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DVSLLAFEWTDTSRHWLIEVPIRIVAYLTVALVIRFVVHRMIDRATTSRTRKDKDAAGARTPPLVRKLRD RVPSSASSEQVIARRQQRAQTIGSVLKSTVSIVLLVWVVLAVLNVLGVNIAPFIASAGVVGLAIGFGAQN LVRDFVTGVFMLLEDQYGVGDTVDLGEAVGEVESVGLRITTVRDIDGTLWYVRNGEIARVGNMSQEYAVA RIEVPVALTADVDRAEQVAHEAAQEAVADPALAGKVIGEPEMLGVQELSPDLIKLRMTVKVRPNAQWAVQ RKLRRAILRAYDEHGIDLPYPGGRMQVAAASE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3795 | - | - | 100% (313) | MscS mechanosensitive ion channel |
| M. vanbaalenii PYR-1 | Mvan_0128 | - | 7e-40 | 35.76% (288) | MscS mechanosensitive ion channel |
| M. vanbaalenii PYR-1 | Mvan_1912 | - | 1e-37 | 32.26% (310) | MscS mechanosensitive ion channel |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3131c | - | 4e-37 | 32.54% (295) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_2744 | - | 1e-152 | 88.39% (310) | MscS mechanosensitive ion channel |
| M. tuberculosis H37Rv | Rv3104c | - | 4e-37 | 32.54% (295) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1411 | - | 2e-93 | 55.38% (325) | putative mechanosensitive ion channel |
| M. marinum M | MMAR_1528 | - | 7e-38 | 34.45% (299) | transmembrane protein |
| M. avium 104 | MAV_4005 | - | 3e-39 | 35.56% (225) | transporter, small conductance mechanosensitive ion channel |
| M. smegmatis MC2 155 | MSMEG_1315 | - | 1e-126 | 73.18% (302) | transporter, small conductance mechanosensitive ion channel |
| M. thermoresistible (build 8) | TH_3952 | - | 1e-130 | 78.07% (301) | PUTATIVE MscS mechanosensitive ion channel |
| M. ulcerans Agy99 | MUL_2411 | - | 8e-38 | 32.21% (298) | transmembrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3795|M.vanbaalenii_PYR-1 ----MDV-----SLLAFEWTDTSRHWLIEVPIRIVAYLTVALVIRFVVHR
Mflv_2744|M.gilvum_PYR-GCK ----MDV-----SSLAFEWTDTSRHWLIEVPIRIVVYIAVALVIRYLVHR
TH_3952|M.thermoresistible__bu ----MDLGFTPATWVALEWTETSQHWLIEVPIRIVAYLVAALIARLVLHR
MSMEG_1315|M.smegmatis_MC2_155 ----MDV-----YNVAFEWTDTNRHWFIEVPIRITAYIVIVLIARYVLHR
MAB_1411|M.abscessus_ATCC_1997 -----------MSDLAIQLSESGRDWLIHRPVDIAIYVVLALAVRYVLHR
Mb3131c|M.bovis_AF2122/97 MTTSGTVLAT---SIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVLAAR
Rv3104c|M.tuberculosis_H37Rv MTTSGTVLAT---SIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVLAAR
MMAR_1528|M.marinum_M MTTNTTAFALATFSPAQYWHDFWRGQIGEWIITRGLRIVMVLIAAVLAAR
MUL_2411|M.ulcerans_Agy99 MTTNTTAFALATFSPAQYWHDFWRGQIGEWIITRGLRIVMVLIAAVLAAR
MAV_4005|M.avium_104 ---------------------------------------MVLIAAVLAAR
* : *
Mvan_3795|M.vanbaalenii_PYR-1 MIDRATTSRTRKDK-----------------------DAAGARTPPLVRK
Mflv_2744|M.gilvum_PYR-GCK MIDRATTGRTRKNRGGG-------------------EDARPQRTPPLVRR
