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SVLMTGFPGFLRSALSPGILRRTDSSAICLVQPKFATQAGVRVAELSAAEPELEGRIRLVQGDITRPGLG LAQADLSDVTETWHLAAAYDLAVARDVAVRINVDGTRNVPDALAQCPNLTRLHYFSTCYVSGRYAGPFGE DDLEVGAPFNNYYEETKHLTEADVRSRMAAGMPATIYRPSIVVGDSATGETQKFDGPYFVMQWLLRQPHR AILPVAGDPTMTRVNVVPRDFVIDAVGYLSGLSQSQGRTYHLADPRPLTVDEMTDVLARATGRDVTKVPL PRKLAKASLARLPGLYRLMRIPPEAVDYFSHPTFYLTDHCRADLAGGPVVGPPPFTAYVDRLVEFMRNHP EVGSAAMF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4346 | acrA1_1 | - | 100% (359) | multi-functional enzyme with acyl-CoA-reductase activity AcrA1_1 |
| M. ulcerans Agy99 | MUL_0918 | acrA1 | 2e-29 | 29.00% (369) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_1722 | - | 1e-09 | 26.07% (303) | fatty-acid-CoA ligase FadD9 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3423 | acrA1 | 1e-22 | 29.89% (348) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4896 | - | 6e-35 | 32.97% (367) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3391 | acrA1 | 1e-22 | 29.89% (348) | short chain dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3710 | - | 3e-35 | 32.04% (362) | short chain dehydrogenase |
| M. marinum M | MMAR_5272 | acrA1_1 | 0.0 | 96.94% (359) | multi-functional enzyme with acyl-CoA-reductase activity |
| M. avium 104 | MAV_4340 | - | 6e-31 | 31.97% (366) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1623 | - | 6e-34 | 32.41% (361) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_1879 | fadD9 | 8e-08 | 27.41% (321) | PROBABLE FATTY-ACID-CoA LIGASE FADD9 (FATTY-ACID-CoA |
| M. vanbaalenii PYR-1 | Mvan_4728 | - | 1e-147 | 68.73% (355) | hypothetical protein Mvan_4728 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4346|M.ulcerans_Agy99 ----------MSVLMTGFPGFLRSALSPGILRRTDSSAICLVQPK-FATQ
MMAR_5272|M.marinum_M ----------MSVLMTGFPGFLGSALLPGILRRTDSSAICLVQPK-FATQ
Mvan_4728|M.vanbaalenii_PYR-1 --------------MTGFPGFLGSALLPRILQRTGGEAVCLVQRR-FLAA
Mb3423|M.bovis_AF2122/97 ----------MRYVVTGGTGFIGRHVVSRLLDGRPEARLWALVRR-QSLS
Rv3391|M.tuberculosis_H37Rv ----------MRYVVTGGTGFIGRHVVSRLLDGRPEARLWALVRR-QSLS
