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MSFVVAVPEALAAAASDVANIGSALSAANAAAAAGTTGLLAAGADEVSAALASLFSGHAVSYQQVAAQAT ALHDQFVQALTGAGGSYALTEAANVQQNLLNAINAPTQALLGRPLIGDGAVGTASSPDGQDGGLLFGNGG AGYNSAATPGMAGGNGGNAGLIGNGGTGGSGGAGAAGGAGGSGGWLYGNGGNGGIGGNAIVAGGAGGNGG AGGAAGLWGSGGSGGQGGNGLTGNDGVNPAPVTNPALNGAAGDSNIEPQTSVLIGTQGGDGTPGGAGVNG GNGGAGGDANGNPANTSIANAGAGGNGAAGGDGGANGGAGGAGGQAASAGSSVGGDGGNGGAGGTGTNGH AGGAGGAGGQAASAGSSVGGDGGNGGAGGTGTNGHAGGAGGAGGAGGRGGWLVGSGGNGGNGGNGAAGGN GAIGGTGGAGGVPANQGGNSALGTQPVSGDGGDGGNGGTGGTGGRGGDGGSGGAGGASGWLMGNGGNGGN GGTGGSGGVGGNGGIGGDGAGGGNATSTSSIPFDAHGGNGGAGGDAGHGGTGGDGGDGGHAGTGGRGGLL AGQHANSGNGGGGGTGGAGGTHGTPGSGNAGGTGTGNADSTNGGPGSDGLGGDAFNGSRGTDGNPG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3402 | PE_PGRS51 | - | 100% (626) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb1121 | PE_PGRS22 | e-176 | 50.13% (742) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb2878 | PE_PGRS48 | e-173 | 53.70% (635) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-122 | 48.11% (555) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3367 | PE_PGRS51 | 0.0 | 86.01% (629) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 4e-14 | 43.48% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 2e-50 | 34.95% (475) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_1161 | - | 0.0 | 60.00% (655) | PE-PGRS family protein |
M. avium 104 | MAV_1346 | - | 5e-23 | 33.33% (300) | PE family protein |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-102 | 40.09% (681) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 1e-42 | 42.14% (299) | PUTATIVE - |
M. ulcerans Agy99 | MUL_3507 | - | 1e-155 | 51.25% (642) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-121 | 48.99% (547) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 -------------------------------------------------- Rv3367|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1161|M.marinum_M -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 ----------MSFVVAVPEALAAAASDVANIGSALSAANAAAAAGTTGLL Rv3367|M.tuberculosis_H37Rv ----------MSFVVAVPEALAAAASDVANIGSALSAANAAAAAGTTGLL MMAR_1161|M.marinum_M ----------MSYVLAAPDAMATAASSVTNIGGALSAANAMATAPTTGVL MUL_3507|M.ulcerans_Agy99 ----------MSFVSVTQEALAAAASDVGVIGSSLQAANMSVAAPTAGVL MAB_4284c|M.abscessus_ATCC_199 -------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 AAGADEVSAALASLFSGHAVSYQQVAAQATALHDQFVQALTGAGGSYALT Rv3367|M.tuberculosis_H37Rv AAGADEVSAALASLFSGHAVSYQQVAAQATALHDQFVQALTGAGGSYALT MMAR_1161|M.marinum_M AAAADEISVAMASVFSDHALSYQQVAARMAAFHDQFVAALHSGAGAYLTA MUL_3507|M.ulcerans_Agy99 AAGADEVSVAMAALFSGHGQAYQTLSAQANAFHAQFLQALTNAGGAYAAA MAB_4284c|M.abscessus_ATCC_199 VMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 EAAN--------------------------------------VQQNLLNA Rv3367|M.tuberculosis_H37Rv EAAN--------------------------------------VQQNLLNA MMAR_1161|M.marinum_M ETANAS--------------------------------PLGTLEQRLLQA MUL_3507|M.ulcerans_Agy99 EVANLS--------------------------------PLQGVEQGVLGV MAB_4284c|M.abscessus_ATCC_199 LLSPRD----------------------------NDFLSHNDTDFASHNP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 IN--------------------APTQALLG--------RPLIGDGAVGTA Rv3367|M.tuberculosis_H37Rv IN--------------------APTQALLG--------RPLIGDGAVGTA MMAR_1161|M.marinum_M IN--------------------APTQTLLG--------RPLIGDGAAGTA MUL_3507|M.ulcerans_Agy99 VN--------------------APAQALLG--------RPLIGDGAAGTA MAB_4284c|M.abscessus_ATCC_199 