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VSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTERARKRGITLSNQQYDGMSRLSGYLTP QARATFEAVLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGLLAGLRALIASGELGQHNG LPVSIVVTTTLTDLQTGAGKGFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRL ASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTGWTSTGRTDITELTLACDPDNRLAEKGWTTRKNTHG HTEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDEPD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3496 | - | - | 100% (317) | hypothetical protein Mb3496 |
| M. bovis AF2122 / 97 | Mb0097c | - | 0.0 | 99.05% (317) | hypothetical protein Mb0097c |
| M. bovis AF2122 / 97 | Mb1613c | - | e-131 | 97.32% (224) | REP13E12 repeat-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1835 | - | 3e-82 | 50.94% (318) | hypothetical protein Mflv_1835 |
| M. tuberculosis H37Rv | Rv3467 | - | 0.0 | 98.11% (317) | hypothetical protein Rv3467 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-92 | 53.27% (306) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_3121 | - | 1e-116 | 62.15% (317) | hypothetical protein MMAR_3121 |
| M. avium 104 | MAV_2352 | - | 1e-116 | 62.58% (318) | hypothetical protein MAV_2352 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-65 | 44.26% (305) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 2e-54 | 38.31% (355) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-116 | 61.27% (315) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_5865 | - | 5e-83 | 51.40% (321) | hypothetical protein Mvan_5865 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3496|M.bovis_AF2122/97 --------------------------------------------------
Rv3467|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3121|M.marinum_M ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRAVDALVEVSFEALTTPERLRVLERLE
MAV_2352|M.avium_104 ---MHS---STREEIRADVDALRAAVSRVLGHSYDALTTPERLRLLEIFD
MAB_0394c|M.abscessus_ATCC_199 -----------MSPIDDLLTTATAVVESS----FDELNNPELLSALRQLE
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
Mflv_1835|M.gilvum_PYR-GCK ----MYVRVMSGGDLQTRIAVLRAAFDEVAACEIELLTRPDLVAALDELE
Mvan_5865|M.vanbaalenii_PYR-1 ----MYVRVMSRDALHAAVTALRATVDEVAACEADLCTRTELVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ----------MDDGVQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
Mb3496|M.bovis_AF2122/97 --------------------------------------------------
Rv3467|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3121|M.marinum_M VVARRLPVAQYALLNQLDEQAGEAELGGRLAAVVASR-LRITRSEAGRRV
MUL_2371|M.ulcerans_Agy99 VVARRLPAAQYALVNQLDEQPGEAELGGRLAAVVASR-LRITRSEAGRRV
MAV_2352|M.avium_104 RETRRLRVPGHQLINQLAEQSDPTELGGRLSFALAER-LHITRSDASRRI
MAB_0394c|M.abscessus_ATCC_199 IAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTATARRRL
TH_3287|M.thermoresistible__bu TQCRINRGLMYRVFAQLADPPDEPAMVPAVRDRLWAR-LRITPGEVKRRL
Mflv_1835|M.gilvum_PYR-GCK ELSCQLPAVGHRLLARLQAEGTPQQMGAKNWSEVLRVRWRISGSEAHRRL
