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NSCNRLPCAHEVLAVFAHPDDESFGLGAVLGDFTAQGTRLRGLCFTHGEASTLGRTDRNLGEVRREELAA AAQVLGVDHVQLLAYPDNGLAQIPLNELTQRVVDALAGADLLLVFDDNGVTGHPDHRRATEAALAAASTP SIPVLAWALPQPIADRLNAEFSASFGGRGHGHLDIMIEVDRSRQLAAIGCHFTQSADNPVLWRRLELLGD REYLRWLRRSVP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0323c | - | - | 100% (223) | hypothetical protein Rv0323c |
| M. tuberculosis H37Rv | Rv1082 | mca | 3e-13 | 31.29% (147) | Mycothiol conjugate amidase Mca (Mycothiol S-conjugate |
| M. tuberculosis H37Rv | Rv1170 | mshB | 1e-10 | 28.92% (249) | N-Acetyl-1-D-myo-Inosityl-2-amino-2-deoxy-alpha- |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0331c | - | 1e-128 | 99.55% (223) | hypothetical protein Mb0331c |
| M. gilvum PYR-GCK | Mflv_2050 | - | 2e-11 | 30.41% (148) | LmbE family protein |
| M. leprae Br4923 | MLBr_02391 | - | 2e-13 | 31.97% (147) | hypothetical protein MLBr_02391 |
| M. abscessus ATCC 19977 | MAB_1203 | - | 3e-13 | 32.26% (155) | LmbE-like protein |
| M. marinum M | MMAR_4385 | mca | 1e-12 | 31.08% (148) | mycothiol conjugate amidase Mca |
| M. avium 104 | MAV_1206 | - | 1e-12 | 31.08% (148) | mycothiol conjugate amidase Mca |
| M. smegmatis MC2 155 | MSMEG_5261 | - | 1e-14 | 33.78% (148) | mycothiol conjugate amidase Mca |
| M. thermoresistible (build 8) | TH_2167 | - | 8e-15 | 33.11% (148) | mycothiol conjugate amidase Mca |
| M. ulcerans Agy99 | MUL_0198 | mca | 1e-12 | 31.08% (148) | mycothiol conjugate amidase Mca |
| M. vanbaalenii PYR-1 | Mvan_4535 | - | 1e-12 | 30.93% (236) | LmbE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5261|M.smegmatis_MC2_155 -------MSELRLMAVHAHPDDESSKGAATTARYAAEGARVMVVTLTGGE
TH_2167|M.thermoresistible__bu -------MTELRLMAVHAHPDDESSKGAATTAKYADEGARVMVVTLTGGE
Mflv_2050|M.gilvum_PYR-GCK -------MSELRLMAVHAHPDDESSKGAAAMARYVDEGVRVMVVTLTGGE
MLBr_02391|M.leprae_Br4923 -------MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGE
MAV_1206|M.avium_104 -------MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGE
MMAR_4385|M.marinum_M -------MSKLRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGE
MUL_0198|M.ulcerans_Agy99 -------MSKLRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGE
MAB_1203|M.abscessus_ATCC_1997 -------MTGLRLMAVHAHPDDEASKGAATTARYAAEGNEVMVVTLTGGE
Rv0323c|M.tuberculosis_H37Rv MNSCNRLPCAHEVLAVFAHPDDESFGLGAVLGDFTAQGTRLRGLCFTHGE
Mb0331c|M.bovis_AF2122/97 MNSCNRLPCAHEVLAVFAHPDDESFGLGAVLGDFTAQGTRLRGLCFTHGE
