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AKLRFGYFIAPFHRAGTNPTLALQRDLEFVEHLDALGFDEAWIGEHHSAGSEIISSPEVFIAAAAERTKR IRLGTGVISLAYHNPLWVADRLMLLDHLTHGRVIGGMGPGSLATDSAMIGLTPTDTRELLETNLDIVVRL LAGQTVTAKTATHQLFDARLQLAPFSEGGIPLAVAAVASPTGARLAGRHGIGLLSIGATLTIEGFDALAY HWGIVEERAAAFGTHADRKNWTLVGPFHIAETDAQARADVKFGIEPWFRYFQKVAAFPQMTMPGEQLDEM IDIINENGAGVIGTPERARAQVQRLWDQSGGFGCMLQMGHEWANPAATRRSAELFAAEVMPHFQGQAQPT LDAAVRAGEVREGLAQTQLQAIDHMTKKYQQELDGK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2949 | - | - | 100% (387) | monooxygenase |
| M. ulcerans Agy99 | MUL_4194 | - | 4e-76 | 42.15% (382) | monooxygenase |
| M. ulcerans Agy99 | MUL_2890 | - | 5e-34 | 29.23% (366) | oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 3e-33 | 28.69% (366) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4429 | - | 1e-100 | 55.07% (345) | luciferase family protein |
| M. tuberculosis H37Rv | Rv3618 | - | 7e-80 | 45.45% (352) | monooxygenase |
| M. leprae Br4923 | MLBr_00269 | - | 1e-08 | 28.29% (205) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0527c | - | 1e-86 | 46.29% (391) | monooxygenase |
| M. marinum M | MMAR_2824 | - | 0.0 | 98.71% (387) | monooxygenase |
| M. avium 104 | MAV_2779 | - | 0.0 | 87.08% (387) | limonene 1,2-monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6107 | - | 7e-86 | 44.85% (388) | limonene 1,2-monooxygenase |
| M. thermoresistible (build 8) | TH_3390 | - | 4e-84 | 46.51% (344) | PUTATIVE luciferase family protein |
| M. vanbaalenii PYR-1 | Mvan_1925 | - | 5e-98 | 54.78% (345) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2949|M.ulcerans_Agy99 --------------MAKLRFGYFIAPFHRAGTNPTLALQRDLEFVEHLDA
MMAR_2824|M.marinum_M --------------MANLRFGYFIAPFHRAGTNPTLALQRDLEFVEHLDA
MAV_2779|M.avium_104 --------------MGKLRFGYFIAPFHRAGTNPTLALQRDLEFIEHLDA
Mflv_4429|M.gilvum_PYR-GCK -----------------MRFGNFMAPFHPVGQNPTLALERDLDLIVAMDR
Mvan_1925|M.vanbaalenii_PYR-1 -----------------MRFGNFMAPFHPVGQNPTLALERDLDLIAAMDR
Rv3618|M.tuberculosis_H37Rv -------------MKAPLRFGVFITPFHPTGQSPTVALQYDMERVVALDR
MSMEG_6107|M.smegmatis_MC2_155 --------------MRPLNFGVFITPFHPAGQSPTTALQYDMDRVEALDR
MAB_0527c|M.abscessus_ATCC_199 ------------MSAPPLRFGAFITPFHPVGQNPTTALEYDLDRVVALDR
TH_3390|M.thermoresistible__bu VTESTSADTSTDTSIYPKRFGVFQAPFHKFGIHPTVLFERDLQLIQRAEE
Mb1971|M.bovis_AF2122/97 -----------------MEIGIFLMPAHPPERTLYDATRWDLDVIELADQ
