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MRFNPPPNWPPPQDGWVPSPGWTPDPSWPPPPSGWQLWIDDETLPAGPTGGVAAPPPGRLGPPGRRKFVV GLAAVAAVIVAVGVAALILVPQTAADPPKSDEDQIREVLSGVVEAYNNADFNKYVSYFCPSERSGLGDAS QLRQNRADTGRLSFDDISIDVTGDTAKVTATATVENEDEPDTQTVDFVKEDGRWMMLLFEDKCSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3583 | - | - | 100% (205) | hypothetical protein MMAR_3583 |
| M. marinum M | MMAR_2581 | pknE | 5e-06 | 28.91% (211) | transmembrane serine/threonine-protein kinase E PknE |
| M. marinum M | MMAR_5199 | - | 2e-05 | 38.71% (62) | hypothetical protein MMAR_5199 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2535 | - | 6e-05 | 33.00% (100) | proline rich membrane protein |
| M. gilvum PYR-GCK | Mflv_2044 | - | 3e-06 | 41.03% (78) | integral membrane protein-like protein |
| M. tuberculosis H37Rv | Rv2507 | - | 7e-05 | 33.00% (100) | proline rich membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0396c | - | 3e-08 | 25.76% (198) | hypothetical protein MAB_0396c |
| M. avium 104 | MAV_3436 | - | 2e-06 | 42.86% (63) | hypothetical protein MAV_3436 |
| M. smegmatis MC2 155 | MSMEG_5317 | - | 1e-07 | 27.72% (184) | hypothetical protein MSMEG_5317 |
| M. thermoresistible (build 8) | TH_4564 | - | 1e-05 | 23.39% (124) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3582 | - | 1e-121 | 99.02% (205) | hypothetical protein MUL_3582 |
| M. vanbaalenii PYR-1 | Mvan_4693 | - | 1e-05 | 32.41% (108) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3436|M.avium_104 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MSMEG_5317|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 MTDPQRGSRVGSQVGPYRLRRLLGKGGMGEVYEAEDTVKDRVVALKLLPE
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3436|M.avium_104 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MSMEG_5317|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 AVSHDPVFRKRLQREAHAAGRLQEPHVVPIHDYGEVDGLLFVDMRLIDGT
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3436|M.avium_104 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MSMEG_5317|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 DLRKLLKEQGPMTPARATAIVAQVASALDAAHQNGIMHRDVKPENILINR
Mb2535|M.bovis_AF2122/97 --------------------------------------------------
Rv2507|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2044|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3436|M.avium_104 --------------------------------------------------
MMAR_3583|M.marinum_M --------------------------------------------------
MUL_3582|M.ulcerans_Agy99 --------------------------------------------------
MAB_0396c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MSMEG_5317|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 DDFAYLVDFGIANAVTDEALTELGTAVGTYAYMAPERFTNGEVTHRADVY
Mb2535|M.bovis_AF2122/97 -------------------------------------MNDPRRPQRFGP-
Rv2507|M.tuberculosis_H37Rv -------------------------------------MNDPRRPQRFGP-
Mflv_2044|M.gilvum_PYR-GCK -------------------------------------MTENPPPGGYPPP
