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AKGVSIAISTGRMLAQGLAAREGQSMPRIDNSQGGDSLAAREFKGVAESFAPSGRAVRRVAVFGLGYVGS VTAACLASRGHSVIGVDVRREKVDMINRGQSPVVEGGLGELIFGEVAAGRLSATTNPADAVANTDIALVC VGTPSAANGSLLTTYLERVSEDIGAALAGRAGRYTVVIRSTVLPWTCEQIVLPRLQAASGLRAGEDFGVA VNPEFLREGSSIRDFFEPPKIVIGQFDAVSGDVVAQLYEGMSAPVFRVPLAVAEMVKYADNGFHALKTGF ANEIGAVCKAMGLDSHAVMDIFVADTKLNISRAYLRPGFAFGGSCLPKDLRALIHRARTSDVPLPILESV CISNNGQIDRAFNVIEATGKRRVGLLGLAFKSGTDDLRESPLVALAERLVGRGFDLQIYDPQVSASRLLG ANRAFAEARIPCLSQCVSDSPDEVVNHAEVCVVGAADPESIAALRRVDGRIVVDLVRFPGSVDYQDDPRY IGISW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5957 | algD | - | 100% (496) | GDP-mannose 6-dehydrogenase AlgD |
| M. smegmatis MC2 155 | MSMEG_5982 | - | 2e-41 | 30.30% (439) | UDP-glucose 6-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0680 | - | 3e-39 | 31.74% (438) | UDP-glucose 6-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0330 | udgA | 6e-43 | 34.17% (436) | UDP-glucose 6-dehydrogenase UdgA |
| M. gilvum PYR-GCK | Mflv_0289 | - | 4e-44 | 34.47% (412) | UDP-glucose 6-dehydrogenase |
| M. tuberculosis H37Rv | Rv0322 | udgA | 7e-43 | 34.17% (436) | UDP-glucose 6-dehydrogenase UdgA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4295c | - | 7e-47 | 33.03% (439) | UDP-glucose 6-dehydrogenase (UdgA) |
| M. marinum M | MMAR_0603 | udgA | 3e-44 | 35.24% (437) | UDP-glucose dehydrogenase UdgA |
| M. avium 104 | MAV_4092 | - | 2e-49 | 35.65% (359) | UDP-glucose 6-dehydrogenase |
| M. thermoresistible (build 8) | TH_0768 | udgA | 3e-43 | 33.18% (437) | PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA (UDP-GLC |
| M. ulcerans Agy99 | MUL_1511 | - | 5e-24 | 28.05% (353) | UDP-glucose 6-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1699 | - | 3e-79 | 41.35% (416) | GDP-mannose 6-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5957|M.smegmatis_MC2_155 MAKGVSIAISTGRMLAQGLAAREGQSMPRIDNSQGGDSLAAREFKGVAES
Mvan_1699|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0289|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4295c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0330|M.bovis_AF2122/97 --------------------------------------------------
Rv0322|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0603|M.marinum_M --------------------------------------------------
TH_0768|M.thermoresistible__bu --------------------------------------------------
MAV_4092|M.avium_104 --------------------------------------------------
MUL_1511|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5957|M.smegmatis_MC2_155 FAPSGRAVRRVAVFGLGYVGSVTAACLASRGHSVIGVDVRREKVDMINRG
