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MVMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAAGDEVSAAIAALFGTHAQEYQALSARV ATFHEQFVRSLTAAGSAYATAEAANASPLQALEQQVLGAINAPTQLWLGRPLIGDGVHGAPGTGQPGGAG GLLWGNGGNGGSGAAGQVGGPGGAAGLFGNGGSGGSGGAGAAGGVGGSGGWLNGNGGAGGAGGTGANGGA GGNAWLFGAGGSGGAGTNGGVGGSGGFVYGNGGAGGIGGIGGIGGNGGDAGLFGNGGAGGPGPRACRVPP ASTAATAATAATAEPAATAGAAGYWLATAGPAGPAASAATVVRAALAIRVSPSTTVPAVTAVTAATPAWA GPVGPAACWRVRTVPPAPPPPAAATAAMAASAPPPTHPYKPAGPAVMAVMAGWSATAAPAAPAVPVMRVP PALPVPPYNRRAVTAPMAAPGATAVMAEMAAPSTATAASAARAVPAVAAAPAETDSTPPPWVRPVPMAVW AATAARAVTAVVAAPAAPRSPAPPARPGTAAPAVTAARPVMAEPVPPVM
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3377c | PE_PGRS50a | - | 100% (539) | hypothetical protein Mb3377c |
M. bovis AF2122 / 97 | Mb1487c | PE_PGRS28 | e-104 | 59.59% (339) | PE-PGRS family protein |
M. bovis AF2122 / 97 | Mb1485c | PE_PGRS27 | e-103 | 58.05% (348) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5091 | - | 6e-44 | 41.37% (249) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3345c | PE_PGRS50 | 1e-158 | 87.86% (313) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 2e-14 | 40.40% (99) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 7e-24 | 36.07% (219) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_2100 | - | 1e-101 | 58.36% (329) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 2e-18 | 44.31% (167) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 7e-37 | 40.91% (264) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 3e-21 | 33.87% (313) | PUTATIVE - |
M. ulcerans Agy99 | MUL_0572 | - | 6e-98 | 53.07% (407) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 3e-43 | 42.86% (238) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT Mb3377c|M.bovis_AF2122/97 -------------------MVMSLMVAPELVAAAAADLTGIGQAISAANA MLBr_01183|M.leprae_Br4923 -------------------MPLFLNAEPQALTAAANTLEGLSAATVASNA Rv3345c|M.tuberculosis_H37Rv -------------------MVMSLMVAPELVAAAAADLTGIGQAISAANA MUL_0572|M.ulcerans_Agy99 --------------------MSYVVAIPDMLASAAADVAGIGSSVGAANT MMAR_2100|M.marinum_M --------------------MSFVSVTPEMVVAAASDLSGINSAIAQANS TH_3810|M.thermoresistible__bu ----------------------------VDGDGGSGGRTGLFSKLSRGGD MAB_4284c|M.abscessus_ATCC_199 -----------------MSIIDFILNLFRDPVEAASYVADPEAALANAGL MAV_4827|M.avium_104 ----------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAI Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA Mb3377c|M.bovis_AF2122/97 AAAGPTTQVLAAAGDEVSAAIAALFGTHAQEYQALSARVATFHEQFVRSL MLBr_01183|M.leprae_Br4923 AAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSL Rv3345c|M.tuberculosis_H37Rv AAAGPTTQVLAAAGDEVSAAIAALFGTHAQEYQALSARVATFHEQFVRSL MUL_0572|M.ulcerans_Agy99 AAVGATTGVMAAADDEVSVAIAALFSGHGQAYQAISAQAAAFHDQFLRAL MMAR_2100|M.marinum_M VAAAATTTVLPAAADEVSAAIAALFGTHAQQYQAISAELAAFHDRFVQSL TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQ MAV_4827|M.avium_104 DVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAA Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP Mb3377c|M.bovis_AF2122/97 TAAGS---------------------------------AYATAEAANASP MLBr_01183|M.leprae_Br4923 LTSSS---------------------------------AYAGTETANHDS Rv3345c|M.tuberculosis_H37Rv TAAGS---------------------------------AYATAEAANASP