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M. bovis AF2122 / 97 Mb0847c (desA1)

annotation: acyl-
coordinates: 918564 - 919580
length: 338

MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMV
QNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRG
FSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEA
AFDLVPNQAMKSLHLILSHFQMPGFQVPEFRRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTG
EGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0847cdesA1-100% (338)acyl-
M. bovis AF2122 / 97Mb1124desA23e-4034.98% (243) acyl-

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_1668-1e-14070.43% (328) fatty acid desaturase, type 2
M. tuberculosis H37RvRv0824cdesA10.0100.00% (338) acyl-
M. leprae Br4923MLBr_02185desA11e-16379.88% (338) acyl-
M. abscessus ATCC 19977MAB_0754c-1e-13267.39% (322) fatty acid desaturase
M. marinum MMMAR_4856desA10.092.31% (338) acyl-
M. avium 104MAV_0772-1e-16983.82% (340) Fatty acid desaturase
M. smegmatis MC2 155MSMEG_5773-1e-15480.00% (315) fatty acid desaturase
M. thermoresistible (build 8)TH_1577-1e-15478.88% (322) fatty acid desaturase
M. ulcerans Agy99MUL_0445desA10.091.42% (338) acyl-
M. vanbaalenii PYR-1Mvan_5085-1e-14372.56% (328) fatty acid desaturase, type 2

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1668|M.gilvum_PYR-GCK          -MSKDLTDLQLLTELEPVVEPLVNRHMRMKKDWNPHDYIPWSDGKNYYAL
Mvan_5085|M.vanbaalenii_PYR-1       -MSKDLTDLQLLTELEPVVEPLINRHMRMTKDWNPHDYIPWSDGKNYYAL
Mb0847c|M.bovis_AF2122/97           -MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYAL
Rv0824c|M.tuberculosis_H37Rv        -MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYAL
MMAR_4856|M.marinum_M               -MSAPLTDLHLLHELEPVVEKYLNRHLSMHKNWNPHDYIPWSDGKNYYAL
MUL_0445|M.ulcerans_Agy99           -MSAPLTDLHLLHELEPVVEKYLNRHLSIHKNWNPHDYIPWSDGKNYYAL
MAV_0772|M.avium_104                -MSAELTNLQLLQELEPFVEKYLNRHESMHKNWNPHDYIPWSDGKNFYAL
MLBr_02185|M.leprae_Br4923          -MSAELTDLQLLHELEPVVEKYMNRHERLHKNWNPHDYIPWSDGKNFYAL
TH_1577|M.thermoresistible__bu      -MHENLTDLHLLRELEPVVEKLLNRHLSMSKDWNPHDYIPWSDGKNYYAL
MSMEG_5773|M.smegmatis_MC2_155      MSTDDYTDLQLLHELEPVVETLIDRHMRMCKDWNPHDYIPWSDGKNYYAL
MAB_0754c|M.abscessus_ATCC_199      MSQKEFTDLELLHELEPVVEENVHRHLGVTKDWNPHDYVPWSEGKNYKAL
                                          *:*.** ****.**  :.**  : * ******:***:***: **

Mflv_1668|M.gilvum_PYR-GCK          GGQDWDPEQSQLSDVARVAMLVNLLTEDNLPSYHREIAMNFSMDGPWGFW
Mvan_5085|M.vanbaalenii_PYR-1       GGQDWDPEQAKLSEVARVAMMVNLLTEDNLPSYHREIAMNFTMDGPWGFW
Mb0847c|M.bovis_AF2122/97           GGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQW
Rv0824c|M.tuberculosis_H37Rv        GGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQW
MMAR_4856|M.marinum_M               GGQEWDPEQSKLSDVAQIAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQW
MUL_0445|M.ulcerans_Agy99           GGQEWDPEQSKLSDVAQIAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQW
MAV_0772|M.avium_104                GGQDWEPGQSKLSDVAQVAMVQNLMTEDNLPSYHREIAMNFGMDGPWGQW
MLBr_02185|M.leprae_Br4923          GGQDWDPEQSQLSDVAQVAMVQNLVTEDNLPSYHREIAMTMGMDGAWGQW
TH_1577|M.thermoresistible__bu      GGQDWYPEEAKLSEVAQTAMVQNLLTEDNLPAYHREIAMNLGMDGAWGQW
MSMEG_5773|M.smegmatis_MC2_155      GGQDWDPEQSKLSEVARTAMVQNLLTEDNLPSYHREIAMNMGMDGAWGQW
MAB_0754c|M.abscessus_ATCC_199      GGQDWDPEQSKLSEVAKIAMITNLLTEDNLPSYHREIAMNFTMDGPWGTW
                                    ***:* * :::**:**: **: **:******:*******.: ***.** *