IASGN---------------QVMSPSGNVDSFNRGPLLDLSFGDLQFGNR MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWN--SDVVGMDGGNGGNGGLFGGNGGNGGNGL Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWN--SEIAGVSGGNGGNAGLFGGNGGNGGNGL MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYD--GSAAGLAGGNGGNAGLFG-NGGNGGVGW TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 SSPDGQDGGLLFGNGGAGYN-SAATPGMAGGNGGNAGLIG-NGGTGGSGG Rv3367|M.tuberculosis_H37Rv SSPDGQDGGLLFGNGGAGYN-SAATPGMAGGNGGNAGLIG-NGGTGGSGG MMAR_1161|M.marinum_M TNPNGGAGGLLYGNGGAGFN-NGATAGAAGGNGGNAGLFG-SGGAGGSGG MUL_3507|M.ulcerans_Agy99 ASPNGGAGGLLYGNGGAGYSYTSGATAEAGGNGGAAGLIG-NGGAGGSGW MAB_4284c|M.abscessus_ATCC_199 DTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRDSNIINADHGSN-VGV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGA Mvan_1264|M.vanbaalenii_PYR-1 GSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGA MSMEG_0868|M.smegmatis_MC2_155 AGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGG TH_3810|M.thermoresistible__bu VDGDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGGG Mb3402|M.bovis_AF2122/97 AGAAGGAGGSGG--WLYGNGGNGGIGGNAIVAG---------GAGGNGGA Rv3367|M.tuberculosis_H37Rv AGAAGGAGGSGG--WLYGNGGNGGIGGNAIVAG---------GAGGNGGA MMAR_1161|M.marinum_M AGAAGGAGGSGG--WLYGSGGNGGSGGNAVIAG---------GNGGAGGA MUL_3507|M.ulcerans_Agy99 AGGAGGAGGNGG--WLYGNGGAGGLGGAAAGDY---------TAGGVGGA MAB_4284c|M.abscessus_ATCC_199 DQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRST MLBr_01183|M.leprae_Br4923 -------------MPLFLNAEPQALTAAAN------------TLEGLSAA MAV_1346|M.avium_104 -------------MS-FVTTRPEALLAVAS------------MLEGLGSS . Mflv_5091|M.gilvum_PYR-GCK TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------------- Mvan_1264|M.vanbaalenii_PYR-1 TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------------- MSMEG_0868|M.smegmatis_MC2_155 TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN TH_3810|M.thermoresistible__bu TGIIS--------------------LLSLAGNGGNGG------------- Mb3402|M.bovis_AF2122/97 GGAAG--------------------LWGSGGSGGQGG------------- Rv3367|M.tuberculosis_H37Rv GGAAG--------------------LWGSGGSGGQGG------------- MMAR_1161|M.marinum_M GGAAG--------------------LWGAGGNGGQGG------------- MUL_3507|M.ulcerans_Agy99 GGNAG--------------------LWGDGGAGGNGSA------TYDYDQ MAB_4284c|M.abscessus_ATCC_199 NIGSGNTTNTEIGSHNQANIGTSTSAGGSAAVGGNAG------------- MLBr_01183|M.leprae_Br4923 TVASN--------------------------------------------- MAV_1346|M.avium_104 MDAQN--------------------------------------------- . Mflv_5091|M.gilvum_PYR-GCK -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG-------------- Mvan_1264|M.vanbaalenii_PYR-1 -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG-------------- MSMEG_0868|M.smegmatis_MC2_155 VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD TH_3810|M.thermoresistible__bu --NGYRTTDNNALDGGHGG------------------------------- Mb3402|M.bovis_AF2122/97 --NGLTGNDGVNPAPVTNP------------------------------- Rv3367|M.tuberculosis_H37Rv --NGLTGNDGVNPAPVTNP------------------------------- MMAR_1161|M.marinum_M --SGLAGSNGVNPAAVTDP------------------------------- MUL_3507|M.ulcerans_Agy99 NFSRLGALEGAGGNGGHGG------------------------------- MAB_4284c|M.abscessus_ATCC_199 -LAGNAGLAGNAGLAGNAG------------------------------- MLBr_01183|M.leprae_Br4923 -AAAAQLTTEIAPPAAD--------------------------------- MAV_1346|M.avium_104 -AAAAAPTTSIAPAAAD--------------------------------- Mflv_5091|M.gilvum_PYR-GCK --AVGAAGAAG------TVGTAGATGGTG---------------TGANGG Mvan_1264|M.vanbaalenii_PYR-1 --AIGTAGVAG------AAGTAGATGGTG---------------VGGNGG MSMEG_0868|M.smegmatis_MC2_155 GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG TH_3810|M.thermoresistible__bu --------------------------------------------NGGNVG Mb3402|M.bovis_AF2122/97 --ALNGAAG------------------------------------DSNIE Rv3367|M.tuberculosis_H37Rv --ALNGAAG------------------------------------DSNIE MMAR_1161|M.marinum_M --ALNGAAG------------------------------------DSNIN MUL_3507|M.ulcerans_Agy99 --LLFGNGG------------------------------------GGGDA MAB_4284c|M.abscessus_ATCC_199 ---LAGNAG-----------------------------------LAGNAG MLBr_01183|M.leprae_Br4923 -----------------------------------------------DVS MAV_1346|M.avium_104 -----------------------------------------------EVS Mflv_5091|M.gilvum_PYR-GCK AGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGG Mvan_1264|M.vanbaalenii_PYR-1 AGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGG MSMEG_0868|M.smegmatis_MC2_155 HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE TH_3810|M.thermoresistible__bu FFSLFNLGG--------------------AGGWGGSGVDG---------- Mb3402|M.bovis_AF2122/97 PQTSVLIGTQGGD-----------------GTPGGAGVNG---------- Rv3367|M.tuberculosis_H37Rv PQTSVLIGTQGGD-----------------GTPGGAGVNG---------- MMAR_1161|M.marinum_M -GNTTWHGTNGDP-----------------GTPGGTGVNG---------- MUL_3507|M.ulcerans_Agy99 GANNKFVTAQATPN----------------GAAGGYGGNAG--------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAG-------------NAGLAGNAGLAGNAG------- MLBr_01183|M.leprae_Br4923 ILLAHFFSGHGRQY------------------------------------ MAV_1346|M.avium_104 ALQAAQFSAYGTWY------------------------------------ Mflv_5091|M.gilvum_PYR-GCK Q--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG--------- Mvan_1264|M.vanbaalenii_PYR-1 Q--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG--------- MSMEG_0868|M.smegmatis_MC2_155 IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG TH_3810|M.thermoresistible__bu -----------VDVVGGNP------------------------------- Mb3402|M.bovis_AF2122/97 ----------GNGGAGGDANGNPANTSIA--------------------- Rv3367|M.tuberculosis_H37Rv ----------GNGGAGGDANGNPANTSIA--------------------- MMAR_1161|M.marinum_M ----------GNGGAGGDANDDVANSSGG--------------------- MUL_3507|M.ulcerans_Agy99 --------LWGNGGAGGDGGFGGTATVIG--------------------- MAB_4284c|M.abscessus_ATCC_199 --------LAGNAGLAGNAGLAGNAGLAG--------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG Mvan_1264|M.vanbaalenii_PYR-1 ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG MSMEG_0868|M.smegmatis_MC2_155 TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG TH_3810|M.thermoresistible__bu -----------DGGTPG------------------------------AHG Mb3402|M.bovis_AF2122/97 -----------NAGAGGNGA---------------------------AGG Rv3367|M.tuberculosis_H37Rv -----------NAGAGGNGA---------------------------AGG MMAR_1161|M.marinum_M -----------LAGSGGSGA---------------------------TGG MUL_3507|M.ulcerans_Agy99 -----------DGGTGGNGG---------------------------LLS MAB_4284c|M.abscessus_ATCC_199 -----------NAGLAGNAG------------------------LAGNAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------Q MAV_1346|M.avium_104 -------------------------------------------------Q Mflv_5091|M.gilvum_PYR-GCK GKGGNGGNGGRGGLFG---------------KGGNAGNGAD--------- Mvan_1264|M.vanbaalenii_PYR-1 