For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ASVSFEGATRRYPGADRPAVDSLDLVVDDGEFVVLVGPSGCGKTTSLRMLAGLEKVDAGRIRIAERDVTN VDPKSRDVAMVFQNYALYPHMTVAQNMGFALKVAKTPKAEIRDRVLQAAKLLDLEAYLDRKPKDLSGGQR QRVAMGRAIVRRPQVFLMDEPLSNLDTKLRVQTRNQIAGLQRQLGTTTVYVTHDQVEAMTMGDRVAVLCD GVLQQCAAPRELYRRPDNVFVAGFIGSPAMNMFILPIVDSSVLLGDWLIQLPREVTVPAPEVVVGVRPEH FEVGNLGVEMEIDVVEELGADAYLYGRISNGGTMIDQSVVARADGSNPPERGSRVRLYPQPAQLHFFTVD GRRIA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2252 | - | - | 100% (356) | sugar-transport ATP-binding protein ABC transporter |
| M. ulcerans Agy99 | MUL_3658 | cysA1 | 1e-53 | 46.40% (222) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. ulcerans Agy99 | MUL_0033 | proV_1 | 3e-44 | 39.59% (245) | osmoprotectant (glycine |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2064c | - | 1e-167 | 82.25% (355) | sugar-transport ATP-binding protein ABC transporter |
| M. gilvum PYR-GCK | Mflv_3778 | - | 4e-84 | 48.61% (360) | ABC transporter related |
| M. tuberculosis H37Rv | Rv2038c | - | 1e-167 | 82.25% (355) | sugar-transport ATP-binding protein ABC transporter |
| M. leprae Br4923 | MLBr_01424 | - | 1e-160 | 77.81% (356) | putative binding-protein-dependent transport protein |
| M. abscessus ATCC 19977 | MAB_1375 | - | 5e-90 | 52.79% (341) | sugar ABC transporter, ATP-binding protein SugC |
| M. marinum M | MMAR_3011 | - | 0.0 | 98.60% (356) | sugar-transport ATP-binding protein ABC transporter |
| M. avium 104 | MAV_2479 | - | 1e-168 | 82.25% (355) | glycerol-phosphate porter |
| M. smegmatis MC2 155 | MSMEG_5571 | - | 1e-108 | 59.34% (364) | ABC transporter ATP-binding protein |
| M. thermoresistible (build 8) | TH_3215 | - | 1e-105 | 58.13% (363) | PUTATIVE ABC transporter ATP-binding protein |
| M. vanbaalenii PYR-1 | Mvan_4484 | - | 7e-90 | 51.90% (343) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2252|M.ulcerans_Agy99 --MASVSFEGATRRYPGADRPAVDSLDLVVDDGEFVVLVGPSGCGKTTSL
MMAR_3011|M.marinum_M --MASVSFEGATRRYPGADRPAVDSLDLEVDDGEFVVLVGPSGCGKTTSL
Mb2064c|M.bovis_AF2122/97 --MASVSFEQATRRYPGTDRPALDRLDLIVGDGEFVVLVGPSGCGKTTSL
Rv2038c|M.tuberculosis_H37Rv --MASVSFEQATRRYPGTDRPALDRLDLIVGDGEFVVLVGPSGCGKTTSL
MAV_2479|M.avium_104 MSMASVTFQQATRRYPGADRPALDNLNLVVGDGEFVVLVGPSGCGKTTSL