Mflv_1668|M.gilvum_PYR-GCK          VNRWTAEENRHGIALRDYLVVTRNVDPVELEMLRVEQMTRGFSPGQNDQI
Mvan_5085|M.vanbaalenii_PYR-1       VNRWTAEENRHGIALRDYLVVTRNVDPVELEMLRLEQMTRGFSPGQNEQI
Mb0847c|M.bovis_AF2122/97           VNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQG
Rv0824c|M.tuberculosis_H37Rv        VNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQG
MMAR_4856|M.marinum_M               VNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQG
MUL_0445|M.ulcerans_Agy99           VNRWTAEENRHSIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQG
MAV_0772|M.avium_104                VNRWTAEENRHGIALRDYLVVTRAVDPVELEKLRIEVVNRGFSPGQNHQV
MLBr_02185|M.leprae_Br4923          VNRWTAEENRHGIALRDYLVVTRAVDPVELEKLRIEVVNRGFSPGQNHQG
TH_1577|M.thermoresistible__bu      VNRWTAEENRHGISLRDYLVVTRACDPVELEELRVEQMTRGFSPGQNQQG
MSMEG_5773|M.smegmatis_MC2_155      VNRWTAEENRHGIALRDYLVVTRACDPVELEELRVEQVTRGFSPGQNQQG
MAB_0754c|M.abscessus_ATCC_199      VNRWTAEENRHGIAIRDYLVVTRSVDPVELEKLRVEQMTRGFSPGQNRQG
                                    ***********.*::********  ****** **:* :.******** * 

Mflv_1668|M.gilvum_PYR-GCK          EADLFADSLFDSVIYVTFQELATRVSHRNTGKACEEPIADQLLQRVSADE
Mvan_5085|M.vanbaalenii_PYR-1       EADLFADSLFDSVIYVTFQELATRVSHRNTGKACEEPVADQLLQRVSADE
Mb0847c|M.bovis_AF2122/97           --HYFAESLTDSVLYVSFQELATRISHRNTGKACNDPVADQLMAKISADE
Rv0824c|M.tuberculosis_H37Rv        --HYFAESLTDSVLYVSFQELATRISHRNTGKACNDPVADQLMAKISADE
MMAR_4856|M.marinum_M               --DYFAESVTDSVIYVSFQELATRVSHRNTGKACNDPIADQLMAKISADE
MUL_0445|M.ulcerans_Agy99           --DYFAESVTDSVIYVSFQELATRVSHRNTGKACNDLIADQLMAKISADE
MAV_0772|M.avium_104                REDLFAESLFDSVIYVTFQELATRISHRNTGKACNETIADQMLAKISADE
MLBr_02185|M.leprae_Br4923          --GLFADTLFDSILYVTFQELATRVSHRNTGKACNETIADQLLAKISSDE
TH_1577|M.thermoresistible__bu      --DLFAESLFDSVIYVTFQELATRVSHRNTGKACNETVADQLLARISADE
MSMEG_5773|M.smegmatis_MC2_155      --DLFAESLFDSVMYVSFQELATRVSHRNTGKACNDPVADQLLQRVSADE
MAB_0754c|M.abscessus_ATCC_199      GDELFAESLFDSVVYVTFQELATRVSHRNTGKACAEPVADELLKRISTDE
                                        **::: **::**:*******:********* : :**::: ::*:**

