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TASQTGNSDRFAVHPLPAGGTPEKVWARPGLRLPPLDLAGCREIVIVGAHPDDETLGFGSAAAMLAESGV RVQIVSASDGGAAFPNVSLLQRYRIEALRRSELWAAADTLGLPTPISLGLPDGDIARHEQRLTDLLIEIL TDTPAGTWCAATWRGDGHPDHEAVGRAAAVAAECTGTVLLEYPVWMWHWARPGDPAVPWERARAVDATPA AVTRKMKAAALFRSQFEPTEYGDEPVLPPYFLPRLLTVGEVVFR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0020 | - | - | 100% (255) | LmbE family protein |
| M. gilvum PYR-GCK | Mflv_2165 | - | 3e-07 | 25.87% (201) | LmbE family protein |
| M. gilvum PYR-GCK | Mflv_2050 | - | 1e-05 | 27.67% (159) | LmbE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0331c | - | 6e-09 | 31.61% (155) | hypothetical protein Mb0331c |
| M. tuberculosis H37Rv | Rv0323c | - | 3e-08 | 30.97% (155) | hypothetical protein Rv0323c |
| M. leprae Br4923 | MLBr_01495 | - | 6e-06 | 27.56% (156) | hypothetical protein MLBr_01495 |
| M. abscessus ATCC 19977 | MAB_1316 | - | 3e-05 | 26.99% (163) | putative |
| M. marinum M | MMAR_4283 | mshB | 1e-06 | 28.82% (170) | N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- |
| M. avium 104 | MAV_4074 | - | 1e-75 | 56.42% (257) | GlcNAc-PI de-N-acetylase family protein |
| M. smegmatis MC2 155 | MSMEG_5129 | - | 2e-05 | 26.90% (171) | N-Acetyl-1-D-myo-Inosityl-2-amino-2-deoxy-alpha- |
| M. thermoresistible (build 8) | TH_1329 | murF | 2e-22 | 43.06% (144) | Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, |
| M. ulcerans Agy99 | MUL_1017 | mshB | 4e-07 | 28.82% (170) | N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- |
| M. vanbaalenii PYR-1 | Mvan_4535 | - | 3e-06 | 31.17% (154) | LmbE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5129|M.smegmatis_MC2_155 --------------------------------------MSSHESPRLLFV
Mvan_4535|M.vanbaalenii_PYR-1 -----------------------------------------METARLLFV
MMAR_4283|M.marinum_M ----------------------------------------MPETPRLLFV
MUL_1017|M.ulcerans_Agy99 ----------------------------------------MPETPRLLFV
MLBr_01495|M.leprae_Br4923 ----------------------------------------MSETPRLLFV
MAB_1316|M.abscessus_ATCC_1997 -----------------------------------------MTTRRLMLV
Mb0331c|M.bovis_AF2122/97 ----------------------------------MNSCNRLPCAHEVLAV
Rv0323c|M.tuberculosis_H37Rv ----------------------------------MNSCNRLPCAHEVLAV
Mflv_0020|M.gilvum_PYR-GCK MTASQTGNSDRFAVHPLPAGGTPEKVWAR--PGLRLPPLDLAGCREIVIV
MAV_4074|M.avium_104 MTTVPAGNRARFAAKPLTHSGTPVPLWLAAFQEAPLPALNLAGCPGLVVV
TH_1329|M.thermoresistible__bu ---VTTEPGAVVSDLGQAARRSAVRTPVTAGSGGGYPRLDLTACPGLVVV
:: *
MSMEG_5129|M.smegmatis_MC2_155 HAHPDDETLTTGGTIAHYVARSAEVHVVTCTLGEEGEVIGERYAQLAVDH
Mvan_4535|M.vanbaalenii_PYR-1 HAHPDDETLTTGATIAHYVARGAQVHVITCTLGEEGEVIGDEWAQLAVDR
MMAR_4283|M.marinum_M HAHPDDESLSNGATIAHYAARGAQVHVVTCTLGEEGEVIGDRWAQLAVDH
MUL_1017|M.ulcerans_Agy99 HAHPDDESLSNGATIAHYAARGAQVHVVTCTLGEEGEVIGDRWAQLAVDH
