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SSINWEEVVAAFDALDAVMTRLQDLCFDGLTTPERLALLQRCEVARRRLPSIEHPLINQLGEQAGEQELG GKLAAVLAGRLRVSRGEASRRLGEAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQV PAEVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDGRYSDEDRARRRGLTLGRQGRDGMSRIS GWLTPEARAGLDAVLAKLAAPGMCNPDDESPVVQAPAGADAVSRDRRSVGQRHHDGLNAAVRALLASGDL GQHNGLPASIIVTTTRGELQRACGRGLTGGGTVLPISDVIRLARHAHHYLAVFDRGKAVGLYHAKRLATA GHAWCCMPKTVVAPVRAVMCRAINARCIMSPRGPPAGAPTSINSLWPAGLTTNCSSRVGALARTPTVIPN GCHRRTSTMDSQEPTPTTTPKNCSATAQPTKAKRGVDRAVVWHAEPMAGKEIDRVRATSALAVIKQHPAM VLFVLSPALALLAVIWWLAGAGWAIAAALAVLVVGVAVVVRKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2416 | - | - | 100% (534) | hypothetical protein MUL_2416 |
| M. ulcerans Agy99 | MUL_2371 | - | e-142 | 71.39% (346) | hypothetical protein MUL_2371 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | 1e-129 | 66.28% (344) | hypothetical protein Mb1159c |
| M. gilvum PYR-GCK | Mflv_1835 | - | 4e-73 | 45.93% (344) | hypothetical protein Mflv_1835 |
| M. tuberculosis H37Rv | Rv1128c | - | 1e-129 | 66.28% (344) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0990c | - | 2e-89 | 51.99% (352) | hypothetical protein MAB_0990c |
| M. marinum M | MMAR_1523 | - | 0.0 | 98.01% (352) | hypothetical protein MMAR_1523 |
| M. avium 104 | MAV_2352 | - | 1e-127 | 66.48% (352) | hypothetical protein MAV_2352 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 4e-56 | 38.84% (345) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 7e-56 | 37.70% (382) | PUTATIVE conserved hypothetical protein |
| M. vanbaalenii PYR-1 | Mvan_3231 | - | 6e-75 | 46.02% (352) | hypothetical protein Mvan_3231 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2416|M.ulcerans_Agy99 ------MSSINWEEVVAAFDALDAVMTRLQDLCFDGLTTPERLALLQRCE
MMAR_1523|M.marinum_M ------MSSMSREEVVAAFDALDAVMARLQDLCFDGLTTPERLALLQRCE
Mb1159c|M.bovis_AF2122/97 -------MCSTREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
Rv1128c|M.tuberculosis_H37Rv -------MCSTREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCE
MAV_2352|M.avium_104 ------MHSSTREEIRADVDALRAAVSRVLGHSYDALTTPERLRLLEIFD
MAB_0990c|M.abscessus_ATCC_199 -----------MSSIGVVEAAVDAFCAES----IEDLTAGEALAMLARLK
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAAYAEMRALCLDEVGTGFRLELAERLE
Mflv_1835|M.gilvum_PYR-GCK ----MYVRVMSGGDLQTRIAVLRAAFDEVAACEIELLTRPDLVAALDELE
Mvan_3231|M.vanbaalenii_PYR-1 ----MYVRAMSGSDVQATVTALRTAFDDMAACDVDLLTRPDLVAALDELE
MSMEG_6573|M.smegmatis_MC2_155 ---------MDDG-VQDAVAALDAALNTLLTLPHSALTDAELLTICAGLQ
: : : . : : .
MUL_2416|M.ulcerans_Agy99 VARR--RLPSIEHPLINQLGEQAGEQELGGK-LAAVLAGRLRVSRGEASR
MMAR_1523|M.marinum_M VARR--RLPSIEHPLINQLVEQAGEQELGGK-LAAVLAGRLRVSRGEASR
Mb1159c|M.bovis_AF2122/97 TARR--QLPSVEHTLINQIGEQSTEEELGGK-LGLTLADRLRITRSEAKR
Rv1128c|M.tuberculosis_H37Rv TARR--QLPSVEHTLINQIGEQSTEEELGGK-LGLTLADRLRITRSEAKR
MAV_2352|M.avium_104 RETR--RLRVPGHQLINQLAEQSDPTELGGR-LSFALAERLHITRSDASR
MAB_0990c|M.abscessus_ATCC_199 VVQRRLASRGLG-LVSAVTGQASPMQLGGTS-YAEVLSRRMHMGKRAARR
TH_3287|M.thermoresistible__bu TQCR--INRGLMYRVFAQLADPPDEPAMVPA-VRDRLWARLRITPGEVKR
Mflv_1835|M.gilvum_PYR-GCK ELSC--QLPAVGHRLLARLQAEGTPQQMGAKNWSEVLRVRWRISGSEAHR
Mvan_3231|M.vanbaalenii_PYR-1 TLGC--RLPSVSHRLLARLQAEATPPQMGAKSWKEVLAVRWRISTSEAHR
MSMEG_6573|M.smegmatis_MC2_155 DARN--RIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKEARR
* * : . *
MUL_2416|M.ulcerans_Agy99 RLGEAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQV
MMAR_1523|M.marinum_M RLREAADLGPRRALTGEQLAPLLSATASAVRQGRIGAGHVRVIREFCGQV
Mb1159c|M.bovis_AF2122/97 RVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRL
Rv1128c|M.tuberculosis_H37Rv RVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRL
MAV_2352|M.avium_104 RIAEAADLGPRRALTGEPLPPLLPATAAAQRDGAIGTDHVAVIRQFFDQL
MAB_0990c|M.abscessus_ATCC_199 RIADAELLAPRRAITGEQLAPQLPHTAQALGRGDIGEEHLRIIRHFFDRL
TH_3287|M.thermoresistible__bu RLRVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVMAAL
Mflv_1835|M.gilvum_PYR-GCK RLTEAALLAPRPSLTGPALPPQLAATAIAQARGLINAEHVAVIRKAVKKL
Mvan_3231|M.vanbaalenii_PYR-1 RLTEAAVLAPRQAMTGEALAPVLPATAAAQAHGLINAEHVEVIRKTMAKV
MSMEG_6573|M.smegmatis_MC2_155 RCTDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFFTKC
* * * * ::* *.* * * * : *: :
MUL_2416|M.ulcerans_Agy99 PAEVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDED
MMAR_1523|M.marinum_M PAEVDLETRERAEAHLARLAGQFRPDQLAKLAQRLMDCVNPDG-RYSDED
Mb1159c|M.bovis_AF2122/97 PSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDED
Rv1128c|M.tuberculosis_H37Rv PSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYTDED
MAV_2352|M.avium_104 PEAVDVETCEHAERQLAAQATQFRPDQLSKLARRLMDCLNPDG-RYSDED
MAB_0990c|M.abscessus_ATCC_199 PVVVDAATREAAEAQLAVMATQFRPEALRVGADRMMALLNPDG-QFSDAD
TH_3287|M.thermoresistible__bu PSAVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYDDQD
Mflv_1835|M.gilvum_PYR-GCK PGWVDVATREQFEVNLVRTAVGHGPKELNDAADRMLFLLDQDGPEPDDAE
Mvan_3231|M.vanbaalenii_PYR-1 PGFVDTATRERIEVDLVRTAVGNGPKELKDSADRTLFLLDQDGPEPDERE
MSMEG_6573|M.smegmatis_MC2_155 PDWVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPTDNP
* * * * * . : : .: ** :
MUL_2416|M.ulcerans_Agy99 RARRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAP--------
MMAR_1523|M.marinum_M RARRRGLTLGRQGRDGMSRISGWLTPEARAGLDAVLAKLAAP--------
Mb1159c|M.bovis_AF2122/97 RARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAP--------
Rv1128c|M.tuberculosis_H37Rv RARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAP--------
MAV_2352|M.avium_104 RARARGLVLGNQQADGMSRLSGWLTPEARAGWEAVLAKLAAP--------
MAB_0990c|M.abscessus_ATCC_199 RARRRGITIGPQGFDGMSAISGLLDPETRAYLDAVFAKLAAP--------
TH_3287|M.thermoresistible__bu RARRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVRPGRHLPHTTT
Mflv_1835|M.gilvum_PYR-GCK RGRKRGVSIGRQGAEAMSALTGQLTPEARAVWEAIFAKYAAP--------
Mvan_3231|M.vanbaalenii_PYR-1 RARKRAVTKHKQREDGMVDVSATLTPEAWAVWEAIFAKFAAP--------
MSMEG_6573|M.smegmatis_MC2_155 PTKPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAP--------
: .: * :. : . : .: * :.: .
MUL_2416|M.ulcerans_Agy99 ------------GMCNPDDESPVVQAPAGADAVSRDR-----RSVGQRHH
MMAR_1523|M.marinum_M ------------GMCNPDDESPVVQAPAGADAVSRDR-----RSVGQRHH
Mb1159c|M.bovis_AF2122/97 ------------GMCNPEQKAPCVNGAPSKEQARRDT-----RSCPQRNH
Rv1128c|M.tuberculosis_H37Rv ------------GMCNPEQKAPCVNGAPSKEQARRDT-----RSCPQRNH
MAV_2352|M.avium_104 ------------GMCNPDDDAPVVDGPPPEAASQRDS-----RSAAQRNH
MAB_0990c|M.abscessus_ATCC_199 ------------GMCNPNDQSPLVDGQPADDAAERDT-----RTVAQRHH
TH_3287|M.thermoresistible__bu DTTGTTGTTETTGTAGTAGTAATAADTAADGVGDIDTGGVDLRSAAQRRH
Mflv_1835|M.gilvum_PYR-GCK ------------GMCNPDDEQPCTSGTPSQAQIDGDH-----RSLAQRQH
Mvan_3231|M.vanbaalenii_PYR-1 ------------GMCNPDDPEPCTSGTPSQAQIDHDQ-----RSLAQRQH
MSMEG_6573|M.smegmatis_MC2_155 ------------GMCNPTDQTPCISGTPSQQQIDSDQ-----RGAPERRH
* ... . . * * :*.*
MUL_2416|M.ulcerans_Agy99 DGLNAAVRALLASGDLGQHNGLPASIIVTTTRGELQRAC-----------
MMAR_1523|M.marinum_M DGLNAAVRALLASGDLGQHNGLPASIIVTTTLGELQRAC-----------
Mb1159c|M.bovis_AF2122/97 DALNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-----------
Rv1128c|M.tuberculosis_H37Rv DALNAELRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-----------
MAV_2352|M.avium_104 DGLNAALRALLAGGKLGQHNGLPASIIVTTTLRDLESAA-----------
MAB_0990c|M.abscessus_ATCC_199 DALRAALRSTLVSTELGSHHGLPVTVVVTTTLKELEDAA-----------
TH_3287|M.thermoresistible__bu DGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAHAVADPRVSMP
Mflv_1835|M.gilvum_PYR-GCK DALLAVGRIALMSGELGQLNGLPVSVIIRTTLQDLESRA-----------
Mvan_3231|M.vanbaalenii_PYR-1 DALLAAGRIALMSGELGKLNGLPVSVIIRTTLQDLESRA-----------
MSMEG_6573|M.smegmatis_MC2_155 DAMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELEKAA-----------
*.: : : **. .* *.:::: ** :*: .
MUL_2416|M.ulcerans_Agy99 GRGLTGGGTVLPISDVIRLARHAHHYLAVFDRG--KAVGLYHAKRLATAG
MMAR_1523|M.marinum_M GRGLTGGGTVLPISDVIRLARHAHHYLAVFDRG--KAVGLYHAKRLATAG
Mb1159c|M.bovis_AF2122/97 GAGLTGGGTILPISDVIRLARHANHYLAIFDRG--KALALYHTKRLASPA
Rv1128c|M.tuberculosis_H37Rv GAGLTGGGTILPISDVIRLARHANHYLAIFDRG--KALALYHTKRLASPA
MAV_2352|M.avium_104 GKGLTGGGTLLPMSEVIRLARHAHHYLAVFDNG--KPLALYHTKRLASPG
MAB_0990c|M.abscessus_ATCC_199 GIAITGAGTRLPMRDLIRMATHAHHYLAIFDDH-GRALYLGRSQRIASPD
TH_3287|M.thermoresistible__bu GPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLYLGRQKRIATAD
Mflv_1835|M.gilvum_PYR-GCK GIGVSGGGTKLPIRDVIRMAGHANHYLAVFDRATGSALDLFRTRRVASPA
Mvan_3231|M.vanbaalenii_PYR-1 GVGVTGGGTVMPIAEVIRMAGHANHYLAVFDRATGSALDLFRTRRIASPA
MSMEG_6573|M.smegmatis_MC2_155 GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGIPLYLGRARRTASAG
* . :.. :.: ::**:* .* ****::* .: * : :* *:.
MUL_2416|M.ulcerans_Agy99 HAWCCMPKTVVAPVRAVMCRAINARCIMSPRGPPAGAPTSIN---SLWPA
MMAR_1523|M.marinum_M QRLVLYAK---------------DRGCTRPGCDVPGYQCEVHHV-AAWAT
Mb1159c|M.bovis_AF2122/97 QRIMLYAK---------------DSGCSAPGCDVPGYYCEVHHV-TPYAQ
Rv1128c|M.tuberculosis_H37Rv QRIMLYAK---------------DSGCSAPGCDVPGYYCEVHHV-TPYAQ
MAV_2352|M.avium_104 QRIVLYAK---------------DRGCSHPGCDVSGYYCEVHHV-TGYAK
MAB_0990c|M.abscessus_ATCC_199 QRLVLHAR---------------DRGCTHPDCHVPGYLCQAHHI-TEWVH
TH_3287|M.thermoresistible__bu QRLICYAR---------------DGGCTAPGCGEPGYHAETHHQ-PAWED
Mflv_1835|M.gilvum_PYR-GCK QRVMLIAR---------------DGGCTKPCCTVGAYGCQVHHAEADYAH
Mvan_3231|M.vanbaalenii_PYR-1 QRIMLIAR---------------DGGCTKPGCTVGAYGCQGHHVEADFAK
MSMEG_6573|M.smegmatis_MC2_155 QRLAIWAR---------------DRGCTRPGCTANGYRCQAHHATTDYAK
: .: * . . : . :
MUL_2416|M.ulcerans_Agy99 GLTTNCSSRVGALARTPTVIPNG---CHRRTSTMDSQEPTPTTTPKNCSA
MMAR_1523|M.marinum_M SGRTDIDQLTLACGPDHKLLEQG---WRTRKNAHGDTEWLP---------
Mb1159c|M.bovis_AF2122/97 CRNTDVNDLTLGCGGHHPLAERG---WTTRKNAHGDTEWLP---------
Rv1128c|M.tuberculosis_H37Rv CRNTDVNDLTLGCGGHHPLAERG---WTTRKNAHGDTEWLP---------
MAV_2352|M.avium_104 CGRTDIDQLTFACGGHHPLAEQG---WITRKNGRGETEWIP---------
MAB_0990c|M.abscessus_ATCC_199 DGPTDIDNLTFACAPHHRLLGHG---WTTRKRKDGTTEWIP---------
TH_3287|M.thermoresistible__bu GGLTDADHLFFACGPHHSGLTEGR--WQATITPTGRLAWTN---------
Mflv_1835|M.gilvum_PYR-GCK GGNTNIDELGLACGPDNRSVT--DGGWTTRMNDRCEVEWIP---------
Mvan_3231|M.vanbaalenii_PYR-1 GGNTNVDELGLACGPDNRSVDN-NGGWTTRMNERCEVEWIP---------
MSMEG_6573|M.smegmatis_MC2_155 GGLTDADALALACGCDNRLVGEAPNKWTTRINNHGQCEWIP---------
*: . . .
MUL_2416|M.ulcerans_Agy99 TAQPTKAKRGVDRAVVWHAEPMAGKEIDRVRATSALAVIKQHPAMVLFVL
MMAR_1523|M.marinum_M ---PPHLDHGQPRTNTYHHP-------EKLLRDSAADEGEEGG-------
Mb1159c|M.bovis_AF2122/97 ---PPHLDHGQPRVNTFHHP-------EKLLADDEGDP------------
Rv1128c|M.tuberculosis_H37Rv ---PPHLDHGQPRVNTFHHP-------EKLLADDEGDP------------
MAV_2352|M.avium_104 ---PPHLERGQPRVNSFHHP-------EDMLCDTEDQQDQQDQQDQADEE
MAB_0990c|M.abscessus_ATCC_199 -------PPQLALPGETRHD-------DIVDQCPHGVGSR----------
TH_3287|M.thermoresistible__bu -------DHHPPTVNHAHHP-------EELLRAHTDPPEDPG--------
Mflv_1835|M.gilvum_PYR-GCK ---PPGLDTGQARVNTYHRP-------ERLLRP--EDPEPLGDN------
Mvan_3231|M.vanbaalenii_PYR-1 ---PPSLDTGQARINNYHRP-------ERLLHPP-DEPEPQGHN------
MSMEG_6573|M.smegmatis_MC2_155 ---PDLLDRGQHRTNTYHHP-------ETLLADINRDQKTDGDNREQHHT
: : :
MUL_2416|M.ulcerans_Agy99 SPALALLAVIWWLAGAG----------------------------WAIAA
MMAR_1523|M.marinum_M --------------------------------------------------
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2352|M.avium_104 DGAA----------------------------------------------
MAB_0990c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mflv_1835|M.gilvum_PYR-GCK DSQAS---------------------------------------------
Mvan_3231|M.vanbaalenii_PYR-1 DTEAEIESAGSAQGNPR---------------------------GDETNG
MSMEG_6573|M.smegmatis_MC2_155 DTGADTGTVHVNGHGEKPAIPPELLDQGQQRTAPYHQAEVPPVNTRDTRS
MUL_2416|M.ulcerans_Agy99 ALAVLVVGVAVVVRKR---------------------
MMAR_1523|M.marinum_M -------------------------------------
Mb1159c|M.bovis_AF2122/97 -------------------------------------
Rv1128c|M.tuberculosis_H37Rv -------------------------------------
MAV_2352|M.avium_104 -------------------------------------
MAB_0990c|M.abscessus_ATCC_199 -------------------------------------
TH_3287|M.thermoresistible__bu -------------------------------------
Mflv_1835|M.gilvum_PYR-GCK -RPADDPGEPGGPAP---------PEGEAA-------
Mvan_3231|M.vanbaalenii_PYR-1 PRPTDDAGKPGGPAP---------PGDQAA-------
MSMEG_6573|M.smegmatis_MC2_155 STTTRDANRHNGNGDRNSAENRNGPSKNAAGDDDEPR