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SLVLAFGVVLLISVSLSGVAARTVLSSALLFLVAGALLGPGILGLDNIGPNDPIVVALADVALFTVLFTD GQRANVRELRETWTLSGRALGVGMPLTMIGIAVPAHFLTGLNWPTAFLVGAILSPTDPVFAAAIVGRSDI PERLRRLLNVESGLNDGLALPFVMIFLATAQGDGSDVLWVGVELVLGLALGVGVAAAVAFAWRAKILTAE THLQPLGPLAIAVVAYSACHLTHANRYLAAFAVGSTLATLDHVAAEQFQPFGDLLSEVTKFAALIVFGAL ITPDRLSGLSWRDWLLAVVVIAVIRPAAMLLSLVRTQLSRQERLTAAWFGPKGFASVVYGLLALQSGLAS KELVFDIVAVTIALSIVLHSSTDVPIAKVLQVEPPDDLPGCREPADADEEATAEV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0677 | nhaP | - | 100% (406) | ion antiporter, NhaP |
| M. ulcerans Agy99 | MUL_3177 | - | 5e-31 | 26.29% (388) | potassium/proton antiporter |
| M. ulcerans Agy99 | MUL_2572 | - | 6e-05 | 24.09% (357) | membrane transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2309 | yjcE | 1e-09 | 24.44% (446) | integral membrane transport protein YjcE |
| M. gilvum PYR-GCK | Mflv_0160 | - | 6e-34 | 26.18% (382) | potassium/proton antiporter |
| M. tuberculosis H37Rv | Rv2287 | yjcE | 1e-09 | 24.44% (446) | integral membrane transport protein YjcE |
| M. leprae Br4923 | MLBr_00782 | - | 6e-06 | 22.28% (359) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_4717c | - | 6e-33 | 27.11% (380) | potassium/proton antiporter |
| M. marinum M | MMAR_0925 | nhaP | 0.0 | 99.01% (406) | ion antiporter, NhaP |
| M. avium 104 | MAV_3491 | - | 2e-11 | 22.38% (429) | Na+/H+ antiporter |
| M. smegmatis MC2 155 | MSMEG_5825 | - | 2e-26 | 26.63% (383) | Na+/H+ antiporter |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0746 | - | 2e-36 | 27.94% (383) | potassium/proton antiporter |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0677|M.ulcerans_Agy99 ---------MSLVLAFGVVLLISVSLSG---VAARTVLSSALLFLVAGAL
MMAR_0925|M.marinum_M ---------MSLVLAFGVVLLISVSLSG---VAARTVLSSALLFLVAGAL
Mb2309|M.bovis_AF2122/97 MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSL
Rv2287|M.tuberculosis_H37Rv MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSL
MAV_3491|M.avium_104 ------MSSMGAQTALTLLLAAIAVIVLVDWISERTRLPSATLLVLVGIG
Mflv_0160|M.gilvum_PYR-GCK ------MTLHQLYVALFLGGLVLLASIAATRLATGVGLPSLLLFLGVGVL
Mvan_0746|M.vanbaalenii_PYR-1 ------MTLHQLYVALMIGGVVLLASIAATRLATGIGLPSLLLFLGVGVL
MAB_4717c|M.abscessus_ATCC_199 ------MSLHQLYLDLLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVV
MSMEG_5825|M.smegmatis_MC2_155 -----------MLLSLIAISVVLAVWSLLSREMQRLRLTAPMVLVLTGMA
MLBr_00782|M.leprae_Br4923 --------MEISGALLSQVGALLTTLAVLGAGARRYSLSPIPVYLMAGLS
