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DLRLVPAALTSWAVTAAGIVWLRAGAVAATLTAVAAAALIGWWAARRRLRGGADRRALGSAVVAVAVVGS GFAVAVSLRVDAAAEHAITGYFGSDTSVVVTPSETPRVLDGGRTMIRGALVALAGAPSSGDVLVFASGAG YANLTAGQPAAFRARVSRPKRRDLTVAVLSAHGEPVPGEAAPIHRAAHRLRARFAESARLALPPDQAATL PALVLGDTSALSAQTTAEFRRSGLAHLTAVSGANVTIVCGAVLLSAVLIGPRAAVALAALTLVGFVVVVQ PSPSVLRAAVMGAITLLAVLSHRRRQALPALAATVIALMIGVPELAVDVGFALSVAATAALVVLAPAWSR RLTGRGWPKPVADAVSVAVAAQLVTAPLVAGISGSVSVVAVLANLVVAPVIPPITVIGCAAAALCPLWPA GAELLIRFTGPEVWWLLGVARWAAGLPIAAVPVPSGAAGVLTVAIAAVAVAATWHWVVSHRRDTIVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3914 | - | - | 100% (488) | ComEC/Rec2-related protein |
| M. vanbaalenii PYR-1 | Mvan_1322 | - | 1e-05 | 28.69% (244) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2437c | - | 1e-149 | 58.09% (482) | hypothetical protein Mb2437c |
| M. gilvum PYR-GCK | Mflv_2663 | - | 0.0 | 78.07% (488) | ComEC/Rec2-related protein |
| M. tuberculosis H37Rv | Rv2414c | - | 1e-150 | 58.70% (477) | hypothetical protein Rv2414c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1627 | - | 1e-124 | 53.33% (480) | hypothetical protein MAB_1627 |
| M. marinum M | MMAR_3735 | comEC | 1e-145 | 57.50% (480) | membrane metal-binding protein ComEC |
| M. avium 104 | MAV_1768 | - | 1e-150 | 61.17% (479) | competence protein |
| M. smegmatis MC2 155 | MSMEG_4573 | - | 1e-164 | 63.75% (480) | competence protein |
| M. thermoresistible (build 8) | TH_1460 | - | 1e-151 | 67.81% (407) | competence protein |
| M. ulcerans Agy99 | MUL_3679 | comEC | 1e-140 | 56.73% (483) | membrane metal-binding protein ComEC |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2437c|M.bovis_AF2122/97 -MGFG---ASRLDVRLVPAALVSWIVTAAGIVWPIGNVCALCCVVVALGG
Rv2414c|M.tuberculosis_H37Rv -MGFG---ASRLDVRLVPAALVSWIVTAAGIVWPIGNVCALCCVVVALGG
MMAR_3735|M.marinum_M MAGAGRDVAERLDVRLVPGALTSWIVTAAGIVWPVGRACASGCLLLALGA
MUL_3679|M.ulcerans_Agy99 MAGAGRDVAERLYVRLVPGALTSWIVTAAGIVWPVGRACASGCLLLALGA
MAV_1768|M.avium_104 -------------MRLVPSALTCWAVTAGGIWWPIGRELAWCCVGLLAIA
Mvan_3914|M.vanbaalenii_PYR-1 -----------MDLRLVPAALTSWAVTAAGIVWLRAGAVAATLTAVAAAA
Mflv_2663|M.gilvum_PYR-GCK ---------MAVDLRLVPAALTSWLVTAAGILWLWAGALAVLAVAVGVTA
MSMEG_4573|M.smegmatis_MC2_155 ----MTDEPELLDLRLVPAALTAWLVTAAGIVWYIAGSVLVVIVVTLLAA
TH_1460|M.thermoresistible__bu --------------------------------------------------