MUL_0572|M.ulcerans_Agy99 TGAGG---------------------------------AYAAAEAANASP MMAR_2100|M.marinum_M NTGAG---------------------------------SYLRAEAANAEQ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 PDGPS------------------------------------ILSPSLLSP MAV_4827|M.avium_104 LR------------------------------------------------ Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA Mb3377c|M.bovis_AF2122/97 LQALEQQVLGAIN---------APTQLWLG--------RPLIGDGVHGAP MLBr_01183|M.leprae_Br4923 L------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv LQALEQQVLGAIN---------APTQLWLG--------RPLIGDGVHGAP MUL_0572|M.ulcerans_Agy99 LQAAEQEVLAVIN---------APTNALLG--------RPLIGNGTDGLA MMAR_2100|M.marinum_M G------LLGLVN---------APTQALFG--------RPLIGDGANGAP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 RD------------------------------------NDFLSHNDTDFA MAV_4827|M.avium_104 --------------------------------------DALAARRIDNVM Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG Mb3377c|M.bovis_AF2122/97 GTGQPGGAGGLLWGNGGNGGSGAAGQVGGPGGAAGLFGNGGSGGSGGAG- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GTGQPGGAGGLLWGNGGNGGSGAAGQVGGPGGAAGLFGNGGSGGSGGAG- MUL_0572|M.ulcerans_Agy99 GTGAAGGAGGLLWGNGGNGGSGAAGQAGGAGGAAGLIGTGGAGGMGGAGG MMAR_2100|M.marinum_M GSGQAGGAGGLLYGNGGAGGSGGVGQAGGAGGAAGLIGSGGAGGAGGAG- TH_3810|M.thermoresistible__bu -----GGDGGLGGNGGHGGGTGIISLLSLAGNGGNGGNGYRTTDNNALDG MAB_4284c|M.abscessus_ATCC_199 SHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVA MAV_4827|M.avium_104 LVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVY Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVG-----ATGAVG--APGVAGA Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAG-----ATGAVG--APGVAGA MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADG-----TSAHVDGGTGGTGGT Mb3377c|M.bovis_AF2122/97 AAGGVGGSGG--WLNGNGGAGGAGGTGAN------GGAGGNAWLFGAGGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv AAGGVGGSGG--WLNGNGGAGGAGGTGAN------GGAGGNAWLFGAGGS MUL_0572|M.ulcerans_Agy99 GAGGMGGSGG--WLLGNGGAGGAGGVGCAGVSGGVGGTGGNAMLFGNGGA MMAR_2100|M.marinum_M GTGGAGGAGG--WLYGNGGAGGVGGAGAVG------GAGGNTWLWGNGGA TH_3810|M.thermoresistible__bu GHGGNGGNVGFFSLFNLGGAGGWGGSGVDG-----------VDVVGGNPD MAB_4284c|M.abscessus_ATCC_199 VGGSNSGPIAS----GQGSTAVNGDVRDSN-----------IINADHGSN MAV_4827|M.avium_104 KQQIRAESYG--DAAGQLSAMVAGLEKLES-------LPGGLLLVGSGVD Mflv_5091|M.gilvum_PYR-GCK TGATG-------------VTSGVVGGNGEDAVGYGATG-----AAGAAGA Mvan_1264|M.vanbaalenii_PYR-1 TGATG-------------VTSNVTGGNGADAVGYGATG-----AAGAAGA MSMEG_0868|M.smegmatis_MC2_155 GGGTG-------------GTGGIGGTGGGLFGLLGHSG-----STGAAGA Mb3377c|M.bovis_AF2122/97 GGAG---------------TNGGVGGSGGFVYGNGGAG-------GIGGI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GGAG---------------TNGGVGGSGGFVYGNGGAG-------GIGGI MUL_0572|M.ulcerans_Agy99 GGMGGAGADGAVGAAGTAGTSTSAGGVGGAGWDATAAG-------VLAAT MMAR_2100|M.marinum_M GGSGGVGS-----------GSGGAGGSGGWLYGNGGAGGTGGVADGVGEG TH_3810|M.thermoresistible__bu GGTPG--------------AHGESHTPGVYTDRQGEDG-------EDGTG MAB_4284c|M.abscessus_ATCC_199 VGVDQ--------------SQTRVGGDYTNVSGHGSADIDKSVTVVDDHS MAV_4827|M.avium_104 VAPLK----------------QVLQTTTFLDVSVAEEP-------ETALA Mflv_5091|M.gilvum_PYR-GCK AGAAGAAG--------------AVGSAGAAGEAGETGTWG--NAGLPGKA