: . . . : *
MUL_0677|M.ulcerans_Agy99 LGPGILGLDNIGPN-DPIVVALADVALFTVLFTDGQRANVRELRETWTLS
MMAR_0925|M.marinum_M LGPGILGLDNIGPN-DPIVVALADVALFTVLFTDGQRANVRELRETWTLS
Mb2309|M.bovis_AF2122/97 LG-LIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIVMFS
Rv2287|M.tuberculosis_H37Rv LG-LIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIVMFS
MAV_3491|M.avium_104 QA-LLPGP-TIGLEPDVVMTCILPPLLYHAALESSLVGIRRNLRTVVSLS
Mflv_0160|M.gilvum_PYR-GCK VG---EGGLGLQFDNAQLGQDLGTAALAVILVEGGLTTRFSDIRKVLAPA
Mvan_0746|M.vanbaalenii_PYR-1 VG---EDGLGLPFDNAQLAQDLGTAALAVILVEGGLTTRFSDIRKVLAPA
MAB_4717c|M.abscessus_ATCC_199 LG---EDGLGLEFDNVELARNVCTAALAVILVEGGLTTRFADIRKVLAPA
MSMEG_5825|M.smegmatis_MC2_155 ISFTMKDHLGVTLN-TDSAEHIAELILAVLLFVDATDVRGGFLGAQPKAA
MLBr_00782|M.leprae_Br4923 LG---KGGIMPVSAADEFITTGAPIGIVLLLLTLGLEFSATEFASSLRRH
. : . . :
MUL_0677|M.ulcerans_Agy99 GRALGVGMPLTMIGIAVPAHFLT-GLNWPTAFLVGAILSPTDPVFAAAIV
MMAR_0925|M.marinum_M GRALGVGMPLTMIGIAVPAHFLT-GLNWPTAFLVGAILSPTDPVFAAAIV
Mb2309|M.bovis_AF2122/97 ---IGLVIATAVAV--SWTARAL-GMESHAAAVLGAVLSPTDAAAVAGLA
Rv2287|M.tuberculosis_H37Rv ---IGLVIATAVAV--SWTARAL-GMESHAAAVLGAVLSPTDAAAVAGLA
MAV_3491|M.avium_104 ---VVLVLLTAASVGVAFSLLVG-GATLAVGMVLGAAVAPTDPVAALAVA
Mflv_0160|M.gilvum_PYR-GCK AVLATLGVAVSTLVTAAAVHWLL-GMNWQLALLLGAVISSTDAAAVFSVL
Mvan_0746|M.vanbaalenii_PYR-1 GVLATVGVAVSTAVTAAAVHWIL-GMDWQLALLLGAVVSSTDAAAVFSVL
MAB_4717c|M.abscessus_ATCC_199 GALATVGVVVSTVVTAFGAHVLL-RMDWQLALLLGAIVSSTDAAAVFSVL
MSMEG_5825|M.smegmatis_MC2_155 LRMLFIAMPVGLALSVLLGLWLLPGLPWAVLLAVACIVVPIDFAPNSALL
MLBr_00782|M.leprae_Br4923 LPSAGVDIILNATPGAVAGWLLG-LDGVAVLALAGVTYISSSGVIARLLA
: : . . . . :
MUL_0677|M.ulcerans_Agy99 GRSDIPERLRRLLNVESGLNDGLALPFVMIFLATAQGDG------SDVLW
MMAR_0925|M.marinum_M GRSDIPERLRRLLNVESGLNDGLALPFVMIFLATAQGAG------SDVLW
Mb2309|M.bovis_AF2122/97 KR--LPRRALTVLRGESLINDGTALVLFAVTVAVAEGAAGI-GPAALVGR
Rv2287|M.tuberculosis_H37Rv KR--LPRRALTVLRGESLINDGTALVLFAVTVAVAEGAAGI-GPAALVGR
MAV_3491|M.avium_104 RKEGLPLNIVTLIEGEGLLNDATALTTLAVAVTVARGAAFS-APSAIR-E
Mflv_0160|M.gilvum_PYR-GCK RVVPLPRRLSGLLEAESGFNDAPAVILVMLFSVVPMELN----AVDIVGT
Mvan_0746|M.vanbaalenii_PYR-1 RVVPLPRRLSGLLEAESGFNDAPAVILVTLFSVVPLDLD----PVTIVGT
MAB_4717c|M.abscessus_ATCC_199 RVLPLPRRLAGLLEAESGFNDAPAVILVLMFSIVPFVFE----PKSTAVQ
MSMEG_5825|M.smegmatis_MC2_155 RDTRIPERVRGLLNVEAGYNDGIVSPVFIFALVLAADSEHASTPMEALGA
MLBr_00782|M.leprae_Br4923 DLRRLGNRETPAVLSVLVLEDFAMAAYLPLFAVLAAGGS-------WLDA
: . : :* . . .