Mvan_1699|M.vanbaalenii_PYR-1 --------MNIAILGLGYVGVTAAACLASQGHYVIGIDPNATKVNAVLEG
Mflv_0289|M.gilvum_PYR-GCK ----MRCT----VFGTGYLGATHAAGMAELGHEVVGVDIDPGKVAKLAAG
MAB_4295c|M.abscessus_ATCC_199 ----MRCT----VFGTGYLGATHAACMAELGHEVLGVDIDPGKVAKLSSG
Mb0330|M.bovis_AF2122/97 ----MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGG
Rv0322|M.tuberculosis_H37Rv ----MRCS----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGG
MMAR_0603|M.marinum_M ----MRCT----VFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGG
TH_0768|M.thermoresistible__bu ----MRCT----VFGAGYLGTTHAAGMAALGHEVIAVDVDAGKVAKLAAG
MAV_4092|M.avium_104 ----MSTEPLVGVVGVGYVGLTTAVCVAAAGRKTVAVDINPDRVGRLRAG
MUL_1511|M.ulcerans_Agy99 -MTTQPSERICIVGGAGHVGLPLALVLADEGYNVDILDTNAEALETIMAG
: * *::* * :* * . :* : : *
MSMEG_5957|M.smegmatis_MC2_155 QSPVVEGGLGELIFGEVAAGRLSATTNPADAVANTDIALVCVGTPSAANG
Mvan_1699|M.vanbaalenii_PYR-1 RSPITEPRIGELIAEAREQGLITANVALGSEVAMCDVAIVCVGTPSAVDG
Mflv_0289|M.gilvum_PYR-GCK EVPFYEPGLREALQRNIEAGRLRFTTDYAEAAEFADVHFLGVGTPQKKGE
MAB_4295c|M.abscessus_ATCC_199 DIPFYEPGLRKILQSNIASGRLRFTTSYAEAAEFADVHFLGVGTPQKKGE
Mb0330|M.bovis_AF2122/97 DIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGE
Rv0322|M.tuberculosis_H37Rv DIPFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGE
MMAR_0603|M.marinum_M DIPFYEPGLRKLLRDNLAAGRLHFTTDYDMAAEFADVHFLGVGTPQKRGE
TH_0768|M.thermoresistible__bu EVPFYEPGLRALVTENLATGRLQFTTDYDAAADFADLHFLGVGTPQQRGD
MAV_4092|M.avium_104 VAVIDEPGLSELLGDGLAGGVLRFSADFAELAD-RDVVFVCVPTPSAP-D
MUL_1511|M.ulcerans_Agy99 RMPFIETGAEDLLKPLLPTGRISGSTD-SQVVRNSDIVICVVGTPVDEYL
. * : * : .. . *: : * **
MSMEG_5957|M.smegmatis_MC2_155 SLLTTYLERVSEDIGAALAGR-AGRYTVVIRSTVLPWTCEQIVLPRLQAA
Mvan_1699|M.vanbaalenii_PYR-1 SHNMSYIAEVSRQLAELVKAHPDASLTVAYRSTVRPGTMENLIQPIFDGV
Mflv_0289|M.gilvum_PYR-GCK YAADLRHVYAVIDTLVPLLRR---PAVIVGKSTVPVGTAAELVER---AA
MAB_4295c|M.abscessus_ATCC_199 YGADLRHVHSVIDTLVPLLSR---SAVIIGKSTVPVGTARELGQR---AA
Mb0330|M.bovis_AF2122/97 YGADLRHVHAVIDALVPRLVR---ASILVGKSTVPVGTAAELGHR---AG
Rv0322|M.tuberculosis_H37Rv YGADLRHVHAVIDALVPRLVR---ASILVGKSTVPVGTAAELGHR---AG
MMAR_0603|M.marinum_M YGADLRHIHAVIDTLVPRLTR---TSVLIGKSTVPVGTAAELARR---AA
TH_0768|M.thermoresistible__bu YSADLTQVHAVVDTLVPRLRR---PAVIVGKSTVPVGTARDLLER---AR
MAV_4092|M.avium_104 GHADLAAVESVIDRLGRVLRR---GAVVALKSTVPVGTTSTMAQR---LC
MUL_1511|M.ulcerans_Agy99 TPQAHTFFRVIDEISPYFHDG----QTLILRSTVYPGLSQRVHDM-----
: : :*** :
MSMEG_5957|M.smegmatis_MC2_155 SGLRAGEDFGVAVNPEFLREGSSIRDFFEPPKIVIGQFD-----AVSGDV
Mvan_1699|M.vanbaalenii_PYR-1 LGGDS-ARIELVYYPEFLRESSAVDDYFSPPKIVIGTKD-----GDRCAK
