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VRLVPSALTCWAVTAGGIWWPIGRELAWCCVGLLAIAGALRWRAARRHRRPRLSSVSAGLAAIGVVGAGF GFAVALRADAVDHHPIAADFGASAPVTVTPSESPVSLGSGTQGRLMFRATLQQLRSDQMSGRVVVFARGP DFGGLMVGQPVRFTARIGRPTRRDLTVAVLTASGRPTLGSASAVQRAAHEVRRRFAAAVRDTLPADQAAL LPALVLGDTSAVPTPTGRDFRAAGMTHLMAVSGANVTIVCAAVLFSARLIGPRAAVLLAALALVAFVVVV QPTASVLRAAVMGAIALAGMLTSRRRQAIPALAATVLVLLAVAPQLSVDVGFALSVLATAALVVLAPAWS RRLADRGWPKPLADAVAVAWAAQLVTAPLVAAISGRFSVVAAAANLLVAAVIAPITVLGTAAAALCPIWP AGARLLIRFTGPELWWVGGVAHRAAGLPGATVPVPDGTAGTLIVGGVTLLAVVAWRWRRFRAAAAAALLI DLAWVLSGLT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1768 | - | - | 100% (500) | competence protein |
| M. avium 104 | MAV_4427 | - | 3e-05 | 22.99% (435) | efflux ABC transporter, permease protein |
| M. avium 104 | MAV_4124 | - | 5e-05 | 30.49% (246) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2437c | - | 0.0 | 71.70% (477) | hypothetical protein Mb2437c |
| M. gilvum PYR-GCK | Mflv_2663 | - | 1e-146 | 59.75% (477) | ComEC/Rec2-related protein |
| M. tuberculosis H37Rv | Rv2414c | - | 0.0 | 70.83% (504) | hypothetical protein Rv2414c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1627 | - | 1e-124 | 52.30% (501) | hypothetical protein MAB_1627 |
| M. marinum M | MMAR_3735 | comEC | 1e-180 | 68.84% (507) | membrane metal-binding protein ComEC |
| M. smegmatis MC2 155 | MSMEG_4573 | - | 1e-148 | 58.48% (501) | competence protein |
| M. thermoresistible (build 8) | TH_1460 | - | 1e-141 | 62.21% (426) | competence protein |
| M. ulcerans Agy99 | MUL_3679 | comEC | 1e-176 | 69.08% (498) | membrane metal-binding protein ComEC |
| M. vanbaalenii PYR-1 | Mvan_3914 | - | 1e-150 | 61.17% (479) | ComEC/Rec2-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2437c|M.bovis_AF2122/97 -MGFG---ASRLDVRLVPAALVSWIVTAAGIVWPIGNVCALCCVVVALGG
Rv2414c|M.tuberculosis_H37Rv -MGFG---ASRLDVRLVPAALVSWIVTAAGIVWPIGNVCALCCVVVALGG
MMAR_3735|M.marinum_M MAGAGRDVAERLDVRLVPGALTSWIVTAAGIVWPVGRACASGCLLLALGA
MUL_3679|M.ulcerans_Agy99 MAGAGRDVAERLYVRLVPGALTSWIVTAAGIVWPVGRACASGCLLLALGA
MAV_1768|M.avium_104 -------------MRLVPSALTCWAVTAGGIWWPIGRELAWCCVGLLAIA
MSMEG_4573|M.smegmatis_MC2_155 ----MTDEPELLDLRLVPAALTAWLVTAAGIVWYIAGSVLVVIVVTLLAA
TH_1460|M.thermoresistible__bu --------------------------------------------------
Mflv_2663|M.gilvum_PYR-GCK ---------MAVDLRLVPAALTSWLVTAAGILWLWAGALAVLAVAVGVTA