MAB_1627|M.abscessus_ATCC_1997 -MTSAGADEPVLDLRLVPPALAAWAATATGILWPTG-----YFTAAALGI
Mb2437c|M.bovis_AF2122/97 GALWWCVARRSWHAPRLGSISAGLVAVGMVGAGYGLAVALRSEAVDRHPI
Rv2414c|M.tuberculosis_H37Rv GALWWCVARRSWHAPRLGSISAGLVAVGMVGAGYGLAVALRSEAVDRHPI
MMAR_3735|M.marinum_M GVLWWITDRRPRSRRWPRAVSAGLVTVGVVGAGFGMAIALRTEALARHPI
MUL_3679|M.ulcerans_Agy99 GVLWWITDRRPRSRRWPCAVSAGLVTVGVVGAGFGMAIALRTEALASHPI
MAV_1768|M.avium_104 GALRWRAARRHR-RPRLSSVSAGLAAIGVVGAGFGFAVALRADAVDHHPI
Mvan_3914|M.vanbaalenii_PYR-1 LIGWWAARRRLRGGADRRALGSAVVAVAVVGSGFAVAVSLRVDAAAEHAI
Mflv_2663|M.gilvum_PYR-GCK AVGWWAARR-TAAEAPRRGRAAATVAVALIGAGFAVAVTARVDAAGDHPI
MSMEG_4573|M.smegmatis_MC2_155 AVTRWAGPA---------RTGAVVIAVAVTGVGFAVAIGLRVNQVREHPV
TH_1460|M.thermoresistible__bu ---------------------------------MAVAITLRTDHLDRHPL
MAB_1627|M.abscessus_ATCC_1997 GAIWVRLSRRRWNG----AVAAAVASILIAGMGFSVAAAIRHHGVQNHPL
..* * . *.:
Mb2437c|M.bovis_AF2122/97 TVAFGTSALVTVTPSESPVSLGR---GRLMFRATVQRLRD--DETSGRVV
Rv2414c|M.tuberculosis_H37Rv TVAFGTSALVTVTPSESPVSLGR---GRLMFRATVQRLRD--DETSGRVV
MMAR_3735|M.marinum_M SAAFGTSAAVTVTPSESALSLGS---DRLMFRATIQRLRD--DEISGRVV
MUL_3679|M.ulcerans_Agy99 SAAFGTSAAVTVTPSESALSLGS---DRLMFRATIQRLRD--DEISGRVV
MAV_1768|M.avium_104 AADFGASAPVTVTPSESPVSLGSGTQGRLMFRATLQQLRS--DQMSGRVV
Mvan_3914|M.vanbaalenii_PYR-1 TGYFGSDTSVVVTPSETPRVLDG---GRTMIRGALVALAG--APSSGDVL
Mflv_2663|M.gilvum_PYR-GCK TGRVGSVVEVTVTPADTPRVLAG---GRTMIRGTLVRLDG--APSSGDVV
MSMEG_4573|M.smegmatis_MC2_155 VDRYGGAATVRVVVSEVPRPTRG---NRLMFRAALTELDG--APVSGRVM
TH_1460|M.thermoresistible__bu TDRYGTVAGVVVTPTEIPRPLGG---GRLMFRGTLRSADG--QRMSGRVV
MAB_1627|M.abscessus_ATCC_1997 RSRVGQIVTAQLRVTDDPRSVTG---GRAMMRADLVGLGDPVQGMTGAVL
* . . : :: . .* *:*. : . :* *:
Mb2437c|M.bovis_AF2122/97 VFARALDF---GELMVGQPVQFRARISRPARHDLTVAVFNATGRPTVGRA
Rv2414c|M.tuberculosis_H37Rv VFARALDF---GELMVGQPVQFRARISRPARHDLTVAVFNATGRPTVGRA
MMAR_3735|M.marinum_M VFARASEFEETGELMVGRPVRFTARISGPARHDLTVAVLNSAGAVKAGRA
MUL_3679|M.ulcerans_Agy99 VFARAFEFEEMGELMVGRPVRFTARISGPARHDLTVAVLNSAGAVKAGRA
MAV_1768|M.avium_104 VFARGPDF---GGLMVGQPVRFTARIGRPTRRDLTVAVLTASGRPTLGSA
Mvan_3914|M.vanbaalenii_PYR-1 VFASGAGYA---NLTAGQPAAFRARVSRPKRRDLTVAVLSAHGEPVPGEA
Mflv_2663|M.gilvum_PYR-GCK VFAAAGDYA---RLSAGQSAAFRARVSRPTRRDLTVAVLSAQGRPVAGDA
MSMEG_4573|M.smegmatis_MC2_155 VFASG-RFG---ALTPGSPVGFRATLSRPMRADLTVAALSARGDPTIGEA
TH_1460|M.thermoresistible__bu VFASAARYG---ELIAGQPAGFTARIGRPARRDLTVATLSATGSPVPGDA