MLBr_01424|M.leprae_Br4923 --MASVTFEQATRQFPDTDRPALDRLDLDVDDGEFVVVVGPSGCGKTTSL
MSMEG_5571|M.smegmatis_MC2_155 --MAAITYRNASCIYEGSDKLAVDSLNLDIADGEFVVLVGPSGSGKSTAL
TH_3215|M.thermoresistible__bu --MATITYRNASCIYEGSDTFAVNSLNLEIEDGEFVVLVGPSGSGKSTAL
MAB_1375|M.abscessus_ATCC_1997 --MAEIVLNQVSKTYTDG-SAAVRDVSLNIADGEFIILVGPSGCGKSTTL
Mvan_4484|M.vanbaalenii_PYR-1 --MAEIVLDRVTKSYADG-TAAVKDLSITVADGEFVTLVGPSGCGKSTTL
Mflv_3778|M.gilvum_PYR-GCK --MATVRFSGVTKAYGST--SVVSDLDLELPDGSLSVLVGPSGCGKSTTL
** : .: : . .: :.: : **.: :*****.**:*:*
MUL_2252|M.ulcerans_Agy99 RMLAGLEKVDAGRIRIAERDVTNVDPKSRDVAMVFQNYALYPHMTVAQNM
MMAR_3011|M.marinum_M RMLAGLERVDAGRIRIAERDVTNVDPKSRDVAMVFQNYALYPHMTVAQNM
Mb2064c|M.bovis_AF2122/97 RMVAGLETLDCGRIRIGERDVTEVDPKDRDVAMVFQNYALYPHMTVAQNM
Rv2038c|M.tuberculosis_H37Rv RMVAGLETLDCGRIRIGERDVTEVDPKDRDVAMVFQNYALYPHMTVAQNM
MAV_2479|M.avium_104 RMVAGLETVDSGRILIGDRDVTNVDPKQRDVAMVFQNYALYPHMTVAQNM
MLBr_01424|M.leprae_Br4923 RMVAGLETLDSGCIRIGDRDVTHVDPKDRDVAMVFQNYALYPHMTVAQNL
MSMEG_5571|M.smegmatis_MC2_155 RMLAGLEDIDEGDIEIGGRNMRGVPSKDRDIAMVFQNYALYPTKTVAENM
TH_3215|M.thermoresistible__bu RMLAGLEDIDDGDIEIGGRNMRGVPSKDRDIAMVFQNYALYPNKTVAENM
MAB_1375|M.abscessus_ATCC_1997 NMIAGLEDISSGELTIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQNI
Mvan_4484|M.vanbaalenii_PYR-1 NMIAGLEEITSGELRIDGERVNERSTKDRDIAMVFQSYALYPHMTVRQNI
Mflv_3778|M.gilvum_PYR-GCK RMLAGLETVTSGTITIGDRDVTHLQPRDRDIAMVFQNYALYPHLTVAENI
.*:**** : * : * . : .:.**:*****.***** ** :*:
MUL_2252|M.ulcerans_Agy99 GFALKVAKTPKAEIRDRVLQAAKLLDLEAYLDRKPKDLSGGQRQRVAMGR
MMAR_3011|M.marinum_M GFALKVAKTPKAEIRDRVLQAAKLLDLEAYLDRKPKDLSGGQRQRVAMGR
Mb2064c|M.bovis_AF2122/97 GFALKVAKIGKAEIRERVLAAAKLLDLQSYLDRKPKDLSGGQRQRVAMGR
Rv2038c|M.tuberculosis_H37Rv GFALKVAKIGKAEIRERVLAAAKLLDLQSYLDRKPKDLSGGQRQRVAMGR
MAV_2479|M.avium_104 GFAMKIAKTPKAQIRERVLDAAKLLDLQPYLDRKPKDLSGGQRQRVAMGR
MLBr_01424|M.leprae_Br4923 GFALKISKISKAEIHDRILVVAKLLDLQPYLDRKPKDLSGGQRQRVAMGR
MSMEG_5571|M.smegmatis_MC2_155 GFALKLRGVPAAERRKKVEEAAKLLDLEQFLDRKPAKLSGGQRQRVAMGR
TH_3215|M.thermoresistible__bu GFALKLRGVAASERRRKVEEAAKLLDLTEFLDRKPAKLSGGQRQRVAMGR
MAB_1375|M.abscessus_ATCC_1997 AFPLTLAKMSKDDINAKVAEAAKILDLTDYLDRKPANLSGGQRQRVAMGR
Mvan_4484|M.vanbaalenii_PYR-1 GFPLTLAKLSRQEIAEKVEQTAKTLDLTDLLDRKPDQLSGGQRQRVAMGR
