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VRYLPVSTRRIWVNPLCHFSFTVISGALFVSARRYDSNMLANSREELVEVFDALDAELDRLDEVSFEVLT TPERLRSLERLECLVRRLPAVGHTLINQLDTQASEEELGGTLCCALANRLRITKPDAALRIADAADLGPR RALTGEPLAPQLTATATAQRQGLIGEAHIKVIRALFRPPARRGGCVHPPGRRSRPGRQSRSISSRRAGPL RPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0098c | - | - | 100% (260) | hypothetical protein Mb0098c |
| M. bovis AF2122 / 97 | Mb1614c | - | e-127 | 100.00% (222) | REP13E12 repeat-containing protein |
| M. bovis AF2122 / 97 | Mb3495 | - | e-125 | 97.75% (222) | hypothetical protein Mb3495 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4397 | - | 5e-19 | 42.62% (122) | hypothetical protein Mflv_4397 |
| M. tuberculosis H37Rv | Rv1588c | - | 1e-125 | 98.20% (222) | REP13E12 repeat-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 4e-21 | 47.83% (115) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_3121 | - | 3e-41 | 59.56% (136) | hypothetical protein MMAR_3121 |
| M. avium 104 | MAV_2352 | - | 3e-34 | 57.25% (138) | hypothetical protein MAV_2352 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-12 | 36.80% (125) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 6e-11 | 33.85% (130) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 6e-41 | 58.82% (136) | hypothetical protein MUL_2371 |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | 3e-21 | 40.44% (136) | hypothetical protein Mvan_3050 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0394c|M.abscessus_ATCC_199 -------------------------------------------MSPIDDL
TH_3287|M.thermoresistible__bu --------------------------------MGQQFVTAGAARARVGEL
Mflv_4397|M.gilvum_PYR-GCK -----------------------------------------MSGGDLQTS
MSMEG_6573|M.smegmatis_MC2_155 -----------------------------------------MDDG-VQDA
Mvan_3050|M.vanbaalenii_PYR-1 ---------------------------------------MGCSREDVLGA
MMAR_3121|M.marinum_M -----------------------------------MHSNGCSDRESVVAT
MUL_2371|M.ulcerans_Agy99 -----------------------------------MHSNGCSDRESVVAT
MAV_2352|M.avium_104 -----------------------------------MHS---STREEIRAD
Mb0098c|M.bovis_AF2122/97 MRYLPVSTRRIWVNPLCHFSFTVISGALFVSARRYDSNMLANSREELVEV
Rv1588c|M.tuberculosis_H37Rv --------------------------------------MLANSREELVEV
:
MAB_0394c|M.abscessus_ATCC_199 LTTATAVVESS----FDELNNPELLSALRQLEIAQRKITAASHTLTARLV
TH_3287|M.thermoresistible__bu LAAVDAAYAEMRALCLDEVGTGFRLELAERLETQCRINRGLMYRVFAQLA
Mflv_4397|M.gilvum_PYR-GCK IAALRAAFEEVAAADVDLLTRPDLVAALDELEELSCQLPAVGHRLLARLQ
MSMEG_6573|M.smegmatis_MC2_155 VAALDAALNTLLTLPHSALTDAELLTICAGLQDARNRIPAVEHRAIAALS
Mvan_3050|M.vanbaalenii_PYR-1 FDALDAVVESILALDYDALSAAERVRLEARLERNLRRIPTVEHELLASVI
