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VGLTSEQLELRHNARDILRAACPPDAARQAMTDPQCWRAPWKTLVDLGWTELAASDCRDDFGSVERALVL EECGRAIAPIPLLSSIDMAAGVLRGCGPAAKDVLSEIAAGVVATLAVQSPGHRLARPPMVLQHGRLRGHA VAVPNLARAALIVTLAATADGPVAAVLRRGDAVTTRTMQSSDPAQPLADLEVDAIPALIAPVASIESVVT APLLAVSADLVGVADAVLQHAVEHAKSRHQFGVPIGGFQGIKHALADNYGSVERARSLTYAAASHPAPDW TAAALAKAAAADAAVRCATTAVQVYGAIAQTWEHHIHLYVRHAWQGAAQLGDSRALYHEVGRRFAGGPQ
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_3840 | - | - | 100% (349) | acyl-CoA dehydrogenase |
M. ulcerans Agy99 | MUL_1194 | fadE6 | 4e-31 | 32.66% (346) | acyl-CoA dehydrogenase FadE6 |
M. ulcerans Agy99 | MUL_2893 | fadE18 | 1e-29 | 31.91% (351) | acyl-CoA dehydrogenase FadE18 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0277c | fadE6 | 2e-31 | 31.98% (344) | acyl-CoA dehydrogenase FADE6 |
M. gilvum PYR-GCK | Mflv_1795 | - | 2e-30 | 31.48% (324) | acyl-CoA dehydrogenase domain-containing protein |
M. tuberculosis H37Rv | Rv0271c | fadE6 | 2e-31 | 31.98% (344) | acyl-CoA dehydrogenase FADE6 |
M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-15 | 26.48% (355) | putative acyl-CoA dehydrogenase |
M. abscessus ATCC 19977 | MAB_4336 | - | 1e-34 | 32.95% (352) | acyl-CoA dehydrogenase FadE |
M. marinum M | MMAR_3979 | - | 0.0 | 97.42% (349) | acyl-CoA dehydrogenase |
M. avium 104 | MAV_1631 | - | 1e-121 | 66.01% (356) | putative acyl-CoA dehydrogenase |
M. smegmatis MC2 155 | MSMEG_5618 | - | 2e-31 | 32.70% (318) | acyl-CoA dehydrogenase |
M. thermoresistible (build 8) | TH_2777 | - | 5e-33 | 32.56% (347) | PUTATIVE acyl-CoA dehydrogenase domain protein |
M. vanbaalenii PYR-1 | Mvan_4007 | - | 5e-34 | 34.19% (351) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MUL_3840|M.ulcerans_Agy99 ------------MGLTSEQLELRHNARDILRAACPPDAARQAMTDPQCWR MMAR_3979|M.marinum_M ----------MDVGLTSEQLELRHNARDILRAACPPDAARQAMTDLQCWR MAV_1631|M.avium_104 ----------MDVGLNSEQLSLRDAVRDILRTECPPDAARQAITDPERWR Mb0277c|M.bovis_AF2122/97 ----------MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENP Rv0271c|M.tuberculosis_H37Rv ----------MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENP MAB_4336|M.abscessus_ATCC_1997 ----------MPIAINSEHVALADSAHAFVERVVPTELLHETLETPLPWP Mflv_1795|M.gilvum_PYR-GCK ----------MRAEFAEFHDELRSVASDLLAKDGHAPEWRVLADAG---- TH_2777|M.thermoresistible__bu ----------MTDQFTEFHDELRAVAAEVLAKD-RTVDWPVLADAG---- MSMEG_5618|M.smegmatis_MC2_155 ------MMTDFTTDFSAIHDELRSVAADLLAKD--SVDWPLLVQAG---- Mvan_4007|M.vanbaalenii_PYR-1 ----------MDFRYHTEHDDLRAALRGFLHQTAPAARVREVAAGDGCDI MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR--FP : * . . MUL_3840|M.ulcerans_Agy99 -APWKTLVDLGWT--ELAASDCRDDFGSVERALVLEECGRAIAPIPLLSS MMAR_3979|M.marinum_M -APWKTLVDLGWT--ELAASDCRDDFGSVERALVLEECGRAIAPIPLLSS MAV_1631|M.avium_104 -ALWKTVVDLGWT--ELAAANT-GDYGPMELVVVLEECGAAIAPIPLLCS Mb0277c|M.bovis_AF2122/97 PPYWQAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPS Rv0271c|M.tuberculosis_H37Rv PPYWQAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPS MAB_4336|M.abscessus_ATCC_1997 PPFWKSAADQGLTSVHLAESVGGQGFGALELAIVVAEFGRGAVPGPFVPS Mflv_1795|M.gilvum_PYR-GCK -----------WTGLEVPDTLGGAGASFAESAVILDQIGRAAGVTGYLGG TH_2777|M.thermoresistible__bu -----------WVGLEVADEFGGAGASFGEVAVICSEMGRAATASSYLGG MSMEG_5618|M.smegmatis_MC2_155 -----------WVGLDAPESLGGAGATFAEVAVICEELGRAAATTGYLGG Mvan_4007|M.vanbaalenii_PYR-1 SLWRRLCTELELPGLHLSQECGGAGGSLVEAAIVFEELGRALTPVP-MAA MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPA . . . :: : . : . MUL_3840|M.ulcerans_Agy99 ID-MAAGVLRGCGPA---AKDVLSEIAAGVVATLAVQSPGHRLARPPMVL MMAR_3979|M.marinum_M IG-MAAGVLRGCGPA---AKDVLSEIAAGVVATLAVQSPGHRLARPPMVL MAV_1631|M.avium_104 VG-LAAGLLRGSG-----LDAVLADIAGGAVATVAVHAEKSRLPGAPMTL Mb0277c|M.bovis_AF2122/97 A--IASALIAAHDPQ---AKVLAELATGAAIAAYALDSGLTATRHGDVLV Rv0271c|M.tuberculosis_H37Rv A--IASALIAAHDPQ---AKVLAELATGAAIAAYALDSGLTATRHGDVLV MAB_4336|M.abscessus_ATCC_1997 V--IASALISAHDPD---HPLLSDLASGASIATFSSTSSFTATPAGDGLS Mflv_1795|M.gilvum_PYR-GCK AV-LATGVLNLLRPSDSRDHLLAAVAGGEPRLAVVTG----------DFS TH_2777|M.thermoresistible__bu AV-LGVGALNAVQPDAARDDLLTAVAAGAERTALVLG----------PFT MSMEG_5618|M.smegmatis_MC2_155 AV-LGVGALLAVAPNTSRDNLLTEVVEGRTRVSLALPGDLVPGDPRVPFT Mvan_4007|M.vanbaalenii_PYR-1 TV-FAIEAVLRLGDDRQRSRLLPALLSGERIATLAAARPDALDPARVTVR MLBr_00737|M.leprae_Br4923 VNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT :. : : : MUL_3840|M.ulcerans_Agy99 QH------GRLRGHAVAVPNLARAALIVTLAATA-----DG-PVAAVLRR MMAR_3979|M.marinum_M QH------GRLRGHAVAVPNLTRAELIVTLAATA-----DG-PVAALLRR MAV_1631|M.avium_104 RQ------GRLRGRAVAVPNLARAELLVTLARTD-----DGGTVAAVARC Mb0277c|M.bovis_AF2122/97 IR------GEVR----AVPAAAQASVLVLPVAIE-----SRDEWVVLRND Rv0271c|M.tuberculosis_H37Rv IR------GEVR----AVPAAAQASVLVLPVAIE-----SRDEWVVLRND MAB_4336|M.abscessus_ATCC_1997 VD------GQAR----SVLSATSATYVVAPVAID-----SDRRWVVLSAD Mflv_1795|M.gilvum_PYR-GCK MS-----AGKLTGRAEFVPDAVGADRLLVVTG--------PEVAVVETAA TH_2777|M.thermoresistible__bu FT-----GGRLTGRAEFVPDASGADRLLVLATDS-----DGTPVLTATAA MSMEG_5618|M.smegmatis_MC2_155 VTT----DGRVHGRAAFVPDAGDAHRLLLPARDA-----TGTTVLVD-AA Mvan_4007|M.vanbaalenii_PYR-1 ADRHAG-RTELSGESSPVLHGHVADLFVVPAVAD-----GRVALYVVAAD MLBr_00737|M.leprae_Br4923 RAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKD : : . MUL_3840|M.ulcerans_Agy99 GD--AVTTR-TMQSSDP-------AQPLADLEVDAIPALIAPVASIESVV MMAR_3979|M.marinum_M GD--GVTTR-TMQSSDP-------AQPLADLEVDAIPALIAPVASIESVL MAV_1631|M.avium_104 GD--GVTALPAAECTDP-------AQPLAWVEIDAEPVAVAPVD-LESAL Mb0277c|M.bovis_AF2122/97 QL--EIEAVKSLDPLRP-------IAHVRANAVDVSDDALLSNLTMTTAH Rv0271c|M.tuberculosis_H37Rv QL--EIEAVKSLDPLRP-------IAHVRANAVDVSDDALLSNLTMTTAH MAB_4336|M.abscessus_ATCC_1997 DV--TLDSQQSVDPLRP-------VAHVTATAVQVPADRVLSNLTDARAT Mflv_1795|M.gilvum_PYR-GCK ATVTAQPVVDETRRLAT-------VAADSATVVDILTFDGNPADAVNALR TH_2777|M.thermoresistible__bu ATVTAQPVLDETRRLAV-------VCAEDSGVEAVWRFAGDPRAAARRLA