MAV_4340|M.avium_104 MRGRHRHDVFMRYVVTGGTGFIGRRVVTRLLQTRPDAQVWVLVRR-QSLG
MSMEG_1623|M.smegmatis_MC2_155 ----------MRYVVTGGTGFIGRRVVSEILVRDASAEVWVLVRR-ESLN
Mflv_4896|M.gilvum_PYR-GCK ----------MRYVVTGGTGFIGSRLIGRLLARPDVTAVHVLVRR-GSLG
MAB_3710|M.abscessus_ATCC_1997 ----------MKYIVTGGTGFIGRRIVTRILETQPAAEVAILVRR-ESLS
TH_1879|M.thermoresistible__bu ---------------VGLSXQARARLADRLPAYMVPAAVVVLDRIPLTVN
.* . : : : :
MUL_4346|M.ulcerans_Agy99 AGVRVAELSAAEPELEGRIRLVQGDITRPGLGLAQA-----DLSDVTETW
MMAR_5272|M.marinum_M AGVRVAELSAADPDLEGRIRLVQGDITRPGLGLAQA-----DLSDVTEAW
Mvan_4728|M.vanbaalenii_PYR-1 ANRRLAELDSDDPSLRQRIRIIEGDITQPGLGIDRD-----VLAEVTEAW
Mb3423|M.bovis_AF2122/97 RFERLAGQ------WGDRVRPLVGDL--TELELSERTI--AELGDIDHVL
Rv3391|M.tuberculosis_H37Rv RFERLAGQ------WGDRVRPLVGDL--TELELSERTI--AELGDIDHVL
MAV_4340|M.avium_104 RFERLSAQG--DTPWGDRVKPLVGEL--PALELSDETL--AELGHVDHLV
MSMEG_1623|M.smegmatis_MC2_155 RFEHLALD------WGERAKPLVGDLRADDLGLTGADV--ADLGDVTHVV
Mflv_4896|M.gilvum_PYR-GCK RFERLARD------WDDRVHALVGDLTDPDLGLTDATV--AELGPVDHVV
MAB_3710|M.abscessus_ATCC_1997 RFEKLAEQ------WDDRVQPLVGDLTQPDLGLPAE----GDPVTADHIV
TH_1879|M.thermoresistible__bu GKLDRRALPAPEYQRADRYRAPETAVEKTLTEIFAHVLGLERVGVDDSFF
* : : :
MUL_4346|M.ulcerans_Agy99 HLAAAYDLAVARDVAVRINVDGTRNVPDALAQCPNLTRLHYFSTCYVSGR
MMAR_5272|M.marinum_M HLAAAYDLAVARDVAVRINVDGTRNVLDALAQCPNLTRMHYFSTCYVSGR
Mvan_4728|M.vanbaalenii_PYR-1 HLAAVYDLTIDRETALRVNVTGTTNMLNALERCTSLSRLHYFSTCYVSGR
Mb3423|M.bovis_AF2122/97 HCAAVHDTTW---------ADATRAVIELAARLD--ATFHHVSSIAVAGD
Rv3391|M.tuberculosis_H37Rv HCAAVHDTTW---------ADATRAVIELAARLD--ATFHHVSSIAVAGD
MAV_4340|M.avium_104 HCAAIYDITAGEAEQRAANVDGTRAVIELAQRLG--ATLHHVSSIAVAGD
MSMEG_1623|M.smegmatis_MC2_155 HCAAIYDITVDEAAQRAANVDGTRAVIALARRLE--ATLHHVSSIAVAGN
Mflv_4896|M.gilvum_PYR-GCK HCAAIYDMTAPENRQRAANVEGTRAVIALSRRLG--ATLHHVSSIAVAGT
MAB_3710|M.abscessus_ATCC_1997 HCAAIYDITVDDKAQRAANVEGTRSVIALAKRTG--AILHHISSIAVAGS
TH_1879|M.thermoresistible__bu DLGGDSISAMRAVAAINTALDTDVAVRTLFEAPTVRRLSRQLEGGADTAP
. .. : : : .. :.
