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MGDTPALKRALSQRQLRMIAIGGVIGAGLFVGSGVVIGDTGPGTFITYGLAGVLIIMVMRMLAEMAVANP STGSFADYSRNALGNWAGFSVGWLYWYFWVIVVGFEAIAGAKIIQFWIDVPLWLTALILLIAMTATNLFS VSSFGEFEYWFAGVKVAAILAFIGLGAFYVLGVWPDKDLDFSNLTAHGGFFPLGATAVTVGVVTVIFSMV GAEIATIAAAESSDPERAVAKAANSVILRIALFFVGSAFLLVTILPWNSDQTVASPFVAAFTEMGIPYAD HIMNAVVLTAVLSCLNSGMYTASRMLFVLAARREAPPQLVAVTRRGVPATAILTSSVIGLICVIAAAFFP DTIFQFLLNSSGAVILFVYLLIAISQIVLRRRTDDSMLKVKMWLFPVLSILTAAAIFAILVQMFVQGGDN RSALVLSLASWAVVIVLFWLNRMFVSRRPQTPDVAPTSEHPHRVLVLANQTVESDELLDELRRIGADRDT TYYVVVPASPIDTGVANTHGPLDISEATQQAAQERLDSTLATLRSGDFEATGTLGEYRPLRALAKAVETF RPDQIVISTLPPEESVWQRFDVVDRARAEHHLPVTHVVSRVRATEPAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5473 | - | - | 100% (608) | transporter |
| M. smegmatis MC2 155 | MSMEG_6196 | - | e-127 | 51.71% (439) | gaba permease |
| M. smegmatis MC2 155 | MSMEG_3587 | - | 3e-78 | 37.11% (450) | D-serine/D-alanine/glycine transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0535 | gabP | 1e-159 | 66.20% (432) | GABA permease GabP |
| M. gilvum PYR-GCK | Mflv_1998 | - | 0.0 | 75.63% (599) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv0522 | gabP | 1e-159 | 66.20% (432) | GABA permease GabP |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 4e-74 | 36.10% (421) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_4909 | - | 1e-165 | 66.97% (445) | GABA permease GabP |
| M. marinum M | MMAR_0862 | gabP | 1e-158 | 64.25% (442) | GabA permease (gamma-aminobutyrate permease) GabP |
| M. avium 104 | MAV_4626 | - | 1e-163 | 65.61% (442) | gaba permease |
| M. thermoresistible (build 8) | TH_0471 | - | 1e-18 | 21.90% (443) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_4508 | gabP_1 | 1e-117 | 47.39% (441) | GabA permease GabP_1 |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 5e-22 | 23.27% (477) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0535|M.bovis_AF2122/97 ------------------------------------------MIAIGGVI
Rv0522|M.tuberculosis_H37Rv ------------------------------------------MIAIGGVI
MMAR_0862|M.marinum_M ------------------------------------------MIAIGGVI
MAV_4626|M.avium_104 --------------------MAGTSQ-----LRQGLSQRQLSMIALGGVI
MSMEG_5473|M.smegmatis_MC2_155 --------------------MGDTPA-----LKRALSQRQLRMIAIGGVI
Mflv_1998|M.gilvum_PYR-GCK --------------------MSAAPT-----LKKALNQRQLTMIAIGGVI
MAB_4909|M.abscessus_ATCC_1997 --------------------MATTAAPSEGGLQHSLQKRHLTMIAIGGVI
MUL_4508|M.ulcerans_Agy99 --------------------MAGADTEHEIALGKGLRQRHLSLIALGGVI
MLBr_01305|M.leprae_Br4923 ------MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAI
TH_0471|M.thermoresistible__bu --------MTDRLRVKSVEQSIADTDEPDSRLRKDLSWWDLTVFGVSVVI
Mvan_1740|M.vanbaalenii_PYR-1 MVQEPGAQTVGRRRTKSVEQSIADTDEPSTRLRKELNWWDLTVFGVSVVI
