAAAE MMAR_1146|M.marinum_M -----------------LPSDVRSAMKGSMAVAHKVIDQLPAGPAAGVRD MUL_0911|M.ulcerans_Agy99 -----------------LPSDVRSAMKGSMAVAHKVIDQLPAGPAAGVRD Mb2486|M.bovis_AF2122/97 ------------ARAIVVDVIVDSANPHAHAAFIGPGHRITAAQEDEIVL Rv2459|M.tuberculosis_H37Rv ------------ARAIVVDVIVDSANPHAHAAFIGPGHRITAAQEDEIVL MAV_1387|M.avium_104 YHDDYDDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPV MLBr_01562|M.leprae_Br4923 ---------------------------PVKFMNDAQLRALDHGYTYGLLW Mflv_0241|M.gilvum_PYR-GCK SAKESFTLGLSVSAGVGAALLLTSAVAVWWLLR--SPGPAEVGVLPDPGV Mvan_0664|M.vanbaalenii_PYR-1 AARASFTHGLASASAAGAVLLLTAAVAVWWLLRPGSPGAAEVGVLADPGV MSMEG_6225|M.smegmatis_MC2_155 SARAAFDSGIAPTAVIAAMLVLAAAAVVGVAFRR---------------- TH_3412|M.thermoresistible__bu LAQDAFAAGVNIAALIGGAAVVVVAVVCATALRHLRPLD----------- MAB_2958|M.abscessus_ATCC_1997 LARTGWADGIHAVASVSTLLLVAIAVAAAVVMRRTQD------------- MMAR_1146|M.marinum_M AVNHAFLDGLQVATLVCAGIALAAAIVVGWLLPARAGQPTPAQTEPALAQ MUL_0911|M.ulcerans_Agy99 AVNHAFLDGLQVATLVCAGIALAAAIVVGWLLPARAGQPTPAQTEPALAQ Mb2486|M.bovis_AF2122/97 AADAVFVSGIKLALGGAAVLLTGAFVLGWTRFPRTPAS------------ Rv2459|M.tuberculosis_H37Rv AADAVFVSGIKLALGGAAVLLTGAFVLGWTRFPRTPAS------------ MAV_1387|M.avium_104 ESRRSVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRF MLBr_01562|M.leprae_Br4923 VAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL------------- . Mflv_0241|M.gilvum_PYR-GCK HHDARGDGGVDTAGGAELGNRHS---------------------- Mvan_0664|M.vanbaalenii_PYR-1 HRDPGRDARVDAPGGAELGDRNS---------------------- MSMEG_6225|M.smegmatis_MC2_155 --------------------------------------------- TH_3412|M.thermoresistible__bu --------------------------------------------- MAB_2958|M.abscessus_ATCC_1997 --------------------------------------------- MMAR_1146|M.marinum_M A-------------------------------------------- MUL_0911|M.ulcerans_Agy99 V-------------------------------------------- Mb2486|M.bovis_AF2122/97 --------------------------------------------- Rv2459|M.tuberculosis_H37Rv --------------------------------------------- MAV_1387|M.avium_104 TRPPRRHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN MLBr_01562|M.leprae_Br4923 ---------------------------------------------