MLBr_01495|M.leprae_Br4923 HAHPDDESLSNGATIAHYTSRGAQVQVVTCTLGEEGEVIGDRWAELTVDH
MAB_1316|M.abscessus_ATCC_1997 HAHPDDESLTTGGTIARYAAEGADVQLVTCTLGEEGEVIGDRWAQLAVDQ
Mb0331c|M.bovis_AF2122/97 FAHPDDESFGLGAVLGDFTAQGTRLRGLCFTHG-EASTLG--------RT
Rv0323c|M.tuberculosis_H37Rv FAHPDDESFGLGAVLGDFTAQGTRLRGLCFTHG-EASTLG--------RT
Mflv_0020|M.gilvum_PYR-GCK GAHPDDETLGFGSAAAMLAESGVRVQIVSASDG------GAAFPNVSLLQ
MAV_4074|M.avium_104 AAHPDDETLGVGAMITQLVAIGVRVQVVCVSDG------GAR-PGSAASE
TH_1329|M.thermoresistible__bu AARPDDELLGLGGAIAALVDLGVEVRVVSVCDRDATLTLTGLPALDRQIP
*:**** : *. . .. :: :
MSMEG_5129|M.smegmatis_MC2_155 ADQLGG----------------YRIAELTAALQSLGLRGPRYLGGAGHWR
Mvan_4535|M.vanbaalenii_PYR-1 ADQLGG----------------YRIGELTAALAELGVDRPRFLGGAGRWR
MMAR_4283|M.marinum_M ADQLGG----------------YRIGELTAALQRLGVDAPIYLGGAGRWR
MUL_1017|M.ulcerans_Agy99 ADQLGG----------------YRIGELTAALQRLGVDAPIYLGGAGRWR
MLBr_01495|M.leprae_Br4923 ADQLGG----------------YRIFELTEALRALGVSAPIYLGGAGRWR
MAB_1316|M.abscessus_ATCC_1997 ADQLGG----------------YRIGELSTALRHLGVDGPTFLGGAGRWR
Mb0331c|M.bovis_AF2122/97 DRNLGE----------------VRREELAAAAQVLGVDHVQLLA----YP
Rv0323c|M.tuberculosis_H37Rv DRNLGE----------------VRREELAAAAQVLGVDHVQLLA----YP
Mflv_0020|M.gilvum_PYR-GCK RYRIEA----------------LRRSELWAAADTLGLPTPISLG----LP
MAV_4074|M.avium_104 RLRAQT----------------IRRFELRSATNTLNAPPPLSLG----LP
TH_1329|M.thermoresistible__bu DQRFDQRVAAEILGVKELHHLGLPADDLDRHAAGLADDLTELLVGPGLWC
. :* * *
MSMEG_5129|M.smegmatis_MC2_155 DSGMAGTPSRGRQRWVDAD-------------------LDEAVGALVAVI
Mvan_4535|M.vanbaalenii_PYR-1 DSGMDGTPARQQQRFVDGD-------------------FAEQTATLAAAI
MMAR_4283|M.marinum_M DSGMAGTEQRGRRRFVDAD-------------------DREAVGALVAII
MUL_1017|M.ulcerans_Agy99 DSGMAGTEQRSRRRFVDAD-------------------DREAVGALVAII
MLBr_01495|M.leprae_Br4923 DSGMRGTAPRRRQRFIDAD-------------------ENEAVGALVAII
MAB_1316|M.abscessus_ATCC_1997 DSGMADTTPLHPRAFAGAD-------------------LNEAVGALTALI
Mb0331c|M.bovis_AF2122/97 DNGLAQIP------------------------------LNELTQRVVDAL
Rv0323c|M.tuberculosis_H37Rv DNGLAQIP------------------------------LNELTQRVVDAL
Mflv_0020|M.gilvum_PYR-GCK DGDIARHEQR-------------------------------LTDLLIEIL
MAV_4074|M.avium_104 GGELTAHEER-------------------------------LTGALTEIL
TH_1329|M.thermoresistible__bu AAPWAGDGDPDSTVVARAAXXXLVAGGLRIVGVTGSSGKTSTKDLLAAVL
: :
MSMEG_5129|M.smegmatis_MC2_155 GEVRPHVVVTYDPNGGYGHPD------------------HIQTHVVTTRA
Mvan_4535|M.vanbaalenii_PYR-1 DELRPHVVVTYDPNGGYGHPD------------------HIHAHRVTTAA
MMAR_4283|M.marinum_M RELRPHVVVTYDPDGGYGHPD------------------HVQAHVVTTAA
MUL_1017|M.ulcerans_Agy99 RELRPHVVVTYDPDGGYGHPD------------------HVQAHVVTTAA
MLBr_01495|M.leprae_Br4923 RELRPHVVVTYDPHGGYGHPD------------------HVHTHFITAAA
MAB_1316|M.abscessus_ATCC_1997 DEHRPHVVVTYDPFGGYGHPD------------------HIQAHTVTTAA