Mvan_1264|M.vanbaalenii_PYR-1 AGAAGKAG--------------AVGSAGTAGSAGAPGVWG--NAGLPGAA MSMEG_0868|M.smegmatis_MC2_155 AGNGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKG Mb3377c|M.bovis_AF2122/97 GGIGGNGGDAGLF---------GNGGAGGPGPRACRVP-------PASTA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GGIGGNGGDAGLF---------GNGGAGGAGAAGLPGA-------AGLNG MUL_0572|M.ulcerans_Agy99 GGDGGDSGGGGAG---------GNGGAGGAGGHGSALFG---ADGANGNG MMAR_2100|M.marinum_M GGHGGAGGNARLL---------GTGGAGGDGGAGLAGAAGISGIAAGEAG TH_3810|M.thermoresistible__bu TGIGGRGGNG--------------GSSSGTHPMAEDGEHVKALDGRPGLD MAB_4284c|M.abscessus_ATCC_199 QRNTTNINDSFNTDR-------STNIGSGNTTNTEIGSHNQANIGTSTSA MAV_4827|M.avium_104 RGAALAAANAPLF----------ASSTAALAYAQDPGTGAVDQYSLPDYL Mflv_5091|M.gilvum_PYR-GCK GDAGGAG----------------AVGAAGAAG------TVGTAGATGGTG Mvan_1264|M.vanbaalenii_PYR-1 GAAGGAG----------------AIGTAGVAG------AAGTAGATGGTG MSMEG_0868|M.smegmatis_MC2_155 GGGGGGGGGAILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTG Mb3377c|M.bovis_AF2122/97 ATAATAATAEPAATAGAAGYWLATAGPAGPAASAATVVRAALAIRVSPST MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GDGSDGGNGGTGGNGGRGGLLVGNGGAGGAGGVGGDGGKGGAGDPSFAVN MUL_0572|M.ulcerans_Agy99 GAGGAGGNPGAPGNGGTGGVGPDAATSGGMGGTGGDPGAVGGRGNSGAAG MMAR_2100|M.marinum_M TGGGIGGDGGVGGDGGAGGWLFGNGGAGGIGGAGGAGGAGGFGASGDLVI TH_3810|M.thermoresistible__bu GGNGSHG------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGSAAVG------------------------------------------- MAV_4827|M.avium_104 YVP----------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ---------------TGANGGAGGVGGVGGTGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 ---------------VGGNGGAGQAGGIGGTGAAG--------------A MSMEG_0868|M.smegmatis_MC2_155 RVIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTA Mb3377c|M.bovis_AF2122/97 TVPAVTAVTAAT----PAWAGPVGPAACWRVRTVP-----PAPPPPAAAT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv NGAGGNGGHGGN----PGVGGAGGAGGLLAGAHGA-----AGATPTSGGN MUL_0572|M.ulcerans_Agy99 GAGAVAGASGAAGTIIAGNGGNGGAGGAGYAADGP-----AGPAIGNGGD MMAR_2100|M.marinum_M NQGSGADGGSGGAGGAGGAGGNGGAGGWLFSAHGAGGVGGAGGTGGTPGD TH_3810|M.thermoresistible__bu -----------------GNGGHGGRGGFLGIGGSG--------------- MAB_4284c|M.abscessus_ATCC_199 -----------------GNAGLAGNAGLAGNAGLAG----------NAGL MAV_4827|M.avium_104 ------------------VDPEPGDDELAYSAVGE--------------- Mflv_5091|M.gilvum_PYR-GCK AGGAGGLGETGTTGGAGGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGG Mvan_1264|M.vanbaalenii_PYR-1 AGQAGTAGETGVTGGVGGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGG MSMEG_0868|M.smegmatis_MC2_155 TGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATGADSLGG Mb3377c|M.bovis_AF2122/97 ---AAMAASAPPPTHPYKPAGP--AVMAVMAGWSATAAPAAPAVPVMRVP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GGDGGIGATANSPLQAGGAGGN--GGHGGLVGNGGTGGAGGAGHAGSTGA MUL_0572|M.ulcerans_Agy99 GGHGGAGGFYGNGGAGGAGGNS--APGGGTGGNGGTGGDSGAMGSSGGRG MMAR_2100|M.marinum_M GGGGAHGSMAVNPGAGFGTGGN--GGNGGDPGAGGAGGTGGSGAGGSRAA TH_3810|M.thermoresistible__bu -GWGGHGGNGGDTDADGGNGGD--GGNGGSAGRGGTGGLRGVFGINGGNG MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG MAV_4827|M.avium_104 -EDAESPTVVIEKLFLPEDSEPRRRPVLLVGSGLAVVGISAVLALEIALA Mflv_5091|M.gilvum_PYR-GCK