Mflv_0289|M.gilvum_PYR-GCK GLAPDGVTVEVAWNPEFLREGFAVQDTLHPDRIVLGVQKDSRIAEPVLRE
MAB_4295c|M.abscessus_ATCC_199 GFAAAGVDVEVAWNPEFLREGYAVKDTLHPDRIVLGVQRDSDRAEKLVRE
Mb0330|M.bovis_AF2122/97 ALAPRGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRE
Rv0322|M.tuberculosis_H37Rv ALAPRGVDVEIAWNPEFLREGFAVHDTLNPDRIVLGVQDDSTRAEVAVRE
MMAR_0603|M.marinum_M GLAVAGVGVEIAWNPEFLREGFAVRDTLRPDRIVLGVQEDSILAEQFVRE
TH_0768|M.thermoresistible__bu RLAPTGVDVEVAWNPEFLREGFAVRDTLHPDRIVVGAPPDSVRAEPMLRE
MAV_4092|M.avium_104 HKG-----IRVVSTPEFLREGRAVDDFRNPDRLVIGSHD--ELAAQLVHQ
MUL_1511|M.ulcerans_Agy99 -FSERGIGVHVTFCPERIAQGHSIRELRIIPQIISGFDA------EGLRV
. :. ** : :. :: : ::: *
MSMEG_5957|M.smegmatis_MC2_155 VAQLYEGMSAPVFRVPLAVAEMVKYADNGFHALKTGFANEIGAVCKAMGL
Mvan_1699|M.vanbaalenii_PYR-1 IDKINEGITAPVFYVRYPESEITKFVDNSFHAVKIAFANEIGRVCTQLGI
Mflv_0289|M.gilvum_PYR-GCK LYAALLADGAPFLVSDLQTAELAKVSANAFLATKISFINAISEVCEAVGA
MAB_4295c|M.abscessus_ATCC_199 LYGPILDEEVPFLVTDLETAELVKVSANAFLATKISFINAISEVCEAVGA
Mb0330|M.bovis_AF2122/97 LYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGA
Rv0322|M.tuberculosis_H37Rv LYAPLLAAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGA
MMAR_0603|M.marinum_M LYGPLLEAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGA
TH_0768|M.thermoresistible__bu LYAPLLGDGVPWLSTDLQTAELVKVSANAFLATKISFINAISDVCEAVGA
MAV_4092|M.avium_104 AYG---LAGHRVLRMSPESAELAKYASNAFLAVKLSYTNSLAALCARVGA
MUL_1511|M.ulcerans_Agy99 VRELFSGIASEIIKVEPQEAELAKLFCNSYRYIQFAVANQFYLLSREAGQ
: :*:.* *.: : . * : :. *
MSMEG_5957|M.smegmatis_MC2_155 DSHAVMDIFVADTKLNISRAYLRPGFAFGGSCLPKDLRALIHRARTSDVP
Mvan_1699|M.vanbaalenii_PYR-1 SAAEVHKIFVSDTKLNVSPYYLRPGGAFGGSCLPKDVRALQHIARVSGSS
Mflv_0289|M.gilvum_PYR-GCK DVTLLADALGHDARIGR--RFLNAGLGFGGGCLPKDIRAFMARAGELGAN
MAB_4295c|M.abscessus_ATCC_199 DVTTLADALGYDPRIGR--RFLNAGLGFGGGCLPKDIRAFMARAGELGAS
Mb0330|M.bovis_AF2122/97 DVSQLADALGYDPRIGR--QCLNAGLGFGGGCLPKDIRAFMARAGELGAD
Rv0322|M.tuberculosis_H37Rv DVSQLADALGYDPRIGR--QCLNAGLGFGGGCLPKDIRAFMARAGELGAD
MMAR_0603|M.marinum_M DVSLLADALGYDTRIGR--QCLNAGLGFGGGCLPKDIRAFMARAGELGAN
TH_0768|M.thermoresistible__bu DVVTLADALGHDPRIGR--RFLNAGLGFGGGCLPKDIRAFMARAGELGAN
MAV_4092|M.avium_104 DIDDVTCCMGADRRIGA--EFLRPGPGWGGSCLPKDTAALLDIAHRHRVS
MUL_1511|M.ulcerans_Agy99 DFDRVHHATTYKNSRVD--SLPRAGLAAG-PCLLKDTMQLAAFSNN----
. : . ..* . * ** ** : :
MSMEG_5957|M.smegmatis_MC2_155 -----LPILESVCISNNGQIDRAFNVIEATGKR--RVGLLGLAFKSGTDD
Mvan_1699|M.vanbaalenii_PYR-1 -----THLIDSLITSNEAHKSFLFDHATRGLEHGAKVLLLGIAFKNASDD
Mflv_0289|M.gilvum_PYR-GCK QALTFLREVDSINMRRRTRMVELATTACGGSLLGANIAVLGAAFKPESDD
MAB_4295c|M.abscessus_ATCC_199 HALTFLREVDSINMRRRTRMVELATKACGGSLLGANVAVLGAAFKPESDD
