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RFNPPPNWPPPQDGWVPSPGWTPDPSWPPPPSGSQLWIDDETLPAGPTGGVAAPPPGRLGPPGRRKFVVG LAAVAAVIVAVGVAALILVPQTAADPPKSDEDQIREVLSGVVEAYNNADFNKYVSYFCPSERSGLGDASQ LRQNRSDTGRLSFDDISIDVTGDTAKVTATATVENEDEPDTQTVDFVKEDGRWMMLLFEDKCSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3582 | - | - | 100% (205) | hypothetical protein MUL_3582 |
| M. ulcerans Agy99 | MUL_4272 | - | 2e-06 | 39.34% (61) | hypothetical protein MUL_4272 |
| M. ulcerans Agy99 | MUL_1750 | - | 6e-06 | 41.94% (62) | proline and glycine rich transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2535 | - | 5e-05 | 33.00% (100) | proline rich membrane protein |
| M. gilvum PYR-GCK | Mflv_2044 | - | 3e-06 | 40.62% (64) | integral membrane protein-like protein |
| M. tuberculosis H37Rv | Rv2507 | - | 5e-05 | 33.00% (100) | proline rich membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0396c | - | 1e-08 | 26.26% (198) | hypothetical protein MAB_0396c |
| M. marinum M | MMAR_3583 | - | 1e-121 | 99.02% (205) | hypothetical protein MMAR_3583 |
| M. avium 104 | MAV_3436 | - | 7e-06 | 42.86% (63) | hypothetical protein MAV_3436 |
| M. smegmatis MC2 155 | MSMEG_0767 | - | 2e-07 | 26.17% (149) | hypothetical protein MSMEG_0767 |
| M. thermoresistible (build 8) | TH_4564 | - | 2e-05 | 23.39% (124) | PUTATIVE conserved hypothetical protein |
| M. vanbaalenii PYR-1 | Mvan_4693 | - | 1e-05 | 32.69% (104) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3436|M.avium_104 --------------------------------------------------
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MSMEG_0767|M.smegmatis_MC2_155 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 MTDPQRGSRVGSQVGPYRLRRLLGKGGMGEVYEAEDTVKDRVVALKLLPE
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3436|M.avium_104 --------------------------------------------------
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MSMEG_0767|M.smegmatis_MC2_155 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 AVSHDPVFRKRLQREAHAAGRLQEPHVVPIHDYGEVDGLLFVDMRLIDGT
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3436|M.avium_104 --------------------------------------------------
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MSMEG_0767|M.smegmatis_MC2_155 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 DLRKLLKEQGPMTPARATAIVAQVASALDAAHQNGIMHRDVKPENILINR
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3436|M.avium_104 --------------------------------------------------
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MSMEG_0767|M.smegmatis_MC2_155 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 DDFAYLVDFGIANAVTDEALTELGTAVGTYAYMAPERFTNGEVTHRADVY
Mb2535|M.bovis_AF2122/97 ---------------------------------------------MNDPR
Rv2507|M.tuberculosis_H37Rv ---------------------------------------------MNDPR
Mflv_2044|M.gilvum_PYR-GCK ---------------------------------------------MTENP
MAV_3436|M.avium_104 ---------------------------------------------MSQPP
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MSMEG_0767|M.smegmatis_MC2_155 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 ALTCVLHECLTGAQPFQGDSVSVVITAHLNDPAPRPSQSRPGIPAGLDDV
Mb2535|M.bovis_AF2122/97 RPQRFGP-PLSGYGPTGPQVPPNPPTADPAYADQSPYASTYGGYVS----
Rv2507|M.tuberculosis_H37Rv RPQRFGP-PLSGYGPTGPQVPPNPPTADPAYADQSPYASTYGGYVS----
Mflv_2044|M.gilvum_PYR-GCK PPGGYPPPPQGGYPPPPPSEGGYPPPPPEGGYPPPPPAGGYQQPPPGGAY
MAV_3436|M.avium_104 EYPGTPPEPPPGYGPPP----GYGPPP---GYGPPP---GYGTPPP----