MUL_4346|M.ulcerans_Agy99 YAGPFGEDDLEVGAPFNNYYEETKHLTEADVRSRMAAGMPATIYRPSIVV
MMAR_5272|M.marinum_M YAGPFGEDDLEVGAPFNNYYEETKHLAEADVRSRMAAGMPATIYRPSIVV
Mvan_4728|M.vanbaalenii_PYR-1 YAGPFSEEELEVGAPFNNFYEETKHLAEAEVRQRMSAGMPATIYRPSIVV
Mb3423|M.bovis_AF2122/97 FAGHYTEADFDVGQRLPTPYHRMTFEAERLVRS--TPGLRYRIYRPAVVV
Rv3391|M.tuberculosis_H37Rv FAGHYTEADFDVGQRLPTPYHRMTFEAERLVRS--TPGLRYRIYRPAVVV
MAV_4340|M.avium_104 FPGEYTEDDFDVGQQLPTPYHQTKFEAELLVRS--APGLRHRIYRPAVVV
MSMEG_1623|M.smegmatis_MC2_155 HRGVFTEDDFDVAQDLPTPYHQTKFEAEMLVRA--TTDVPHRIYRPAVVV
Mflv_4896|M.gilvum_PYR-GCK HPGVFTEDDVDVGQELPTPYHRTKFEAEQLVRA--ADGLRFRIYRPAVVV
MAB_3710|M.abscessus_ATCC_1997 YEGEFTEDDFDVNQDLPTPYHQTKFEAELLVRS--EPGLRYRIYRPAVVV
TH_1879|M.thermoresistible__bu QGADLGAVTYESVHGATATEVRAADLTLDRFIDAATLRTAADLPRPTGQV
. : . : . : **: *
MUL_4346|M.ulcerans_Agy99 GDSATGETQKFDGPYFVMQWLLRQPHRAILPVAGDPTMTRVNVVP-----
MMAR_5272|M.marinum_M GDSATGETQKFDGPYFVMQWLLRQPRRAILPVAGDPTMTRVNVVP-----
Mvan_4728|M.vanbaalenii_PYR-1 GDSRTGETQKFDGPYFVMQWLLRQPRKAVLPVVGDPAMARVNLVP-----
Mb3423|M.bovis_AF2122/97 GDSRTGEMDTIDGPYYLFGVLAKLAVLPSFTPMLLPDIGRTNIVP-----
Rv3391|M.tuberculosis_H37Rv GDSRTGEMDTIDGPYYLFGVLAKLAVLPSFTPMLLPDIGRTNIVP-----
MAV_4340|M.avium_104 GDSRTGEMDKVDGPYYFFGVLAKLAVLPRFTPMLLPDTGRTNIVP-----
MSMEG_1623|M.smegmatis_MC2_155 GDSRTGEMDKIDGPYYFFGVLARLAALPRFTPMALPDTGRTNVVP-----
Mflv_4896|M.gilvum_PYR-GCK GDSRTGEIDKIDGPYYFFGVLSALAALPRFTPMMLPDVGRTNLVP-----
MAB_3710|M.abscessus_ATCC_1997 GDSRTGEMDKIDGPYYFFGVFAKLAKLPSFTPMMLPRAGRSNIVP-----
TH_1879|M.thermoresistible__bu QTVLLTGATGFLGRYLLLEWLRRLRRVDDTVICLVRGRSDADARQRLEAV
. * * .: : :
MUL_4346|M.ulcerans_Agy99 --------RDFVIDAVGYLSGLSQSQGR-TYHLADPRPLTVDEMTDVLAR
MMAR_5272|M.marinum_M --------RDFVIDAVGYLSGLSQSQGR-TYHLADPRPLTVDEMTDVLAR
Mvan_4728|M.vanbaalenii_PYR-1 --------RDFVVDAVAYLSGQSSSAGR-TYHVADPHPLTVAELISVLAE
Mb3423|M.bovis_AF2122/97 --------VDYVADALVALMHADGRDGQ-TFHLTAPTAIGLRGIYRGIAG
Rv3391|M.tuberculosis_H37Rv --------VDYVADALVALMHADGRDGQ-TFHLTAPTAIGLRGIYRGIAG
MAV_4340|M.avium_104 --------VDYVADALVALMHADGLDGQ-TFHLTAEKTIGLRGIYRGVAK
MSMEG_1623|M.smegmatis_MC2_155 --------VDFVAKALVHLMHVEGADGQ-TFHLTAPNTVGLVDIYRGVAG
Mflv_4896|M.gilvum_PYR-GCK --------VDFVVDALDVLMHADGRDGQ-TFHLTAPKNTGLRGIYRGVAR
MAB_3710|M.abscessus_ATCC_1997 --------VDYVVDATVELMHQEGRDGQ-AFHLTNPEVTYLRDIYSGIAA
TH_1879|M.thermoresistible__bu FDTDPALRRHFRELAAERLQVIAGDKGQPNLGLDVQTWRRLAERVDLIVD
.: * * *: : : :.
