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VRAVHVAIVGAGPSGFFAAGSLLKHTDFDVHVDMLEMLPTPWGLVRSGVAPDHPKIKSVSAVFEKTAAHP RFRFFGNIEVGAKITAEELASRYDAVIYAVGAQSDKPLGIPGDQLSGCIAAVDVVGWYNANPTYQKVSVD LSGERAVVVGNGNVALDVARILGMDPESLHTTDIADRALDSLDHNAIREVVIIGRRGPLQATFTPLELRE MGELPGVDVVVDPEDLADITDEQLAAAPKPTRTNIETLRKFSERPHTEGHRRVVFRFRTSPIELHSDSAG VGVVESITVGRNKLVEEDGYVVAHDTGERQTLPTHLVVRAIGYRGVPVPGLPFDSRRGVILNEAGRIQGR DNEYVVGWIKRGPVGVIGTNKSDSQETVDTLLADLATAELRDAPDVAALEEWLLGHEPHIVSQSDWLTID SHERATGEPQGRPRVKLETVPDLLAATGRHGEP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3482 | - | - | 100% (453) | NADPH-ferredoxin reductase FprA |
| M. abscessus ATCC 19977 | MAB_0930 | - | 2e-94 | 44.23% (459) | putative ferredoxin/ferredoxin--NADP reductase |
| M. abscessus ATCC 19977 | MAB_4171c | - | 9e-77 | 36.73% (452) | NADPH-ferredoxin reductase FprA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3133 | fprA | 1e-152 | 61.32% (455) | NADPH:adrenodoxin oxidoreductase FprA |
| M. gilvum PYR-GCK | Mflv_4452 | - | 1e-150 | 60.31% (456) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv3106 | fprA | 1e-152 | 61.32% (455) | NADPH:adrenodoxin oxidoreductase FPRA (NADPH-ferredoxin |
| M. leprae Br4923 | MLBr_00666 | fprA | 1e-151 | 62.50% (448) | putative NADPH-ferredoxin reductase |
| M. marinum M | MMAR_1526 | fprA_1 | 1e-159 | 63.33% (450) | NADPH:adrenodoxin oxidoreductase FprA_1 |
| M. avium 104 | MAV_4007 | - | 1e-159 | 63.56% (461) | NADPH-ferredoxin reductase fpra |
| M. smegmatis MC2 155 | MSMEG_5681 | - | 2e-79 | 40.62% (448) | ferredoxin/ferredoxin--NADP reductase |
| M. thermoresistible (build 8) | TH_2151 | fprA | 1e-155 | 63.86% (451) | NADPH:ADRENODOXIN OXIDOREDUCTASE FPRA (NADPH-FERREDOXIN |
| M. ulcerans Agy99 | MUL_2413 | fprA_1 | 1e-157 | 62.89% (450) | NADPH:adrenodoxin oxidoreductase FprA_1 |
| M. vanbaalenii PYR-1 | Mvan_1910 | - | 1e-154 | 61.44% (459) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3133|M.bovis_AF2122/97 --------------------------------------------------
Rv3106|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00666|M.leprae_Br4923 --------------------------------------------------
MAV_4007|M.avium_104 --------------------------------------------------
MMAR_1526|M.marinum_M --------------------------------------------------
MUL_2413|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4452|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1910|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2151|M.thermoresistible__bu --------------------------------------------------
MAB_3482|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_5681|M.smegmatis_MC2_155 MPHVITQSCCSDGSCVYACPVNCIHPSPDEPGFATAEMLYIDPDACVDCG
Mb3133|M.bovis_AF2122/97 --------------------------------------------------
Rv3106|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00666|M.leprae_Br4923 --------------------------------------------------
MAV_4007|M.avium_104 --------------------------------------------------
MMAR_1526|M.marinum_M -------------------------------------------------M
MUL_2413|M.ulcerans_Agy99 ------------------------MHRATATLSAHVPPARSRARTEGRTM