Mvan_5865|M.vanbaalenii_PYR-1 TVGCRLPALSYRLLARLQAETTPPQMGAKSWKEVLAVRWRISTSEAHRRL
MSMEG_6573|M.smegmatis_MC2_155 DARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARRRC
Mb3496|M.bovis_AF2122/97 --------------------------------------------------
Rv3467|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3121|M.marinum_M AEAADVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRRLPA
MUL_2371|M.ulcerans_Agy99 AEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFFRQLPA
MAV_2352|M.avium_104 AEAADLGPRRALTGEPLPPLLPATAAAQRDGAIGTDHVAVIRQFFDQLPE
MAB_0394c|M.abscessus_ATCC_199 ADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFFDVLPD
TH_3287|M.thermoresistible__bu RVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAALPS
Mflv_1835|M.gilvum_PYR-GCK TEAALLAPRPSLTGPALPPQLAATAIAQARGLINAEHVAVIRKAVKKLPG
Mvan_5865|M.vanbaalenii_PYR-1 TEAAVLAPRQAMTGEALAPVLPATATAQAHGLINAEHVEVIRKTMAKVPG
MSMEG_6573|M.smegmatis_MC2_155 TDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKCPD
Mb3496|M.bovis_AF2122/97 ---MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDG-DLTDTERA
Rv3467|M.tuberculosis_H37Rv ---MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDG-DLTDTERA
MMAR_3121|M.marinum_M GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MUL_2371|M.ulcerans_Agy99 GVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHSDEDRA
MAV_2352|M.avium_104 AVDVETCEHAERQLAAQATQFRPDQLSKLARRLMDCLNPDG-RYSDEDRA
MAB_0394c|M.abscessus_ATCC_199 AVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFSDIDRA
TH_3287|M.thermoresistible__bu AVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQDRA
Mflv_1835|M.gilvum_PYR-GCK WVDVATREQFEVNLVRTAVGHGPKELNDAADRMLFLLDQDGPEPDDAERG
Mvan_5865|M.vanbaalenii_PYR-1 FVDTATRERIEVDLVRTAVGNGPKELKDSADRTLFLLDQDGPEPDERERA
MSMEG_6573|M.smegmatis_MC2_155 WVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNPPT
* * . . : : .. ** :
Mb3496|M.bovis_AF2122/97 RKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDD---
Rv3467|M.tuberculosis_H37Rv RKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDD---
MMAR_3121|M.marinum_M RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPED---
MUL_2371|M.ulcerans_Agy99 RRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNPED---
MAV_2352|M.avium_104 RARGLVLGNQQADGMSRLSGWLTPEARAGWEAVLAKLAAPGMCNPDD---
MAB_0394c|M.abscessus_ATCC_199 RRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDPRD---
TH_3287|M.thermoresistible__bu RRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLPHTTTD
Mflv_1835|M.gilvum_PYR-GCK RKRGVSIGRQGAEAMSALTGQLTPEARAVWEAIFAKYAAPGMCNPDD---
Mvan_5865|M.vanbaalenii_PYR-1 RKRAVTKHKQREDGMVDVSATLTPEAWAVWEAIFAKFAAPGMCNPDD---
MSMEG_6573|M.smegmatis_MC2_155 KPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNPTD---
: .: * :. : . : .: * :.: ** *
Mb3496|M.bovis_AF2122/97 --------HTPVIDTTPDAAAIDRDT---------------RSQAQRNHD
Rv3467|M.tuberculosis_H37Rv --------HTPVIDTTPDAAAIDRDT---------------RSQAQRNHD