MAB_1627|M.abscessus_ATCC_1997 VFGSSSLLG---RVAVGDTVRARAAVARPGRRDLTVATLTVVAEPSIFGH
**. . : * .. * :. * * *****.:. .
Mb2437c|M.bovis_AF2122/97 GPVHRAAHIVRHRFAAAVREVLPADQATMLPALVLGDTSTVTALTSREFR
Rv2414c|M.tuberculosis_H37Rv GPVHRAAHIVRHRFAAAVREVLPADQATMLPALVLGDTSTVTALTSREFR
MMAR_3735|M.marinum_M GALQRAAHQVRGRFAAAARRVLPADQAAMLPALVLGDTSTVSTETGRAFR
MUL_3679|M.ulcerans_Agy99 GALQRAAHQVCGRFAAAARRVLPADQAAMLPALVLGDTSTVSTETGRAFR
MAV_1768|M.avium_104 SAVQRAAHEVRRRFAAAVRDTLPADQAALLPALVLGDTSAVPTPTGRDFR
Mvan_3914|M.vanbaalenii_PYR-1 APIHRAAHRLRARFAESARLALPPDQAATLPALVLGDTSALSAQTTAEFR
Mflv_2663|M.gilvum_PYR-GCK APIHRAAHGLRTEFADAARLALAADPAAMLPALVLGDTTAVPARIAGEFR
MSMEG_4573|M.smegmatis_MC2_155 PAVQRGAQRIRTSFAETARLVLPADQAAILPGLVLGDTSTVSTQTTAEFR
TH_1460|M.thermoresistible__bu PALLRAAHRVRAGFAESARAVLPAEQAAMLPALVLGDTSAVSGRVTAEFR
MAB_1627|M.abscessus_ATCC_1997 SPIHGVANGIRDRFVDVSRNALPAGEAALLPGLVLGDTSALDAQTVAMFR
.: *: : *. * .*.. *: **.******::: **
Mb2437c|M.bovis_AF2122/97 AAGLTHLTAVSGANVTIVCA-----AALVSARLIGPRAAVVCAAVALVAF
Rv2414c|M.tuberculosis_H37Rv AAGLTHLTAVSGANVTIVCA-----AALVSARLIGPRAAVVCAAVALVAF
MMAR_3735|M.marinum_M SAGMTHLTAVSGANVTIVCG-----AVLFSARWVGPRAAVALAGIALVAF
MUL_3679|M.ulcerans_Agy99 SAGMTHLTAVSGANVTIVCGAVRCGAVLFSARWVGPRAAVALAGIALVAF
MAV_1768|M.avium_104 AAGMTHLMAVSGANVTIVCA-----AVLFSARLIGPRAAVLLAALALVAF
Mvan_3914|M.vanbaalenii_PYR-1 RSGLAHLTAVSGANVTIVCG-----AVLLSAVLIGPRAAVALAALTLVGF
Mflv_2663|M.gilvum_PYR-GCK ASGLAHLTAVSGANVTIVCG-----AVLLSAVLIGPRAAVGLAAITLLAF
MSMEG_4573|M.smegmatis_MC2_155 SSGLTHLTAVSGANVTIVCG-----ALLLSAAVVGPRIAVGLALVGLIAF
TH_1460|M.thermoresistible__bu AAGLTHLTAVSGANVTIVCG-----AVLLSAAVVGPRCAVAAAAVALVAF
MAB_1627|M.abscessus_ATCC_1997 TSGLTHLMAVSGANVSIVCG-----AVLLLGRLIGLRTSVVLAGLVLVGF
:*::** *******:***. * *. . :* * :* * : *:.*
Mb2437c|M.bovis_AF2122/97 VILVQPTASVLRAAVMGAIALVGMLSARRRQAIPALSGSVLVLLAAAPHL
Rv2414c|M.tuberculosis_H37Rv VILVQPTASVLRAAVMGAIALVGMLSARRRQAIPALSGSVLVLLAAAPHL