Mflv_4452|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1910|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2151|M.thermoresistible__bu --------------------------------------------------
MAB_3482|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_5681|M.smegmatis_MC2_155 ACVSACPVGAIAPDTRLEPRQLPFVEINAAFYPKREGKLPPTSKLAPVIE
Mb3133|M.bovis_AF2122/97 ---MRP---YYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPT
Rv3106|M.tuberculosis_H37Rv ---MRP---YYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPT
MLBr_00666|M.leprae_Br4923 ---MRPHHIHHIAIVGSGPSGFFAAASVLKAADASDEINVAVDMLEMLPT
MAV_4007|M.avium_104 ---MRP---YHVAIVGSGPSGFFAAASLLKAADGSEHPDIAVDMLEMLPT
MMAR_1526|M.marinum_M PQNQRP---YHVAVVGSGPSGFFAAASLLKAADSSDEIEVAVDILEMLPT
MUL_2413|M.ulcerans_Agy99 PQNQRP---YHVAVVGSGPSGFFAAASLLKAADSSDEIEVAVDILEMLPT
Mflv_4452|M.gilvum_PYR-GCK MPPLRP---YYVAIVGSGPSGYFAAASLLKSGGADGNRDVCVDMLEMLPT
Mvan_1910|M.vanbaalenii_PYR-1 MPVMRP---YYVAIVGSGPSGFFAAASLLKFGDSPENRDVRVDMLEMLPT
TH_2151|M.thermoresistible__bu ---------LQVAIVGSGPSGFFAAASLLKSADSAEGRDVRVDMLEMLPT
MAB_3482|M.abscessus_ATCC_1997 ---MRA---VHVAIVGAGPSGFFAAGSLLKHTD----FDVHVDMLEMLPT
MSMEG_5681|M.smegmatis_MC2_155 APKITRDGPLTVAIVGSGPAAMYAADELLTQRG------VRVNVFEKLPT
:*:**:**:. :** .:*. . : *:::* ***
Mb3133|M.bovis_AF2122/97 PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELS
Rv3106|M.tuberculosis_H37Rv PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELS
MLBr_00666|M.leprae_Br4923 PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVIVGKHIEPAELA
MAV_4007|M.avium_104 PWGLVRSGVAPDHPKIKSISKQFEKTAADPRFRFFGNVSVGEHVQASELA
MMAR_1526|M.marinum_M PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRIRFFGNVVVGEHVTTAELT
MUL_2413|M.ulcerans_Agy99 PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRVRFFGNVVVGEHVTTAELT
Mflv_4452|M.gilvum_PYR-GCK PWGLVRSGVAPDHPKIKSISAQFDKTSADPRFRFFGNVVIGEHVHPDELA
Mvan_1910|M.vanbaalenii_PYR-1 PWGLVRSGVAPDHPKIKSISAQFEKTSLDPRFRFFGNVDVGEHVHPSELA
TH_2151|M.thermoresistible__bu PWGLVRSGVAPDHPKIKSISAQFEKVAADPRFRFFGNITVGDHVRPDELA
MAB_3482|M.abscessus_ATCC_1997 PWGLVRSGVAPDHPKIKSVSAVFEKTAAHPRFRFFGNIEVGAKITAEELA
MSMEG_5681|M.smegmatis_MC2_155 PYGLVRAGVAPDHQSTKRVTELFDRMAAQRGFTFYLNVEVGKHLTHADLL
*:****:****** . * :: *:: : . . *: *: :* :: :*
Mb3133|M.bovis_AF2122/97 ERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQISPD
Rv3106|M.tuberculosis_H37Rv ERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPD
MLBr_00666|M.leprae_Br4923 ERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFHERSPD
MAV_4007|M.avium_104 ERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFEEATPD
MMAR_1526|M.marinum_M ERYDAVIYAIGAQSDKPLNIPGENLPGSVAAVDFVGWYNAHPNFEHSTPD
MUL_2413|M.ulcerans_Agy99 ERYDAVIYAIGAQSDKPLNIPGENLPGSMAAVDFVGWYNAHPNFEHSTPD
Mflv_4452|M.gilvum_PYR-GCK ERYDAVIYAIGAQSDRALGIPGEDLPGSVPAVDFVGWYNAHPHFVDMAPD
Mvan_1910|M.vanbaalenii_PYR-1 ERYDAVIYAIGAQADRELGIPGEDLPGSLAAVDFVGWYNAHPYFEGMAPD
TH_2151|M.thermoresistible__bu ERYDAVIYAIGTQADRALNIPGEELPGSVAAVDFVGWYNAHPHFENIDPD
MAB_3482|M.abscessus_ATCC_1997 SRYDAVIYAVGAQSDKPLGIPGDQLSGCIAAVDVVGWYNANPTYQKVSVD
MSMEG_5681|M.smegmatis_MC2_155 GHHHAVVYAVGAPNDRRLDIEGMDLPGTATATEVVAWINGHPDHTDLPVR
::.**:**:*: *: *.* * :*.* .*.:.*.* *.:* .