MMAR_3121|M.marinum_M --------EAAVVDGPVSPDAADRDS---------------RSVGQRQHD
MUL_2371|M.ulcerans_Agy99 --------EAAVVDGPVSRDAADRDS---------------RSVSQRQHD
MAV_2352|M.avium_104 --------DAPVVDGPPPEAASQRDS---------------RSAAQRNHD
MAB_0394c|M.abscessus_ATCC_199 --------ESPMTEGEPDSAAAERDT---------------RTSAQRNHD
TH_3287|M.thermoresistible__bu TTGTTGTTETTGTAGTAGTAATAADTAADGVGDIDTGGVDLRSAAQRRHD
Mflv_1835|M.gilvum_PYR-GCK --------EQPCTSGTPSQAQIDGDH---------------RSLAQRQHD
Mvan_5865|M.vanbaalenii_PYR-1 --------PEPCTSGTPSQAQIDHDQ---------------RSLAQRQHD
MSMEG_6573|M.smegmatis_MC2_155 --------QTPCISGTPSQQQIDSDQ---------------RGAPERRHD
. * * :*.**
Mb3496|M.bovis_AF2122/97 GLLAGLRALIASGELGQHNGLPVSIVVTTTLTDLQTGA-----------G
Rv3467|M.tuberculosis_H37Rv GLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGA-----------G
MMAR_3121|M.marinum_M GFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-----------G
MUL_2371|M.ulcerans_Agy99 GFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-----------G
MAV_2352|M.avium_104 GLNAALRALLAGGKLGQHNGLPASIIVTTTLRDLESAA-----------G
MAB_0394c|M.abscessus_ATCC_199 GLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA-----------G
TH_3287|M.thermoresistible__bu GLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAHAVADPRVSMPG
Mflv_1835|M.gilvum_PYR-GCK ALLAVGRIALMSGELGQLNGLPVSVIIRTTLQDLESRA-----------G
Mvan_5865|M.vanbaalenii_PYR-1 ALLAGGRIALMSGQLGQLNGLPVSVIIRTTLQDLESRA-----------G
MSMEG_6573|M.smegmatis_MC2_155 AMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELEKAA-----------G
.: : : ** .* *.:::: *** :*: * *
Mb3496|M.bovis_AF2122/97 KGFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHG--TPLALYHT
Rv3467|M.tuberculosis_H37Rv KGFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHG--TPLALYHT
MMAR_3121|M.marinum_M RGLTGGGTLLPMSDVIRLARHAHHY--------LAVFDRG--EAIGLYHA
MUL_2371|M.ulcerans_Agy99 RGLTGGGTLLPMSDVIRLARHAHHY--------LAVFDRG--EAIGLYHA
MAV_2352|M.avium_104 KGLTGGGTLLPMSEVIRLARHAHHY--------LAVFDNG--KPLALYHT
MAB_0394c|M.abscessus_ATCC_199 RAISGSGNLVPIPDLIRMATHAFHY--------LTIFGDD-GRPLHLGRS
TH_3287|M.thermoresistible__bu PARTGGTGVLPMRELIRMAADAIHY--------LAVFDDHTERPLYLGRQ
Mflv_1835|M.gilvum_PYR-GCK IGVSGGGTKLPIRDVIRMAGHANHY--------LAVFDRATGSALDLFRT
Mvan_5865|M.vanbaalenii_PYR-1 VGVTGGGTVMPIAEVIRMAGHANHY--------LAVFDRATGSALDLFRT
MSMEG_6573|M.smegmatis_MC2_155 VAITAGGTKLSIPDLIRLASQALHY--------LAVYDEHTGIPLYLGRA
. :.. :.: ::**:: .* ** :::. .: * :
Mb3496|M.bovis_AF2122/97 KRLASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTG-WTSTGRTDITE
Rv3467|M.tuberculosis_H37Rv KRLASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTA-WTSTGRTDITE
MMAR_3121|M.marinum_M KRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVAA-WAISGRTDINQ
MUL_2371|M.ulcerans_Agy99 KRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVAA-WAISGRTDINQ
MAV_2352|M.avium_104 KRLASPGQRIVLYAKDRGCSHPGCDVSGYYCEVHHVTG-YAKCGRTDIDQ
MAB_0394c|M.abscessus_ATCC_199 KRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVDD-WRDDGPTDIDN