Mflv_3778|M.gilvum_PYR-GCK AFPLRANKTPRREALARAATVAESLGLSALLGRKPKDLSGGQQQRVAIGR
.*.: : : .*: *.* *.*** .*****:****:**
MUL_2252|M.ulcerans_Agy99 AIVRRPQVFLMDEPLSNLDTKLRVQTRNQIAGLQRQLGTTTVYVTHDQVE
MMAR_3011|M.marinum_M AIVRRPQVFLMDEPLSNLDAKLRVQTRNQIAGLQRQLGTTTVYVTHDQVE
Mb2064c|M.bovis_AF2122/97 AIVRRPQVFLMDEPLSNLDAKLRGQTRNQIAALQRQLGTTTVYVTHDQVE
Rv2038c|M.tuberculosis_H37Rv AIVRRPQVFLMDEPLSNLDAKLRGQTRNQIAALQRQLGTTTVYVTHDQVE
MAV_2479|M.avium_104 AIVRRPQVFLMDEPLSNLDAKLRVQTRNQIAALQRRLGTTTVYVTHDQVE
MLBr_01424|M.leprae_Br4923 AIVRRPQVFLMDEPLSNLDAKLRAQTRNQIAELQCQLGTTTVYVTHDQVE
MSMEG_5571|M.smegmatis_MC2_155 AIVREPQVFCMDEPLSNLDAKLRVQTRTQIAALQRRLGTTTVYVTHDQVE
TH_3215|M.thermoresistible__bu AIVREPQVFCMDEPLSNLDAKLRVQTRTQIAALQRRLGTTTVYVTHDQVE
MAB_1375|M.abscessus_ATCC_1997 AIVRSPKAFLMDEPLSNLDAKLRVQMRTEIARLQKRLGTTTVYVTHDQTE
Mvan_4484|M.vanbaalenii_PYR-1 AIVRNPKAFLMDEPLSNLDAKLRVQMRGEIARLQKRLGTTTVYVTHDQTE
Mflv_3778|M.gilvum_PYR-GCK AIIREPSVFLFDEPLSNLDAKLRVETRTELAQIQRRLGITSVYVTHDQEE
**:* *..* :********:*** : * ::* :* :** *:******* *
MUL_2252|M.ulcerans_Agy99 AMTMGDRVAVLCDGVLQQCAAPRELYRRPDNVFVAGFIGSPAMNMFILPI
MMAR_3011|M.marinum_M AMTMGDRVAVLCDGVLQQCAAPRELYRRPDNVFVAGFIGSPAMNMFILPI
Mb2064c|M.bovis_AF2122/97 AMTMGDRVAVLSDGVLQQCASPRELYRNPGNVFVAGFIGSPAMNLFRLSI
Rv2038c|M.tuberculosis_H37Rv AMTMGDRVAVLSDGVLQQCASPRELYRNPGNVFVAGFIGSPAMNLFRLSI
MAV_2479|M.avium_104 AMTMGDRVAVLRDGVLQQFAPPRELYRNPSNVFVAGFIGSPAMNLFTLPV
MLBr_01424|M.leprae_Br4923 AMTMGDRVAVLCYGVLQQFATPRELYHKPENVFVAGFIGSPGMNLVTLSI
MSMEG_5571|M.smegmatis_MC2_155 AMTMGDRVAVLRNGKLQQFASPNELYDKPVNEFVAGFIGSPAMNLVKLPI
TH_3215|M.thermoresistible__bu AMTMGDRVAVLKHGRLQQFASPGDLYHRPANAFVAGFIGSPAMNLFNAQL
MAB_1375|M.abscessus_ATCC_1997 AMTLGDRVVVLRAGKVQQVGAPQELYDTPANLFVAGFIGSPSMNFFPATL
Mvan_4484|M.vanbaalenii_PYR-1 AMTLGDRVVVMLGGAVQQIGTPDELYRGPANLFVAGFIGSPAMNFFPAAL
Mflv_3778|M.gilvum_PYR-GCK AMTLSDRMIVMRDGKIAQQGAPQDVYARPADTFVAAFVGSPKMNLLEGTL
***:.**: *: * : * ..* ::* * : ***.*:*** **:. :
MUL_2252|M.ulcerans_Agy99 VDSSVLLGD-WLIQLPREVTVPA------PEVVVGVRPEHFEVGNLG---
MMAR_3011|M.marinum_M VDSSVLLGD-WLIQLPREVTVPA------PEVVVGVRPEHFEVGNLG---
Mb2064c|M.bovis_AF2122/97 ADSTVSLGD-WQILLPRAVVGTA------AEVIIGVRPEHLELGGAG---
Rv2038c|M.tuberculosis_H37Rv ADSTVSLGD-WQILLPRAVVGTA------AEVIIGVRPEHLELGGAG---