TH_3952|M.thermoresistible__bu MIDRATG---RMGRS----------------------DGHPHTRPLLLRP
MSMEG_1315|M.smegmatis_MC2_155 LIDRATTGRSHQERE---------------------EGKPPSRRPPLLRY
MAB_1411|M.abscessus_ATCC_1997 AIDRLVQGARRPESAEHPRRQWWAFLRRGRDLGESDRLDETARLPARTRT
Mb3131c|M.bovis_AF2122/97 FVTWLANRVTRRLDLG----------------------------------
Rv3104c|M.tuberculosis_H37Rv FVTWLANRVTRRLDLG----------------------------------
MMAR_1528|M.marinum_M FVTWVAKRVTQRLDLG----------------------------------
MUL_2411|M.ulcerans_Agy99 FVTWVAKRVTQRLDLG----------------------------------
MAV_4005|M.avium_104 FVNWVALQVSRQLTTG----------------------------------
: . :
Mvan_3795|M.vanbaalenii_PYR-1 LRDRVPSSASSEQVIARRQQRAQTIGSVLKSTVSIVLLVWVVLAVLNVLG
Mflv_2744|M.gilvum_PYR-GCK LRDRVPSSTTSEQIIARRQQRAQTIGSVLKSTVSIVLLVWVVLAVLNVVG
TH_3952|M.thermoresistible__bu LRDRKSSGATSQKIAERRQQRAKTIGSVLKSTVSIVLIIWVSLAILSVLG
MSMEG_1315|M.smegmatis_MC2_155 LRERAPAAASSSQTAKRRQQRAQTIGSVLKSTVSIVLLGWMVLGVLSVLG
MAB_1411|M.abscessus_ATCC_1997 LRGRAQDPARDARRRKRRAQRAQTLGSVLKSAVSFLVLVWVILQSLAILG
Mb3131c|M.bovis_AF2122/97 ------FTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEVIDVLP
Rv3104c|M.tuberculosis_H37Rv ------FTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEVIDVLP
MMAR_1528|M.marinum_M ------FTESDALVRSEVSKHRQAVASVISWVSIVLIYVIVLYEIVDILP
MUL_2411|M.ulcerans_Agy99 ------FTESDALVRSEVSKHRQAVASVISWVSIVVIYVIVLYEIVDILP
MAV_4005|M.avium_104 ------FVESDALVRSEASKHRQAVASVISWVSVVIIGIWVMLQIASILQ
. . :: :::.**:. . .:: : ::
Mvan_3795|M.vanbaalenii_PYR-1 VNIAPFIASAGVVGLAIGFGAQNLVRDFVTGVFMLLEDQYGVGDTVDLG-
Mflv_2744|M.gilvum_PYR-GCK VNIAPFIASAGVVGLAIGFGAQNLVRDFVTGVFMLLEDQYGVGDTVDLG-
TH_3952|M.thermoresistible__bu VNIAPFIASAGVVGLAIGFGAQNLVRDFVTGVFMLLEDQYGVGDIVDLG-
MSMEG_1315|M.smegmatis_MC2_155 VNIAPLIASAGVAGVAIGFGAQNLVRDFVTGMFMLLEDQYGVGDTVDLG-
MAB_1411|M.abscessus_ATCC_1997 VNVAPFIASAGIVGVALGFGAQNLVRDFITGIFMLFEDQYGVGDVVDVG-
Mb3131c|M.bovis_AF2122/97 VPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSM
Rv3104c|M.tuberculosis_H37Rv VPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSM
MMAR_1528|M.marinum_M FPVGSLVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSM
MUL_2411|M.ulcerans_Agy99 FPVGSLVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSM
MAV_4005|M.avium_104 FSVGGLVAPATVVGAALGFGAQQLVKDLLSGFFILAERQYGFGDLVTLTV
. :. ::..* : * *:*****.**:*:::*.*:: * ***.** * :
Mvan_3795|M.vanbaalenii_PYR-1 -----EAVGEVESVGLRITTVRDIDGTLWYVRNGEIARVGNMSQEYAVAR
Mflv_2744|M.gilvum_PYR-GCK -----EAVGEVESVGLRITTVRDIDGTLWYVRNGEIARVGNMSQEYAVAR
TH_3952|M.thermoresistible__bu -----EVVGQVETVGLRITTVRDIDGTLWYVRNGEILRVGNMSQEYAVAR
MSMEG_1315|M.smegmatis_MC2_155 -----AAVGQVESVGLRITTLRDIDGTLWYVRNGEIARVGNMSQDYAVAR