KG----IQGGQG-------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 KG----IQGGQG-------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 RGGTSWVQAGYGPTTGGKASG----------------------------- Mb3377c|M.bovis_AF2122/97 PALP--VPPYNRRAVT---------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv TGTA--LQPTGGNGTNGGAGGHGGNGGNGGAQHGDGGVGGKGGAGGSGGA MUL_0572|M.ulcerans_Agy99 GDGG--VGTNGGAGGGGG-------------------------------- MMAR_2100|M.marinum_M TGATGSTPSSGGNGGAGGAG------------------------------ TH_3810|M.thermoresistible__bu RAG----------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NAG----------------------------------------------- MAV_4827|M.avium_104 IGIR---------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------LQGGKGGDGGAGGKGGDADSMGS------------------A Mvan_1264|M.vanbaalenii_PYR-1 --------LQGGQGGDGGTGGTGGDATSMGE------------------A MSMEG_0868|M.smegmatis_MC2_155 ----TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAA Mb3377c|M.bovis_AF2122/97 -------APMAAPGATAVMAEMAAP-STATA------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GGNGFDAATLGSPGADGGMGGNGGKGGDGGK------------------- MUL_0572|M.ulcerans_Agy99 -----NATSYGTANATGGAGGDGGTGSTGNG------------------- MMAR_2100|M.marinum_M ----ADSITTGGAGAAGGTGGDGGLVGDGGA------------------- TH_3810|M.thermoresistible__bu ---------LGGRGXXXXGGGVGAAVRSGNG------------------V MAB_4284c|M.abscessus_ATCC_199 --------LAGNAGLAGNAGLAGNAGLAGNAG-----------------L MAV_4827|M.avium_104 --------TTGTVALQPTPNQHLIVPTEQAP------------------- Mflv_5091|M.gilvum_PYR-GCK GATGGKGGNGGNGGRGGLFG---------------KGGNAGNGAD----- Mvan_1264|M.vanbaalenii_PYR-1 GATGGKGGNGGNGGRGSLFG---------------RGGNAGNGGN----- MSMEG_0868|M.smegmatis_MC2_155 SANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQA Mb3377c|M.bovis_AF2122/97 -ASAARAVPAVAAAPAETDSTPPPWVRPVPMAVWAATAARAVTAVVAAP- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv -AGDGGAGAAGDVTLAVNQGAGGDGGNGGEVGVGGKGGAGGVSANPALNG MUL_0572|M.ulcerans_Agy99 -GSGGDGGNGGTGHGGGGGPGGTAINYGAGDAFGGAAGKGGTGVVGGNGG MMAR_2100|M.marinum_M -GGDGGAGLGGAPGTSVIFPGGQPGSSGGDGGAGGAGGAGGDGGLVAGNG TH_3810|M.thermoresistible__bu FSGGGGTPSAGFGVPTTIQFPAGSCTSRAVSREGIMPSSRAASAR----- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGNAAVAGNAAVAGNAAVAGN----- MAV_4827|M.avium_104 -APPPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAPP----- Mflv_5091|M.gilvum_PYR-GCK -----------------GGTGGAGGAGGTGG-TGGAGGTGG--------- Mvan_1264|M.vanbaalenii_PYR-1 -----------------GGTGGNGGNGGTGG-TGGNGGTGG--------- MSMEG_0868|M.smegmatis_MC2_155 YDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANG Mb3377c|M.bovis_AF2122/97 AAPRSPAPPARPGTAAPAVTAARPVMAEPVPPVM---------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv SAGANGTAPTSGGNGGNGGAGATPTVAGENGGAGGNGGHGGSVGNGGAGG MUL_0572|M.ulcerans_Agy99 SGGAAYNYGTGNATGAGGSSGSGGAASVPNSASTATATSG---------- MMAR_2100|M.marinum_M GVGGAGGIGGVGGTGGDGSVGVDAAGAGQDGGVGGAGGAGGAGGAGGAGG TH_3810|M.thermoresistible__bu ----------------AGAACASSTSRSRRSFCCSRA------------- MAB_4284c|M.abscessus_ATCC_199 ------------------AAVGGVLNTGVSGAIGGSSHVGG--------- MAV_4827|M.avium_104 ---------------LPEAPPIPAAPPVVPVPVVVPPVPVP--------- Mflv_5091|M.gilvum_PYR-GCK -----------------------------------------TGGTGGIGG Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------------TGGTGGIGG