TH_3287|M.thermoresistible__bu KRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQPA-WEDGGLTDADH
Mflv_1835|M.gilvum_PYR-GCK RRVASPAQRVMLIARDGGCTKPCCTVGAYGCQVHHAEADYAHGGNTNIDE
Mvan_5865|M.vanbaalenii_PYR-1 RRIASPAQRIMLIARDGGCTKPGCAVGAYGCQGHHVEADFAKGGNTNVDE
MSMEG_6573|M.smegmatis_MC2_155 RRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTDADA
:* *:. **: *.* **: * * .* .: ** : * *:
Mb3496|M.bovis_AF2122/97 LTLACDPDNRLAEKG--WTTRK-NTHGHTEWLPPPHLDHGQPRTNTFHHP
Rv3467|M.tuberculosis_H37Rv LTLACGPDNRLAEKG--WTTHN-NTHGHTEWLPPPHLDHGQPRTNTFHHP
MMAR_3121|M.marinum_M LTLACGPDHKLLEQG--WRTRK-NAHGDTEWLPPPHLDHGQPRTNTYHHP
MUL_2371|M.ulcerans_Agy99 LTLACGPDHKLLEQG--WRTRK-NAHGDTEWLPPPHLDHGQPRTNSYHHP
MAV_2352|M.avium_104 LTFACGGHHPLAEQG--WITRK-NGRGETEWIPPPHLERGQPRVNSFHHP
MAB_0394c|M.abscessus_ATCC_199 LTFACGPHHRLLQQG--WTTRKRRSDGITEWIPPPHLDTGQSRTNDHHHP
TH_3287|M.thermoresistible__bu LFFACGPHHSGLTEG--RWQATITPTGRLAWTNDHHPPT----VNHAHHP
Mflv_1835|M.gilvum_PYR-GCK LGLACGPDNRSVTD--GGWTTRMNDRCEVEWIPPPGLDTGQARVNTYHRP
Mvan_5865|M.vanbaalenii_PYR-1 LGLACGPDNRDVNDR-GGWTTRMNDRCEVEWIPPPALDTGQARVNNYHRP
MSMEG_6573|M.smegmatis_MC2_155 LALACGCDNRLVGEAPNKWTTRINNHGQCEWIPPDLLDRGQHRTNTYHHP
* :**. .: . * .* *:*
Mb3496|M.bovis_AF2122/97 ERFLHNQDDDDE----------PD--------------------------
Rv3467|M.tuberculosis_H37Rv ERFLHNQDDDDK----------PD--------------------------
MMAR_3121|M.marinum_M EKLLRDSADDDD---------EGHGAA-----------------------
MUL_2371|M.ulcerans_Agy99 EKLLRDSADDDD---------EGHGAA-----------------------
MAV_2352|M.avium_104 EDMLCDTEDQQDQQDQQDQADEEDGAA-----------------------
MAB_0394c|M.abscessus_ATCC_199 ERFIRRF-------------------------------------------
TH_3287|M.thermoresistible__bu EELLRAHTDPPE----------DPG-------------------------
Mflv_1835|M.gilvum_PYR-GCK ERLLRP--EDPEPLGDN---------------------------------
Mvan_5865|M.vanbaalenii_PYR-1 ERLLRPP-DDPEPPGDNTIAAEAASAGTD---------------------
MSMEG_6573|M.smegmatis_MC2_155 ETLLADINRDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPAIPPELLDQ
* ::
Mb3496|M.bovis_AF2122/97 --------------------------------------------------
Rv3467|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3121|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAV_2352|M.avium_104 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK -------------------DSQASRPADDPGEPGGPAP---------PEG
Mvan_5865|M.vanbaalenii_PYR-1 -----------QADPRGDAESDAPQPTDDPGEPGGPAP---------PGD
MSMEG_6573|M.smegmatis_MC2_155 GQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSAENRNGPSK
Mb3496|M.bovis_AF2122/97 ----------
Rv3467|M.tuberculosis_H37Rv ----------
MMAR_3121|M.marinum_M ----------
MUL_2371|M.ulcerans_Agy99 ----------
MAV_2352|M.avium_104 ----------
MAB_0394c|M.abscessus_ATCC_199 ----------
TH_3287|M.thermoresistible__bu ----------
Mflv_1835|M.gilvum_PYR-GCK EAA-------
Mvan_5865|M.vanbaalenii_PYR-1 QAA-------
MSMEG_6573|M.smegmatis_MC2_155 NAAGDDDEPR