MLBr_00269|M.leprae_Br4923 --------------MAELRLG-YKASAEQFAPRELVELGVAAEAHG-MDS
.:* : . . : :
MUL_2949|M.ulcerans_Agy99 LGFDEAWIGEHHSAGSEIISSPEVFIAAAAERTKRIRLGTGVISLAY-HN
MMAR_2824|M.marinum_M LGFDEAWIGEHHSAGSEIISSPEVFIAAAAERTKRIRLGTGVISLAY-HN
MAV_2779|M.avium_104 LGFDEVWLGEHHSAGSEIISSPEIFIAAAAERAKRIRFGTGVISLSY-HN
Mflv_4429|M.gilvum_PYR-GCK LGFHEAWVGEHHSAGFEIIASPEVFLGVAAERTKHIRLGTGVSSLPY-HH
Mvan_1925|M.vanbaalenii_PYR-1 LGFHEAWVGEHHSAGFEIIASPEVFIGIAAERTKHIKLGTGVSSLPY-HH
Rv3618|M.tuberculosis_H37Rv LGYDEAWFGEHHSGGYELIACPEVFIAAAAERTTHIRLGTGVVSLPY-HH
MSMEG_6107|M.smegmatis_MC2_155 LGYDEAWFGEHHSGGYELIACPEVFIAAAAERTRHIRLGTGVVSLPY-HH
MAB_0527c|M.abscessus_ATCC_199 LGYHEAWFGEHHSGGYELISCPEVFIATAAERTKHIKLGTGVVSLPY-HH
TH_3390|M.thermoresistible__bu LGFHEAWIGEHHSGGHEPIASPEVFMAAASQRTHTIKLGTGVVSLPY-HN
Mb1971|M.bovis_AF2122/97 LGYVEAWVGEHFTVPWEPICAPDLLLAQALLRTQQIKLAPGAHLLPY-HH
MLBr_00269|M.leprae_Br4923 ATVSDHFQPWRHQGGHASFSLS--WMTAVGERTNRILLGTSVLTPTFRYN
: : :. :. . : . *: * :.... .: ::
MUL_2949|M.ulcerans_Agy99 PLWVADRLMLLDHLTHGRVIGGMGPGSLATDSAM--IGLTPT--DTRELL
MMAR_2824|M.marinum_M PLWVADRLMLLDHLTHGRVIGGMGPGSLPTDSAM--IGLTPT--DTRELL
MAV_2779|M.avium_104 PLWVADRLMLLDHLTHGRIIGGVGPGSLPTDSSM--IGLTPT--DTRELL
Mflv_4429|M.gilvum_PYR-GCK PLMLADRMVLLDHLTRGRVMLGCGPGQLTSDAHM--LGIPAD--EQRPRM
Mvan_1925|M.vanbaalenii_PYR-1 PLLLADRMVLLDHLTRGRVMLGCGPGQLTSDAHM--LGIPAD--AQRPRM
Rv3618|M.tuberculosis_H37Rv PLMVADRWVLLDHLTRGRVMFGTGPGALPSDAYM--MGIDPV--EQRRMM
MSMEG_6107|M.smegmatis_MC2_155 PLMVADRWVLLDHLTRGRVMFGTGPGALPSDAYM--MGIDPV--DQRPMM
MAB_0527c|M.abscessus_ATCC_199 PLMVVDRWILLDHITRGRVIFGTGPGALPTDAYM--MGIDPV--DQRRMQ
TH_3390|M.thermoresistible__bu PFMVAERHVLLDHLSRGRAIMGFGPGQLASDAHM--MAVETA--EQREMM
Mb1971|M.bovis_AF2122/97 PVELAHRVAYFDHLAQGRFMLGVGASGIPGDWAL--YDVDGKNGEHREMT
MLBr_00269|M.leprae_Br4923 PAVIGQAFATMGCLYPNRVFLGVGTGEALNEVATGYQGAWPEFKERFARL
* : . :. : .* : * *.. :
MUL_2949|M.ulcerans_Agy99 ETNLDIVVRLLAG---QTVTAKTATHQLF--------DARLQLAPFSEGG
MMAR_2824|M.marinum_M ETNLDIVVRLLAG---QTVTAKTATHQLF--------DARLQLAPFSEGG
MAV_2779|M.avium_104 ETNLDIVVRLLAG---ETVSAKTATHQLF--------DAKLQLGPYSDGG
Mflv_4429|M.gilvum_PYR-GCK EQCLDAIVRLLRG---ETVTMHTDGFTLQ--------DARLQLKPYSEPC
Mvan_1925|M.vanbaalenii_PYR-1 EQSLDAIVRLLRG---ETVTMHTDGFTLQ--------DARLQLKPYSDPC
Rv3618|M.tuberculosis_H37Rv QESLEAILALFRAAPDERIDRHSDWFTLR--------EAQLHIRPYTWPY