MUL_0677|M.ulcerans_Agy99 VGVELVLGLALGVGVAAAVAFAWR-A-KILTAETHLQPLGPLAIAVVAYS
MMAR_0925|M.marinum_M VGVELVLGLALGVGVAAAVAFAWR-A-KILTAETHLQPLGPLAIAVVVYS
Mb2309|M.bovis_AF2122/97 FVVSYLGGIMAGLLVGGLVTLLRRRI-DAPLEEGALSLLTPFAAFLLAQS
Rv2287|M.tuberculosis_H37Rv FVVSYLGGIMAGLLVGGLVTLLRRRI-DAPLEEGALSLLTPFAAFLLAQS
MAV_3491|M.avium_104 FVLAAVGGLVVGQVFAYARRLLRRWR-HDVLTANAISLATPFLTYLVAEK
Mflv_0160|M.gilvum_PYR-GCK LVYELGIGTVLGLGFGVLGAMTLR---RIALPAAGLYPLATFGLGMLAFA
Mvan_0746|M.vanbaalenii_PYR-1 LAYELAIGTVLGLAAGVLGAMALR---RIALPATGLYPLATFGLGMLAFA
MAB_4717c|M.abscessus_ATCC_199 IVYELLAGSAIGLLCGFLGAMALR---RVALPASGLYPIATFGIGLVAFA
MSMEG_5825|M.smegmatis_MC2_155 AVPEAVKALIAGVVVGAGLALAANAAERRDFMTAQAKRMILVAAPLLSFG
MLBr_00782|M.leprae_Br4923 VVGMIVAVCALFAAFAASYHWGHHVGRLVAHPDSEQLLLRVLGVTLIVAA
. . . ::
MUL_0677|M.ulcerans_Agy99 ACHLTHANRYLAAFAVGSTLATLDHV-AAEQFQPFGDLLSEVTKFAALIV
MMAR_0925|M.marinum_M ACHLTHANPYLAAFAAGSTLATLDHV-AAEQFQPFGDLLSEVTKFAALIV
Mb2309|M.bovis_AF2122/97 LKCSGVVAVLVSALVLTYVGPTVIRA-RSRLQAHAFWDIATFLINGSLWV
Rv2287|M.tuberculosis_H37Rv LKCSGVVAVLVSALVLTYVGPTVIRA-RSRLQAHAFWDIATFLINGSLWV
MAV_3491|M.avium_104 LSASGVLAVVVCGLIVGHDSPRVESG-ASRLQTRAVWRLVNFLLEGVVFL
Mflv_0160|M.gilvum_PYR-GCK AAGTAHGSGFLAAYLASVVLANSGLP-HRSATRSFAEGAGWLAQIGVFVI
Mvan_0746|M.vanbaalenii_PYR-1 AAGSAHGSGFLAAYLAGVVLANSGLP-HRSATRSFAEGAGWLAQIGVFVI
MAB_4717c|M.abscessus_ATCC_199 ASGTVHASGFIAAYLAAVVLANSGLP-HRSATRSFAEGLGWLAQIGLFVL
MSMEG_5825|M.smegmatis_MC2_155 ASLAIGGNGFVAAFVCGIAFNYFRRSEQFHTELELVDDVGFLMTALMWFV
MLBr_00782|M.leprae_Br4923 VAESLHASAAVGAFLVGLTLT----GDTAERARKVLGPLRDLFAAIFFLA
: . .