Mb0330|M.bovis_AF2122/97 QALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDD
Rv0322|M.tuberculosis_H37Rv QALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDD
MMAR_0603|M.marinum_M QALTFLREVDSINMRRRTRMVELATTACGGSLLGANLAVLGAAFKPESDD
TH_0768|M.thermoresistible__bu HTLTLLREVDSINMRRRARMVELATTACGGSLLGANIAVLGAAFKPDSDD
MAV_4092|M.avium_104 --FAEVEAARQTNTAQARRIVTALRHTLGRPLSGRRITALGLTFKAATSD
MUL_1511|M.ulcerans_Agy99 ---NFMLGHSAMLINEGQPQFIVNMLKRRVNLRDKTVGILGMTFKADCDD
. : ** :** .*
MSMEG_5957|M.smegmatis_MC2_155 LRESPLVALAERLVGRGFDLQIYDPQVSASRLLGANRAFAEARIPCLSQC
Mvan_1699|M.vanbaalenii_PYR-1 LRESPNIDLARMLITAGYQLSIFDQYVTPQNLIGQNLG-ALSNSPFIREL
Mflv_0289|M.gilvum_PYR-GCK VRDSPALNVAGMLQLHGATVNVYDPKAMDNSRRLFP--TLNYSASALDAC
MAB_4295c|M.abscessus_ATCC_199 VRDSPALNVAGLLQLNGAAVNVYDPKALENSRRLFP--TLNYATSVLEAA
Mb0330|M.bovis_AF2122/97 VRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEAC
Rv0322|M.tuberculosis_H37Rv VRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFP--TLNYAVSVAEAC
MMAR_0603|M.marinum_M VRDSPALNVAGQLQLNGAAVNVYDPKALDNANRLFP--TLNYAVSVAEAC
TH_0768|M.thermoresistible__bu VRDSPALNVAGMLQLNGATVTVYDPKAMENSRRVFP--TLTYSTSVAEAC
MAV_4092|M.avium_104 TRESPALAACRELAAAGAQVAGYDPQLPNIDPAVLQQNRVTAVDDPYRAA
MUL_1511|M.ulcerans_Agy99 TRDSLSFKLRHLLMLEAKEVILHDPFLEGKDYHPLQTVVDRSDVIVVGVP
*:* . * . : .*
MSMEG_5957|M.smegmatis_MC2_155 VSDSPDEVVNHAEVCV--VGAADPESIAALRRVDGRIVVDLVRFPGSVDY
Mvan_1699|M.vanbaalenii_PYR-1 LVDQSVVESTHWDLVIDSRGSADKYALTTSRTIN------ISRLA-----
Mflv_0289|M.gilvum_PYR-GCK ERADAVLVLTEWSEFVGMHPDELSAAVRTKVIVDGRNCLDIGVWRDAGWQ
MAB_4295c|M.abscessus_ATCC_199 DRADAVLLLTEWQEFVDFDPDALAKVVRTKVIVDGRNCLDAAKWVNAGWR
Mb0330|M.bovis_AF2122/97 ERADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWR
Rv0322|M.tuberculosis_H37Rv ERADAVLVLTEWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWR
MMAR_0603|M.marinum_M ERADAVLILTEWQEFVDLDPDDLADRVRARVIVDGRNCLDVSRWERAGWR
TH_0768|M.thermoresistible__bu DRADAVLVLTEWQEFIDLNPAELADIVRAKVIVDGRNCLDVRRWQRAGWK
MAV_4092|M.avium_104 KAADAVVVLTEWPQFRSLDWRAVAQDAPLAVVLDARNSLDPATVREAGLR
MUL_1511|M.ulcerans_Agy99 HSAYRGLRVPRGKVVEDVWGCLD----VTEFDVDPCNGANLAELGTAAAR
. ::
MSMEG_5957|M.smegmatis_MC2_155 QDDPRYIGISW---
Mvan_1699|M.vanbaalenii_PYR-1 --------------
Mflv_0289|M.gilvum_PYR-GCK VHALGRTVEVGA--
MAB_4295c|M.abscessus_ATCC_199 VFCLGKRVEELAHT
Mb0330|M.bovis_AF2122/97 VFRLGVPRLGH---
Rv0322|M.tuberculosis_H37Rv VFRLGVPRLGH---
MMAR_0603|M.marinum_M VFRLGARIRAAS--
TH_0768|M.thermoresistible__bu VFCLGRTP------
MAV_4092|M.avium_104 YLGNGVPQGF----
MUL_1511|M.ulcerans_Agy99 --------------