MMAR_3121|M.marinum_M LDRLDRAVDALVEVSFEALTTPERLRVLERLEVVARRLPVAQYALLNQLD
MUL_2371|M.ulcerans_Agy99 LDRLDRAVDALVEVSFEALTTPERLRVLERLEVVARRLPAAQYALVNQLD
MAV_2352|M.avium_104 VDALRAAVSRVLGHSYDALTTPERLRLLEIFDRETRRLRVPGHQLINQLA
Mb0098c|M.bovis_AF2122/97 FDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHTLINQLD
Rv1588c|M.tuberculosis_H37Rv FDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHALINQLD
. . : : :: : :
MAB_0394c|M.abscessus_ATCC_199 QRGSPVALGGTSFAEVLARYLSITTATARRRLADAAHLGPRRALTGEPLR
TH_3287|M.thermoresistible__bu DPPDEPAMVPAVRDRLWAR-LRITPGEVKRRLRVAALLRPRRRLSGPPLP
Mflv_4397|M.gilvum_PYR-GCK VETSAREMGAKSWNQVLAVRWRISTGEAHRRLTEAALLAPRQSLTGTPLP
MSMEG_6573|M.smegmatis_MC2_155 QQTTPAAIGAKSWPLVLATRLGISSKEARRRCTDAAELGPRVSMTGEALA
Mvan_3050|M.vanbaalenii_PYR-1 AETEPARLGEGSWKKVLTTALRISGAEAGRRLKRAKTLGPRRGLTGTPLP
MMAR_3121|M.marinum_M EQAGEAELGGR-LAAVVASRLRITRSEAGRRVAEAADVGPRRALSGQPVG
MUL_2371|M.ulcerans_Agy99 EQPGEAELGGR-LAAVVASRLRITRSEAGRRVAEAAEVGPRRALSGQPVG
MAV_2352|M.avium_104 EQSDPTELGGR-LSFALAERLHITRSDASRRIAEAADLGPRRALTGEPLP
Mb0098c|M.bovis_AF2122/97 TQASEEELGGT-LCCALANRLRITKPDAALRIADAADLGPRRALTGEPLA
Rv1588c|M.tuberculosis_H37Rv AQASEEELGGT-LCCALANRLRITKPDAARRIADAADLGPRRALTGEPLA
: : *: . * * : ** ::* .:
MAB_0394c|M.abscessus_ATCC_199 PALPYVAHALREGRLGDEHVRIIRRFFDVLPDAVDADTREAAEKQLASMG
TH_3287|M.thermoresistible__bu PVLARVAGAVESGLLGEEHLRVITTVMAALPSAVSVTDREAVEASLIAEA
Mflv_4397|M.gilvum_PYR-GCK PALPATAVAQSRGLINAEHVEVIRKAVKKLPGWVDVATREQFEVNLVRTA
MSMEG_6573|M.smegmatis_MC2_155 PKREHIAAAQADGTLTPDHVAELFKFFTKCPDWVTYAEQCRLEEKLVTGA
Mvan_3050|M.vanbaalenii_PYR-1 PLWESTAAAQAQGLLSEEHVAVIAAFHKRLPAWVDIETRAEADRQLAHAG
MMAR_3121|M.marinum_M PVLTATAAALRQGVVGEGHVRVIRDFFRRLPAGVDVGTRDRAEAHLAKLA
MUL_2371|M.ulcerans_Agy99 PVLTATAAALRQGVVGEGHVRVIRDFFRQLPAGVDVGTRDRAEAHLAKLA
MAV_2352|M.avium_104 PLLPATAAAQRDGAIGTDHVAVIRQFFDQLPEAVDVETCEHAERQLAAQA
Mb0098c|M.bovis_AF2122/97 PQLTATATAQRQGLIGEAHIKVIRALFR----------------PPARRG
Rv1588c|M.tuberculosis_H37Rv PQLTATATAQRQGLIGEAHVKVIRALFR----------------PPARRG
* * * * : *: : .
MAB_0394c|M.abscessus_ATCC_199 TEFGPEQLRAGADRIAALVNPDG-RFSDIDRARRRGISIGRQGADGMSAL
TH_3287|M.thermoresistible__bu ARSDAGIVRQVGRRIEEIFNPDG-HYDDQDRARRRGIHLGDQQRDGMSAI
Mflv_4397|M.gilvum_PYR-GCK VGNGPKELRDAAELTLFLLDQDGPEPDDTERARKRGLTKGKQRPDGMIDL
MSMEG_6573|M.smegmatis_MC2_155 IGADPETVRQAVDHAVFLLDQDGPAPTDNPPTKPFGITFGPQQPDGSYHL
Mvan_3050|M.vanbaalenii_PYR-1 SGLDPEGLDEAAGVLLAMINPDGAQPCDKERARKRGIRISKQHPDGTATI
MMAR_3121|M.marinum_M TQFRPDQLARLAGRLMDCLNPDG-RHSDEDRARRRGLSLGRQGLDGMSRI
MUL_2371|M.ulcerans_Agy99 TQFRPDQLARLAGRLMDCLNPDG-RHSDEDRARRRGLSLGRQGLDGMSRI
