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AKELKPHFDDVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLGLEPGMTLLDV GCGWGATMRRAFEKYDVNVVGLTLSKNQAAHVQKSFDQLDTARTRRVLLEGWEQFDEPVDRIVSIGAFEH FGHDRYDDFFTLAHNILPSEGVMLLHTITGLIFQQATDRGMPLTFEIARFIKFIVTEIFPGGRLPSIEKV ADHSSKADFTLTRRQSLQPHYARTLDL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0731 | mmaA2 | - | 100% (238) | methoxy mycolic acid synthase 2, MmaA2 |
| M. ulcerans Agy99 | MUL_3772 | mmaA5 | e-119 | 86.55% (238) | methoxy mycolic acid synthase 5 MmaA5 |
| M. ulcerans Agy99 | MUL_4539 | pcaA | e-101 | 73.11% (238) | mycolic acid synthase PcaA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0663c | mmaA2 | 1e-111 | 79.83% (238) | methoxy mycolic acid synthase |
| M. gilvum PYR-GCK | Mflv_3304 | - | 9e-97 | 69.36% (235) | cyclopropane-fatty-acyl-phospholipid synthase |
| M. tuberculosis H37Rv | Rv0644c | mmaA2 | 1e-112 | 80.25% (238) | methoxy mycolic acid synthase |
| M. leprae Br4923 | MLBr_02459 | umaA2 | 1e-101 | 73.11% (238) | Mycolic acid synthase |
| M. abscessus ATCC 19977 | MAB_3881 | - | 1e-87 | 66.24% (234) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. marinum M | MMAR_0979 | mmaA5_1 | 1e-136 | 98.32% (238) | methoxy mycolic acid synthase 5 MmaA5_1 |
| M. avium 104 | MAV_4541 | - | 1e-101 | 73.53% (238) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. smegmatis MC2 155 | MSMEG_1351 | - | 1e-108 | 76.17% (235) | cyclopropane-fatty-acyl-phospholipid synthase 1 |
| M. thermoresistible (build 8) | TH_4640 | - | 1e-109 | 78.06% (237) | PUTATIVE methoxy mycolic acid synthase 5 MmaA5_1 |
| M. vanbaalenii PYR-1 | Mvan_3025 | - | 1e-98 | 71.06% (235) | cyclopropane-fatty-acyl-phospholipid synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3304|M.gilvum_PYR-GCK MSDTPNGSADLQPHFDDVQSHYDLSDDFYRLFLDPTQTYSCAYFERD-DM
Mvan_3025|M.vanbaalenii_PYR-1 MPETTSGSADLQPHFEDVQSHYDLSDDFYRLFLDPTQTYSCAYFERD-DM
MLBr_02459|M.leprae_Br4923 ------MSVQLTPHFRNVQAHYDLSDDFFRLFLDPTLTYSCAYFERD-DM
MUL_0731|M.ulcerans_Agy99 ------MAKELKPHFDDVQAHYDLSDDFFRLFLDPTQTYSCAYFERD-DM
MMAR_0979|M.marinum_M ------MAKELKPHFDDVQAHYDLSDDFFRLFLDPTQTYSCAYFERD-DM
Mb0663c|M.bovis_AF2122/97 ------MVNDLTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFERE-DM
Rv0644c|M.tuberculosis_H37Rv ------MVNDLTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFERE-DM
TH_4640|M.thermoresistible__bu ---MAEPAKKLKPHFADVQAHYDLSDEFFGLFLDPTRTYSCAYFERD-DM
MAV_4541|M.avium_104 ------MAENLTPHFEEVQAHYDLSDDFFRLFLDPTMTYSCAYWDRNRDI