Mvan_3914|M.vanbaalenii_PYR-1 -----------MDLRLVPAALTSWAVTAAGIVWLRAGAVAATLTAVAAAA
MAB_1627|M.abscessus_ATCC_1997 -MTSAGADEPVLDLRLVPPALAAWAATATGILWPTG-----YFTAAALGI
Mb2437c|M.bovis_AF2122/97 GALWWCVARRSWHAPRLGSISAGLVAVGMVGAGYGLAVALRSEAVDRHPI
Rv2414c|M.tuberculosis_H37Rv GALWWCVARRSWHAPRLGSISAGLVAVGMVGAGYGLAVALRSEAVDRHPI
MMAR_3735|M.marinum_M GVLWWITDRRPRSRRWPRAVSAGLVTVGVVGAGFGMAIALRTEALARHPI
MUL_3679|M.ulcerans_Agy99 GVLWWITDRRPRSRRWPCAVSAGLVTVGVVGAGFGMAIALRTEALASHPI
MAV_1768|M.avium_104 GALRWRAARRHR-RPRLSSVSAGLAAIGVVGAGFGFAVALRADAVDHHPI
MSMEG_4573|M.smegmatis_MC2_155 AVTRWAGPA---------RTGAVVIAVAVTGVGFAVAIGLRVNQVREHPV
TH_1460|M.thermoresistible__bu ---------------------------------MAVAITLRTDHLDRHPL
Mflv_2663|M.gilvum_PYR-GCK AVGWWAARR-TAAEAPRRGRAAATVAVALIGAGFAVAVTARVDAAGDHPI
Mvan_3914|M.vanbaalenii_PYR-1 LIGWWAARRRLRGGADRRALGSAVVAVAVVGSGFAVAVSLRVDAAAEHAI
MAB_1627|M.abscessus_ATCC_1997 GAIWVRLSRRRWNG----AVAAAVASILIAGMGFSVAAAIRHHGVQNHPL
..* * . *.:
Mb2437c|M.bovis_AF2122/97 TVAFGTSALVTVTPSESPVSLGR---GRLMFRATVQRLRD--DETSGRVV
Rv2414c|M.tuberculosis_H37Rv TVAFGTSALVTVTPSESPVSLGR---GRLMFRATVQRLRD--DETSGRVV
MMAR_3735|M.marinum_M SAAFGTSAAVTVTPSESALSLGS---DRLMFRATIQRLRD--DEISGRVV
MUL_3679|M.ulcerans_Agy99 SAAFGTSAAVTVTPSESALSLGS---DRLMFRATIQRLRD--DEISGRVV
MAV_1768|M.avium_104 AADFGASAPVTVTPSESPVSLGSGTQGRLMFRATLQQLRS--DQMSGRVV
MSMEG_4573|M.smegmatis_MC2_155 VDRYGGAATVRVVVSEVPRPTRG---NRLMFRAALTELDG--APVSGRVM
TH_1460|M.thermoresistible__bu TDRYGTVAGVVVTPTEIPRPLGG---GRLMFRGTLRSADG--QRMSGRVV
Mflv_2663|M.gilvum_PYR-GCK TGRVGSVVEVTVTPADTPRVLAG---GRTMIRGTLVRLDG--APSSGDVV
Mvan_3914|M.vanbaalenii_PYR-1 TGYFGSDTSVVVTPSETPRVLDG---GRTMIRGALVALAG--APSSGDVL
MAB_1627|M.abscessus_ATCC_1997 RSRVGQIVTAQLRVTDDPRSVTG---GRAMMRADLVGLGDPVQGMTGAVL
* . . : :: . .* *:*. : . :* *:
Mb2437c|M.bovis_AF2122/97 VFARALDF---GELMVGQPVQFRARISRPARHDLTVAVFNATGRPTVGRA
Rv2414c|M.tuberculosis_H37Rv VFARALDF---GELMVGQPVQFRARISRPARHDLTVAVFNATGRPTVGRA
MMAR_3735|M.marinum_M VFARASEFEETGELMVGRPVRFTARISGPARHDLTVAVLNSAGAVKAGRA
MUL_3679|M.ulcerans_Agy99 VFARAFEFEEMGELMVGRPVRFTARISGPARHDLTVAVLNSAGAVKAGRA
MAV_1768|M.avium_104 VFARGPDF---GGLMVGQPVRFTARIGRPTRRDLTVAVLTASGRPTLGSA
MSMEG_4573|M.smegmatis_MC2_155 VFASG-RFG---ALTPGSPVGFRATLSRPMRADLTVAALSARGDPTIGEA
TH_1460|M.thermoresistible__bu VFASAARYG---ELIAGQPAGFTARIGRPARRDLTVATLSATGSPVPGDA