Mflv_1668|M.gilvum_PYR-GCK          NLHMIFYRDVSEAGFEIAPDQAMRSLHKVLLNFKMPGYTIPDFRRRAVTI
Mvan_5085|M.vanbaalenii_PYR-1       NLHMIFYRDVSEAGFEIAPDQAMKSLHKVLRNFKMPGYTIPDFRRRAVTI
Mb0847c|M.bovis_AF2122/97           NLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEFRRKAVVI
Rv0824c|M.tuberculosis_H37Rv        NLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEFRRKAVVI
MMAR_4856|M.marinum_M               NLHMIFYRDVSEAAFDLAPNQAMKSLHLILHNFKMPGFQVPEFRRKAVII
MUL_0445|M.ulcerans_Agy99           NLHMIFYRDVSEAAFDLAPNQAMKSLHLILHNFKMPGFQVPEFRRKAVII
MAV_0772|M.avium_104                NLHMIFYRDVSEAGFAIAPNQAMKSLHKVLRNFQMPGYQVPEFRRKAVMI
MLBr_02185|M.leprae_Br4923          NLHMIFYRDVSEAGIELAPNLAIKALHKILHNFKMPGFLVPEFRRKAVII
TH_1577|M.thermoresistible__bu      NLHMIFYRDVSEAGFEIAPDQAMHSLHRVLRNFKMPGFTVPEFRRKAVVI
MSMEG_5773|M.smegmatis_MC2_155      NLHMIFYRDVSAAGLDIAPNQAMASLHRVLANFKMPGYTVPDFRRKAVVI
MAB_0754c|M.abscessus_ATCC_199      NLHMIFYRNLVEAGMHIAPDQALKSIHKVLDNFKMPGYTIPGFRRNAVTI
                                    ********::  *.: :.*: *: ::* :* :*:***: :* ***.** *

Mflv_1668|M.gilvum_PYR-GCK          ASGGVYDPRIHLEDIVMPVLKKWRIFEREDFNGESARMRDEIGAHVEELQ
Mvan_5085|M.vanbaalenii_PYR-1       ASGGVYDPRIHLEDIVMPVLKKWRIFEREDFNGESARLRDDLGLLVEELQ
Mb0847c|M.bovis_AF2122/97           AVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLE
Rv0824c|M.tuberculosis_H37Rv        AVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLE
MMAR_4856|M.marinum_M               AVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKMRDELALLVKELE
MUL_0445|M.ulcerans_Agy99           AVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKMRDELALLVKELE
MAV_0772|M.avium_104                AVGGVYDPRIHLDDVVMPVLKKWRIFEREDFTGEAAALRDDLALLIKELE
MLBr_02185|M.leprae_Br4923          AVGGVYDIRIHLDEVVMPVLKKWRILEREDFSGEGTRLRDEIGEHLTELE
TH_1577|M.thermoresistible__bu      AVGGVYDPRIHLDDVVMPVLKKWRIFEREDFTGEAARMRDDLGKLVEELE
MSMEG_5773|M.smegmatis_MC2_155      AVGGVYDPRIHLDDVVMPVLRKWRIFEREDFTGEGARLRDDLGRLVEELE
MAB_0754c|M.abscessus_ATCC_199      ATGGVYDPQSHLDEVVMPVLRKWRIFERDDISSEGEWYREDLDRIIGDLK
                                    * ***** : **:::*****:****:**:*:..*.   *:::   : :*:

Mflv_1668|M.gilvum_PYR-GCK          ETVQKFEIAKQRREERLRQMAEKKAAKNLLVGSSAS-----
Mvan_5085|M.vanbaalenii_PYR-1       EAVDKFEVAKQRREERLRQMAEKKAAKNLLVGSSAS-----
Mb0847c|M.bovis_AF2122/97           LACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
Rv0824c|M.tuberculosis_H37Rv        LACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
MMAR_4856|M.marinum_M               MSCDKFEESKQRQLDREARTGKRVSAFELHKTAGKLPMSRR
MUL_0445|M.ulcerans_Agy99           MSCDKFEESKQRQLDREARTGKRVSAFELHKTAGKLPMSRR
MAV_0772|M.avium_104                TTCDKFEISKRRQLEREARTGKRTTALELHTTAGTLTMSRR
MLBr_02185|M.leprae_Br4923          AACDKFEVSKQRYIEREARRTEKITARKVLSTEGTLRMSGR
TH_1577|M.thermoresistible__bu      EACEKFEVSKQRRLEREARQAEKAAEKKKSFAASTAS----
MSMEG_5773|M.smegmatis_MC2_155      DACDKFEVAKERRLERERKMAEKREMKNLLVSSSSS-----
MAB_0754c|M.abscessus_ATCC_199      KTSADFEEVKAKYLERQAKRAERQAAKAAREAVSV------
                                     :  .**  * :  :*  :  ::          .