MAV_3436|M.avium_104 -------------------------------------MSQPPEYPGTPPE
MMAR_3583|M.marinum_M --------------------------------------MRFNPPPNWPP-
MUL_3582|M.ulcerans_Agy99 --------------------------------------MRFNPPPNWPP-
MAB_0396c|M.abscessus_ATCC_199 -------------------------------------MTQPQYPQGQFQQ
TH_4564|M.thermoresistible__bu -------------------------------------MTEQPDAAGDRPT
MSMEG_5317|M.smegmatis_MC2_155 -------------------------------MCEHLRMDPQDDPEARIRD
Mvan_4693|M.vanbaalenii_PYR-1 ALTCVLHECLTGAQPFQGDSVSVVITAHLNDPAPRPSQSRPGIPAGLDDV
Mb2535|M.bovis_AF2122/97 PLSGYGPTGPQVPPNPPTADPAYADQSPYASTYGGYVS-----PPWSPGG
Rv2507|M.tuberculosis_H37Rv PLSGYGPTGPQVPPNPPTADPAYADQSPYASTYGGYVS-----PPWSPGG
Mflv_2044|M.gilvum_PYR-GCK PQGGYPPPPPSEGGYPPPPPEGGYPPPPPAGGYQQPPPGGAYPPPPGPGG
MAV_3436|M.avium_104 PPPGYGPPP----GYGPPP---GYGPPP---GYGTPPP-----PPP---G
MMAR_3583|M.marinum_M PQDGWVPSP----GWTPDP---SWPPPPSGWQLWIDDET-----------
MUL_3582|M.ulcerans_Agy99 PQDGWVPSP----GWTPDP---SWPPPPSGSQLWIDDET-----------
MAB_0396c|M.abscessus_ATCC_199 TQPQQFPTYQ-----QPSP----YGMPPGGYAPAPKPPR-----------
TH_4564|M.thermoresistible__bu ATP-----------------------------------------------
MSMEG_5317|M.smegmatis_MC2_155 LERSLAERAKELGTGADEGHAPPAPPPPPPTQPWTQTFG----------T
Mvan_4693|M.vanbaalenii_PYR-1 ISRGMAKRPEDRYASAGEMARAATAALTGAQQDQADSILQRSQAATMMAP
Mb2535|M.bovis_AF2122/97 PPPRPPQWPPGPHEASPTQQLPQYWQYDQPPPGGFPPDGLTPPPPQGPRT
Rv2507|M.tuberculosis_H37Rv PPPRPPQWPPGPHEASPTQQLPQYWQYDQPPPGGFPPDGLTPPPPQGPRT
Mflv_2044|M.gilvum_PYR-GCK YPPPPGQGGYPPPPGGYGMPPAGFGGGYPPPGQGYPPVGGPPSLDIGAAF
MAV_3436|M.avium_104 YGPPPGYG--APPPG-YG-PPPGYG---PPPGFGGPPK---PAFSVGEAF
MMAR_3583|M.marinum_M LPAGPTGGVAAPPPGRLG-----------PPG------------------
MUL_3582|M.ulcerans_Agy99 LPAGPTGGVAAPPPGRLG-----------PPG------------------
MAB_0396c|M.abscessus_ATCC_199 PPLTPQQKALAIVGGSLG--------------------------------
TH_4564|M.thermoresistible__bu --------------------------------------------------
MSMEG_5317|M.smegmatis_MC2_155 AYPPPPPGPPAPWPGYAEDFP-------APPRQHVP--------------
Mvan_4693|M.vanbaalenii_PYR-1 LPPPPPPPPPSTPGGPLPYGGSPVPPPPPPPGQPTQASGFHTPPPPGGPP
Mb2535|M.bovis_AF2122/97 PR-----------WLWFAAGSAVLLVVALVIALVIANGSVKKQTAIEPLP
Rv2507|M.tuberculosis_H37Rv PR-----------WLWFAAGSAVLLVVALVIALVIANGSVKKQTAIEPLP
Mflv_2044|M.gilvum_PYR-GCK SWS----------FNKFSKNAVPLIVPTLVYALVIGVLGAVIFGLASLFP
MAV_3436|M.avium_104 GWA----------WNAFTKNPVALIVPTLVYLVVLGGASTLIG--LSQDV
MMAR_3583|M.marinum_M -----------------RRKFVVGLAAVAAVIVAVGVAALILVPQTAADP
MUL_3582|M.ulcerans_Agy99 -----------------RRKFVVGLAAVAAVIVAVGVAALILVPQTAADP
MAB_0396c|M.abscessus_ATCC_199 --------------VFLIALLVLGLTTNNSSTESVRTHASDQIIDSPRSS
TH_4564|M.thermoresistible__bu --------------------FLGALVIIIGVLIIVG-----LINLFDREP
MSMEG_5317|M.smegmatis_MC2_155 --------------VAHTGRILMILVAVAVFLITTGIAAFLMFTNTVTSS
Mvan_4693|M.vanbaalenii_PYR-1 PGWPPQPPQSSGGGGGSKGPMIALLAGAAVIILVLAGLGIWLVVKPDSTS
:.
Mb2535|M.bovis_AF2122/97 PMPGPSPTRPTTTTPTPPSPS-----------------------------
Rv2507|M.tuberculosis_H37Rv PMPGPSPTRPTTTTPTPPSPS-----------------------------
Mflv_2044|M.gilvum_PYR-GCK ADYTSYSGADGAGMSLDMGPAATIILFLGLIMLFVVGGAISAAYMAGVLD
MAV_3436|M.avium_104 GTSGGGSGDDYFTFTANLNGGGMALLVLGYLVAYLVGAFAQSAYLSGCLD
MMAR_3583|M.marinum_M PKSDEDQIREVLSGVVEAYNN-----------------------------
MUL_3582|M.ulcerans_Agy99 PKSDEDQIREVLSGVVEAYNN-----------------------------
MAB_0396c|M.abscessus_ATCC_199 GSNDEQDIKAIKQTISGMAEA-----------------------------
TH_4564|M.thermoresistible__bu VTPEQEIIGAVIAQNDALQRQ-----------------------------
MSMEG_5317|M.smegmatis_MC2_155 LQPVADNPAGRPALPYSPPSN-----------------------------
Mvan_4693|M.vanbaalenii_PYR-1 DPVASRTSTSAAPTTTSRGST-----------------------------
Mb2535|M.bovis_AF2122/97 AAPAPTTTTGTPSETVAGAMQTVVYDVTGEGRAIS-------------IT
Rv2507|M.tuberculosis_H37Rv AAPAPTTTTGTPSETVAGAMQTVVYDVTGEGRAIS-------------IT
Mflv_2044|M.gilvum_PYR-GCK IANGQQVEFGSFFKPRNIGAVVIASLIVGIATSIGYVLCIVPGLIVSIFA
MAV_3436|M.avium_104 LADGRPVTIGSFFKPRNFGMVFLAALLVGILTSIASALCFLPGLILGLFA
MMAR_3583|M.marinum_M ---ADFNKYVSYFCPSERSGLGDASQLRQNRADTG------------RLS
MUL_3582|M.ulcerans_Agy99 ---ADFNKYVSYFCPSERSGLGDASQLRQNRSDTG------------RLS
MAB_0396c|M.abscessus_ATCC_199 AKANDFKKMLTFFCAKYREAFKDIAGS-GQAPDLN------------ALT
TH_4564|M.thermoresistible__bu ----DYADYTTFTCAAQHKTESEVLDEQRNSVDRR------------GER
MSMEG_5317|M.smegmatis_MC2_155 -PVFPAIETPSVAGPGEVINVAGASNDREVTCDGG----------TVMVS
Mvan_4693|M.vanbaalenii_PYR-1 ---TRTRTSTSTPPPTESYDQQLMALLSGGHDSSN--CEPVDPPAPTILA
: .
Mb2535|M.bovis_AF2122/97 YMDSGNVIQTEFNVALPWRKEVSLSKS-------------SLHPASVTIV
Rv2507|M.tuberculosis_H37Rv YMDSGNVIQTEFNVALPWRKEVSLSKS-------------SLHPASVTIV
Mflv_2044|M.gilvum_PYR-GCK LFTTVFIVDRNLSAIDGIKASIAVAKANFLQVFLTWLIFNVLISVGSFVC
MAV_3436|M.avium_104 QFTIAYAIDRSESAVKALSSSFSTVTANLANALLVWLAEFALVVVGALAC
MMAR_3583|M.marinum_M FDDISIDVTGDTAKVTATATVENEDEP---------------------DT
MUL_3582|M.ulcerans_Agy99 FDDISIDVTGDTAKVTATATVENEDEP---------------------DT
MAB_0396c|M.abscessus_ATCC_199 KSDNGPSKITGLDINGDTAVIHITDAKG---------------------K
TH_4564|M.thermoresistible__bu YLDDVTDVTIDGDRATARAIYHFDNAPD------------------DEVA
MSMEG_5317|M.smegmatis_MC2_155 GVENTITITGHCAAVTISGIRNVIEVDEADTIG---------------VS
Mvan_4693|M.vanbaalenii_PYR-1 TVDCTQALTPGGPAFTRYSLFEDRGALDAAFEEAIR-------VNSELVQ
Mb2535|M.bovis_AF2122/97 NIGHNVTCSVTVAGVQVRQRTGAGLTICDAPS------------------
Rv2507|M.tuberculosis_H37Rv NIGHNVTCSVTVAGVQVRQRTGAGLTICDAPS------------------
Mflv_2044|M.gilvum_PYR-GCK YIGLIVTVPLAVLYMVYAYRTLTGGYVAP-------------------AT
MAV_3436|M.avium_104 GVGLLLAAPVAALVGIYAYRKLSGGQVAPPPGYQPGPPPGYQPGPPPGAP
MMAR_3583|M.marinum_M QTVDFVKEDGRWMMLLFEDKCSA---------------------------
MUL_3582|M.ulcerans_Agy99 QTVDFVKEDGRWMMLLFEDKCSA---------------------------
MAB_0396c|M.abscessus_ATCC_199 HDIEFKKETGGWKFCPRA--------------------------------
TH_4564|M.thermoresistible__bu AEMTFVREAGSWKVCSPGPR------------------------------
MSMEG_5317|M.smegmatis_MC2_155 GFENRVTYSSGEPEITKSGMDNTVERRAP---------------------
Mvan_4693|M.vanbaalenii_PYR-1 CPGSGVDSPTTWHYTETPDQVVGQIACGTYDGNPDLVWTKDDDLLLADAQ
Mb2535|M.bovis_AF2122/97 ---------------
Rv2507|M.tuberculosis_H37Rv ---------------
Mflv_2044|M.gilvum_PYR-GCK P--------------
MAV_3436|M.avium_104 PA-------------
MMAR_3583|M.marinum_M ---------------
MUL_3582|M.ulcerans_Agy99 ---------------
MAB_0396c|M.abscessus_ATCC_199 ---------------
TH_4564|M.thermoresistible__bu ---------------
MSMEG_5317|M.smegmatis_MC2_155 ---------------
Mvan_4693|M.vanbaalenii_PYR-1 GPNLEELHNWWLEFG