MUL_4346|M.ulcerans_Agy99 ATGRDVTKVPLPRKLAKASLARLPGLYRLMR--------IPPEAVDYFSH
MMAR_5272|M.marinum_M ATGRDVTKVPLPRKLAKASLARVPGLYRLMR--------IPPETVDYFSH
Mvan_4728|M.vanbaalenii_PYR-1 ATGRDVVSIPLPRRLAKASIRHVPGIYRLLR--------MPAEAVDYFAH
Mb3423|M.bovis_AF2122/97 AAGLPPLLGTLP-GFVAAPVLNARGRAKVLRNMAATQLGIPAEIFDVVGC
Rv3391|M.tuberculosis_H37Rv AAGLPPLLGTLP-GFVAAPVLNARGRAKVLRNMAATQLGIPAEIFDVVGC
MAV_4340|M.avium_104 AAGLPPLRGSLP-GAVAAPVLKVRGRARVVRDMAATQLGIPAQVFDLVDL
MSMEG_1623|M.smegmatis_MC2_155 AAGLPPLRAKLP-RVTAAPVLDARGRARIVRNMVATQLGIPGEVFDVAEL
Mflv_4896|M.gilvum_PYR-GCK AAGLPPLVGVLP-RAAAAPLLQVSGRAKAIRNMAATQLGIPGEVLDVVEL
MAB_3710|M.abscessus_ATCC_1997 AAGLPPVRGSLP-HAVATPFLRARGTLKVWRNMVVTQLGIPPEVIDITEI
TH_1879|M.thermoresistible__bu SAAFVNSVLPYRELFGPNVVGTAELIRFALTAKLKPYNFVSTSDIGRQIE
::. . :. . ..
MUL_4346|M.ulcerans_Agy99 PTFYLTDHCRADLAGGPVVGPPPFTAYVDRLVEFMRNHPEVGSAAMF---
MMAR_5272|M.marinum_M PTFYLTDHCRADLAGGPVVGPPPFTAYVDRLVEFMRNHPEVGSAAMF---
Mvan_4728|M.vanbaalenii_PYR-1 PTYYLTEHIREDLAG-SGIEAPPFPSYVDRLVAFMRAHPDLGSAAMY---
Mb3423|M.bovis_AF2122/97 APTFTSDTTREALRG-TGIHVPEFATYAPGLWRYWAEHLDPDRARRNDP-
Rv3391|M.tuberculosis_H37Rv APTFTSDTTREALRG-TGIHVPEFATYAPGLWRYWAEHLDPDRARRNDP-
MAV_4340|M.avium_104 APTFVSEKTRNALAG-TGIEVPEFAGYAPRLWRYWAEHLDPDRARRDDPR
MSMEG_1623|M.smegmatis_MC2_155 RPTFTADNTDTALRG-TGIAVPEFASYAPQLFRYWAEHLDPDRARRCDPA
Mflv_4896|M.gilvum_PYR-GCK APTFTSERTDEALCD-SGISVPEFASYAPGLWRYWAEHLDPNRARQDDPA
MAB_3710|M.abscessus_ATCC_1997 MPTFISESTQEALRP-SGIKVPPFGSYAGRLYQYWRRNLDPERYRRDDPA
TH_1879|M.thermoresistible__bu PDLFTEDADIRTISPTRTVDASYANGYGNSKWAGEVLLREAHDLCGLPVA
: : : : . * :
MUL_4346|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5272|M.marinum_M --------------------------------------------------
Mvan_4728|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3423|M.bovis_AF2122/97 --LLGRHVIITGASSGIGRASAIAVAKRGATVFALARNGNALDELVTEIR
Rv3391|M.tuberculosis_H37Rv --LLGRHVIITGASSGIGRASAIAVAKRGATVFALARNGNALDELVTEIR
MAV_4340|M.avium_104 GPLYGRHVIVTGASSGIGRASAIAIAQRGATVFALARNGAALDALVDEIR
MSMEG_1623|M.smegmatis_MC2_155 GPLVGRHVIITGASSGIGRASAIAVARRGAVVFALARNGEALDELIAEIR
Mflv_4896|M.gilvum_PYR-GCK GPLVGRHVVITGASSGIGRASAVAVAARGATVFALARNAEALDDLIAEIR