MSMEG_6107|M.smegmatis_MC2_155 QESLEAILALFRAEPGERIDRKTDWFTLR--------DAALHIRPYTWPY
MAB_0527c|M.abscessus_ATCC_199 EESLEAILALLRATPQERINRETSWFTLR--------DAQLQLRPYTHPY
TH_3390|M.thermoresistible__bu REAAEVIVRLMRG---ETVTAKTSWFELR--------DARLQVLPYNGAG
Mb1971|M.bovis_AF2122/97 REALEIMLRIWTE--DEPWEHRGKYWNANGIAPMFEGLMRRHIKPYQKPH
MLBr_00269|M.leprae_Br4923 RESVRLMRELWRG---DRVDFDGDYYQLKG------------ASIYDVPE
. : : : :
MUL_2949|M.ulcerans_Agy99 IPLAVAAVAS-PTGARLAGRHGIGLLSIGATLTIEGFDALAYHWGIVEER
MMAR_2824|M.marinum_M IPLAVAAVAS-PTGARLAGRHGIGLLSIGATLTIEGFDALAYHWGIVEER
MAV_2779|M.avium_104 IPLAVAAVAS-PTGARLAGKHGIGLLSIGATLTVEGFNALSYHWGIVEER
Mflv_4429|M.gilvum_PYR-GCK FDIAVAASFS-PTGPRGAGRHGIGMLSIAATA-RQGMDLLAQHWNTWDEV
Mvan_1925|M.vanbaalenii_PYR-1 FDIAVAASFS-PTGPRGAGRHGIGMLSIAATA-KQGMDLLAQHWNTWEEV
Rv3618|M.tuberculosis_H37Rv PEIATAAMIS-PSGPRLAGALGTSLLSLSMSV-PGGYAALETAWGVVREQ
MSMEG_6107|M.smegmatis_MC2_155 PEISTAAMIS-PSGPRLAGKLGTSLLSLSMSV-PGGYAAVETTWNVVRDE
MAB_0527c|M.abscessus_ATCC_199 PEILTAAMFS-PSGPRLAGKLGAGLLSLSASI-PGGFAALENAWEVVREQ
TH_3390|M.thermoresistible__bu LETVVASVAS-PSGPRTAGELGLGMINLASSG-PGAFEALRDHWSIVESE
Mb1971|M.bovis_AF2122/97 PPIGVTGFSAGSETLKLAGERGYIPMSLDLNT-----EYVATHWDAVEEG
MLBr_00269|M.leprae_Br4923 GGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKG---EELYTEKLIPAVLEG
. . : ** * : . .
MUL_2949|M.ulcerans_Agy99 AAAFGT-HADRKNWTLVGPFHIAETDAQARADVKFG---------IEPWF
MMAR_2824|M.marinum_M AAAFGT-HADRKNWTLVGPFHIAETDTQARADVKFG---------IEPWF
MAV_2779|M.avium_104 AAAFGT-QVDRTNWSLVGLFHLAETEKQAREEVKFG---------IEPWF
Mflv_4429|M.gilvum_PYR-GCK AREHGH-QADRSKWRLVGPMHLAETREQAERDVEYG---------IAEFS
Mvan_1925|M.vanbaalenii_PYR-1 AREHGH-VADRAKWRLVGPMHLAETREQAERDVEYG---------IAQFS
Rv3618|M.tuberculosis_H37Rv AAKAGRGEPDRADWRVLSIMHLSDSRDQAIDDCTYG---------LPDFS
MSMEG_6107|M.smegmatis_MC2_155 AAAAGRPEPDRENWRVLGIVHLADTREQAIEDCTYG---------LQDFA
MAB_0527c|M.abscessus_ATCC_199 AEIHGHPEPDRSSWRVLGIMHLAETRDQAIADCTYG---------LPDYA
TH_3390|M.thermoresistible__bu AAKSGA-EVSRDQWRLAAIMHIAETEEQARRDCEYG---------FAEIW
Mb1971|M.bovis_AF2122/97 ALRSGR-TPDRRDWRLVREVLVAETDEQAFRYAVDGTMGRAMREYVLPTF
MLBr_00269|M.leprae_Br4923 AAVAGR-DADDIDKMIEIKMSYDPDPEQALSNIRFW----------APLS
* * . . : . **
MUL_2949|M.ulcerans_Agy99 RYFQKVAAFP-QMTMPGEQ----LDEMIDIINENGAGVIGTPERARAQVQ
MMAR_2824|M.marinum_M RYFQKVAAFP-QMTMPGEQ----LDEMIDIINENGAGVIGTPQRARAQVQ