Mb3133|M.bovis_AF2122/97 LSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEV
Rv3106|M.tuberculosis_H37Rv LSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEV
MLBr_00666|M.leprae_Br4923 LSGSRAVVIGNGNVALDVTRILITDPDVLAFTDIADHALESLRPRGIEEV
MAV_4007|M.avium_104 LSGSRAVVVGNGNVALDVARILVTDPDVLGLTDIADHALESLRPCGVDEV
MMAR_1526|M.marinum_M LSGRRAVVIGNGNVAIDVARILVTDPEVLALTDIADHALESLRPRGVEEV
MUL_2413|M.ulcerans_Agy99 LSGRRAVVIGNGNVAIDVARILVTDPEVLALTDIADHALGSLRPRGVEEV
Mflv_4452|M.gilvum_PYR-GCK VSGGRAVVVGNGNVAIDVARILVSDPDVLAETDIADHALESLHARGVEEV
Mvan_1910|M.vanbaalenii_PYR-1 LSGGRAVVVGNGNVAIDVARILVSDPDVLAETDIADHALRSLHARGVEEV
TH_2151|M.thermoresistible__bu LSGGRAVVIGNGNVALDVARILVTDPEALAKTDIADHALEALRSRGIEEV
MAB_3482|M.abscessus_ATCC_1997 LSGERAVVVGNGNVALDVARILGMDPESLHTTDIADRALDSLDHNAIREV
MSMEG_5681|M.smegmatis_MC2_155 LDHERVVIVGNGNVALDVARVLTSDPDALARTDISDHALAALRSSAVQEV
:. *.*::******:**:*:* **: * ***:*:** :* .: **
Mb3133|M.bovis_AF2122/97 VIVGRRGPLQAAFTTLELRELADLDG---VDVVIDPAELDGITDEDAAAV
Rv3106|M.tuberculosis_H37Rv VIVGRRGPLQAAFTTLELRELADLDG---VDVVIDPAELDGITDEDAAAV
MLBr_00666|M.leprae_Br4923 VIVGRRGPLQTAFTTLELRELADIEG---VDVLVDPAQLEGISDENAAAA
MAV_4007|M.avium_104 VVIGRRGPLQTAFTTLELRELGELDN---VDVIVDPAQLEGVTDEDVAAA
MMAR_1526|M.marinum_M VIIGRRGPLQAAFTTLELRELGELEG---VDVVVDPAQLEGISDADAEAA
MUL_2413|M.ulcerans_Agy99 VIIGRRGPLQAAFTTLELRELGELEG---VDVVVDPAQLEGISDADAEAA
Mflv_4452|M.gilvum_PYR-GCK LIIGRRGPLQAPFTTLELRELGDLEALGDVDVIVDPGDFADITDEDLEAA
Mvan_1910|M.vanbaalenii_PYR-1 MIIGRRGPLQAPFTTLELRELGDLEALGDVDIVIDPADFADITDDDLEAA
TH_2151|M.thermoresistible__bu VIVGRRGPLQATFTTLELRELGALEGLADVDVVVDPADFADITDEDLEAA
MAB_3482|M.abscessus_ATCC_1997 VIIGRRGPLQATFTPLELREMGELPG---VDVVVDPEDLADITDEQLAAA
MSMEG_5681|M.smegmatis_MC2_155 VIAARRGPAASAFT---LPELIGLTS--TCDVVLDSADHDLVLRDLAQET
:: .**** :.** * *: : *:::*. : : .