Mflv_2663|M.gilvum_PYR-GCK VFAAAGDYA---RLSAGQSAAFRARVSRPTRRDLTVAVLSAQGRPVAGDA
Mvan_3914|M.vanbaalenii_PYR-1 VFASGAGYA---NLTAGQPAAFRARVSRPKRRDLTVAVLSAHGEPVPGEA
MAB_1627|M.abscessus_ATCC_1997 VFGSSSLLG---RVAVGDTVRARAAVARPGRRDLTVATLTVVAEPSIFGH
**. . : * .. * :. * * *****.:. .
Mb2437c|M.bovis_AF2122/97 GPVHRAAHIVRHRFAAAVREVLPADQATMLPALVLGDTSTVTALTSREFR
Rv2414c|M.tuberculosis_H37Rv GPVHRAAHIVRHRFAAAVREVLPADQATMLPALVLGDTSTVTALTSREFR
MMAR_3735|M.marinum_M GALQRAAHQVRGRFAAAARRVLPADQAAMLPALVLGDTSTVSTETGRAFR
MUL_3679|M.ulcerans_Agy99 GALQRAAHQVCGRFAAAARRVLPADQAAMLPALVLGDTSTVSTETGRAFR
MAV_1768|M.avium_104 SAVQRAAHEVRRRFAAAVRDTLPADQAALLPALVLGDTSAVPTPTGRDFR
MSMEG_4573|M.smegmatis_MC2_155 PAVQRGAQRIRTSFAETARLVLPADQAAILPGLVLGDTSTVSTQTTAEFR
TH_1460|M.thermoresistible__bu PALLRAAHRVRAGFAESARAVLPAEQAAMLPALVLGDTSAVSGRVTAEFR
Mflv_2663|M.gilvum_PYR-GCK APIHRAAHGLRTEFADAARLALAADPAAMLPALVLGDTTAVPARIAGEFR
Mvan_3914|M.vanbaalenii_PYR-1 APIHRAAHRLRARFAESARLALPPDQAATLPALVLGDTSALSAQTTAEFR
MAB_1627|M.abscessus_ATCC_1997 SPIHGVANGIRDRFVDVSRNALPAGEAALLPGLVLGDTSALDAQTVAMFR
.: *: : *. * .*.. *: **.******::: **
Mb2437c|M.bovis_AF2122/97 AAGLTHLTAVSGANVTIVCA-----AALVSARLIGPRAAVVCAAVALVAF
Rv2414c|M.tuberculosis_H37Rv AAGLTHLTAVSGANVTIVCA-----AALVSARLIGPRAAVVCAAVALVAF
MMAR_3735|M.marinum_M SAGMTHLTAVSGANVTIVCG-----AVLFSARWVGPRAAVALAGIALVAF
MUL_3679|M.ulcerans_Agy99 SAGMTHLTAVSGANVTIVCGAVRCGAVLFSARWVGPRAAVALAGIALVAF
MAV_1768|M.avium_104 AAGMTHLMAVSGANVTIVCA-----AVLFSARLIGPRAAVLLAALALVAF
MSMEG_4573|M.smegmatis_MC2_155 SSGLTHLTAVSGANVTIVCG-----ALLLSAAVVGPRIAVGLALVGLIAF
TH_1460|M.thermoresistible__bu AAGLTHLTAVSGANVTIVCG-----AVLLSAAVVGPRCAVAAAAVALVAF
Mflv_2663|M.gilvum_PYR-GCK ASGLAHLTAVSGANVTIVCG-----AVLLSAVLIGPRAAVGLAAITLLAF
Mvan_3914|M.vanbaalenii_PYR-1 RSGLAHLTAVSGANVTIVCG-----AVLLSAVLIGPRAAVALAALTLVGF
MAB_1627|M.abscessus_ATCC_1997 TSGLTHLMAVSGANVSIVCG-----AVLLLGRLIGLRTSVVLAGLVLVGF
:*::** *******:***. * *. . :* * :* * : *:.*
Mb2437c|M.bovis_AF2122/97 VILVQPTASVLRAAVMGAIALVGMLSARRRQAIPALSGSVLVLLAAAPHL