MUL_3582|M.ulcerans_Agy99 --------------------------------MRFNPPPNWPPPQDGWVP
MMAR_3583|M.marinum_M --------------------------------MRFNPPPNWPPPQDGWVP
MSMEG_0767|M.smegmatis_MC2_155 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 ------------------------------------------------MT
Mvan_4693|M.vanbaalenii_PYR-1 ISRGMAKRPEDRYASAGEMARAATAALTGAQQDQADSILQRSQAATMMAP
Mb2535|M.bovis_AF2122/97 -PPWSPGGPPPRP-----PQWPPGPHEASPTQQLPQYWQYDQPPPGGFPP
Rv2507|M.tuberculosis_H37Rv -PPWSPGGPPPRP-----PQWPPGPHEASPTQQLPQYWQYDQPPPGGFPP
Mflv_2044|M.gilvum_PYR-GCK PPPPGPGGYPPPP-----GQGGYPPPPGGYGMPPAGFGGGYPPPGQGYPP
MAV_3436|M.avium_104 -PPP---GYGPPP-----GYG--APPPG-YG-PPPGYG---PPPGFGGPP
MUL_3582|M.ulcerans_Agy99 SPGWTPDPSWPPP-----PSGSQLWIDDETLPAGPTGGVAAPPPGRLGPP
MMAR_3583|M.marinum_M SPGWTPDPSWPPP-----PSGWQLWIDDETLPAGPTGGVAAPPPGRLGPP
MSMEG_0767|M.smegmatis_MC2_155 -------------------------MADNTRNSEDPG----DPQPAPDRP
TH_4564|M.thermoresistible__bu -------------------------MTE-------------QPDAAGDRP
MAB_0396c|M.abscessus_ATCC_199 QPQYPQGQFQQTQ-----PQQFPTYQQPSPYGMPPGG---YAPAPKPPRP
Mvan_4693|M.vanbaalenii_PYR-1 LPPPPPPPPPSTPGGPLPYGGSPVPPPPPPPGQPTQASGFHTPPPPGGPP
* *
Mb2535|M.bovis_AF2122/97 DGLTPPPPQGPRTPR-WLWFAAGSAVLLVVALVIALVIANGSVKKQTAIE
Rv2507|M.tuberculosis_H37Rv DGLTPPPPQGPRTPR-WLWFAAGSAVLLVVALVIALVIANGSVKKQTAIE
Mflv_2044|M.gilvum_PYR-GCK VGGPPSLDIGAAFSWSFNKFSKNAVPLIVPTLVYALVIGVLGAVIFGLAS
MAV_3436|M.avium_104 K---PAFSVGEAFGWAWNAFTKNPVALIVPTLVYLVVLGGASTLIG--LS
MUL_3582|M.ulcerans_Agy99 G-------------------RRKFVVGLAAVAAVIVAVGVAALILVPQTA
MMAR_3583|M.marinum_M G-------------------RRKFVVGLAAVAAVIVAVGVAALILVPQTA
MSMEG_0767|M.smegmatis_MC2_155 T-------------------AAPFLTALVVIVLVVIGVFLVNAFSG----
TH_4564|M.thermoresistible__bu T-------------------ATPFLGALVIIIGVLIIVGLINLFDR----
MAB_0396c|M.abscessus_ATCC_199 P-------------------LTPQQKALAIVGGSLGVFLIALLVLGLTTN
Mvan_4693|M.vanbaalenii_PYR-1 PGWPPQPPQSSGGGGGSKGPMIALLAGAAVIILVLAGLGIWLVVKPDSTS
. .
Mb2535|M.bovis_AF2122/97 PLPPMPGPSPTRPTTTTPTPPSP---------------------------
Rv2507|M.tuberculosis_H37Rv PLPPMPGPSPTRPTTTTPTPPSP---------------------------
Mflv_2044|M.gilvum_PYR-GCK LFPADYTSYSGADGAGMSLDMGPAATIILFLGLIMLFVVGGAISAAYMAG
MAV_3436|M.avium_104 QDVGTSGGGSGDDYFTFTANLNGGGMALLVLGYLVAYLVGAFAQSAYLSG
MUL_3582|M.ulcerans_Agy99 ADPPKSDEDQIREVLSGVVEAYN---------------------------
MMAR_3583|M.marinum_M ADPPKSDEDQIREVLSGVVEAYN---------------------------
MSMEG_0767|M.smegmatis_MC2_155 -GDGLSEEERVGRAAVGQNDAMQ---------------------------
TH_4564|M.thermoresistible__bu -EPVTPEQEIIG-AVIAQNDALQ---------------------------
MAB_0396c|M.abscessus_ATCC_199 NSSTESVRTHASDQIIDSPRSSG---------------------------
Mvan_4693|M.vanbaalenii_PYR-1 DPVASRTSTSAAPTTTSRGSTTR-------------------------TR
Mb2535|M.bovis_AF2122/97 --SAAPAPTTTTGTPSETVAGAMQTVVYDVTGEGRAIS------------
Rv2507|M.tuberculosis_H37Rv --SAAPAPTTTTGTPSETVAGAMQTVVYDVTGEGRAIS------------
Mflv_2044|M.gilvum_PYR-GCK VLDIANGQQVEFGSFFKPRNIGAVVIASLIVGIATSIGYVLCIVPGLIVS
MAV_3436|M.avium_104 CLDLADGRPVTIGSFFKPRNFGMVFLAALLVGILTSIASALCFLPGLILG
MUL_3582|M.ulcerans_Agy99 --NADFNKYVSYFCPSERSGLGDASQLRQNRSDTGRLS------------
MMAR_3583|M.marinum_M --NADFNKYVSYFCPSERSGLGDASQLRQNRADTGRLS------------
MSMEG_0767|M.smegmatis_MC2_155 --REDYSAFAGYTCADQRGNEAEFLARQRDSVQDQGPR------------
TH_4564|M.thermoresistible__bu --RQDYADYTTFTCAAQHKTESEVLDEQRNSVDRRGER------------
MAB_0396c|M.abscessus_ATCC_199 --SNDEQDIKAIKQTISGMAEAAKANDFKKMLTFFCAK------------
Mvan_4693|M.vanbaalenii_PYR-1 TSTSTPPPTESYDQQLMALLSGGHDSSNCEPVDPPAPTILATVDCTQALT
.