Mb3133|M.bovis_AF2122/97 GKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIK----GKRKVERI
Rv3106|M.tuberculosis_H37Rv GKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIK----GKRKVERI
MLBr_00666|M.leprae_Br4923 GKTTRQNIKVLRDYTVRTPKPGHRRIVFRFLTSPIEIK----GKGKVERI
MAV_4007|M.avium_104 GKTAKQNISVLRDYAKRSPRPGHRRIVLRFMTSPIEIK----GDGRVESI
MMAR_1526|M.marinum_M GKGIKQNIKVLRGYTERAPRPGHRRIVFKFMTSPVEIR----GTDRVEQI
MUL_2413|M.ulcerans_Agy99 GKGVKQNIKVLRGYTERAPRPGHRRIVFKFMTSPVEIK----GTDRVEQI
Mflv_4452|M.gilvum_PYR-GCK GKTVRNNIKVLRGYAETTPKGAKRRIVFRFRTSPIEIR----GDGKVESI
Mvan_1910|M.vanbaalenii_PYR-1 GKTVRNNIKVLRGYADKAPKGARRRIVFRFRTSPIEIK----GGDRVQSI
TH_2151|M.thermoresistible__bu GKTVKQNVKVLRGYAEQGVRGAPRRIVFRFRTSPIEIR----GDGRVQSI
MAB_3482|M.abscessus_ATCC_1997 PKPTRTNIETLRKFSERPHTEGHRRVVFRFRTSPIELHSDSAGVGVVESI
MSMEG_5681|M.smegmatis_MC2_155 DPLTRNKLEILAKLGDASAPITRPRIRFAYQLTPRRVL----GENQVTAV
: ::. * *: : : :* .: * * :
Mb3133|M.bovis_AF2122/97 VLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQ
Rv3106|M.tuberculosis_H37Rv VLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQ
MLBr_00666|M.leprae_Br4923 VLGQNELVTDDNGRVAAKDTGVREELPAQLIVRSIGYRGVPTPGLPFDDS
MAV_4007|M.avium_104 VLGRNELVTDETGRVLARDTGEREELPVQLVVRSVGYRGVPTPGLPFDEK
MMAR_1526|M.marinum_M VLGHNELVTDEDGWVSAKDTGEREELPVQLVVRSVGYRGVPTPGLPFDQK
MUL_2413|M.ulcerans_Agy99 VLGHNELVTDEDGWVSAKDTGEREEVPVQLVVRSVGYRGVPTPGLPFDQK
Mflv_4452|M.gilvum_PYR-GCK VLGRNELIRGDDGRISAKDTGERDEVAAQLVVRAVGYRGLPTPGLPFDDR
Mvan_1910|M.vanbaalenii_PYR-1 VLGRNELTKGADGRVSAADTGEREEVPAQLVVRAVGYRGLPTPGLPFDER
TH_2151|M.thermoresistible__bu VLGRNELVSDATGRIVAKDTGAREELPAQLVVRAIGYRGLPTPGLPFDER
MAB_3482|M.abscessus_ATCC_1997 TVGRNKLVE-EDGYVVAHDTGERQTLPTHLVVRAIGYRGVPVPGLPFDSR
MSMEG_5681|M.smegmatis_MC2_155 EFG-------------VTGTDEVRTLDAGLLLTSIGYRGKAIADLPFDED
.* . .*. : . *:: ::**** . ..****.
Mb3133|M.bovis_AF2122/97 SGTIPNVGGRINGSPN------EYVVGWIKRGPTGVIGTNKKDAQDTVDT
Rv3106|M.tuberculosis_H37Rv SGTIPNVGGRINGSPN------EYVVGWIKRGPTGVIGTNKKDAQDTVDT
MLBr_00666|M.leprae_Br4923 SVTIPNTNGRVNGSRN------EYVVGWIKRGPTGVIGTNKKDSQDTVDT
MAV_4007|M.avium_104 TATIPNTGGRVEGSRN------EYVVGWIKRGPTGVIGTNKKDSQDTVDT
MMAR_1526|M.marinum_M RGIIPNTAGRVQGSSN------EYVVGWIKRGPTGVIGTNKKDSQDTVDT
MUL_2413|M.ulcerans_Agy99 CGIIPNTAGRVQGSSN------EYVVGWIKRGPTGVIGTNKKDSQDTVDT
Mflv_4452|M.gilvum_PYR-GCK AGTIPHVDGKVEGRRN------DYVVGWIKRGPTGVIGSNKKDSADTVAT
Mvan_1910|M.vanbaalenii_PYR-1 AGTIPHTDGRVAGSRN------EYVVGWIKRGPTGVIGSNKKDSADTVDT
TH_2151|M.thermoresistible__bu SGTIPHTDGRIEGSRN------EYVVGWIKRGPSGVIGSNKKDSQDTVDT
MAB_3482|M.abscessus_ATCC_1997 RGVILNEAGRIQGRDN------EYVVGWIKRGPVGVIGTNKSDSQETVDT
MSMEG_5681|M.smegmatis_MC2_155 ASVVPNDGGRVIDPATGAPVPGAYVAGWIKRGPTGFIGTNKSCAAQTVHH
: : *:: . . **.******* *.**:**. : :**
Mb3133|M.bovis_AF2122/97 LIKDLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFER
Rv3106|M.tuberculosis_H37Rv LIKNLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFER
MLBr_00666|M.leprae_Br4923 LMENLAGAND---TEKFGADHADRLAEWLAERQPKLVTSAHWQAIDRFER
MAV_4007|M.avium_104 LLADLANAGPDG-LADFPDDHADRLADWLASRQPKLVTTAHWELIDAHER
MMAR_1526|M.marinum_M LMADLTAAELN----TFPSGHTADLADWLSSRQPELVTAEHWKSIDHFER
MUL_2413|M.ulcerans_Agy99 LMADLTAAELN----TFPSSHTADLADWLSSRQPELVTAEHWKSIDHFER
Mflv_4452|M.gilvum_PYR-GCK LLNDLSSAELA----DFGSDHPDKVQQWLQERQPKLITSEHWKLIDTHER
Mvan_1910|M.vanbaalenii_PYR-1 LLADLAAAELT----EFDAGHLEDIERWLLERQPKLVTNEHWKLIDAHER
TH_2151|M.thermoresistible__bu LLADLRDAELA----DFGPDHHDELAAWLSSRQPKLVTADHWNVIDEHER
MAB_3482|M.abscessus_ATCC_1997 LLADLATAELR------DAPDVAALEEWLLGHEPHIVSQSDWLTIDSHER
MSMEG_5681|M.smegmatis_MC2_155 LVDDYNAGALTD-----PPRKPSALDKLVRARQPDVVDAAGWRAIDAAEI
*: : . . : : ::*.:: * ** *
Mb3133|M.bovis_AF2122/97 AAGEPHGRPRVKLASLAELLRIG--LG--------------
Rv3106|M.tuberculosis_H37Rv AAGEPHGRPRVKLASLAELLRIG--LG--------------
MLBr_00666|M.leprae_Br4923 AAGEPHGRPRVKLPNLAELLRIG--HG--------------
MAV_4007|M.avium_104 AAGEARGRPRVKLPSLAKLLRVS--HG--------------
MMAR_1526|M.marinum_M AAGEALGRPRVKLPNVTEMLRIG--HA--------------
MUL_2413|M.ulcerans_Agy99 AAGEALGRPRVKLPNVTEMLRIG--HA--------------
Mflv_4452|M.gilvum_PYR-GCK TAGEGSGRPRVKVTSVEDLLRIG--HA--------------
Mvan_1910|M.vanbaalenii_PYR-1 SAGAGSGRPRVKLSNVAEMLRVG--GRG-------------
TH_2151|M.thermoresistible__bu GAGQQCGRPRVKLASVAELLRVG--HG--------------
MAB_3482|M.abscessus_ATCC_1997 ATGEPQGRPRVKLETVPDLLAATGRHGEP------------
MSMEG_5681|M.smegmatis_MC2_155 ARG-GDDRPRDKFTTVPEMLAVAVTAPKPSVRQRLTAGLLG
* .*** *. .: .:*