MSMEG_5618|M.smegmatis_MC2_155 ATVIEQPVLDETRRLAI-------VEADGAEARDVWPLEDP-----HALA Mvan_4007|M.vanbaalenii_PYR-1 APGVTVDRLPSFDTTRP-------VARLRLQQAPAEPLVAGPHDGIERVL MLBr_00737|M.leprae_Br4923 DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATL MUL_3840|M.ulcerans_Agy99 TAPLLAVSADLVGVADAVLQHAVEHAKSRHQFGVPIGGFQGIKHALADNY MMAR_3979|M.marinum_M TAPLLAVSADLVGVADAVLQHAVEHAKSRHQFGAPIGGFQGIKHALADNY MAV_1631|M.avium_104 PAPWVACAADLVGVAGAALRRSVEHAKTRRQFGKPIGAFQGVKHALADNY Mb0277c|M.bovis_AF2122/97 ALMSTLLSAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMI Rv0271c|M.tuberculosis_H37Rv ALMSTLLSAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMI MAB_4336|M.abscessus_ATCC_1997 SIISTIVSAEAVGVARWATDTASEYAKVREQFGRPIGQFQGIKHKCATMA Mflv_1795|M.gilvum_PYR-GCK HRAEIAVACDSLGVAEQMLSDTVDYVKVRHQFGRPIGSFQAVKHACADML TH_2777|M.thermoresistible__bu DRAAVAVAIDSLGLAEAMLSATVSYAKVRHQFGRPIGSFQAVKHACADMQ MSMEG_5618|M.smegmatis_MC2_155 RRAALAVACDSLGIAAAMLDATVSYASMRQQFGRPIGSFQAVKHACADML Mvan_4007|M.vanbaalenii_PYR-1 DTARVLLSAEMLGGAEACLAMAVEYSCTREQFDRPIGSFQAVKHSCADMM MLBr_00737|M.leprae_Br4923 DHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMA . : :* * : : *.**. .*. **.::. * MUL_3840|M.ulcerans_Agy99 GSVERARSLTYAAAS-------HPAPDWTAAALAKAAAADAAVRCATTAV MMAR_3979|M.marinum_M VSVERARSLTYAAAS-------HPAPDWTAAALAKAAAADAAVRCATTAV MAV_1631|M.avium_104 VSVERARSLTYAAAARLADPGTAPGDAWTAAALAKAAAGEAATGCARTAV Mb0277c|M.bovis_AF2122/97 ADTERATAAVWDAARALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCI Rv0271c|M.tuberculosis_H37Rv ADTERATAAVWDAARALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCI MAB_4336|M.abscessus_ATCC_1997 AVTERATAAVWDAARALDDADENPGVVEFAASVAATLAPAAAQQCAQDCI Mflv_1795|M.gilvum_PYR-GCK VAVEVSRQLVADAVDVLAG----GGDAAIPAAMAKSYVCAAAVEVAGKAM TH_2777|M.thermoresistible__bu VQITVARQLVGRAVAALCDP--DSDDTAAAAAMAKSFVCSAAVEVVGKAM MSMEG_5618|M.smegmatis_MC2_155 VQVTAARQLIAGAIS---------APDAHTVAKAKSYATEAAVGVAGKAM Mvan_4007|M.vanbaalenii_PYR-1 IEIDATRAAVMFAAMSAAD----PDELRITAPLVKAQAADTFTLCAGAAF MLBr_00737|M.leprae_Br4923 MKVEAARLIVYAAAARAERG---EPDLGFISAASKCFASDIAMEVTTDAV : * . . . .. MUL_3840|M.ulcerans_Agy99 QVYGAIAQTWEHHIHLYVRHAWQGAAQLG--------------------- MMAR_3979|M.marinum_M QVYGAIAQTWEHHIHLYVRHAWQGAAQLG--------------------- MAV_1631|M.avium_104 QVHGALGQTWEHDAHLYVRHAWQTAALLG--------------------- Mb0277c|M.bovis_AF2122/97 QVHGGIGFTWEHDTNVYYRRALMLAACFGRGSEYPQRVVDTATTAGMRPV Rv0271c|M.tuberculosis_H37Rv QVHGGIGFTWEHDTNVYYRRALMLAACFGRGSEYPQRVVDTATTAGMRPV MAB_4336|M.abscessus_ATCC_1997 QVHGGIGYTWEHDAHIYYRRALGLTAALGRSGGAPATVVRTAVEHGLRKV Mflv_1795|M.gilvum_PYR-GCK QLHGGIGYTWESGIHTYLKRATLNRSLFG--------------------- TH_2777|M.thermoresistible__bu QLHGGIGYTWESGVHVYLKRATLNRALYG--------------------- MSMEG_5618|M.smegmatis_MC2_155 QLHGGIGYTWESGVHTYLKRAALNRSLFG--------------------- Mvan_4007|M.vanbaalenii_PYR-1 QVHGGIAFTWEHDMHLYFRRAKTTEALFG--------------------- MLBr_00737|M.leprae_Br4923 QLFGGAGYTSDFPVERFMRDAKITQIYEG--------------------- *:.