MSMEG_0868|M.smegmatis_MC2_155 QHSTG---------------------------------QTDTGGNGGRGG Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv AGGNG---------------VAGTGLALNGGNGGNGGIGGNGGSAAGTGG MUL_0572|M.ulcerans_Agy99 --------------------------------------------SGGAGG MMAR_2100|M.marinum_M EGGAGGHALAAGYADGSQGAGGAGGAGGIGGDGAAGGKGAEGAAAAGAGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------AINESLGG MAV_4827|M.avium_104 -------------------------------------------VPVRIPV Mflv_5091|M.gilvum_PYR-GCK AGSTGGTGGTGGTGGTGGTGGTG--GTGGTGGTGGTGGKGGTGGTGGAGG Mvan_1264|M.vanbaalenii_PYR-1 AGSTGGTGGTGGTGGTGGTGGTG--GTGGTGGTGGTGGKGGTGGTGGDGG MSMEG_0868|M.smegmatis_MC2_155 DGGTFVNAGANGNGGAGGAGGVSE-GEGGTGGHGGDGGRGGDGALGGNGG Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv DGGKGGNGGAGANGQDFSASANG--------ANGGQGGNGGNGGIGGKGG MUL_0572|M.ulcerans_Agy99 DGTDGGNGGSGGFAFTFGTGNII--------AGVGGGGGTGSTGVGGIGG MMAR_2100|M.marinum_M DGNDGGNGGRGGAGGRGGDGGVGGAGPEGQTGMQGVGGAGGDGGLGGQAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SGSVGGSTAVGGGAHTGVGGGVS--------TGVGVGSHVGGGISESLGG MAV_4827|M.avium_104 PDPVSPPQLLAPPRLSVPQPVQP---------PVRVPQPPSPPQVGGTVP Mflv_5091|M.gilvum_PYR-GCK TG----GDGGTGGTGGTGGTG---------GTGGTGGTGGAG-------- Mvan_1264|M.vanbaalenii_PYR-1 TG----GTGGTGGTGGTGGTG---------GTGGTGGTGGAG-------- MSMEG_0868|M.smegmatis_MC2_155 TGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGT Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv DAFATFAKAGNGGAGGNGGNVGVAGQGGAGGKGAIPAMKGAT--GADGTA MUL_0572|M.ulcerans_Agy99 S---------GGGADINNGAFTVVPQGGAGGHGGDGATDGG--------- MMAR_2100|M.marinum_M NGSDGADAIVGGGKGGDGGDGGDPGLGGAGGQGGAGSTAGMEGLTAGDDG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SGSVGGSTAVGGGAHTGVGGG----------------------------- MAV_4827|M.avium_104 QSPPQHQTPPGEGTPPK--------------------------------- Mflv_5091|M.gilvum_PYR-GCK ---DGTGGTGGTGG----TGGQGGQGGQGG-----------------TGG Mvan_1264|M.vanbaalenii_PYR-1 ---DGLGGTGGTGG----TGGFGGQGGQGG-----------------TGG MSMEG_0868|M.smegmatis_MC2_155 ATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGG Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv PTSGGDGGNGGNGASPTVAGGNGGDGGKGGSGGNVGNGGNGGAGGNGAAG MUL_0572|M.ulcerans_Agy99 --AGGAGGFTEIDSSASVIAATGGAGGDGGSGGTGRGGTGGGGTGGGGTG MMAR_2100|M.marinum_M PGHGGDGGAGGDGAAAVTTGSAGGDGGAGGDGGLVGDGGVGGNGGTGADG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---VSTGVGVGSHVGGGISESLGGSGSVGG-------------------- MAV_4827|M.avium_104 -----PDGPGNYGGGHVPTPGAGGSGGSGG-------------------- Mflv_5091|M.gilvum_PYR-GCK TGGQGG-LGGGGGTG-----------------------GQGGTGGTGGQG Mvan_1264|M.vanbaalenii_PYR-1 TGGQGG-LGGVGGTG-----------------------GTGGTGGTGGQG MSMEG_0868|M.smegmatis_MC2_155 DGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHG Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv QAGTPGPTSGDSGTSGTDGGAGGNGGAGGAGGTLAGHGGNGGKGGNGGQG MUL_0572|M.ulcerans_Agy99 GG----------------GGVGINNGSGEAIGGAPGAGGTGAVGGDGGQG MMAR_2100|M.marinum_M SPGITFISPG--GLSGTDGGAGSIGGTGGAGGAGGLHAGDGGAGGIGGTG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------STAVGGGAHTGVG MAV_4827|M.avium_104 --------------------------------------GHVPTPGAGGSG Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTG----------GTGGAGGDGGLGGLGGFGGSGGTGGQGG Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTG----------GTGGAGGDGGLGGLGGFGGVGGTGGQGG MSMEG_0868|M.smegmatis_MC2_155 GNGGQGTIEANGPSAVASGI--GAGGNGGDGIDGGLGGNGGDGVVNTTAN Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GIGGAGERGADGAGPNANGANGENGGSGGNGGDGGAGGNGGAGGKAQAAG MUL_0572|M.ulcerans_Agy99 GAAYSYGTGDATG----------SAGAAGTAGTTGVGGTGGAGGAAYTLN MMAR_2100|M.marinum_M GDGGHGGSGSAGADATIAGAAGQTGGDGGDGGAGGAGGAGGAGGLAQATG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGVNTGVG---------------VGSHVGGGISESLGGSGSVGGSTAVGG MAV_4827|M.avium_104 GSG---------------------GGHVPTPGTGGPGGTGGSGGGHVPTP Mflv_5091|M.gilvum_PYR-GCK LGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGA Mvan_1264|M.vanbaalenii_PYR-1 QGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGA MSMEG_0868|M.smegmatis_MC2_155 AANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTA Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv YTDGATGTGGDGGNGGDGGKAGDGGAGENGLNSGAMLPGGGTVGNPGTGG MUL_0572|M.ulcerans_Agy99 GASTATATGGIGGNGGDGGTANGSNGGNGGAGGYASTTGTGTASVGNGGR MMAR_2100|M.marinum_M YLDGSHGSGGSGGAGGQAGNAGDGGDGADATVAG---------GKGGAGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GAHTSAINDALGGSGSVGGSTAVGGG---------------AHTSAINES MAV_4827|M.avium_104 GAGTPGGSGGGHLPFPGAGSTPGGSGG-------------GHLPTPGAGT Mflv_5091|M.gilvum_PYR-GCK SGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAA Mvan_1264|M.vanbaalenii_PYR-1 SGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVA MSMEG_0868|M.smegmatis_MC2_155 TAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGAT Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv NGGNGGNAGVGGTGGKAGTGSLTGLDGTDGITPNGGNGGNGGNGGKGGTA MUL_0572|M.ulcerans_Agy99 GGDGTATVATGGTGGVGGNAHAPAGSPVPGVGGKGGNPGPGGKPGPNGAD MMAR_2100|M.marinum_M NGGDAGVGGSGGLGGDSGNGTHAANGASAGAYGTGGNGGAGGDGADATAA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 MNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLP MAV_4827|M.avium_104 PGGGLGGFGGGHAPAPGGGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLG Mflv_5091|M.gilvum_PYR-GCK GSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGA Mvan_1264|M.vanbaalenii_PYR-1 GSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGA MSMEG_0868|M.smegmatis_MC2_155 GGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGP Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GNGSGAAGGNGGNGGSGLNGGDAGNGGNGGGALNQAGFFGTGGKGGNGGN MUL_0572|M.ulcerans_Agy99 GIVV---------------------------------------------- MMAR_2100|M.marinum_M GQAGG-AGGAGGDGGVVGDGGVGGNGGDGKAGVDGTSAVTFGASGADGGD TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GAEHH--------------------------------------------- MAV_4827|M.avium_104 GGHK---------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK TG------------------------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 TG------------------------------------------------ MSMEG_0868|M.smegmatis_MC2_155 VGS-------------------------------------------KIAN Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GGAGMINGGLGGFGGAGGGGAVDVAATTGGAGGNGGAGGFASTGLGGPGG MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M