Mvan_4535|M.vanbaalenii_PYR-1 -------METARLLFVHAHPDDETLTTGATIAHYVARGAQVHVITCTLGE
.:: *.******: .*. . :. .* .: : * **
MSMEG_5261|M.smegmatis_MC2_155 RGDILNPAMDLPEVH--GRIAEVRRDEMAKAAEILGVEHHWLGFVDSGLP
TH_2167|M.thermoresistible__bu RGDILNPAMDLPEVR--GRIAEVRRDEMAKAAEILGVEHRWLGFVDSGLP
Mflv_2050|M.gilvum_PYR-GCK RGDILNPAMDLPEVH--GRIHEIRIDEMARAAEILGVEHHWLGFVDSGLP
MLBr_02391|M.leprae_Br4923 RGEILNPAMDLPDVH--GHIAEIRRDEMAKAAEILGVEHTWLGFIDSGLP
MAV_1206|M.avium_104 RGDILNPAMDLPEVH--GHIAEIRRDEMAKAAEILGVEHTWLGFVDSGLP
MMAR_4385|M.marinum_M RGEILNPAMDLPDVH--GHISEIRRDEMAKAAEILGVEHTWLGFVDSGLP
MUL_0198|M.ulcerans_Agy99 RGEILNPAMDLPDVH--GHISEIRRDEMAKAAEILGVEHTWLGFVDSGLP
MAB_1203|M.abscessus_ATCC_1997 RGDILNPAMDRPEVA--ANIGAIRREEMAKAAAELGVRHRWLGYVDSGLP
Rv0323c|M.tuberculosis_H37Rv AS-------TLGRTD--RNLGEVRREELAAAAQVLGVDHVQL--------
Mb0331c|M.bovis_AF2122/97 AS-------TLGRTD--RNLGEVRREELAAAAQVLGVDHVQL--------
Mvan_4535|M.vanbaalenii_PYR-1 EGEVIGDEWAQLAVDRADQLGGYRIGELTAALAELGVDRPRFLGGAGRWR
. . .: * *:: * *** : :
MSMEG_5261|M.smegmatis_MC2_155 EG--DPLPPLPDGCFALVPLEEPVKRLVRVIREFRPHVMTTYDENGGYPH
TH_2167|M.thermoresistible__bu EG--DPPPPLPEGCFATVPLEQATERLVRLIREFRPHVMTTYDENGGYPH
Mflv_2050|M.gilvum_PYR-GCK EG--DPLPPLPEGCFALEPLEVPTEALVKVIRDFRPHVMTTYDENGGYPH
MLBr_02391|M.leprae_Br4923 KG--DPPPPLPDDCFALVPLEVCTEALVRVVRKFRPHVLTTYDENGGYPH
MAV_1206|M.avium_104 KG--DPPPPLPEGCFALVPLEEAIEALVRVVREFRPHVMTTYDETGGYPH
MMAR_4385|M.marinum_M KG--DPPPPLPEGCFALVPLEDSIEALVRVVREFRPHVMTTYDENGGYPH
MUL_0198|M.ulcerans_Agy99 KG--DPPPPLPEGCFALVPLEDSIEALVRVVREFRPHVMTTYDENGGYPH
MAB_1203|M.abscessus_ATCC_1997 QG--DPLPPLPSDSFALVPIEEPIAKLVAVVREFRPHVMTTYDENGGYPH
Rv0323c|M.tuberculosis_H37Rv -------LAYPDNGLAQIPLNELTQRVVDALAG--ADLLLVFDDNGVTGH
Mb0331c|M.bovis_AF2122/97 -------LAYPDNGLAQIPLNELTQRVVDALAG--ADLLLVFDDNGVTGH
Mvan_4535|M.vanbaalenii_PYR-1 DSGMDGTPARQQQRFVDGDFAEQTATLAAAIDELRPHVVVTYDPNGGYGH
. . :. : :. : ..:: .:* .* *
MSMEG_5261|M.smegmatis_MC2_155 PDHIRCHQVSVAAYEAAADHLLYPDAGEPWAVQKLYYNHGFLRQRMQLLQ
TH_2167|M.thermoresistible__bu PDHIRCHQVSVAAYEAAADYRLFPDAGPPWAVLKLYYNHGFIRQRMKLLQ
Mflv_2050|M.gilvum_PYR-GCK PDHIKCHQVSVAAYEAAADHLLYPDAGEPWSVSKLYYNHGFLRQRMQVLQ
MLBr_02391|M.leprae_Br4923 PDHIRCHQVSVDAYEAACDYRRFPDAGKPWTVSKLYYNHGFLRARMQLLH
MAV_1206|M.avium_104 PDHIRCHQVSVGAYEAAGDYRRFPDAGEPWTVSKLYYNHGFLRARMQLLH
MMAR_4385|M.marinum_M PDHIRCHQVSIGAYEAAADYLRFPDAGEPWTVSKLYYIHGFLRERMRILQ
MUL_0198|M.ulcerans_Agy99 PDHIRCHQVSIGAYEAAADYLRFPDAGEPWTVSKLYYIHGFLRERMRILQ
MAB_1203|M.abscessus_ATCC_1997 PDHIRCHEVSMAAFEAAADPEQFPEAGEPWTVSKIYYNHGFMRARMQLLN