MSMEG_1351|M.smegmatis_MC2_155 ---MTKQPGKLQPHFDEVQAHYDLSDDFFALFLDPSRTYSCAYFERD-DM
MAB_3881|M.abscessus_ATCC_1997 -------MSKLTPKFSDVQAHYDLSDDFFALFLDPSRTYSCAYFEPE-TL
.* *:* :**:******:*: *****: *****::: : :
Mflv_3304|M.gilvum_PYR-GCK TLEEAQRAKIDLALGKLGLEPGMTLLDIGCGWGGTLLRALEKYDVNVIGL
Mvan_3025|M.vanbaalenii_PYR-1 TLEEAQIAKIDLSLGKLGLQPGMTLLDIGCGWGATLLRALDKYDVNVIGL
MLBr_02459|M.leprae_Br4923 TLEEAQLAKVDLALGKLKLEPGMTLLDIGCGWGATMKRAIEIYDVNVIGL
MUL_0731|M.ulcerans_Agy99 TLEEAQIAKIDLALGKLGLEPGMTLLDVGCGWGATMRRAFEKYDVNVVGL
MMAR_0979|M.marinum_M TLEEAQIAKIDLALGKLGLEPGMTLLDVGCGWGATMRRAIEKYDVNVVGL
Mb0663c|M.bovis_AF2122/97 TLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGL
Rv0644c|M.tuberculosis_H37Rv TLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGL
TH_4640|M.thermoresistible__bu SLEEAQLAKIDLALGKLGLQPGMTLLDIGCGWGSTMLRALERHDVDVVGL
MAV_4541|M.avium_104 SLEEAQLRKIDLSLGKLGLRPGMTLLDVGCGWGATMRRAVENYDVNVIGL
MSMEG_1351|M.smegmatis_MC2_155 TLEEAQLAKIDLSLGKLGLQPGMTLLDVGCGWGATMLRALERYDVNVVGL
MAB_3881|M.abscessus_ATCC_1997 TLEQAQQAKIDLALGKLNLEPGMTLLDVGCGWGSTMKRALEHYDVNVIGL
:**:** *:**:**** *.*******:*****.*: **. :**:*:**
Mflv_3304|M.gilvum_PYR-GCK TLSRNQQAHVQKVLDEHDSPRSKTVLLQGWEQFDQPVDRIVSIGAFEHFG
Mvan_3025|M.vanbaalenii_PYR-1 TLSRNQQAHVQKRLDAHGSGRSKRVLLAGWEQFDEPVDRIVSIGAFEHFG
MLBr_02459|M.leprae_Br4923 TLSENQAAHVQKTFDELDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFG
MUL_0731|M.ulcerans_Agy99 TLSKNQAAHVQKSFDQLDTARTRRVLLEGWEQFDEPVDRIVSIGAFEHFG
MMAR_0979|M.marinum_M TLSKNQAAHVQKSFDQLDTARTRRVLLEGWEQFDEPVDRIVSIGAFEHFG
Mb0663c|M.bovis_AF2122/97 TLSKNQAAHVQKSFDEMDTPLDRRVLLAGWEQFNEPVDRIVSIGAFEHFG
Rv0644c|M.tuberculosis_H37Rv TLSKNQAAHVQKSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFG
TH_4640|M.thermoresistible__bu TLSANQHAHVEQLLADSPSRRSRRVLLRGWEEFDEPVDRIVSIGAFEHFG
MAV_4541|M.avium_104 TLSRHQAAHVQQLLDAMDTPRSRRVLLHGWEEFDEPVDRIVSIGAFEHFG
MSMEG_1351|M.smegmatis_MC2_155 TLSRNQQAHVERRFSESSSPRTKRVLLAGWEEFDEPVDRIVSIGAFEHFG
MAB_3881|M.abscessus_ATCC_1997 TLSKNQFAYVNTLLDSAGSSRNYEVRLAGWEEFEGTVDRIVSIGAFEHFG
*** :* *:*: : : * * ***:*. .**************
Mflv_3304|M.gilvum_PYR-GCK SDRYDEFFRRAYSVLPDDGVMLLHTIVKPSDEEFAERKLPLTMTKLKFFK
Mvan_3025|M.vanbaalenii_PYR-1 RDRYDEFFKKAYQVLPDGGVMMLHTIIKPTDEEFADRGLKLTMSIVRFSK
MLBr_02459|M.leprae_Br4923 RQRYARFFKMAHEVLPADSVMLLHTIVRPTFKDARARGMTLTHEIVHFTQ
MUL_0731|M.ulcerans_Agy99 HDRYDDFFTLAHNILPSEGVMLLHTITGLIFQQATDRGMPLTFEIARFIK
MMAR_0979|M.marinum_M HDRYDDFFTLAHNILPSDGVMLLHTITGLTFQQATDRGMPLTFEIARFIK
Mb0663c|M.bovis_AF2122/97 HDRHADFFARAHKILPPDGVLLLHTITGLTRQQMVDHGLPLTLWLARFLK