MAB_1411|M.abscessus_ATCC_1997 -----DAVGTVESVGLRITTVRDLQGTLWYVRNGGIARVGNFSQDYAVAF
Mb3131c|M.bovis_AF2122/97 VGSPENAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAV
Rv3104c|M.tuberculosis_H37Rv VGSPENAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAV
MMAR_1528|M.marinum_M VGSPENAAGTVEEVTLRVTKLRSSDGEVYTVPNGNIVKSINLSKDWARAV
MUL_2411|M.ulcerans_Agy99 VGSPENAAGTVEEVTLRVTKLRSSDGEVYTVPNGNIVKSINLSKDWARAV
MAV_4005|M.avium_104 VAATE-ASGTVENVTLRVTRLRSPDGEVLTIPNGQIVKVVNLSKDWARAV
. * ** * **:* :*. :* : : ** * : *:*:::* *
Mvan_3795|M.vanbaalenii_PYR-1 IEVPVALTADVDRAEQVAHEAAQEAVADPALAGKVIGEPEMLGVQELSPD
Mflv_2744|M.gilvum_PYR-GCK IEVPVALSADIERAEQVAVEAAEAAVAEKSLAGKVLGEPEMLGVQELSPD
TH_3952|M.thermoresistible__bu VEVPVALTVDVDRAEQVAVEAAERALADESLADKVLGKPEMLGIQELSPD
MSMEG_1315|M.smegmatis_MC2_155 VEVPVAVTTDLNRAEEIALQAAEEALADPKVSDKTLGEPEMLGVQDFSAD
MAB_1411|M.abscessus_ATCC_1997 LQIPLSYSADVDLACTIALEAAREAVAEEALRDDVIGAPEMLGIDGITAD
Mb3131c|M.bovis_AF2122/97 VDIPVPTSADLGRVNEVLHQECEHARHDSLLGELLLDEPTVMGVERIEVD
Rv3104c|M.tuberculosis_H37Rv VDIPVPTSADLGRVNEVLHQECEHARHDSLLGELLLDEPTVMGVERIEVD
MMAR_1528|M.marinum_M IDIPVPTGADLNRVNEVLHRECQHAREDAILGDLLLDEPTVMGVEKLEMD
MUL_2411|M.ulcerans_Agy99 IDIPVPTGADLNRVNEVLHRECQHAREDAILGDLLLDEPTVMGVEKLEMD
MAV_4005|M.avium_104 VDIPVSTSADLNRVNEVLHQECDRAMDNPVLGQLLLDSPTVMGVESIEVD
:::*:. .*: . : . . * : : :. * ::*:: : *
Mvan_3795|M.vanbaalenii_PYR-1 LIKLRMTVKVRPNAQWAVQRKLRRAILRAYDEHGIDLPYPGGRMQVAAAS
Mflv_2744|M.gilvum_PYR-GCK LIKLRMTVKVRPNAQWAVQRRLRRAILQAYDEHGIALPYPNGRVHAVGE-
TH_3952|M.thermoresistible__bu LLTLRMTVKTRPNEQWAVQRRLRREILRAYDEHGIDLPYPRGRIHAVVGE
MSMEG_1315|M.smegmatis_MC2_155 HVTLRMTVKTRPNAQWSVQRRLRREILRAYDEHEIYAPNA----------
MAB_1411|M.abscessus_ATCC_1997 AISLRLTVAVRANAQWAVERELRRRILIAFDENGIRPLYLDGLSSGTVET
Mb3131c|M.bovis_AF2122/97 TVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAGIVTAADARAAV-----
Rv3104c|M.tuberculosis_H37Rv TVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAGIVTAADARAAV-----
MMAR_1528|M.marinum_M TVTLRLVARTLPGKQFAAGRQLRVLVIRALTGAGIITPADAQAAVGVMAH
MUL_2411|M.ulcerans_Agy99 TVTLRLVARTLPGKQFAAGRQLRVLVIRALTGAGIITPADAQAAVGVMAH
MAV_4005|M.avium_104 TVTLRLVARTLPGKQFEVGRQLRVLVIRALARAGIVTAADARVGLVEDAS
:.**:.. . .. *: . *.** :: * *
Mvan_3795|M.vanbaalenii_PYR-1 E---------------------
Mflv_2744|M.gilvum_PYR-GCK ----------------------
TH_3952|M.thermoresistible__bu SR--------------------
MSMEG_1315|M.smegmatis_MC2_155 ----------------------
MAB_1411|M.abscessus_ATCC_1997 LEKASR----------------
Mb3131c|M.bovis_AF2122/97 -------AESP---EQ------
Rv3104c|M.tuberculosis_H37Rv -------AESP---EQ------
MMAR_1528|M.marinum_M PATVSGAADAPAGAEQQR----
MUL_2411|M.ulcerans_Agy99 PATVSGAADAPAGAEQQR----
MAV_4005|M.avium_104 VPAAQAAEQQSDDDVQGAVQKR