Rv2414c|M.tuberculosis_H37Rv VILVQPTASVLRAAVMGAIALVGMLSARRRQAIPALSGSVLVLLAAAPHL
MMAR_3735|M.marinum_M VIVVQPTASVLRAALMASIALAAMLSSRRRQAIPALSTTVLVLLVAAPHL
MUL_3679|M.ulcerans_Agy99 VVVVQPTASVLRAALMASIALAAMLSSRRRQAIPALSTTVLVLLVAAPHL
MAV_1768|M.avium_104 VVVVQPTASVLRAAVMGAIALAGMLTSRRRQAIPALAATVLVLLAVAPQL
MSMEG_4573|M.smegmatis_MC2_155 VIVVQPSASVLRSAVMGAVTLLAIVTHRRRQAIPALAASVLVLMAAAPEL
TH_1460|M.thermoresistible__bu VIVVLPSASVLRAAVMAAITLLAMVSHRRRQAIPALAASVLGLVVAAPEL
Mflv_2663|M.gilvum_PYR-GCK VVVVQPSPSVLRAAVMGAITLLAVLSHRRRQALPALSATVIALMVGAPEL
Mvan_3914|M.vanbaalenii_PYR-1 VVVVQPSPSVLRAAVMGAITLLAVLSHRRRQALPALAATVIALMIGVPEL
MAB_1627|M.abscessus_ATCC_1997 VILVRPSPSVLRAAVMGAIGLLGVLTARRRQAIPALAATILVLLAVSPGL
*::* *:.****:*:*.:: * .::: *****:***: ::: *: * *
Mb2437c|M.bovis_AF2122/97 AVDIGFALSVAATGALVVIAPVWSRRLVDRGCPKVLADALAVAAAAQLVT
Rv2414c|M.tuberculosis_H37Rv AVDIGFALSVAATGALVVIAPVWSRRLVDRGCPKVLADALAVAAAAQLVT
MMAR_3735|M.marinum_M AVDMGFALSVVATAALVVVAPGWSDGLVARGWPKVLADGLAVATAAQVVT
MUL_3679|M.ulcerans_Agy99 AVDMGFALSVVATAALVVVAPGWSDGLVVRGWPKVLADGLAVATAAQVVT
MAV_1768|M.avium_104 SVDVGFALSVLATAALVVLAPAWSRRLADRGWPKPLADAVAVAWAAQLVT
MSMEG_4573|M.smegmatis_MC2_155 AVDVGFALSVCATAAIVVIAPVWARRLEARGWPSTLAAAVSVAAAAQLVT
TH_1460|M.thermoresistible__bu AVDAGFALSVAATAALIVIAPAWSRRLTARGWPKPLADAVSIATAAQVVT
Mflv_2663|M.gilvum_PYR-GCK AVDVGFALSVSATAALVVIAPAWSRRLTERGWPKPPADAVSVALAAQLVT
Mvan_3914|M.vanbaalenii_PYR-1 AVDVGFALSVAATAALVVLAPAWSRRLTGRGWPKPVADAVSVAVAAQLVT
MAB_1627|M.abscessus_ATCC_1997 AVDIGFALSVVATAALVVLAPRWSMRLTARGWPKPLADALCVAVAAQLVT
:** ****** **.*::*:** *: * ** *. * .:.:* ***:**
Mb2437c|M.bovis_AF2122/97 APLVAAISGRVSLVAVVANLAVAAVIAPITVLGSVAAVLVVPWPAGAQVL
Rv2414c|M.tuberculosis_H37Rv APLVAAISGRVSLVAVVANLAVAAVIAPITVLGSVAAVLVVPWPAGAQVL
MMAR_3735|M.marinum_M APLVAAISGRFSVVAVVANLAVAAVIAPITVLGSAAAVLVIPWPAGAQLL
MUL_3679|M.ulcerans_Agy99 APLVAAISGRFSVVAVVANLAVAAVIAPITVLGSAAAVLVIPWPAGAQLL
MAV_1768|M.avium_104 APLVAAISGRFSVVAAAANLLVAAVIAPITVLGTAAAALCPIWPAGARLL