Mb2535|M.bovis_AF2122/97 -ITYMDSGNVIQTEFNVALPWRKEVSLSKS-------------SLHPASV
Rv2507|M.tuberculosis_H37Rv -ITYMDSGNVIQTEFNVALPWRKEVSLSKS-------------SLHPASV
Mflv_2044|M.gilvum_PYR-GCK IFALFTTVFIVDRNLSAIDGIKASIAVAKANFLQVFLTWLIFNVLISVGS
MAV_3436|M.avium_104 LFAQFTIAYAIDRSESAVKALSSSFSTVTANLANALLVWLAEFALVVVGA
MUL_3582|M.ulcerans_Agy99 -FDDISIDVTGDTAKVTATATVENEDEPD----------------TQTVD
MMAR_3583|M.marinum_M -FDDISIDVTGDTAKVTATATVENEDEPD----------------TQTVD
MSMEG_0767|M.smegmatis_MC2_155 -YVDDVTGVRIDGDRATATVVYHYEKAPDD-------------KIDVETT
TH_4564|M.thermoresistible__bu -YLDDVTDVTIDGDRATARAIYHFDNAPDD-------------EVAAEMT
MAB_0396c|M.abscessus_ATCC_199 -YREAFKDIAGSGQAPDLNALTKSDNGPSK---------------ITGLD
Mvan_4693|M.vanbaalenii_PYR-1 PGGPAFTRYSLFEDRGALDAAFEEAIRVNSELVQCPGSGVDSPTTWHYTE
Mb2535|M.bovis_AF2122/97 TIVNIGHNVTCSVTVAGVQVRQRTGAGLTICDAPS---------------
Rv2507|M.tuberculosis_H37Rv TIVNIGHNVTCSVTVAGVQVRQRTGAGLTICDAPS---------------
Mflv_2044|M.gilvum_PYR-GCK FVCYIGLIVTVPLAVLYMVYAYRTLTGGYVAP------------------
MAV_3436|M.avium_104 LACGVGLLLAAPVAALVGIYAYRKLSGGQVAPPPGYQPGPPPGYQPGPPP
MUL_3582|M.ulcerans_Agy99 FVKEDGRWMMLLFEDKCSA-------------------------------
MMAR_3583|M.marinum_M FVKEDGRWMMLLFEDKCSA-------------------------------
MSMEG_0767|M.smegmatis_MC2_155 FVREDGEWRVCTSMGDSRP-------------------------------
TH_4564|M.thermoresistible__bu FVREAGSWKVCS--PGPR--------------------------------
MAB_0396c|M.abscessus_ATCC_199 INGDTAVIHITDAKGKHDIEFKKETGGWKFCPRA----------------
Mvan_4693|M.vanbaalenii_PYR-1 TPDQVVGQIACGTYDGNPDLVWTKDDDLLLADAQGPNLEELHNWWLEFG-
Mb2535|M.bovis_AF2122/97 -----
Rv2507|M.tuberculosis_H37Rv -----
Mflv_2044|M.gilvum_PYR-GCK -ATP-
MAV_3436|M.avium_104 GAPPA
MUL_3582|M.ulcerans_Agy99 -----
MMAR_3583|M.marinum_M -----
MSMEG_0767|M.smegmatis_MC2_155 -----
TH_4564|M.thermoresistible__bu -----
MAB_0396c|M.abscessus_ATCC_199 -----
Mvan_4693|M.vanbaalenii_PYR-1 -----