*. . * : . : : * * MUL_3840|M.ulcerans_Agy99 ------DSRALYHEVGRRFAGGPQ-------------------------- MMAR_3979|M.marinum_M ------DSRALYHEVGRRFAGGPQ-------------------------- MAV_1631|M.avium_104 ------DSRALYHEVGRRFCGGAA-------------------------- Mb0277c|M.bovis_AF2122/97 DIDLDPSTEKLRAQIRAEVAALKAMPREPRTVAIAEGGWVLPYLPKPWGR Rv0271c|M.tuberculosis_H37Rv DIDLDPSTEKLRAQIRAEVAALKAMPREPRTVAIAEGGWVLPYLPKPWGR MAB_4336|M.abscessus_ATCC_1997 DIDLAPETEALRAEIRAEVAALKEIPSGKRNTAIAEGGWVLPYLPTPWGR Mflv_1795|M.gilvum_PYR-GCK ------SPAAQRRRLSQRYH------------------------------ TH_2777|M.thermoresistible__bu ------SPAAHRSQLVSRYR------------------------------ MSMEG_5618|M.smegmatis_MC2_155 ------SPREHRTMLSARYRSAPG-------------------------- Mvan_4007|M.vanbaalenii_PYR-1 ------GSAHHRSLLADRVGL----------------------------- MLBr_00737|M.leprae_Br4923 ------TNQIQRVVMSRALLR----------------------------- : MUL_3840|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3979|M.marinum_M -------------------------------------------------- MAV_1631|M.avium_104 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 AASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGTDNQKQRLLPPT Rv0271c|M.tuberculosis_H37Rv AASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGTDNQKQRLLPPT MAB_4336|M.abscessus_ATCC_1997 AASPVEQVIISQEFLTGKVRRPQLGIATWLVPSIVAYGTEEQKQRFLPPT Mflv_1795|M.gilvum_PYR-GCK -------------------------------------------------- TH_2777|M.thermoresistible__bu -------------------------------------------------- MSMEG_5618|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_4007|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MUL_3840|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3979|M.marinum_M -------------------------------------------------- MAV_1631|M.avium_104 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 FRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQYSQ Rv0271c|M.tuberculosis_H37Rv FRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQYSQ MAB_4336|M.abscessus_ATCC_1997 FRGEMMWCQLFSEPGAGSDLAGLSTKAVKVEGGWRLTGQKIWTSVAQFAD Mflv_1795|M.gilvum_PYR-GCK -------------------------------------------------- TH_2777|M.thermoresistible__bu -------------------------------------------------- MSMEG_5618|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_4007|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MUL_3840|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3979|M.marinum_M -------------------------------------------------- MAV_1631|M.avium_104 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 WGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLD Rv0271c|M.tuberculosis_H37Rv WGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLD MAB_4336|M.abscessus_ATCC_1997 WGACLARTDPSAPKHNGITYFLVDMKSEGVTVRPLREMTGGALFNEVFID Mflv_1795|M.gilvum_PYR-GCK -------------------------------------------------- TH_2777|M.thermoresistible__bu -------------------------------------------------- MSMEG_5618|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_4007|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MUL_3840|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3979|M.marinum_M -------------------------------------------------- MAV_1631|M.avium_104 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 DVFVPDELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVR Rv0271c|M.tuberculosis_H37Rv DVFVPDELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVR MAB_4336|M.abscessus_ATCC_1997 DVFVPDELVVGEVNRGWEVSRNTLTAERVSIGSSDLPFLASLDDLVAFVG Mflv_1795|M.gilvum_PYR-GCK -------------------------------------------------- TH_2777|M.thermoresistible__bu -------------------------------------------------- MSMEG_5618|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_4007|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MUL_3840|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3979|M.marinum_M -------------------------------------------------- MAV_1631|M.avium_104 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 DYRFEGQFDQVARHRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAIS Rv0271c|M.tuberculosis_H37Rv DYRFEGQFDQVARHRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAIS MAB_4336|M.abscessus_ATCC_1997 THDLG----EVARDRAGQLIAEGHGVKLLNLRSTLLTLAGGDPMPSAAVS Mflv_1795|M.gilvum_PYR-GCK -------------------------------------------------- TH_2777|M.thermoresistible__bu -------------------------------------------------- MSMEG_5618|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_4007|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MUL_3840|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3979|M.marinum_M -------------------------------------------------- MAV_1631|M.avium_104 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 KLLSMRTGQGYAEFAVSSFGTDAVIGDTERLPGKWGEYLLASRATTIYGG Rv0271c|M.tuberculosis_H37Rv KLLSMRTGQGYAEFAVSSFGTDAVIGDTERLPGKWGEYLLASRATTIYGG MAB_4336|M.abscessus_ATCC_1997 KLLGMRTGQGYAEFVVNHFGQDGAIGDSEQEQGRWADYLLASRATTIYGG Mflv_1795|M.gilvum_PYR-GCK -------------------------------------------------- TH_2777|M.thermoresistible__bu -------------------------------------------------- MSMEG_5618|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_4007|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- MUL_3840|M.ulcerans_Agy99 -------------------- MMAR_3979|M.marinum_M -------------------- MAV_1631|M.avium_104 -------------------- Mb0277c|M.bovis_AF2122/97 TSEVQLNIIAERLLGLPRDP Rv0271c|M.tuberculosis_H37Rv TSEVQLNIIAERLLGLPRDP MAB_4336|M.abscessus_ATCC_1997 TSEVQLNIIAERLLGLPRDP Mflv_1795|M.gilvum_PYR-GCK -------------------- TH_2777|M.thermoresistible__bu -------------------- MSMEG_5618|M.smegmatis_MC2_155 -------------------- Mvan_4007|M.vanbaalenii_PYR-1 -------------------- MLBr_00737|M.leprae_Br4923 --------------------