MUL_0677|M.ulcerans_Agy99 FGALITPDRLSGLSWRDWLLAVVVIAVIRPAAMLLSL-------------
MMAR_0925|M.marinum_M FGALITPDRLSGLSWRDWLLAVVVIAVIRPAAMLLSL-------------
Mb2309|M.bovis_AF2122/97 FVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATRIAWVQATTVLGH
Rv2287|M.tuberculosis_H37Rv FVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATRIAWVQATTVLGH
MAV_3491|M.avium_104 LIGHQVPVILDELGG--YALSTILVAVGVTVAVVLLVRPLWLLLTQALPR
Mflv_0160|M.gilvum_PYR-GCK LGLLVSPDQLLDEVVPAIVAGLALLLLARPISVFLSL-------------
Mvan_0746|M.vanbaalenii_PYR-1 LGLLVSPDELLDEVVPAIVAGLVLLLLARPLSVVLSL-------------
MAB_4717c|M.abscessus_ATCC_199 LGLLVNPSELMDDLLPAILVGLVLLLVARPLSVVVSL-------------
MSMEG_5825|M.smegmatis_MC2_155 FGLTAVLALGSGVPLGLVAFCLLALTVVRIVPVLLAL-------------
MLBr_00782|M.leprae_Br4923 IGISVDPHKLLPMFPTALILATVTAVTKVATGILAAR-------------
: :.
MUL_0677|M.ulcerans_Agy99 -----------------------VRTQLSRQERLTAAWFGPKGFASVVYG
MMAR_0925|M.marinum_M -----------------------VRTQLSRQERLTAAWFGPKGFASVVYG
Mb2309|M.bovis_AF2122/97 TVDRVLK---------------KPTRHVGFRQRCVTSWAGFRGAVSLAAA
Rv2287|M.tuberculosis_H37Rv TVDRVLK---------------KPTRHVGFRQRCVTSWAGFRGAVSLAAA
MAV_3491|M.avium_104 SLHTRLGNVDDSATDDAEPRPERTRERLSGREIVVLSWAGTRGVVSLAAI
Mflv_0160|M.gilvum_PYR-GCK -----------------------IGFRVPWREKMFLSWAGLRGAVPIVLC
Mvan_0746|M.vanbaalenii_PYR-1 -----------------------IGFRVPWREQLFLSWAGLRGAVPIVLC
MAB_4717c|M.abscessus_ATCC_199 -----------------------IGFGVPWREQAFLSWAGLRGAVPVVLA
MSMEG_5825|M.smegmatis_MC2_155 -----------------------LFSPVSWPERLLLGWLGPRGTTSIVFG
MLBr_00782|M.leprae_Br4923 -----------------------YDGVARRGQLRAGTALVARGEFSLIII
: :* .:
MUL_0677|M.ulcerans_Agy99 LLALQSG-----LASKELVFDIVAVTIALSIVLHSSTDVPIAKVLQVEP-
MMAR_0925|M.marinum_M LLALQSG-----LASKELVFDIVAVTIALSIVLHSSTDVPIAKVLQVEP-
Mb2309|M.bovis_AF2122/97 LAVPMTTNSGAPFPDRNLIIFVVSVVILVTVLVQGTSLPTVVRWARMPED
Rv2287|M.tuberculosis_H37Rv LAVPMTTNSGAPFPDRNLIIFVVSVVILVTVLVQGTSLPTVVRWARMPED
MAV_3491|M.avium_104 FAVPVLTEGNAPFPDRDLLLFCTLVVVLVTLIGQGVTFGPLVRALGLRAK
Mflv_0160|M.gilvum_PYR-GCK TYPIVAG-----VPDSWRLLHIVFILVVLYTAIQGPSLRRVAEWLNLIPR
Mvan_0746|M.vanbaalenii_PYR-1 TYPIVAG-----VPDSWRLLNIVFILVVLFTVIQGPSLRPVAEWLHLIPR
MAB_4717c|M.abscessus_ATCC_199 TFPIVAG-----VPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLGLITR
MSMEG_5825|M.smegmatis_MC2_155 LLAFNALDG----VAESTVAMVLVVSVLGSVVLHGVGAPAAARAYQRQQ-
MLBr_00782|M.leprae_Br4923 GLVGTSTP-----AVAALATAYVFIMAIAGPVLARYTPGSLPTSSGSAN-
:
MUL_0677|M.ulcerans_Agy99 -------------------PDDLPGCREP---------------------
MMAR_0925|M.marinum_M -------------------PDDLPGCREP---------------------
Mb2309|M.bovis_AF2122/97 VAHANELQ-LARTRSAQAALDALPTVADELGVAPD-----LVKHLEKEYE
Rv2287|M.tuberculosis_H37Rv VAHANELQ-LARTRSAQAALDALPTVADELGVAPD-----LVKHLEKEYE
MAV_3491|M.avium_104 TTDELRLRNRARAAALRAALDRLDSLDPEDGADVDPRVIDVVRQQLSAQL
Mflv_0160|M.gilvum_PYR-GCK DTTREIQVDAAPLDVLGAELLTMTVLPGSRLHNVT---------------
Mvan_0746|M.vanbaalenii_PYR-1 DTTREIQVDAAPLDVLGAELLTMTVSPGSRLHNVT---------------
MAB_4717c|M.abscessus_ATCC_199 EATREIQVEAAPLDVLDAELLTMKVQPASRLRNVT---------------
MSMEG_5825|M.smegmatis_MC2_155 --------------------TKLSS-------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MUL_0677|M.ulcerans_Agy99 ----------ADADEEATAEV-----------------------------
MMAR_0925|M.marinum_M ----------ADADEEATAEV-----------------------------
Mb2309|M.bovis_AF2122/97 ERAVLVMADGADSATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLID
Rv2287|M.tuberculosis_H37Rv ERAVLVMADGADSATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLID
MAV_3491|M.avium_104 ERYEHRLTLLSDVDELPAAPAYEAAVGLRRVAIDAQRDELVRWRDAGMLP
Mflv_0160|M.gilvum_PYR-GCK --VLELRLPDPSVITLIIRDGQSFVPQPVTRLQIGDELLIVTTSVTRDQA
Mvan_0746|M.vanbaalenii_PYR-1 --VLELRLPDPSVITLIIRAGQPFVPQPVTRLRVGDELLIVTTSVTRDLA
MAB_4717c|M.abscessus_ATCC_199 --ILELRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTSKTRALT
MSMEG_5825|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MUL_0677|M.ulcerans_Agy99 -------------------------
MMAR_0925|M.marinum_M -------------------------
Mb2309|M.bovis_AF2122/97 DIVLRELQAAMDLEEVQLLDPADAE
Rv2287|M.tuberculosis_H37Rv DIVLRELQAAMDLEEVQLLDPADAE
MAV_3491|M.avium_104 DQSLRAIERELDHEESMLPMG----
Mflv_0160|M.gilvum_PYR-GCK ERRLRAVSRRGKLAYWFDEYGDPA-
Mvan_0746|M.vanbaalenii_PYR-1 ERRLRAVSRRGKLAYWFDEYGDQA-
MAB_4717c|M.abscessus_ATCC_199 ESRLRAVSRRGKLAYWFDEYGDVG-
MSMEG_5825|M.smegmatis_MC2_155 -------------------------
MLBr_00782|M.leprae_Br4923 -------------------------