Mb0331c|M.bovis_AF2122/97 AG--ADLLLVFDDNGVTGHPD------------------HRRATEAALAA
Rv0323c|M.tuberculosis_H37Rv AG--ADLLLVFDDNGVTGHPD------------------HRRATEAALAA
Mflv_0020|M.gilvum_PYR-GCK TDTPAGTWCAATWRG-DGHPD------------------HEAVGRAAAVA
MAV_4074|M.avium_104 RAAAPGAWCAAPWRG-AGHPD------------------HEAVGHAAWAA
TH_1329|M.thermoresistible__bu APLGSVVAPPGSFNNELGHPWTVLRADRDTDYLVLEMSARHRGNIAALAE
. . *** : :
MSMEG_5129|M.smegmatis_MC2_155 VAAAP------------------EAVGWTVPKFYWTVTAISAMTAGLQAL
Mvan_4535|M.vanbaalenii_PYR-1 VAAS----------------------TWQVPKLYWTVTSSSALAAALASM
MMAR_4283|M.marinum_M VAAAG-----------SVGDCDYPGDPWVVPKFYWTILGLSAFLAGRQAL
MUL_1017|M.ulcerans_Agy99 VAAAG-----------SVGDCDYPGDPWVVPKFYWTVLGVSAFLAGRQAL
MLBr_01495|M.leprae_Br4923 VASSGV------AAGLEVGADEYPGKPWKVPKFYWSVFALSAFEAGMNAL
MAB_1316|M.abscessus_ATCC_1997 VEKAS----------------------WQVAKLYWTVIATSALETGLASI
Mb0331c|M.bovis_AF2122/97 ASTPG------------------------IPVLAWALPQP----------
Rv0323c|M.tuberculosis_H37Rv ASTPS------------------------IPVLAWALPQP----------
Mflv_0020|M.gilvum_PYR-GCK AECTG------------------------TVLLEYPVWMW----------
MAV_4074|M.avium_104 CAHTG------------------------AALLEYPVWMW----------
TH_1329|M.thermoresistible__bu IAPPSVGVVLNVGTAHLGEFGSRDAIAATKAELAEAVPSTGLVVLNADDP
. : .:
MSMEG_5129|M.smegmatis_MC2_155 G--DVPSEWIRVNAEDIP-------------------------FGFGDDQ
Mvan_4535|M.vanbaalenii_PYR-1 G--AVPEEWIRVSADDLPL------------------------FGYSDEA
MMAR_4283|M.marinum_M TPDDLLPEWVLPP-EDIP-------------------------FIYPDER
MUL_1017|M.ulcerans_Agy99 TPDDLLPEWVLPP-EDIP-------------------------FIYPDER
MLBr_01495|M.leprae_Br4923 QGKDLRPEWTIPPREEFY-------------------------FGYSDKD
MAB_1316|M.abscessus_ATCC_1997 T--QLPPGCQPAPLDLIP--------------------------TFADEK
Mb0331c|M.bovis_AF2122/97 ----IADRLNAEFSASFG--------------------------GRGHGH
Rv0323c|M.tuberculosis_H37Rv ----IADRLNAEFSASFG--------------------------GRGHGH
Mflv_0020|M.gilvum_PYR-GCK -------HWARPGDPAVP------------------------------WE
MAV_4074|M.avium_104 -------HWAVPGDPAVP------------------------------WD
TH_1329|M.thermoresistible__bu AVAAMAERTAARVVRVAQDPGERQVDVWAERVSLDELARPRFTLRTPDGA
MSMEG_5129|M.smegmatis_MC2_155 IDAVVDVT-------AEL-PAKVGAMRAHATQITVAPDGRAFALSNNIAL
Mvan_4535|M.vanbaalenii_PYR-1 IDAALDLT-------AHE-SARVAALRAHRTQVSVSPDGRSFALSNNVAL
MMAR_4283|M.marinum_M IDAVVTGD-------SDARAAKIAALAAHATQVTVGPSGRACALSNNMAL
MUL_1017|M.ulcerans_Agy99 IDAVVTGD-------SDARAAKIAALAAHATQVTVGPSGRACALSNNMAL
MLBr_01495|M.leprae_Br4923 IDAVVEAT-------SDVWAAKTAALTAHATQVVVGPTGRACALSNNMVM
MAB_1316|M.abscessus_ATCC_1997 ISAAIDVS-------GHR-EAKVAALRAHATQLTVSDDGSSMALSNLIAL
Mb0331c|M.bovis_AF2122/97 LDIMIEVD-------RSR---QLAAIGCHFTQSADNP-------VLWRRL
Rv0323c|M.tuberculosis_H37Rv LDIMIEVD-------RSR---QLAAIGCHFTQSADNP-------VLWRRL
Mflv_0020|M.gilvum_PYR-GCK RARAVDAT-------PAAVTRKMKAAALFRSQFEPTEYGDEPVLPPYFLP