MAB_3710|M.abscessus_ATCC_1997 GPLVGRHVIITGASSGIGRAAAIAVARRGGTVFAVARDGEALDQLVAEIR
TH_1879|M.thermoresistible__bu VFRSGMILVDPTYAGQLN-------------------VTDTVSRMVLSIV
MUL_4346|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5272|M.marinum_M --------------------------------------------------
Mvan_4728|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3423|M.bovis_AF2122/97 AHGGQAHAFTCDVTDSASVEHTVKDILGRFDHVDYLVNNAGRSIRRSVVN
Rv3391|M.tuberculosis_H37Rv AHGGQAHAFTCDVTDSASVEHTVKDILGRFDHVDYLVNNAGRSIRRSVVN
MAV_4340|M.avium_104 ANGGAAHAFTCDVTDSASVEHTVKDILGRFDHVDYLVNNAGRSIRRSVVN
MSMEG_1623|M.smegmatis_MC2_155 ADGGQAHAFTCDVTDSASVEHTVKDILGRFDHVDYLVNNAGRSIRRSVAN
Mflv_4896|M.gilvum_PYR-GCK ESGGDAHAFTCDVTDPSAVEHTVKDILGRFGHVDYLVNNAGRSIRRSVTA
MAB_3710|M.abscessus_ATCC_1997 EDGGKAHAFPCDLTDYAAVDDTVKSILGQFGHVDYLVNNAGRSIRRSVVN
TH_1879|M.thermoresistible__bu ATGVAPKSFYRLGDDGSRQRAHFDGLP--VDFVAEAVATLGWQIARTATG
MUL_4346|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5272|M.marinum_M --------------------------------------------------
Mvan_4728|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3423|M.bovis_AF2122/97 STDRLHDYERVMAVNYFGAVRMVLALLPHWRERRFGHVVNVSSAGVQARN
Rv3391|M.tuberculosis_H37Rv STDRLHDYERVMAVNYFGAVRMVLALLPHWRERRFGHVVNVSSAGVQARN
MAV_4340|M.avium_104 STDRLHDYERVMAVNYFGAVRMVLALLPHWRERRFGHVVNVSSAGVQARN
MSMEG_1623|M.smegmatis_MC2_155 STDRLHDYERVMAVNYFGAVRMVLALLPHWRERRFGHVVNVSSAGVQAHT
Mflv_4896|M.gilvum_PYR-GCK STDRFHDYERVMAVNYFGAVRMVLALLPHWRERRFGHVVNVSSAGVQANN
MAB_3710|M.abscessus_ATCC_1997 TVDRFHDYERVMAINYFGAVRLVLALLPHWRERKFGHVVNVSTAGVQTRN
TH_1879|M.thermoresistible__bu SPAGDFRTYHVMNP-------------------------HDDGIGIDEYV
MUL_4346|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5272|M.marinum_M --------------------------------------------------
Mvan_4728|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3423|M.bovis_AF2122/97 PKYSSYLPTKAALDAFADVVASETLSDHITFTNIHMPLVATPMIVPSRRL
Rv3391|M.tuberculosis_H37Rv PKYSSYLPTKAALDAFADVVASETLSDHITFTNIHMPLVATPMIVPSRRL
MAV_4340|M.avium_104 PKYSSYLPTKAALDAFADVVGSEVLSDHITFTNIHMPLVRTPMIVPSHRL
MSMEG_1623|M.smegmatis_MC2_155 PKYSAYLPSKAALDAFSDVVSTETLSDHITFTNIHMPLVKTPMIAPSRRL