MAV_2352|M.avium_104 TQFRPDQLSKLARRLMDCLNPDG-RYSDEDRARARGLVLGNQQADGMSRL
Mb0098c|M.bovis_AF2122/97 GCVHPPGRRSRPGRQSRSISSRR---------------AGPLRPAG----
Rv1588c|M.tuberculosis_H37Rv GCVHPPGRRSRPGRQSRSISSRR---------------AGPLRPAG----
. .. . *
MAB_0394c|M.abscessus_ATCC_199 SGLLDPETRAYFDAVLSKLAAPGMCDPRD-----------ESPMTEG---
TH_3287|M.thermoresistible__bu SGWIDPQLRAYLEAVTAAVR-PGRHLPHTTTDTTGTTGTTETTGTAG---
Mflv_4397|M.gilvum_PYR-GCK AGTLTPEAWAVLEVIFAKYAAPGMCNPAD-----------PEPCTYG---
MSMEG_6573|M.smegmatis_MC2_155 RGKVSAEFKATFDPIDEKLAAPGMCNPTD-----------QTPCISG---
Mvan_3050|M.vanbaalenii_PYR-1 SGTLTPEALAIWQAIFAKEAAPGANNPESEH---------TEDSTSGGAA
MMAR_3121|M.marinum_M SGWLTPEARAGLEAVWAKLAAPGMCNPED-----------EAAVVDG---
MUL_2371|M.ulcerans_Agy99 SGWLTPEARAGLEAVWAKLAAPGMCNPED-----------EAAVVDG---
MAV_2352|M.avium_104 SGWLTPEARAGWEAVLAKLAAPGMCNPDD-----------DAPVVDG---
Mb0098c|M.bovis_AF2122/97 HGLATPRRRPHRH-------------------------------------
Rv1588c|M.tuberculosis_H37Rv HGLATPRRRPHRH-------------------------------------
* .. . .
MAB_0394c|M.abscessus_ATCC_199 ---------------------------EPDSAAAERDT------------
TH_3287|M.thermoresistible__bu ---------------------------TAGTAATAADTAADGVGDIDTGG
Mflv_4397|M.gilvum_PYR-GCK ---------------------------TPTQAQIDNDQ------------
MSMEG_6573|M.smegmatis_MC2_155 ---------------------------TPSQQQIDSDQ------------
Mvan_3050|M.vanbaalenii_PYR-1 DDASDAPGDHAGAASSAASGASDAAEHDPQPERCGSDT------------
MMAR_3121|M.marinum_M ---------------------------PVSPDAADRDS------------
MUL_2371|M.ulcerans_Agy99 ---------------------------PVSRDAADRDS------------
MAV_2352|M.avium_104 ---------------------------PPPEAASQRDS------------
Mb0098c|M.bovis_AF2122/97 --------------------------------------------------
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 ---RTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA
TH_3287|M.thermoresistible__bu VDLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAA
Mflv_4397|M.gilvum_PYR-GCK ---RSLAQRQHDALVAVGRIALMSGELGQLNGLPVSIIIRTTLQDLESRA
MSMEG_6573|M.smegmatis_MC2_155 ---RGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELEKAA
Mvan_3050|M.vanbaalenii_PYR-1 ---RTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELEKGA
MMAR_3121|M.marinum_M ---RSVGQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA
MUL_2371|M.ulcerans_Agy99 ---RSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA
MAV_2352|M.avium_104 ---RSAAQRNHDGLNAALRALLAGGKLGQHNGLPASIIVTTTLRDLESAA
Mb0098c|M.bovis_AF2122/97 ---RTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL--------------
Rv1588c|M.tuberculosis_H37Rv ---RTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL--------------
* : .*. : : * .