MAV_2479|M.avium_104 VDSAVSLGD-WPIALPREIAAAA------SEVVVGVRPEHFELGGLG---
MLBr_01424|M.leprae_Br4923 VDSSVLLGD-WPIRIPREIASAA------SEVIIGVRPEHFELGSLG---
MSMEG_5571|M.smegmatis_MC2_155 VPDGVRVGDNSTLELERDQMTRLSQLGL-SEVTIGIRPEQLEIEESGR--
TH_3215|M.thermoresistible__bu VPEGVQIGD-TVLELERAQLTALHEAKL-DTVTVGLRPEHLELSDAGG--
MAB_1375|M.abscessus_ATCC_1997 TDVGVQLPF-GEVTLDAGLYAGITARKPSGDVIVGIRPEQFEDAALVDTY
Mvan_4484|M.vanbaalenii_PYR-1 TEIGVRLPF-GEIPLTGQVYERLKGHRTCDDLIAGIRPEHLEDAAVIDAY
Mflv_3778|M.gilvum_PYR-GCK TGGTFTLANGFALPIDEGATDGP--------LTLGVRPDDLLPTVGAAD-
. . : : : : *:**:.:
MUL_2252|M.ulcerans_Agy99 -------VEMEIDVVEELGADAYLYGRI-------------SNGGTMIDQ
MMAR_3011|M.marinum_M -------VEMEIDVVEELGADAYLYGRI-------------INGGAMIDQ
Mb2064c|M.bovis_AF2122/97 -------IEMDVDMVEELGADAYLYGRI-------------VSGGCEMDQ
Rv2038c|M.tuberculosis_H37Rv -------IEMDVDMVEELGADAYLYGRI-------------VSGGCEMDQ
MAV_2479|M.avium_104 -------VEMEVDVVEELGADAYLYGRI-------------TGSGKVIDA
MLBr_01424|M.leprae_Br4923 -------VEVEIDMVEELGADAYLYGRI-------------AGASKVTDQ
MSMEG_5571|M.smegmatis_MC2_155 -------VEVVVDLVEDLGSEAYVYTHA-------------ASGSGVE--
TH_3215|M.thermoresistible__bu -------VEVVVDLVEDLGSEAYLYTH---------------TGSGVD--
MAB_1375|M.abscessus_ATCC_1997 KRITGLTLTVNADVVESLGSDKYVHFTTEGGAAHSDELTELAQESEVAEN
Mvan_4484|M.vanbaalenii_PYR-1 ARIGALVFDVTVEMVESLGADKYVYFGVDGPGAEAVQLTEVAAESTVGEN
Mflv_3778|M.gilvum_PYR-GCK -------APARVALIEHLGPRAIVTVDA--------------RGTELTSV
::* **. :
MUL_2252|M.ulcerans_Agy99 SVVARADGSNPPERGSRVRLYPQP-AQLHFFTVD-GRRIA------
MMAR_3011|M.marinum_M SVVARADGSNPPERGSRVRLYPQP-AQLHFFTVD-GRRIA------
Mb2064c|M.bovis_AF2122/97 SIVARVDGRGPPERGSRVRLCPTP-GHLHFFAVD-GRRIPG-----
Rv2038c|M.tuberculosis_H37Rv SIVARVDGRGPPERGSRVRLCPTP-GHLHFFAVD-GRRIPG-----
MAV_2479|M.avium_104 PIVARVDGRNPPEKGSRVRLHPAP-GHLHFFGRN-GQRIGVRGSW-
MLBr_01424|M.leprae_Br4923 LVVARVDGRNPPAKGSRVRLYTEP-GNVHFFGVD-GHRIS------
MSMEG_5571|M.smegmatis_MC2_155 -LVARCNPRRAPKLAQTVRLRKSPDGVVHLFHPDTGERI-------
TH_3215|M.thermoresistible__bu -LVARCLDRVPAKLADTVRLRKRTDGVVHLFHPDTGERVGE-----
MAB_1375|M.abscessus_ATCC_1997 EFVARLSAASKVAEGQPIELIIDT-GKLVIFDAESGENLSLAATAE
Mvan_4484|M.vanbaalenii_PYR-1 EFVARVPAQSGAAVGRTLQLALNP-DNVLLFDPRTGANLSLPAVGA
Mflv_3778|M.gilvum_PYR-GCK VDTARLSG---ITEGTGVELAVRQ-GATHLFDTTTGRRIAGETR--
.** . :.* :* * .: