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MALVLAAAGAVTVVQFRDAAHEADPDGALRGLTDDITADLVRELVTILPIVLVIAAVAAYLLSRAALRPV DRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWLATTLNTMLTRLQRALAHEQQFVADASHELRTPLALL TTELELRCAGPDPPTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0617c | - | - | 100% (156) | two component sensor kinase |
| M. bovis AF2122 / 97 | Mb3023c | - | 4e-13 | 53.62% (69) | hypothetical protein Mb3023c |
| M. bovis AF2122 / 97 | Mb1008 | mprB | 4e-13 | 40.00% (110) | two component sensor kinase MprB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1888 | - | 1e-15 | 38.13% (139) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0601c | - | 3e-84 | 100.00% (156) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00175 | - | 1e-13 | 37.19% (121) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_1077 | - | 5e-12 | 37.40% (123) | two component sensor kinase MprB |
| M. marinum M | MMAR_4528 | mprB | 7e-14 | 37.19% (121) | two-component sensor kinase MprB |
| M. avium 104 | MAV_3405 | - | 9e-18 | 43.12% (109) | hypothetical protein MAV_3405 |
| M. smegmatis MC2 155 | MSMEG_5487 | - | 4e-15 | 37.41% (139) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2428 | - | 9e-16 | 40.50% (121) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_4700 | mprB | 5e-14 | 37.19% (121) | two component sensor kinase MprB |
| M. vanbaalenii PYR-1 | Mvan_4843 | - | 2e-13 | 39.47% (114) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5487|M.smegmatis_MC2_155 MASATCCGKRLRSEMAFPPNS-WRPTGPLPTSS-LSLRWRVMMLAMSMVA
TH_2428|M.thermoresistible__bu ----------MTFAQPYPPSPPQRQATSQPASS-LSLRWRVMLLAMSMVA
Mflv_1888|M.gilvum_PYR-GCK MAGDP-------NTATWPPQPPGPPPP--PASS-ISLRWRVMLLAMSMAV
Mvan_4843|M.vanbaalenii_PYR-1 MAAD--------NAGRWPGQPPGPPAPTHPASS-VSLRWRVMLLAMSMVV
MMAR_4528|M.marinum_M ----------------MVGFRRGPRAPLRATSS-LSLRWRVMLLAMSMVA
MUL_4700|M.ulcerans_Agy99 ----------------MVGFRRGPRAPLRATSS-LSLRWRVMLLAMSMVA
MLBr_00175|M.leprae_Br4923 ----------------MVRFAWRRRASLRATSS-LSLRWRVMLLAMSMVA
MAB_1077|M.abscessus_ATCC_1997 -------MSTLRMPRRMRDSSTAIFTPLRATSSSVSLRWRVMLLAMSMVA
Mb0617c|M.bovis_AF2122/97 ---------------------------------------------MALVL
Rv0601c|M.tuberculosis_H37Rv ---------------------------------------------MALVL
MAV_3405|M.avium_104 --------------MFSGGPRACRIEGVHLGISARSAAVAAIVVFCALTV
::.
MSMEG_5487|M.smegmatis_MC2_155 LVVVLMAVAVYAVVSRALYDDLDNQLHSRARLLIESGSLAADPGKAIEGT
TH_2428|M.thermoresistible__bu MVVVLMSIALYAVVSRALYNDIDNQLHSRARLLIESGSLAADPGRAIEGT
Mflv_1888|M.gilvum_PYR-GCK IPVVLMGVAGYAVVSRALYDDIDDQLRTRAQMLIESGSLDADPGKAIEGT
Mvan_4843|M.vanbaalenii_PYR-1 ISVVLMAVAVFAVTSRALYDDIDNQLRSRAQMLIESRSLDIDPGKAIEGT
MMAR_4528|M.marinum_M MVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGT
MUL_4700|M.ulcerans_Agy99 MVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGT
MLBr_00175|M.leprae_Br4923 MVVVLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGT
MAB_1077|M.abscessus_ATCC_1997 MVVVLMAVASYLLVSTALYRDVDKQLNDRANLLIGSGLLSVDPRRAIEGT
Mb0617c|M.bovis_AF2122/97 AAAGAVTVVQFR-----------------------DAAHEAD--------
Rv0601c|M.tuberculosis_H37Rv AAAGAVTVVQFR-----------------------DAAHEAD--------
MAV_3405|M.avium_104 AGAG-LDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNALLTTDQ
. : : . *
MSMEG_5487|M.smegmatis_MC2_155 AYS-DVNAMLVIPGRSIYTANQQGQTLPLGEPEKD--VISGELLMSLRTA
TH_2428|M.thermoresistible__bu AYS-DVNAMLVNPGRSIYTANQQGEALPLGEPERQ--VLSGELVMSLRTA
Mflv_1888|M.gilvum_PYR-GCK AYS-DMNAMFYIPGRSKYTAKQQGQTLPVGRPEQD--VMDGTLWMSLRTV
Mvan_4843|M.vanbaalenii_PYR-1 AYS-DMNAMFYIPGRSKYTANQQGQTLPVGQPEQD--VMDGTLLLSLRTV
MMAR_4528|M.marinum_M AYS-DVNAMLVNPGRSIYTANQPGQTLPVGAPEKA--VIHGDLFLSRRTV
MUL_4700|M.ulcerans_Agy99 AYS-DVNAMLVNPGRSIYTANQPGQTLPVGAPEKA--VIHGDLFLSRRTV
MLBr_00175|M.leprae_Br4923 AYS-DVNAMLVNPGHSIYTANQPGQTLPVGTAEKA--VIRGELFMSQRTA
MAB_1077|M.abscessus_ATCC_1997 AYSADVNAKLIFPGLITFSATQQGQTIPYGTPEQA--VTRGDLQQSLRTV
Mb0617c|M.bovis_AF2122/97 ------------PDG----------------------ALR-GLTDDITAD
Rv0601c|M.tuberculosis_H37Rv ------------PDG----------------------ALR-GLTDDITAD
MAV_3405|M.avium_104 RVV---ATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSG
*. . * . :
MSMEG_5487|M.smegmatis_MC2_155 NHQRVLAVHLANGS---SLLISKSLAPTVQVLRRLGTVLLIVGGIGVAVA
TH_2428|M.thermoresistible__bu DQQRVLAIHLSNGS---SLLISKSLAPTMEVLRRLGTVLLIVGGIGVAVA
Mflv_1888|M.gilvum_PYR-GCK EHQRVLAVHLASGN---SLLLSKSLAPTGQVLKRLGTVLLIVGGIGVVVA
Mvan_4843|M.vanbaalenii_PYR-1 EHQRVLAIRLASGN---TLLLSKSLAPTGKVLKRLGTVLLIVGGLGVAVA
MMAR_4528|M.marinum_M SDQRVLAIHLPNGS---SLLISKSLKPTEAVMTKLRAVLLIVGGVGVAVA
MUL_4700|M.ulcerans_Agy99 SDQRVLAIHLPNGS---SLLISKSLKPTEAVMTKLRAVLLIVGGVGVAVA
MLBr_00175|M.leprae_Br4923 SDQRILAIHLPNDS---SLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVA
MAB_1077|M.abscessus_ATCC_1997 NHQRVLALRLDNGS---TLIMAKSLDPTDTVLRRLGWVLLIVGGVGVAVA
Mb0617c|M.bovis_AF2122/97 ----------------------------------LVRELVTILPIVLVIA
Rv0601c|M.tuberculosis_H37Rv ----------------------------------LVRELVTILPIVLVIA
MAV_3405|M.avium_104 DDMRVSGQKVATRSGVYTVLVGGGSEAVEATARTLAILLATTAPVIVAVA
* * : :.:*
MSMEG_5487|M.smegmatis_MC2_155 AIAGGAVARAGLRPVGRLTEAAERVART---DDLRPIPVVGS-DELARLT
TH_2428|M.thermoresistible__bu AIAGGMVARAGLRPVSRLTEAAERVART---DDLRPIPVVGS-DELARLT
Mflv_1888|M.gilvum_PYR-GCK AIAGGMVARAGLRPVARLTQAAERVART---DDLHPIPVVGN-DELARLT
Mvan_4843|M.vanbaalenii_PYR-1 AIAGGMVASAGLRPVGRLTQAAERVART---DDLRPIPVIGN-DELARLT
MMAR_4528|M.marinum_M AVAGGMVTRAGLRPVGRLTEAAERVART---DDLRPIPVFGS-DELARLT
MUL_4700|M.ulcerans_Agy99 AVAGGMVTRAGLRPVGRLTEAAERVART---DDLRPIPVFGS-DELARLT
MLBr_00175|M.leprae_Br4923 AVAGGMVTRAGLRPVGRLTEAAERVART---DDLRPIPVFGS-DELARLT
MAB_1077|M.abscessus_ATCC_1997 AAAGAMVAGTGLRPVARLTDAAERVART---DDLRPIAVTGS-DELARLT
Mb0617c|M.bovis_AF2122/97 AVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWLA
Rv0601c|M.tuberculosis_H37Rv AVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWLA
MAV_3405|M.avium_104 AGATYWLVRRSLKSVDAIRARVADISAS---DLAERVPVPDGRDEIAALA
* * : .*:.* : . :: : * :.* **:* *:
MSMEG_5487|M.smegmatis_MC2_155 EAFNMMLRALAESRERQARLVSDAGHELRTPLTSLRTNVELLMAAQEPGA
TH_2428|M.thermoresistible__bu EAFNMMLRALAESRERQARLVADAGHELRTPLTSLRTNVELLMASQQPGA
Mflv_1888|M.gilvum_PYR-GCK ETFNMMLRALTESRDRQSRLVADAGHELRTPLTSLRTNVELLMSSMKPGA
Mvan_4843|M.vanbaalenii_PYR-1 ETFNMMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMESMKPGA
MMAR_4528|M.marinum_M EAFNLMLRALAESRERQARLVSDAGHELRTPLTSLRTNVELLMASMEPGA
MUL_4700|M.ulcerans_Agy99 EAFNLMLRALAESRERQARLVSDAGHELRTPLTSLRTNVELLMASMEPGA
MLBr_00175|M.leprae_Br4923 EAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLIASMAPEA
MAB_1077|M.abscessus_ATCC_1997 ISFNTMLRALAESRDRQARLVTDAGHELRTPLTSLRTNTELLMAAMQPGA
Mb0617c|M.bovis_AF2122/97 TTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPT
Rv0601c|M.tuberculosis_H37Rv TTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPT
MAV_3405|M.avium_104 VTMNEMLSRLEAGHRAQQRFVGDASHELRSPLTTIISGLEVAEAHPELLD
::* ** * . : ::* **.****:**: : : *:
MSMEG_5487|M.smegmatis_MC2_155 PPLPEDEMAGLRADVIAQIEELSTLVGDLVDLTREDAGGITPEPVDMADV
TH_2428|M.thermoresistible__bu PGLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDDAGGVIHEPVDIADV
Mflv_1888|M.gilvum_PYR-GCK PRIPEEDMDDLRSDVIGQIEELSTLVGDLVDLTRDEAGNAVHDTVEMSEV
Mvan_4843|M.vanbaalenii_PYR-1 PRIPEEDMAELRTDVIAQIEEMSTLVGDLVDLTRDDAGNAVHETVEITEV
MMAR_4528|M.marinum_M PRLPEQEMVGLREDVVAQIEELSTLVGDLVDLTRGDAGVVVHEPVDMAEV
MUL_4700|M.ulcerans_Agy99 PRLPEQEMVGLREDVVAQIEELSTLVGDLVDLTRGDAGVVVHEPVDMAEV
MLBr_00175|M.leprae_Br4923 PRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPIDMSEV
MAB_1077|M.abscessus_ATCC_1997 PRLPDEEMQALQQDVIAQIEELSTLVGDLVDLARGDGADIVHEPVDMVEV
Mb0617c|M.bovis_AF2122/97 S-------------------------------------------------
Rv0601c|M.tuberculosis_H37Rv S-------------------------------------------------
MAV_3405|M.avium_104 AELAVN-------TLLPEAHRMRALIDDLLLLARADERNLLRRKELVALD
.
MSMEG_5487|M.smegmatis_MC2_155 IDRSLERVRRRRN-DIEFDVDVIGWQVFGDAQGLGRAVLNLLDNAAKWSP
TH_2428|M.thermoresistible__bu VDRSLERVRRRRN-DIDFDIEVVPWQVYGDAAGLSRAVMNLLDNAAKWSP
Mflv_1888|M.gilvum_PYR-GCK IERSLERVRRRRN-DIEFHVEITPWQVYGDAAGLGRAVLNLLDNAAKWSP
Mvan_4843|M.vanbaalenii_PYR-1 IDRSLERVRRRRN-DIQFDVAVTPWQVYGDAAGLGRAVLNLLDNAAKWSP
MMAR_4528|M.marinum_M VDRSLERVRRRRN-DIHFDVDVVGWQVYGDAAGLSRAALNLMDNAAKWSP
MUL_4700|M.ulcerans_Agy99 VDRSLERVRRRRN-DIHFDVDVVGWQVYGDAAGLSRAALNLMDNAAKWSP
MLBr_00175|M.leprae_Br4923 LYRSLERVRRRRN-DIHFDVQAIGWQIYGDAAGLSRAVLNLMDNAAKWSP
MAB_1077|M.abscessus_ATCC_1997 VEGTLERVRRRRN-DIEFDVVMQPWQVYGDAAGLSRAVLNLLDNAAKWSP
Mb0617c|M.bovis_AF2122/97 --------------------------------------------------
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3405|M.avium_104 DLAEAEAARVRRDADCAVHTDIRPARLLADPAAMTRMIRNLVDNAVRHAV