::.:. .*
Mb0535|M.bovis_AF2122/97 GAGLFVGSGVVIR-ATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGA
Rv0522|M.tuberculosis_H37Rv GAGLFVGSGVVIR-ATGPAAFLTYALCGALIVLVMRMLGEMAAANPSTGA
MMAR_0862|M.marinum_M GAGLFVGSGVVIR-ATGPAAFLTYALCGLLILLVMRMLAEMAAANPSTGS
MAV_4626|M.avium_104 GAGLFVGSGVVIK-DTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGS
MSMEG_5473|M.smegmatis_MC2_155 GAGLFVGSGVVIG-DTGPGTFITYGLAGVLIIMVMRMLAEMAVANPSTGS
Mflv_1998|M.gilvum_PYR-GCK GAGLFVGSGVVIA-DTGPGAFLTYGMAGVLIIMVMRMLAEMAVANPSTGS
MAB_4909|M.abscessus_ATCC_1997 GAGLFVGSGATIQ-AAGPAAFLTYAITGVLIVLVMRMLGEMAVANPSTGS
MUL_4508|M.ulcerans_Agy99 GAGLFVGSGVVIA-GTGPAAVISFLIAGLITMLIMRMLAEMAASQPVVGS
MLBr_01305|M.leprae_Br4923 GTGLFLGAGGRLA-KAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGS
TH_0471|M.thermoresistible__bu GAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVAGS
Mvan_1740|M.vanbaalenii_PYR-1 GAGIFTITASTAANITGPAISLSFIIAAIACGLAALCYAEFASTVPVAGS
*:*:* :. :**. : : : . : .*:. * *:
Mb0535|M.bovis_AF2122/97 FADYAAKALGGWAGFSVGWLYWYFWVIVVGFEAVAGGKVLTYWI------
Rv0522|M.tuberculosis_H37Rv FADYAAKALGGWAGFSVGWLYWYFWVIVVGFEAVAGGKVLTYWI------
MMAR_0862|M.marinum_M FADFAADALGGWAGFSVGWLYWYFWVIVVGFEAVAGAKVLMYWI------
MAV_4626|M.avium_104 FADYAAAALGRWAGFSVAWLYWYFWVIVVGFEAVAGGKVLNYWF------
MSMEG_5473|M.smegmatis_MC2_155 FADYSRNALGNWAGFSVGWLYWYFWVIVVGFEAIAGAKIIQFWI------
Mflv_1998|M.gilvum_PYR-GCK FADYSRNALGHWAGFSVGWLYWYFWVIVVGFEAIAGAKIVQYWM------
MAB_4909|M.abscessus_ATCC_1997 FADYSRRALGDWAGFSVGWLYWYFWVIVVGFEAVAGGKLIQDWLP-----
MUL_4508|M.ulcerans_Agy99 FYVYARQALGPRGGFVTGWMYWYFFVVVVAVETVAGGRILQLWVP-----
MLBr_01305|M.leprae_Br4923 FVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFT---
TH_0471|M.thermoresistible__bu AYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLGEVFEFAGAT
Mvan_1740|M.vanbaalenii_PYR-1 AYTFSYATFGEFVAWIIGWDLILEFAVAAAVVAKGWSSYLGTVFGFAGGT
:: :* .: .* : :.. . : . . :
Mb0535|M.bovis_AF2122/97 ----DAPLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLV
Rv0522|M.tuberculosis_H37Rv ----DAPLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLV
MMAR_0862|M.marinum_M ----HAPLWLLSLCLMIMMTATNLFSVSSFGEFEFWFAGIKVAVIVVFLA
MAV_4626|M.avium_104 ----HAPLWVLSLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLV
MSMEG_5473|M.smegmatis_MC2_155 ----DVPLWLTALILLIAMTATNLFSVSSFGEFEYWFAGVKVAAILAFIG
Mflv_1998|M.gilvum_PYR-GCK ----DVPLWLSALIFMVLMTATNLFSVASYGEFEFWFAGIKVAAIIAFIA
MAB_4909|M.abscessus_ATCC_1997 ----HAPLWLIALLLMLAMTATNLFSVRSYGEFEYWFASVKVAAIVAFLV
MUL_4508|M.ulcerans_Agy99 ----QIPLWVLSLGLLLALTATNLVSARSFGEFEYWFSSIKVIAVVVFLG
MLBr_01305|M.leprae_Br4923 ----ALPQWTLALLALAVVLVMNLISVEWFGELEFWAALIKVCALMAFLV
TH_0471|M.thermoresistible__bu TRLGPITLDWGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVI
Mvan_1740|M.vanbaalenii_PYR-1 TEVAGFQLDWGALVIIALVTLILVMGTKLSAGVSLAITAVKVSVVLLVVI
:* : : .. . .. : :** .:: .:
Mb0535|M.bovis_AF2122/97 LGTAFAFGLLP---------------GHGMDFSNLSAHGGFFPDGVGAVF
Rv0522|M.tuberculosis_H37Rv LGTAFAFGLLP---------------GHGMDFSNLSAHGGFFPDGVGAVF
MMAR_0862|M.marinum_M LGAAFAFGLLP---------------GHHMDFGNLTSHGGLFPMGVEPVF
MAV_4626|M.avium_104 VGAAYVIGLVP---------------GHHDGLTNLVSHGGFFPRGVGAVF
MSMEG_5473|M.smegmatis_MC2_155 LGAFYVLGVWP---------------DKDLDFSNLTAHGGFFPLGATAVT
Mflv_1998|M.gilvum_PYR-GCK VGAAFVLGLWP---------------GKGADFSNLTSHGGFMPLGFGAIT
MAB_4909|M.abscessus_ATCC_1997 AGTCYVLGLWP---------------GKKLDFSNLTVHEGFMPHGPGAIF
MUL_4508|M.ulcerans_Agy99 LGLLWTMGLWP---------------SATPGLGKLVDFGGFAPLGWGAVL
MLBr_01305|M.leprae_Br4923 VGTIFLGGRYPV-------------DGHNTGLSLWTSHGGLFPTGVAPLI
TH_0471|M.thermoresistible__bu VGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLL
Mvan_1740|M.vanbaalenii_PYR-1 VGAFYIKAENFSPFVPAPEEGGSGGTGTEQSLFSLLTGAEGSHYGWYGVL
* : . . .: * :
Mb0535|M.bovis_AF2122/97 AAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVF
Rv0522|M.tuberculosis_H37Rv AAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMSTVVARIVIFFVGSVF
MMAR_0862|M.marinum_M ATVVIAIFSMTGTEIITIAAAETPDPEYAVQRAMSTVVARIAVFFVGSVF
MAV_4626|M.avium_104 AAIVVVIFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVF
MSMEG_5473|M.smegmatis_MC2_155 VGVVTVIFSMVGAEIATIAAAESSDPERAVAKAANSVILRIALFFVGSAF
Mflv_1998|M.gilvum_PYR-GCK VGIVTVIFSMVGAEIATIAAAESQDPERAVAKAANSVILRILIFYVGAVL
MAB_4909|M.abscessus_ATCC_1997 SSIVIVIFSMVGAEIATIAAAESKDPAKAISQATNSVIYRVAIFFVGSIF
MUL_4508|M.ulcerans_Agy99 AAVVPCVAFYTGAEIVTVAAAESAEPEGSVSRAMKSIVARIIAFYVGSIL
MLBr_01305|M.leprae_Br4923 VVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVI
TH_0471|M.thermoresistible__bu AGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSL
Mvan_1740|M.vanbaalenii_PYR-1 AGASIVFFAFIGFDIVATTAEETRNPQRDVPRGILASLAIVTVLYVAVAV
. . :: :* *: :* : :. : : : ::*. .
Mb0535|M.bovis_AF2122/97 LLTVILPWNSLELG--ASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNS
Rv0522|M.tuberculosis_H37Rv LLTVILPWNSLELG--ASPYVAALRHMGIGGADQIMNAVVLTAVLSCLNS
MMAR_0862|M.marinum_M LLVVILPWDSIDPG--ASPYVAAFQRMGIPGADQIMNAVVVTAVLSCLNS
MAV_4626|M.avium_104 LLVAILPWDSVELG--ASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNS
MSMEG_5473|M.smegmatis_MC2_155 LLVTILPWNSDQTV--ASPFVAAFTEMGIPYADHIMNAVVLTAVLSCLNS
Mflv_1998|M.gilvum_PYR-GCK LLVLIVPWNDESVS--ASPFVAAFNAMGIPYADHVMNAVVLTAVLSCLNS
MAB_4909|M.abscessus_ATCC_1997 LIAVIVPWNSPELG--TSPYVTAFKTMGIPAADHIMRVVVLTAVLSCLNS
MUL_4508|M.ulcerans_Agy99 VVVAVVPWNTKSVG--VSPYASALAVIGIPGVTTVMNAIVLTAVLSCLNS
MLBr_01305|M.leprae_Br4923 LLALLLPYSAFKAS--ESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNA
TH_0471|M.thermoresistible__bu VLTGMVHYTELRAAGENANLATAFAANGIDWAAKVISIGALAGLTTVVIV