GKGGNGGNGGRGSLFG---------------RGGNAGNGGN--------- MSMEG_0868|M.smegmatis_MC2_155 AVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN TH_3810|M.thermoresistible__bu ESHTPGVYTDRQ-------------------------------------- Mb3402|M.bovis_AF2122/97 DGGANGGAGGAG-------------------------------------- Rv3367|M.tuberculosis_H37Rv DGGANGGAGGAG-------------------------------------- MMAR_1161|M.marinum_M DGGANGGTGGAG-------------------------------------- MUL_3507|M.ulcerans_Agy99 GDGGAGGVGGTG-------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAG-------------------------------------- MLBr_01183|M.leprae_Br4923 AHASQGATNHQD-------------------------------------- MAV_1346|M.avium_104 QVSAQAKAIHQT-------------------------------------- . Mflv_5091|M.gilvum_PYR-GCK -------------GGTGGAGGAGGTGG-TGGAGGTGG------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------GGTGGNGGNGGTGG-TGGNGGTGG------------- MSMEG_0868|M.smegmatis_MC2_155 GPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHST TH_3810|M.thermoresistible__bu -----------------GEDGEDGTGTGIGGRGGNGG------------- Mb3402|M.bovis_AF2122/97 ----------------GQAASAGSSVGGDGGNGGAGG------------- Rv3367|M.tuberculosis_H37Rv ----------------GQAASAGSSVGGDGGNGGAGG------------- MMAR_1161|M.marinum_M ----------------GQAASYGYSSGGNGGTGGAGG------------- MUL_3507|M.ulcerans_Agy99 ----------------GIQIYSGGGIGGVGGIGGNGG------------- MAB_4284c|M.abscessus_ATCC_199 ---------------LAGNAGLAGNAGLAGNAAVAGN------------- MLBr_01183|M.leprae_Br4923 -----------------LIQSLLTSSSAYAGTETAN-------------- MAV_1346|M.avium_104 -----------------LVQNLDTNADSYGATEAANR------------- . . Mflv_5091|M.gilvum_PYR-GCK ----TGGTGGIGGAGSTGGT--------------------------GGTG Mvan_1264|M.vanbaalenii_PYR-1 ----TGGTGGIGGAGSTGGT--------------------------GGTG MSMEG_0868|M.smegmatis_MC2_155 GQTDTGGNGGRGGDGGTFVN--------------------------AGAN TH_3810|M.thermoresistible__bu ---SSSGTHPMAEDG----------------------------------E Mb3402|M.bovis_AF2122/97 ----TGTNGHAGGAGGAGGQAASAGSSVGGDGGNGGAGGTGTNGHAGGAG Rv3367|M.tuberculosis_H37Rv ----TGTNGHAGGAG----------------------------------- MMAR_1161|M.marinum_M ----TGADGGAGGDG----------------------------------- MUL_3507|M.ulcerans_Agy99 ----AGGTSGLIGDG----------------------------------- MAB_4284c|M.abscessus_ATCC_199 --AAVAGNAAVAGNAAVGGVLN---------------------------T MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTG-GTGGTGGTGGTGGKGGTGGTGGAGGTG----GDGGTG Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTG-GTGGTGGTGGTGGKGGTGGTGGDGGTG----GTGGTG MSMEG_0868|M.smegmatis_MC2_155 GNGGAGGAGGVSEGEGGTGGHGGDGGRGGDGALGGNGGTGGVGLGNGGKG TH_3810|M.thermoresistible__bu HVKALDGRPGLD---GGNGSHGGNGGHGGRGGFLGIGGSG-------GWG Mb3402|M.bovis_AF2122/97 GAGGAGGRGGWLVGSGGNGGNGGNGAAGGNGAIGGTGGAG--GVP-ANQG Rv3367|M.tuberculosis_H37Rv GAGGAGGRGGWLVG---NGGNGGNGAAGGNGAIGGTGGAG--GVP-ANQG MMAR_1161|M.marinum_M GHGGAGGRGGWLLGDGGNGGAGGDGATGGSGATGGNGGAG--GITTADQN MUL_3507|M.ulcerans_Agy99 GAGGAGGTGGGNAG---VGGVGGVGGTGGAARLFGSGGSG--GIG--GTG MAB_4284c|M.abscessus_ATCC_199 GVSGAIG-GSSHVGGAINESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVG MLBr_01183|M.leprae_Br4923 -----------------------------HDSL----------------- MAV_1346|M.avium_104 VNTSAAALQGLAPNVIPNAAPAADPPPAGTTSLGTSIGWA--------QN Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTG---------GTGGTGGTGGAG-----------DGTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTG---------GTGGTGGTGGAG-----------DGLGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGN TH_3810|M.thermoresistible__bu GHGGNGGD-----------TDADGGNGGDG---------------GNGGS Mb3402|M.bovis_AF2122/97 GNSALGTQP----------VSGDGGDGGNG------------GTGGTGGR Rv3367|M.tuberculosis_H37Rv GNSALGTQP----------VGGDGGDGGNG------------GTGGTGGR MMAR_1161|M.marinum_M GYSAVGTQA----------VGGDGGNGGNG------------GSGGSGGT MUL_3507|M.ulcerans_Agy99 GHSLINSGGG---------IGGKGGGGGAA------------GLIGDGGA MAB_4284c|M.abscessus_ATCC_199 VGSHVGGGIS----------ESLGGSGSVG---------------GSTAV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 VGAAASDFIT----------LGEGQFAPVP---------------GAAGI Mflv_5091|M.gilvum_PYR-GCK GG----TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGG Mvan_1264|M.vanbaalenii_PYR-1 GG----TGGFGGQGGQGG-----------------TGGTGGQGG-LGGVG MSMEG_0868|M.smegmatis_MC2_155 GGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATN TH_3810|M.thermoresistible__bu AG---------------------------------RGGTGGLRGVFGING Mb3402|M.bovis_AF2122/97 GG-------------DGG-----------------SGGAGGASGWLMGNG Rv3367|M.tuberculosis_H37Rv GG-------------DGG-----------------SGGAGGASGWLMGNG MMAR_1161|M.marinum_M GG-------------AAG-----------------SGGAGGDGGWLVGNG MUL_3507|M.ulcerans_Agy99 GG-------------AGG-----------------NGGDGTGAGGLGGNG MAB_4284c|M.abscessus_ATCC_199 GG----------------------------------GAHTGVGGGVSTGV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 PNFN-------------------------------PGLTAATTAGPPAPA Mflv_5091|M.gilvum_PYR-GCK GTG-----------------------GQGGTGGTGGQGGTGGTGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 GTG-----------------------GTGGTGGTGGQGGTGGTGGTGGTG MSMEG_0868|M.smegmatis_MC2_155 GTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANG TH_3810|M.thermoresistible__bu GNG------------------------RAGLGGRGXXXXGGGVGAAVRSG Mb3402|M.bovis_AF2122/97 GNG-----------------------GNGGTGGSGGVGGNGGIGGDGAGG Rv3367|M.tuberculosis_H37Rv GNG-----------------------GNGGTGGSGGVGGNGGIGGDGAGG MMAR_1161|M.marinum_M GTG-----------------------GTGGIGGQGGIGGQGGVGGNGAVG MUL_3507|M.ulcerans_Agy99 ASA-----------------------DWIGNGGSGGAGGSGGLGAHAGAG MAB_4284c|M.abscessus_ATCC_199 GVG-----------------------SHVGGGISESLGGSGSVGGSTAVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 APA-----------------------AAAGAPVLASMGRGPSIGGLSVPP Mflv_5091|M.gilvum_PYR-GCK --------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGA Mvan_1264|M.vanbaalenii_PYR-1 --------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGA MSMEG_0868|M.smegmatis_MC2_155 PSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGG TH_3810|M.thermoresistible__bu ---------------NGVFSGGGGTPSAGFGVPTTIQFPAGSCTSRAVSR Mb3402|M.bovis_AF2122/97 --------GNATSTSSIPFDAHGGNGGAGGDAGHGGTGGDGGDGGHAGTG Rv3367|M.tuberculosis_H37Rv --------GNATSTSSIPFDAHGGNGGAGGDAGHGGTGGDGGDGGHAGTG MMAR_1161|M.marinum_M --------GNAHSP---ILDAHGGDGGAGGDAGHGGTGGDGGDGGLSGAG MUL_3507|M.ulcerans_Agy99 --------GNGGSLY-----GNDGSGGAGG-TGASGAGGNGGGGGAAGMM MAB_4284c|M.abscessus_ATCC_199 --------GGAHTGVGGGVNTGVGVGSHVGGGISESLGGSGSVGGSTAVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ------------------SWAPGGVAPAANATPAQLVGAGFTSAAPDTAP Mflv_5091|M.gilvum_PYR-GCK GG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQG Mvan_1264|M.vanbaalenii_PYR-1 GG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQG MSMEG_0868|M.smegmatis_MC2_155 DGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVA TH_3810|M.thermoresistible__bu