Rv0323c|M.tuberculosis_H37Rv PDHRRATEAALAAASTPS------IPVLAWALPQPIADR---------LN
Mb0331c|M.bovis_AF2122/97 PDHRRATEAALAAASTPG------IPVLAWALPQPIADR---------LN
Mvan_4535|M.vanbaalenii_PYR-1 PDHIHAHRVTTAAVAAST-----------WQVPKLYWTVTSSSALAAALA
*** :. ..: * :. * : : *
MSMEG_5261|M.smegmatis_MC2_155 EEFAKNGQEGPFAKWLEHWDPDNDVFANRVTTRVHCAEYFHQRDDALRAH
TH_2167|M.thermoresistible__bu DEFEKNGMEGPFAKWLERWDPENDVFEKRVTTRVECAKYFGRRDDALRAH
Mflv_2050|M.gilvum_PYR-GCK DEFAKHGEEGPFAKWLEKWDPDDDVLDKRVTTRIECAKYFGKRDDALLAH
MLBr_02391|M.leprae_Br4923 DEFAKHGQAGPFDKWLAQSNPAHDPFESRVTTRVECSAYFSQRDDALRAH
MAV_1206|M.avium_104 DEAVKHGHEPPFKKWLEHWDPAHDPFESRVTTRVECSAYFSQRDDALRAH
MMAR_4385|M.marinum_M DEFIKRGQEGPFGKWLEHWHPDHDPFANRVTTRVECSGYFAQRDDALRAH
MUL_0198|M.ulcerans_Agy99 DEFIKRGQEDPFGKWLEHWHPDHDPFANRVTTRVECSGYFGQRDDALRAH
MAB_1203|M.abscessus_ATCC_1997 DECKKHGYKGPFDEWLERWPADDDTFDRRVTTRVPCADFFDARDAALRAH
Rv0323c|M.tuberculosis_H37Rv AEFS--------ASFGGRGHGHLDIMIEVDRS---------RQLAAIGCH
Mb0331c|M.bovis_AF2122/97 AEFS--------ASFGGRGHGHLDIMIEVDRS---------RQLAAIGCH
Mvan_4535|M.vanbaalenii_PYR-1 SMGAVP---EEWIRVSADDLPLFGYSDEAIDAALDLTAHESARVAALRAH
. : : *: .*
MSMEG_5261|M.smegmatis_MC2_155 ATQIDPKGD--FFHAPIEWQQRLWPTEEFELARARVPVTLP---EDDLFK
TH_2167|M.thermoresistible__bu ATQIDPNSF--FFAAPIEWQERLWPTEEFELARSRVPVRLP---ETDLFA
Mflv_2050|M.gilvum_PYR-GCK ATQIDPNSF--FFTTPMEWQQRLWPTEEFELARSRVPVVLP---ETDLFA
MLBr_02391|M.leprae_Br4923 ATQIDPKAE--FFAAPISWQQRLWPTEEFELARSRVPTRLP---EHDLFA
MAV_1206|M.avium_104 TTQIDPDHD--FFAAPIAWQQRLWPTEEFELARSRVPVRLP---EDDLFA
MMAR_4385|M.marinum_M ATQIDPNAE--FFAAPLSWQRELWPTEEFELARSRIPIGLP---ETELFA
MUL_0198|M.ulcerans_Agy99 ATQIDPNAE--FFAAPLSWQRELWPTEEFELARSRIPIGLP---ETELFA
MAB_1203|M.abscessus_ATCC_1997 ASQIPPDSS--FFAVPREFERKLWPTEDFELAKSRVPTSTP---EDDLFA
Rv0323c|M.tuberculosis_H37Rv FTQSADNPV--LWRR----LELLGDREYLRWLRRSVP-------------
Mb0331c|M.bovis_AF2122/97 FTQSADNPV--LWRR----LELLGDREYLRWLRRSVP-------------
Mvan_4535|M.vanbaalenii_PYR-1 RTQVSVSPDGRSFALSNNVALPVDPTEYYVLAAGSAGARDERGWETDLLS
:* . : : *
MSMEG_5261|M.smegmatis_MC2_155 GVEP------
TH_2167|M.thermoresistible__bu GIEDHVDKLD
Mflv_2050|M.gilvum_PYR-GCK GIEDLGD---
MLBr_02391|M.leprae_Br4923 GIEAAG----
MAV_1206|M.avium_104 GIEPDA----
MMAR_4385|M.marinum_M GIESSQ----
MUL_0198|M.ulcerans_Agy99 GIESSQ----
MAB_1203|M.abscessus_ATCC_1997 GVETK-----
Rv0323c|M.tuberculosis_H37Rv ----------
Mb0331c|M.bovis_AF2122/97 ----------
Mvan_4535|M.vanbaalenii_PYR-1 GLSVG-----