MAB_0394c|M.abscessus_ATCC_199 -----------GRAISGSGNLVPIPDLIRMATHAFHYLTIFGDD-GRPLH
TH_3287|M.thermoresistible__bu HAVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLY
Mflv_4397|M.gilvum_PYR-GCK -----------GVGTTGGGTVVPIKDVIRMAGHANHYLAVFDRATGSALD
MSMEG_6573|M.smegmatis_MC2_155 -----------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGIPLY
Mvan_3050|M.vanbaalenii_PYR-1 -----------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGKSLY
MMAR_3121|M.marinum_M -----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVFDRG--EAIG
MUL_2371|M.ulcerans_Agy99 -----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVFDRG--EAIG
MAV_2352|M.avium_104 -----------GKGLTGGGTLLPMSEVIRLARHAHHYLAVFDNG--KPLA
Mb0098c|M.bovis_AF2122/97 --------------------------------------------------
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 LGRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVD-DWRDDGPT
TH_3287|M.thermoresistible__bu LGRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQP-AWEDGGLT
Mflv_4397|M.gilvum_PYR-GCK LFRTRRVASPAQRVMLIARDGGCTKPCCTVGAYGCQVHHAETDYAHGGNT
MSMEG_6573|M.smegmatis_MC2_155 LGRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLT
Mvan_3050|M.vanbaalenii_PYR-1 LGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDGGLT
MMAR_3121|M.marinum_M LYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRT
MUL_2371|M.ulcerans_Agy99 LYHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRT
MAV_2352|M.avium_104 LYHTKRLASPGQRIVLYAKDRGCSHPGCDVSGYYCEVHHVT-GYAKCGRT
Mb0098c|M.bovis_AF2122/97 --------------------------------------------------
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 DIDNLTFACGPHHRLLQQGW--TTRKRRSDGITEWIPPPHLDTGQSRTND
TH_3287|M.thermoresistible__bu DADHLFFACGPHHSGLTEGR--WQATITPTGRLAWTNDHHPPT----VNH
Mflv_4397|M.gilvum_PYR-GCK NIDELGLACGPDNRSVTEGG--WTTRINDRCEVEWIPPPGLDTGQARVNT
MSMEG_6573|M.smegmatis_MC2_155 DADALALACGCDNRLVGEAPNKWTTRINNHGQCEWIPPDLLDRGQHRTNT
Mvan_3050|M.vanbaalenii_PYR-1 NIDDLTLACPCDHRMLDNTG--WRTRKNGKNQTEWLPPPDLDTGQHRVNG
MMAR_3121|M.marinum_M DINQLTLACGPDHK-LLEQG--WRTRKNAHGDTEWLPPPHLDHGQPRTNT
MUL_2371|M.ulcerans_Agy99 DINQLTLACGPDHK-LLEQG--WRTRKNAHGDTEWLPPPHLDHGQPRTNS
MAV_2352|M.avium_104 DIDQLTFACGGHHP-LAEQG--WITRKNGRGETEWIPPPHLERGQPRVNS
Mb0098c|M.bovis_AF2122/97 --------------------------------------------------
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 HHHPERFIRRF---------------------------------------
TH_3287|M.thermoresistible__bu AHHPEELLRAHT--------------------------------------
Mflv_4397|M.gilvum_PYR-GCK YHRPERLLAPP-------------------------------DDPEPP--
MSMEG_6573|M.smegmatis_MC2_155 YHHPETLLADINRDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPAIPPE
Mvan_3050|M.vanbaalenii_PYR-1 HHHPERYLLPE---------------------------------------
MMAR_3121|M.marinum_M YHHPEKLLRDS---------------------------------------
MUL_2371|M.ulcerans_Agy99 YHHPEKLLRDS---------------------------------------
MAV_2352|M.avium_104 FHHPEDMLCDT---------------------------------------
Mb0098c|M.bovis_AF2122/97 --------------------------------------------------
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu ----------------DPPEDPG---------------------------
Mflv_4397|M.gilvum_PYR-GCK ----NQTRTTATEPVEDQAIDDPETDAPPPLDDPGEPGGP----------
MSMEG_6573|M.smegmatis_MC2_155 LLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSAENRN
Mvan_3050|M.vanbaalenii_PYR-1 ---------------DDLPEDDQGP-------------------------
MMAR_3121|M.marinum_M -------------------ADDDD---------EGHGAA-----------
MUL_2371|M.ulcerans_Agy99 -------------------ADDDD---------EGHGAA-----------
MAV_2352|M.avium_104 -------------------EDQQDQQDQQDQADEEDGAA-----------
Mb0098c|M.bovis_AF2122/97 --------------------------------------------------
Rv1588c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------
TH_3287|M.thermoresistible__bu --------------
Mflv_4397|M.gilvum_PYR-GCK APPDNRAA------
MSMEG_6573|M.smegmatis_MC2_155 GPSKNAAGDDDEPR
Mvan_3050|M.vanbaalenii_PYR-1 --------------
MMAR_3121|M.marinum_M --------------
MUL_2371|M.ulcerans_Agy99 --------------
MAV_2352|M.avium_104 --------------
Mb0098c|M.bovis_AF2122/97 --------------
Rv1588c|M.tuberculosis_H37Rv --------------