Mvan_1740|M.vanbaalenii_PYR-1 VLTGMVSYTELRDA-ETQNLATAFSLNGVDWAAKVISIGALAGLTTVVIV
::. :: : .: : *. . :: .::. : :
Mb0535|M.bovis_AF2122/97 GLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSVVGFLCVIMAW
Rv0522|M.tuberculosis_H37Rv GLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSVVGFLCVIMAW
MMAR_0862|M.marinum_M GLYTASRMMFVLAGRREAPASLVKVSRRGVPYVAILASSAVGFLCVIMAW
MAV_4626|M.avium_104 GLYTASRMLFVLAERGEAPARLVRLSGRGVPHIAILCSSAVGFLCVVMAR
MSMEG_5473|M.smegmatis_MC2_155 GMYTASRMLFVLAARREAPPQLVAVTRRGVPATAILTSSVIGLICVIAAA
Mflv_1998|M.gilvum_PYR-GCK GMYTASRMLFVLAARREAPAALVKVTNRGVPANAILASSVVGFLCVIAAA
MAB_4909|M.abscessus_ATCC_1997 AMYTASRMLFVLAGRGEAPRSWLKVNARGVPVQAILASSFIGFVCVILAY
MUL_4508|M.ulcerans_Agy99 ALYTTSRMAFALTIHGDGPRFFTKLSRSGVPRRAIILGTTVGYASVVATY
MLBr_01305|M.leprae_Br4923 GLYATGRVMHSIAINGSGPKFTARMSKNGVPYGGILLAAVICLCGVALNA
TH_0471|M.thermoresistible__bu LVLGQTRVLFAMSRDGLLPRPLSKTGPRGTP---VRITVLVGALVAIAAS
Mvan_1740|M.vanbaalenii_PYR-1 LVLGQTRVLFAMSRDGLLPRQLAKTGEHGTP---VRITLIVGAVVAVTAT
: *: . :: * *.* : : .
Mb0535|M.bovis_AF2122/97 VSPATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQN---LGVRMWL
Rv0522|M.tuberculosis_H37Rv VSPATVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQN---LGVRMWL
MMAR_0862|M.marinum_M VAPTTVFIFLLNSSGAVLLFVYLLIAFSQIVLRGRTPPEK---LRVRMWF
MAV_4626|M.avium_104 VAPNTVFLFLLNSSGAIILFVYWLIALSQIVLRRRTPAER---LSVKMWF
MSMEG_5473|M.smegmatis_MC2_155 FFPDTIFQFLLNSSGAVILFVYLLIAISQIVLRRRTDDSM---LKVKMWL
Mflv_1998|M.gilvum_PYR-GCK VSPDTIFAFLLNSSGAIILFVYLLIAISQIVLRYRTPDSK---LRVKMWL
MAB_4909|M.abscessus_ATCC_1997 FFEHTVFLFLLNSSGAVILFVYLMIAISQYVLRRRTPEEK---LLVKMWG
MUL_4508|M.ulcerans_Agy99 VWGDVVFEFLVNSYGAVALFVYLIIAISQVILRRRAEREDPGGLRLKMWL
MLBr_01305|M.leprae_Br4923 FNPGQAFEIVLSVAALGIIAGWGTIVLCQLRLHKMAKAGIMRRPRFRMPL
TH_0471|M.thermoresistible__bu VFPVGNLEEMVNIG---TLFAFALVSAGVIVLRRTRPDLK------RGFR
Mvan_1740|M.vanbaalenii_PYR-1 VFPIGKLEEMVNIG---TLFAFVLVSAGVLVLRRTRPDLK------RGFR
. : ::. : : : *: :
Mb0535|M.bovis_AF2122/97 FPGLSIVTVTGIVAVLARMAFDY-AARSQLWLSLLSWAVVVGCYLVTTLV
Rv0522|M.tuberculosis_H37Rv FPGLSIVTVTGIVAVLARMAFDY-AARSQLWLSLLSWAVVVGCYLVTTLV
MMAR_0862|M.marinum_M FPWLPILTVVGIVVVLVRMAFDD-AAHSQFWLSMLSWVAVLGIYGITRLI
MAV_4626|M.avium_104 FPVLSVLTLAGITAVLVQMAFDA-TARSQLWLSLLSWAVVVALYFVARSR
MSMEG_5473|M.smegmatis_MC2_155 FPVLSILTAAAIFAILVQMFVQGGDNRSALVLSLASWAVVIVLFWLNRMF
Mflv_1998|M.gilvum_PYR-GCK FPVLSGLTALGILAILVQMFIDT-ALRSQLVLSLLSWAVVIALFAANKWF
MAB_4909|M.abscessus_ATCC_1997 YPALTILTAIGIVAILVAMGFQD-ATRTQLWTSLLSWGVILLLFAILRLT
MUL_4508|M.ulcerans_Agy99 FPWLSYATIALMASVILAMAALS-ATRSRFLMSGVTLVLILATYEVRRRR
MLBr_01305|M.leprae_Br4923 APYSGYLTLAFLFAVLVVMAFDKPIGTWTVASLIVIVPALIAGWYSIRKR
TH_0471|M.thermoresistible__bu VPFVPWLPLAAIAACLWLMLNLTGLTWVRFLGWMALGLVLYFFYGRHHSM