Mflv_4896|M.gilvum_PYR-GCK PRYSAYIPSKAALDAFSEVVGAETLSDHITFTNIHMPLVKTPMIAPSGRL
MAB_3710|M.abscessus_ATCC_1997 PKYASYIPTKAALDAFADVVATETVSDHITFTNIHMPLVKTPMITPSHKL
TH_1879|M.thermoresistible__bu DWLIEAGHPIERIDDFGEWLRRFEAG-------LHALPERQRQHSVLQML
MUL_4346|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5272|M.marinum_M --------------------------------------------------
Mvan_4728|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3423|M.bovis_AF2122/97 NPVRAISAERAAAMVIRGLVEKPARIDTPLGTLAEAGNYVAPRLSRRILH
Rv3391|M.tuberculosis_H37Rv NPVRAISAERAAAMVIRGLVEKPARIDTPLGTLAEAGNYVAPRLSRRILH
MAV_4340|M.avium_104 NPVRAISPERAAAMVVRGLVEKPARIDTPLGTLAEAGNYFAPRTSRRVLH
MSMEG_1623|M.smegmatis_MC2_155 NPVPPISAEHAAAMVVRALVEKPPRIDTPLGTFADFGNYLTPRVARRFLH
Mflv_4896|M.gilvum_PYR-GCK NPAPAISPEHAAAMVVRALVDKPARIDTPIGTVADLGMYLTPKLARRVLH
MAB_3710|M.abscessus_ATCC_1997 NVVRGLTPEHAAAMVVRGLIEKPTRIDHPMGTFADIGQYLTPKLSRRVLH
TH_1879|M.thermoresistible__bu TLLRQQGGEPQPPEPRHGSDAPADRFEAAVKRAGINGGQGIPHVTPEVIV
MUL_4346|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5272|M.marinum_M --------------------------------------------------
Mvan_4728|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3423|M.bovis_AF2122/97 QLYLGYPDSAAAQGISRPD-------ADRPP--APRRPRRSARAG-----
Rv3391|M.tuberculosis_H37Rv QLYLGYPDSAAAQGISRPD-------ADRPP--APRRPRRSARAG-----
MAV_4340|M.avium_104 QLYLGYPDSAAARGVATEPR-----PAERIERTAPRKPRRPVRAVTRGLR
MSMEG_1623|M.smegmatis_MC2_155 QLYLGYPDSAAARGLAPAEPRPASTAGPGLPERRPKRPARSRRGVRVPRA
Mflv_4896|M.gilvum_PYR-GCK QLYLGFPDSAAAQGIAENDR---VHSATRTPERKPWPPRRPVPSVR----
MAB_3710|M.abscessus_ATCC_1997 QMYLAYPDSKAARGLEPVDD----RRDLSTSRRRPRAAKRVAAVSR--LR
TH_1879|M.thermoresistible__bu RYVTDLRQLGLL--------------------------------------
MUL_4346|M.ulcerans_Agy99 -----------------
MMAR_5272|M.marinum_M -----------------
Mvan_4728|M.vanbaalenii_PYR-1 -----------------
Mb3423|M.bovis_AF2122/97 VPRPLRRLGRLVPGVHW
Rv3391|M.tuberculosis_H37Rv VPRPLRRLGRLVPGVHW
MAV_4340|M.avium_104 TPRPVRRLVRLVPGVHW
MSMEG_1623|M.smegmatis_MC2_155 VGRPVKRAVRTLPGVHW
Mflv_4896|M.gilvum_PYR-GCK IPSAVKQAIRLVPGVHW
MAB_3710|M.abscessus_ATCC_1997 VPGPLMKAVRLIPGVHW
TH_1879|M.thermoresistible__bu -----------------