MAV_2779|M.avium_104 RYFQKVAAFP-QMTMPGDQ----LDEMIDVINENGAGVIGTPERAREQVQ
Mflv_4429|M.gilvum_PYR-GCK RYF---THILPSGPVQGDT----PEEIIANNRQSGFAVIGTPDDAIAKIS
Mvan_1925|M.vanbaalenii_PYR-1 QYF---SHILPAGPVQGDT----PAEIIANNHASGFAVIGTPQDAIAKIE
Rv3618|M.tuberculosis_H37Rv RYFGAAGFVPLANTVEGTQ---SSREFVEQYAAKGNCCIGTPDDAIAHIE
MSMEG_6107|M.smegmatis_MC2_155 NYFGAAGFVPLSNQAEGGG---TPYEFVENYASKGNCCIGTPDDAIVYIQ
MAB_0527c|M.abscessus_ATCC_199 HYFGAVGVLPLANSADGADGAIDPHEFVKAYADEGNCCIGTPEDAIEYIQ
TH_3390|M.thermoresistible__bu DYLGQISPLPPSKETSVEG-------KLNEAIESGMVCIGTPDTAIELIR
Mb1971|M.bovis_AF2122/97 RMFGMTKFYKHNPSVPDDE-------VTPEYLAENTFVVGSVQTVVDKLE
MLBr_00269|M.leprae_Br4923 LAAEQKHSIDDPIEMEKVA-----DALPIEQVAKRWIVVSDPDEAVARVG
. :. : . :
MUL_2949|M.ulcerans_Agy99 RLWDQS-GGFGCMLQMGHEWAN-PAATRRSAELFAAEVMPHFQGQAQPTL
MMAR_2824|M.marinum_M RLWDQS-GGFGCMLQMGHEWAN-PAATRRSAELFAAEVMPHFQGQAQPTL
MAV_2779|M.avium_104 RCWDQS-GGFGCMLQMGHEWAN-PAATKRSAELFAAEVMPHFQGQAQPTL
Mflv_4429|M.gilvum_PYR-GCK ELVEASDGGFGAFLLFDHDWAP-PAAKLRSYELFAQYVIPHFTGQLSAPI
Mvan_1925|M.vanbaalenii_PYR-1 ELVEASNGGFGTFLLFDHDWAP-PAAKLRSYELFAEYVIPHFTGQLSAPI
Rv3618|M.tuberculosis_H37Rv DLLHRS-GGFGTLLLLGHDWAP-PPATFHSYELFARAVIPYFKGQLAAPR
MSMEG_6107|M.smegmatis_MC2_155 DLLDRS-GGFGTFLLLGHDWAP-PAATFHSYELFAREVIPHFKGQLTAAR
MAB_0527c|M.abscessus_ATCC_199 GLLDTS-GGFGTFLMLGHDWAA-PEATFKSYELFARKVIPHFTGQLTAAQ
TH_3390|M.thermoresistible__bu KLAKQT-GGFGVFIMNLADFAA-PAAKLRSIELFAEYVIPEFTGHLDALR
Mb1971|M.bovis_AF2122/97 ATYDQV-GGFGHLLILGFDYSDNPGPWKESLRLLAHEVMPRLNARLATKP
MLBr_00269|M.leprae_Br4923 QYVTWG---LNHLVFHAPGHNQ-----RRFLELFEKDLAPRLRRLG----
:. :: . .*: : * :
MUL_2949|M.ulcerans_Agy99 DAAVRAG-EVREGLAQTQLQAIDHMTKKYQQELDGK------
MMAR_2824|M.marinum_M DAAVRAG-EVREGLAQTQLQAIDHMTKKYQQELDSK------
MAV_2779|M.avium_104 DAAARAG-QARDSLAQSQLDAVAHMTKKYQGEVESK------
Mflv_4429|M.gilvum_PYR-GCK ASRDWVT-ESGRVFVDQATHAIGRAIESHAAEQQAKQSRTSD
Mvan_1925|M.vanbaalenii_PYR-1 ASRDWVT-ESGRTFVDQAAHAIGKAIEDHAAEQQAKSPTPS-
Rv3618|M.tuberculosis_H37Rv ASHEWAR-GKRDQLIGRAGEAVVKAITEHVAEQGEAGS----
MSMEG_6107|M.smegmatis_MC2_155 ASHDWAK-GMRDQLLGRAGQAIVNAITEHTQAHPAENEN---
MAB_0527c|M.abscessus_ATCC_199 ASHDWAQ-AKRGELLGRAGDAVAKAIGEHVAQKASH------
TH_3390|M.thermoresistible__bu ASHEWVLGAKNEEDTTIWRDQTNAAIAAATAEFQRSRG----
Mb1971|M.bovis_AF2122/97 ATAVV-------------------------------------
MLBr_00269|M.leprae_Br4923 ------------------------------------------