MAV_4074|M.avium_104 RAHAVPAP-------AWAVSRKRLAAQRYRSRFEPTG-GSAPALPGFVLA
TH_1329|M.thermoresistible__bu VEVALTVHGEHQVSNALAAAAVALHCGATLEQVVAALAGAGPASPRRMQV
: :
MSMEG_5129|M.smegmatis_MC2_155 PVLGEEHYVLVSGEAGPRDSRGWETDLLAGLDLE----------------
Mvan_4535|M.vanbaalenii_PYR-1 PVDPTEYYVLAAGSAGARDERGWETDLLSGLSVG----------------
MMAR_4283|M.marinum_M PILADEHYLLVAGRAGARDERGWETDLLAGLGFTGFGT------------
MUL_1017|M.ulcerans_Agy99 PILADEHYLLVAGRAGARDERGWEIDLLAGLGFTGFGT------------
MLBr_01495|M.leprae_Br4923 PIFAQEHYVLAAGSAGNRDERGWETDLLAGLCLDGFDAR-----------
MAB_1316|M.abscessus_ATCC_1997 PIADIEHFVLVRGEPG--VDTGWESDLFAGVEL-----------------
Mb0331c|M.bovis_AF2122/97 ELLGDREYLRWLRRSVP---------------------------------
Rv0323c|M.tuberculosis_H37Rv ELLGDREYLRWLRRSVP---------------------------------
Mflv_0020|M.gilvum_PYR-GCK RLLTVGEVVFR---------------------------------------
MAV_4074|M.avium_104 RLLAVGEVVFR---------------------------------------
TH_1329|M.thermoresistible__bu STRSDGVTVINDAYNANPDSMRAALKSLVWMAKAGGRAGGPPRRSWAVLG
:
MSMEG_5129|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4535|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4283|M.marinum_M --------------------------------------------------
MUL_1017|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01495|M.leprae_Br4923 --------------------------------------------------
MAB_1316|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0331c|M.bovis_AF2122/97 --------------------------------------------------
Rv0323c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0020|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4074|M.avium_104 --------------------------------------------------
TH_1329|M.thermoresistible__bu EMAELGDDAITEHDNIGRLAVRLDVSRLIVVGTGRAMSAMHHGAVMEGSW
MSMEG_5129|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4535|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4283|M.marinum_M --------------------------------------------------
MUL_1017|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01495|M.leprae_Br4923 --------------------------------------------------
MAB_1316|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0331c|M.bovis_AF2122/97 --------------------------------------------------
Rv0323c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0020|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4074|M.avium_104 --------------------------------------------------
TH_1329|M.thermoresistible__bu GAESTMVSDADAALRLLRSELQAGDVVLVKASNAAGLGALADALAAESGD
MSMEG_5129|M.smegmatis_MC2_155 ---
Mvan_4535|M.vanbaalenii_PYR-1 ---
MMAR_4283|M.marinum_M ---
MUL_1017|M.ulcerans_Agy99 ---
MLBr_01495|M.leprae_Br4923 ---
MAB_1316|M.abscessus_ATCC_1997 ---
Mb0331c|M.bovis_AF2122/97 ---
Rv0323c|M.tuberculosis_H37Rv ---
Mflv_0020|M.gilvum_PYR-GCK ---
MAV_4074|M.avium_104 ---
TH_1329|M.thermoresistible__bu TGR