MSMEG_4573|M.smegmatis_MC2_155 APLVAGISGRFSVVAVAANLAVVGVIPPITVLGTAAAALAAVWPAGAGLL
TH_1460|M.thermoresistible__bu APLIAGISGRLSLVSIAANLAVAVVIPPITVLGTVAAALGACWPDGAQLL
Mflv_2663|M.gilvum_PYR-GCK APLVAGISGSVSLVGVLANLAVAPVIPPITVFGTAAAALCALWPSGAELL
Mvan_3914|M.vanbaalenii_PYR-1 APLVAGISGSVSVVAVLANLVVAPVIPPITVIGCAAAALCPLWPAGAELL
MAB_1627|M.abscessus_ATCC_1997 APVIAAISGSVSMASIAANVLAGLVIVPITVLGTAAAALTVVSPQVAGLL
**::*.*** .*:.. **: . ** ****:* .**.* * * :*
Mb2437c|M.bovis_AF2122/97 IRFTGPEVWWVLRVAHWASGVPAATVPVAAGLPGVLLVGGATVFTVAQWR
Rv2414c|M.tuberculosis_H37Rv IRFTGPEVWWVLRVAHWASGVPAATVPVAAGLPGVLLVGGATVFTVAQWR
MMAR_3735|M.marinum_M IRFTGPQVWWVLHVARWAADVPGATVAVPAGLAGVLIVGGVTVLVVALWR
MUL_3679|M.ulcerans_Agy99 IRFTGPQVWWVLHVARWAADVPGATVAVPAGLAGVLIVGGVTVLVVALWR
MAV_1768|M.avium_104 IRFTGPELWWVGGVAHRAAGLPGATVPVPDGTAGTLIVGGVTLLAVVAWR
MSMEG_4573|M.smegmatis_MC2_155 IRFTGPEVWWLLSVARWASGMPAATVPTPSGWAGVLLVAISGVTLTVLWR
TH_1460|M.thermoresistible__bu IRFAGPEVWWLLEVARWSAAVPGSAVPVPSGVAGVTVVAGGAVAAVLLWR
Mflv_2663|M.gilvum_PYR-GCK IRFTGPEVWWLLTVARWAARMPAATVPVPSGIAGVLTVAVLAVAVAAVWH
Mvan_3914|M.vanbaalenii_PYR-1 IRFTGPEVWWLLGVARWAAGLPIAAVPVPSGAAGVLTVAIAAVAVAATWH
MAB_1627|M.abscessus_ATCC_1997 ARFCGPELWWLLRVADYASAGGTTAIPVPAGVLGFAVVAVLLGIAVWLWR
** **::**: ** :: :::... * * *. . *:
Mb2437c|M.bovis_AF2122/97 LALVSRGHVQNDGGGRHMSACLVAVRAGRPFVTPSWGERG
Rv2414c|M.tuberculosis_H37Rv WRWFRAAMCKT---MAVAVICLLAWSLSG-LVGPS-----
MMAR_3735|M.marinum_M FRWIRLAMISA----LLATLGSGLAWSVAGLVGPS-----
MUL_3679|M.ulcerans_Agy99 FRWIRLAMISA----LLATQGS-------GVVD-------
MAV_1768|M.avium_104 WRRFRAAAAAA----LLIDLAWVLSGLT------------
MSMEG_4573|M.smegmatis_MC2_155 SRWVRRAVAGA----AVVMLAWTVAGQVVGAVGPT-----
TH_1460|M.thermoresistible__bu RPWIRWATAGT----VLSLVAWTVAGP--GPSG-------
Mflv_2663|M.gilvum_PYR-GCK -----RVVSGR----RETIMR-------------------
Mvan_3914|M.vanbaalenii_PYR-1 -----WVVSHR----RDTIVR-------------------
MAB_1627|M.abscessus_ATCC_1997 RRWFRGLVWTG----VLCALALMISARVVS----------