MMAR_3735|M.marinum_M VIVVQPTASVLRAALMASIALAAMLSSRRRQAIPALSTTVLVLLVAAPHL
MUL_3679|M.ulcerans_Agy99 VVVVQPTASVLRAALMASIALAAMLSSRRRQAIPALSTTVLVLLVAAPHL
MAV_1768|M.avium_104 VVVVQPTASVLRAAVMGAIALAGMLTSRRRQAIPALAATVLVLLAVAPQL
Mvan_3914|M.vanbaalenii_PYR-1 VVVVQPSPSVLRAAVMGAITLLAVLSHRRRQALPALAATVIALMIGVPEL
Mflv_2663|M.gilvum_PYR-GCK VVVVQPSPSVLRAAVMGAITLLAVLSHRRRQALPALSATVIALMVGAPEL
MSMEG_4573|M.smegmatis_MC2_155 VIVVQPSASVLRSAVMGAVTLLAIVTHRRRQAIPALAASVLVLMAAAPEL
TH_1460|M.thermoresistible__bu VIVVLPSASVLRAAVMAAITLLAMVSHRRRQAIPALAASVLGLVVAAPEL
MAB_1627|M.abscessus_ATCC_1997 VILVRPSPSVLRAAVMGAIGLLGVLTARRRQAIPALAATILVLLAVSPGL
*::* *:.****:*:*.:: * .::: *****:***: ::: *: * *
Mb2437c|M.bovis_AF2122/97 AVDIGFALSVAATGALVVIAPVWSRRLVDRGCPKVLADALAVAAAAQLVT
Rv2414c|M.tuberculosis_H37Rv AVDIGFALSVAATGALVVIAPVWSRRLVDRGCPKVLADALAVAAAAQLVT
MMAR_3735|M.marinum_M AVDMGFALSVVATAALVVVAPGWSDGLVARGWPKVLADGLAVATAAQVVT
MUL_3679|M.ulcerans_Agy99 AVDMGFALSVVATAALVVVAPGWSDGLVVRGWPKVLADGLAVATAAQVVT
MAV_1768|M.avium_104 SVDVGFALSVLATAALVVLAPAWSRRLADRGWPKPLADAVAVAWAAQLVT
Mvan_3914|M.vanbaalenii_PYR-1 AVDVGFALSVAATAALVVLAPAWSRRLTGRGWPKPVADAVSVAVAAQLVT
Mflv_2663|M.gilvum_PYR-GCK AVDVGFALSVSATAALVVIAPAWSRRLTERGWPKPPADAVSVALAAQLVT
MSMEG_4573|M.smegmatis_MC2_155 AVDVGFALSVCATAAIVVIAPVWARRLEARGWPSTLAAAVSVAAAAQLVT
TH_1460|M.thermoresistible__bu AVDAGFALSVAATAALIVIAPAWSRRLTARGWPKPLADAVSIATAAQVVT
MAB_1627|M.abscessus_ATCC_1997 AVDIGFALSVVATAALVVLAPRWSMRLTARGWPKPLADALCVAVAAQLVT
:** ****** **.*::*:** *: * ** *. * .:.:* ***:**
Mb2437c|M.bovis_AF2122/97 APLVAAISGRVSLVAVVANLAVAAVIAPITVLGSVAAVLVVPWPAGAQVL
Rv2414c|M.tuberculosis_H37Rv APLVAAISGRVSLVAVVANLAVAAVIAPITVLGSVAAVLVVPWPAGAQVL
MMAR_3735|M.marinum_M APLVAAISGRFSVVAVVANLAVAAVIAPITVLGSAAAVLVIPWPAGAQLL
MUL_3679|M.ulcerans_Agy99 APLVAAISGRFSVVAVVANLAVAAVIAPITVLGSAAAVLVIPWPAGAQLL
MAV_1768|M.avium_104 APLVAAISGRFSVVAAAANLLVAAVIAPITVLGTAAAALCPIWPAGARLL