Rv0644c|M.tuberculosis_H37Rv HDRHADFFARAHKILPPDGVLLLHTITGLTRQQMVDHGLPLTLWLARFLK
TH_4640|M.thermoresistible__bu HDRYDDFFATAHRLLPDDGVMLLHTITALTVPQMVDRGIPLTFEVARFVK
MAV_4541|M.avium_104 YDRYDDFFATAYRVLPDDGVMLLHTITMLTPEQIVERGLPLTEEQTSFNE
MSMEG_1351|M.smegmatis_MC2_155 HERYDDFFRFAHRVLPDDGVMLLHTITGIHPKHAQELGVPLTFEMARFIR
MAB_3881|M.abscessus_ATCC_1997 HERYDSFFAMAHRVLPSDGKMLLHTIVSHHPDEWKRMGIPLLMSRVRFIY
:*: ** *: :** . ::**** . : * *
Mflv_3304|M.gilvum_PYR-GCK FIMDEIFPGGMLPKVDDVEKHATKASFKVNRIQPLRLHYARTLQIWAASL
Mvan_3025|M.vanbaalenii_PYR-1 FIMDEIFPGGDLPKPTTVAEHATKAGFRLTREQRLREHYAKTLDIWADAL
MLBr_02459|M.leprae_Br4923 FILAEIFPGGWLPTVPTVEEHATAAGFKFTRIQSLQLHYAKTLDLWAARL
MUL_0731|M.ulcerans_Agy99 FIVTEIFPGGRLPSIEKVADHSSKADFTLTRRQSLQPHYARTLDL-----
MMAR_0979|M.marinum_M FIVTEIFPGGRLPSIEKVADHSSKAGFTLTRRQSLQPHYARTLDLWAQAL
Mb0663c|M.bovis_AF2122/97 FIATEIFPGGQPPTIEMVEEQSAKTGFTLTRRQSLQPHYARTLDLWAEAL
Rv0644c|M.tuberculosis_H37Rv FIATEIFPGGQPPTIEMVEEQSAKTGFTLTRRQSLQPHYARTLDLWAEAL
TH_4640|M.thermoresistible__bu FILTEIFPGGRLPSIEKVEDHSGANGFTLTRRQSLQSHYARTLDLWAEAL
MAV_4541|M.avium_104 FIATEIFPGGQLPAIEVVEFHSSKMGFTLKRRQSLQLHYARTLDHWADAL
MSMEG_1351|M.smegmatis_MC2_155 FIVTEIFPGGRLPTVDMVIDHATRASFTLERRQSLQLHYARTLDMWAAAL
MAB_3881|M.abscessus_ATCC_1997 FIGTEIFPGGRLPSVPMVDKHAALAGFHITRHHSLQPHYARTLDCWATNL
** ****** * * :: .* . * : *: ***:**:
Mflv_3304|M.gilvum_PYR-GCK ESRRDDAIAIQSEEVYDRYMKYLTGCAELFTEGYTDVCQFTLAK------
Mvan_3025|M.vanbaalenii_PYR-1 RKREDDAVAIQSREDYDRYMKYLTGCADLFRDGYTDICQFTLEK------
MLBr_02459|M.leprae_Br4923 EANKNKAIAIQSEEVYDRYMKYLTGCAKLFRDGYTDVDQFTLEKQPATAR
MUL_0731|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0979|M.marinum_M QARRDEAIEVQSEEVYERYMKYLTGCADGFRVGYIDVNQFTLEKS-----
Mb0663c|M.bovis_AF2122/97 QEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVNQFTLAK------
Rv0644c|M.tuberculosis_H37Rv QEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVNQFTLAK------
TH_4640|M.thermoresistible__bu QQHREEAITVQSDEVYDRYIKYLTGCAKGFRVGYIDVNQFTLQK------
MAV_4541|M.avium_104 RAHHSEAVAIQSEEVYQRYMRYLTGCADAFRAGYIDVNQFTLAK------
MSMEG_1351|M.smegmatis_MC2_155 ESHHDDAVRIQSQEVYDRYMHYLTGCANAFRVGYIDVNQFTLAK------
MAB_3881|M.abscessus_ATCC_1997 AAHEDEAISVQSQEVYDRYIKYLTGCAEGFREGWIDVVQFTCEK------
Mflv_3304|M.gilvum_PYR-GCK --
Mvan_3025|M.vanbaalenii_PYR-1 --
MLBr_02459|M.leprae_Br4923 RH
MUL_0731|M.ulcerans_Agy99 --
MMAR_0979|M.marinum_M --
Mb0663c|M.bovis_AF2122/97 --
Rv0644c|M.tuberculosis_H37Rv --
TH_4640|M.thermoresistible__bu --
MAV_4541|M.avium_104 --
MSMEG_1351|M.smegmatis_MC2_155 --
MAB_3881|M.abscessus_ATCC_1997 --