EG------------------------IMPSSRAASARAG----------- Mb3402|M.bovis_AF2122/97 GR----------------------GGLLAGQHANSGNGG----------- Rv3367|M.tuberculosis_H37Rv GR----------------------GGLLAGQHANSGNGG----------- MMAR_1161|M.marinum_M GR----------------------GGLLAGLQGSTGSGG----------- MUL_3507|M.ulcerans_Agy99 GD----------------------GGAGGDGGDGSAAGG----------- MAB_4284c|M.abscessus_ATCC_199 GG-------------------AHTSAINDALGGSGSVGG----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 VT------------------------AVPGGVPSMATAG----------- Mflv_5091|M.gilvum_PYR-GCK ATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG---------- Mvan_1264|M.vanbaalenii_PYR-1 ATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG---------- MSMEG_0868|M.smegmatis_MC2_155 GNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHG TH_3810|M.thermoresistible__bu ----------------AACASSTSRSRRSFCCSRA--------------- Mb3402|M.bovis_AF2122/97 ----------------GGGTGGAGGTHGTPGSGNAGGTG----------- Rv3367|M.tuberculosis_H37Rv ----------------GGGTGGAGGTHGTPGSGNAGGTG----------- MMAR_1161|M.marinum_M ----------------AGGTGGDGGSPGTVGSGKAGGTG----------- MUL_3507|M.ulcerans_Agy99 ----------------LGGDGGNADWLGN-GGGGTGGFG----------- MAB_4284c|M.abscessus_ATCC_199 ------------STAVGGGAHTSAINESMNSSINASHSSSMN-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ----------------RGGYGLGAPRYGVKPTVMPKPAI----------- Mflv_5091|M.gilvum_PYR-GCK -TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGE Mvan_1264|M.vanbaalenii_PYR-1 -TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGD MSMEG_0868|M.smegmatis_MC2_155 AITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGN TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 ---TGNADSTNGGPGSDGLGGDAFNGSRGTDGNPG--------------- Rv3367|M.tuberculosis_H37Rv ---TGNADSTNGGPGSDGLGGDAFNGSRGTDGNPG--------------- MMAR_1161|M.marinum_M ---TGDGNSTNGGPGANGLGGAAFDGARGADGNPG--------------- MUL_3507|M.ulcerans_Agy99 ---LPPATGGFGGRGGRLFGSPGAQGRRALMCLSAACRC----------- MAB_4284c|M.abscessus_ATCC_199 -ESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK DGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDGGKGGAGA Mvan_1264|M.vanbaalenii_PYR-1 AGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAGGAGGDGS MSMEG_0868|M.smegmatis_MC2_155 GGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGS TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 -------------------------------------------------- Rv3367|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1161|M.marinum_M -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK E--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAA Mvan_1264|M.vanbaalenii_PYR-1 E--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAA MSMEG_0868|M.smegmatis_MC2_155 EPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTT TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb3402|M.bovis_AF2122/97 -------------------------------------------------- Rv3367|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1161|M.marinum_M -------------------------------------------------- MUL_3507|M.ulcerans_Agy99 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GDSDD Mvan_1264|M.vanbaalenii_PYR-1 GDSD- MSMEG_0868|M.smegmatis_MC2_155 GANNP TH_3810|M.thermoresistible__bu ----- Mb3402|M.bovis_AF2122/97 ----- Rv3367|M.tuberculosis_H37Rv ----- MMAR_1161|M.marinum_M ----- MUL_3507|M.ulcerans_Agy99 ----- MAB_4284c|M.abscessus_ATCC_199 ----- MLBr_01183|M.leprae_Br4923 ----- MAV_1346|M.avium_104 -----