MSMEG_5487|M.smegmatis_MC2_155 PGGRVGVRLHQVDHMHAEIVVSDQGPGIPPEERRLVFERFYR--SDAARA
TH_2428|M.thermoresistible__bu SGGRVGVRLTQVDPVHAELVVSDHGPGIPPQERRLVFERFYR--STTARS
Mflv_1888|M.gilvum_PYR-GCK PGGGVWVRLRQLDQLTAEVVVSDLGPGIPPAERELVFERFFR--STTARA
Mvan_4843|M.vanbaalenii_PYR-1 PGGRVGVGLTQIDALHAELVVSDRGPGIPPQERALVFERFFR--STSARS
MMAR_4528|M.marinum_M PGGRVGIRLRQLDPSHAELVVSDNGPGISPQERRLVFERFYR--STSARA
MUL_4700|M.ulcerans_Agy99 PGGRVGIRLRQLDPSHAELVVSDNGPGISPQERRLVFERFYR--STSARA
MLBr_00175|M.leprae_Br4923 SGGRVVVTMRQFDPSHVELVVSDYGPGIPPQERRLVFERFYR--STTARS
MAB_1077|M.abscessus_ATCC_1997 SGTAVSVRLAQVDAAHAELVISDHGPGIPPAERDLVFERFYR--ATPARG
Mb0617c|M.bovis_AF2122/97 --------------------------------------------------
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3405|M.avium_104 SCVAIEVGSRDGT---AVLTVGDDGPGIPPAQRSRVFERFVRLDTDRARS
MSMEG_5487|M.smegmatis_MC2_155 MPGSGLGLAIVQQVVLKHGGALRIDETVP-----GGNPPGASVHMLLPGQ
TH_2428|M.thermoresistible__bu MPGSGLGLAIVKQVVLKHGGTLRVEDTVP-----GGQPPGTSIHVVLPGR
Mflv_1888|M.gilvum_PYR-GCK MPGSGLGLAIVKQVVLKHGGSLRVEDTVP-----GGEPPGTSVHVVLPGR
Mvan_4843|M.vanbaalenii_PYR-1 MPGSGLGLAIVKQVVLKHGGTLRIEDTVP-----GGTPPGTAMHVVLPGR
MMAR_4528|M.marinum_M MPGSGLGLAIVKQVVLNHGGSLRIEDTVP-----GGQPPGTAICMLLPGR
MUL_4700|M.ulcerans_Agy99 MPGSGLGLAIVKQVVLNHGGSLRIEDTVP-----GGQPPGTAICMLLPGR
MLBr_00175|M.leprae_Br4923 LPGSGLGLAIVKQVVINHGGLLRVEDTAP-----GVQPPGTSIYVLLPGR
MAB_1077|M.abscessus_ATCC_1997 MPGSGLGLAIVKQVVLKHGGAIKVEETDPGAVIDGEPAPGTSMHVLLPGR
Mb0617c|M.bovis_AF2122/97 --------------------------------------------------
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3405|M.avium_104 GGGAGLGLAIVAEVVAAHGGTVTIGDRPG---------GGTTLTVALPQH
MSMEG_5487|M.smegmatis_MC2_155 RIP---------------------DPGATRSAEGFVDDRGGHTVATE---
TH_2428|M.thermoresistible__bu PLSGVPPASQEPQ-------PPQHAPGADPHAPTQTGNDAVQSVFTAENK
Mflv_1888|M.gilvum_PYR-GCK PSA-----------------------NLARGGE-----------------
Mvan_4843|M.vanbaalenii_PYR-1 PSP-----------------------AGSDEAER----------------
MMAR_4528|M.marinum_M PMPDSAYPAAPDD--------KKTEPVDTRGANGANSRGSANVISVDSQS
MUL_4700|M.ulcerans_Agy99 PMPDSAYPAAPDD--------KKTEPVDTRGANGANSRGSANVISVDSQS
MLBr_00175|M.leprae_Br4923 PMPVSAYSTLADQDMGEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQS
MAB_1077|M.abscessus_ATCC_1997 PGP-------------------IVRPNMGDTAGRRNSGPNAREISVDSQS
Mb0617c|M.bovis_AF2122/97 --------------------------------------------------
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3405|M.avium_104 PAQHSSR-------------------------------------------
MSMEG_5487|M.smegmatis_MC2_155 --------
TH_2428|M.thermoresistible__bu --------
Mflv_1888|M.gilvum_PYR-GCK --------
Mvan_4843|M.vanbaalenii_PYR-1 --------
MMAR_4528|M.marinum_M ARAR----
MUL_4700|M.ulcerans_Agy99 ARAR----
MLBr_00175|M.leprae_Br4923 ARAR----
MAB_1077|M.abscessus_ATCC_1997 VPAAWRPS
Mb0617c|M.bovis_AF2122/97 --------
Rv0601c|M.tuberculosis_H37Rv --------
MAV_3405|M.avium_104 --------