Mvan_1740|M.vanbaalenii_PYR-1 TPWVPLLPILAIAACVWLMLNLTGLTWIRFLIWMAIGVVVYFLYGRRHSL
* . : : * . : :
Mb0535|M.bovis_AF2122/97 RR-PLNRPW-----------------------------------------
Rv0522|M.tuberculosis_H37Rv RR-PLNRPW-----------------------------------------
MMAR_0862|M.marinum_M NRNSRMRTRGQTSDV-----------------------------------
MAV_4626|M.avium_104 GR-VAAR-------------------------------------------
MSMEG_5473|M.smegmatis_MC2_155 VSRRPQTPDVAPTSEHPHRVLVLANQTVESDELLDELRRIGADRDTTYYV
Mflv_1998|M.gilvum_PYR-GCK VKKRPAEGDSGAPTGPPHRVLVLANRTVDSDELLAELSRIGADQTAEYLV
MAB_4909|M.abscessus_ATCC_1997 RRRTPEPGERTTR-------------------------------------
MUL_4508|M.ulcerans_Agy99 RVAVARNATVAARAFQPG-------------------------------V
MLBr_01305|M.leprae_Br4923 VMTIARERMGYTGPFP---------------------------------A
TH_0471|M.thermoresistible__bu LGRGMTDISARRTG------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 VGRRMG--------------------------------------------
Mb0535|M.bovis_AF2122/97 --------------------------------------------------
Rv0522|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0862|M.marinum_M --------------------------------------------------
MAV_4626|M.avium_104 --------------------------------------------------
MSMEG_5473|M.smegmatis_MC2_155 VVPASPIDTGVANTHGPLDISEATQQAAQERLDSTLATLRSGDFEATGTL
Mflv_1998|M.gilvum_PYR-GCK VVPASAVDTGAAATHGPRDVTEATQEAATARLESTLAALRGKNLTVQGEL
MAB_4909|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4508|M.ulcerans_Agy99 PMPACAQRCG----------------------------------------
MLBr_01305|M.leprae_Br4923 IANPPVQPSERSHSQNP---------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0535|M.bovis_AF2122/97 --------------------------------------------------
Rv0522|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0862|M.marinum_M --------------------------------------------------
MAV_4626|M.avium_104 --------------------------------------------------
MSMEG_5473|M.smegmatis_MC2_155 GEYRPLRALAKAVETFRPDQIVISTLPPEESVWQRFDVVDRARAEHHLPV
Mflv_1998|M.gilvum_PYR-GCK GDYRPLRALDHAVAEFGPDQIVIATLPPEFSMWHRFDVVDRARAQFTVPV
MAB_4909|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4508|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01305|M.leprae_Br4923 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mvan_1740|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0535|M.bovis_AF2122/97 ---------------
Rv0522|M.tuberculosis_H37Rv ---------------
MMAR_0862|M.marinum_M ---------------
MAV_4626|M.avium_104 ---------------
MSMEG_5473|M.smegmatis_MC2_155 THVVSRVRATEPAP-
Mflv_1998|M.gilvum_PYR-GCK THVVATSAVGNQVPR
MAB_4909|M.abscessus_ATCC_1997 ---------------
MUL_4508|M.ulcerans_Agy99 ---------------
MLBr_01305|M.leprae_Br4923 ---------------
TH_0471|M.thermoresistible__bu ---------------
Mvan_1740|M.vanbaalenii_PYR-1 ---------------