GGAGGAGG------AGGDGGAVAGDGGRGGAGGDGAMG--------GNGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ---AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDG Mvan_1264|M.vanbaalenii_PYR-1 ---AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAG MSMEG_0868|M.smegmatis_MC2_155 SSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNG Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv AGGPGGAGDFASGVGGVGGAGGDGGAGGVGGFGGQGGIGGEGRTGGNGGS MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M NGFDGLHGTTPGANGQYGGDGGEGGRGGVGGAGGAGGAAAAGQAGSQGDG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GKGGAGAE--------GGAGGGGGAGGSGAGGAG---GAGGSGGSGGSGG Mvan_1264|M.vanbaalenii_PYR-1 GAGGDGSE--------GGAGGSGGAGGSGTGGAG---GAGGSGGSGGSGG MSMEG_0868|M.smegmatis_MC2_155 GNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGN-GGNGGNGGNGGADG Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GGDGGGGISLGGNGGLGGNGGVSETGFGGAGGNGGYGGPGGPEGNGGLGG MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M GNGGDGGDGGTPGNGGSGADG-ANSAIGVSAGDGGYGGAGGNAGAGGLGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK SGGSGGAAGDSDD------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 AGGSGGAAGDSD-------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 TPGTAGTTGANNP------------------------------------- Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv NGGAGGNGGVSTTGGDGGAGGKGGNGGDGGNVGLGGDAGSGGAGGNGGIG MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M EGGAGSTSGASGLDGSQAAGGDGGNGGFGGTGGLFEAAGSGGAGGVGGD- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv TDAGGAGGAGGAGGNGGSSKSTTTGNAGSGGAGGNGGTGLNGAGGAGGAG MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M ---GSQGGDGGDGGAGGSSPGATGGWGGQGGLGGVGTAGVGGHGGDGGDA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GNAGVAGVSFGNAVGGDGGNGGNGGHGGDGTTGGAGGKGGNGSSGAASGS MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M GDSGSSAFGVGSPGGGGGQGGFGVAGGGDGGDGGNGGAGGFGQNG----- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GVVNVTAGHGGNGGNGGNGGNGSAGAGGQGGAGGSAGNGGHGGGATGGDG MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M ----------GPGGRGGGGGHSLVGPGGDGGLGGTGGNGGNG-------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GNGGNGGNSGNSTGVAGLAGGAAGAGGNGGGTSSAAGHGGSGGSGGSGTT MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M ----SQPPFGSTPAGSGGDGGNGGAGGSSGFVSGQSGTDGQDGGDPSGQF TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv GGAGAAGGNGGAGAGGGSLSTGQSGGPRRQRWCRWQRRRWLGRQRRRRWC MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M GGTGGAGGSGGAGAGT---------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- Mb3377c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- Rv3345c|M.tuberculosis_H37Rv RWQRRCRRQRWRWRCRQRRLRRQWRQGRRRCRPWLHRRRGRQGRRWRQRR MUL_0572|M.ulcerans_Agy99 -------------------------------------------------- MMAR_2100|M.marinum_M -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------ Mvan_1264|M.vanbaalenii_PYR-1 ------------ MSMEG_0868|M.smegmatis_MC2_155 ------------ Mb3377c|M.bovis_AF2122/97 ------------ MLBr_01183|M.leprae_Br4923 ------------ Rv3345c|M.tuberculosis_H37Rv FQQRQRSRWQRR MUL_0572|M.ulcerans_Agy99 ------------ MMAR_2100|M.marinum_M ------------ TH_3810|M.thermoresistible__bu ------------ MAB_4284c|M.abscessus_ATCC_199 ------------ MAV_4827|M.avium_104 ------------