Mvan_3914|M.vanbaalenii_PYR-1 APLVAGISGSVSVVAVLANLVVAPVIPPITVIGCAAAALCPLWPAGAELL
Mflv_2663|M.gilvum_PYR-GCK APLVAGISGSVSLVGVLANLAVAPVIPPITVFGTAAAALCALWPSGAELL
MSMEG_4573|M.smegmatis_MC2_155 APLVAGISGRFSVVAVAANLAVVGVIPPITVLGTAAAALAAVWPAGAGLL
TH_1460|M.thermoresistible__bu APLIAGISGRLSLVSIAANLAVAVVIPPITVLGTVAAALGACWPDGAQLL
MAB_1627|M.abscessus_ATCC_1997 APVIAAISGSVSMASIAANVLAGLVIVPITVLGTAAAALTVVSPQVAGLL
**::*.*** .*:.. **: . ** ****:* .**.* * * :*
Mb2437c|M.bovis_AF2122/97 IRFTGPEVWWVLRVAHWASGVPAATVPVAAGLPGVLLVGGATVFTVAQWR
Rv2414c|M.tuberculosis_H37Rv IRFTGPEVWWVLRVAHWASGVPAATVPVAAGLPGVLLVGGATVFTVAQWR
MMAR_3735|M.marinum_M IRFTGPQVWWVLHVARWAADVPGATVAVPAGLAGVLIVGGVTVLVVALWR
MUL_3679|M.ulcerans_Agy99 IRFTGPQVWWVLHVARWAADVPGATVAVPAGLAGVLIVGGVTVLVVALWR
MAV_1768|M.avium_104 IRFTGPELWWVGGVAHRAAGLPGATVPVPDGTAGTLIVGGVTLLAVVAWR
Mvan_3914|M.vanbaalenii_PYR-1 IRFTGPEVWWLLGVARWAAGLPIAAVPVPSGAAGVLTVAIAAVAVAATWH
Mflv_2663|M.gilvum_PYR-GCK IRFTGPEVWWLLTVARWAARMPAATVPVPSGIAGVLTVAVLAVAVAAVWH
MSMEG_4573|M.smegmatis_MC2_155 IRFTGPEVWWLLSVARWASGMPAATVPTPSGWAGVLLVAISGVTLTVLWR
TH_1460|M.thermoresistible__bu IRFAGPEVWWLLEVARWSAAVPGSAVPVPSGVAGVTVVAGGAVAAVLLWR
MAB_1627|M.abscessus_ATCC_1997 ARFCGPELWWLLRVADYASAGGTTAIPVPAGVLGFAVVAVLLGIAVWLWR
** **::**: ** :: :::... * * *. . *:
Mb2437c|M.bovis_AF2122/97 LALVSRGHVQNDGGGRHMSACLVAVRAGRPFVTPSWGERG
Rv2414c|M.tuberculosis_H37Rv WRWFRAAMCKT---MAVAVICLLAWSLSG-LVGPS-----
MMAR_3735|M.marinum_M FRWIRLAMISA----LLATLGSGLAWSVAGLVGPS-----
MUL_3679|M.ulcerans_Agy99 FRWIRLAMISA----LLATQGS-------GVVD-------
MAV_1768|M.avium_104 WRRFRAAAAAA----LLIDLAWVLSGLT------------
Mvan_3914|M.vanbaalenii_PYR-1 -----WVVSHR----RDTIVR-------------------
Mflv_2663|M.gilvum_PYR-GCK -----RVVSGR----RETIMR-------------------
MSMEG_4573|M.smegmatis_MC2_155 SRWVRRAVAGA----AVVMLAWTVAGQVVGAVGPT-----
TH_1460|M.thermoresistible__bu RPWIRWATAGT----VLSLVAWTVAGP--GPSG-------
MAB_1627|M.abscessus_ATCC_1997 RRWFRGLVWTG----VLCALALMISARVVS----------