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MSSMGAQTALTLLLAAIAVIVLVDWISERTRLPSATLLVLVGIGQALLPGPTIGLEPDVVMTCILPPLLY HAALESSLVGIRRNLRTVVSLSVVLVLLTAASVGVAFSLLVGGATLAVGMVLGAAVAPTDPVAALAVARK EGLPLNIVTLIEGEGLLNDATALTTLAVAVTVARGAAFSAPSAIREFVLAAVGGLVVGQVFAYARRLLRR WRHDVLTANAISLATPFLTYLVAEKLSASGVLAVVVCGLIVGHDSPRVESGASRLQTRAVWRLVNFLLEG VVFLLIGHQVPVILDELGGYALSTILVAVGVTVAVVLLVRPLWLLLTQALPRSLHTRLGNVDDSATDDAE PRPERTRERLSGREIVVLSWAGTRGVVSLAAIFAVPVLTEGNAPFPDRDLLLFCTLVVVLVTLIGQGVTF GPLVRALGLRAKTTDELRLRNRARAAALRAALDRLDSLDPEDGADVDPRVIDVVRQQLSAQLERYEHRLT LLSDVDELPAAPAYEAAVGLRRVAIDAQRDELVRWRDAGMLPDQSLRAIERELDHEESMLPMG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3491 | - | - | 100% (553) | Na+/H+ antiporter |
| M. avium 104 | MAV_2145 | - | 9e-67 | 34.12% (554) | Na+/H+ antiporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2309 | yjcE | 3e-67 | 34.35% (559) | integral membrane transport protein YjcE |
| M. gilvum PYR-GCK | Mflv_2583 | - | 8e-69 | 34.52% (562) | sodium/hydrogen exchanger |
| M. tuberculosis H37Rv | Rv2287 | yjcE | 3e-67 | 34.35% (559) | integral membrane transport protein YjcE |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4246 | - | 1e-86 | 39.89% (549) | putative Na+/H+ antiporter |
| M. marinum M | MMAR_3437 | yjcE | 5e-67 | 32.31% (554) | integral membrane transport protein YjcE |
| M. smegmatis MC2 155 | MSMEG_0764 | - | 2e-88 | 40.37% (545) | Na+/H+ antiporter |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3177 | - | 3e-18 | 24.03% (462) | potassium/proton antiporter |
| M. vanbaalenii PYR-1 | Mvan_4050 | - | 1e-69 | 35.40% (565) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2309|M.bovis_AF2122/97 ---------------MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHR
Rv2287|M.tuberculosis_H37Rv ---------------MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHR
MMAR_3437|M.marinum_M ---------------------------MFGLVVIVALVATVVIGTVLGRR
MAB_4246|M.abscessus_ATCC_1997 MIHAETAASYLSSRMPTWMLQPLCAQNTNVNVSLLAVLTAALVLAAISRR
MSMEG_0764|M.smegmatis_MC2_155 -----------------------------MGASLLAALVVAVLVAAVARR
Mflv_2583|M.gilvum_PYR-GCK ------------------------MSLENLPVELILVVVGAIVVTAMAQR
Mvan_4050|M.vanbaalenii_PYR-1 -------------------------------MELILVVVGAIVVTAIAQR
MAV_3491|M.avium_104 ---------------------MSSMGAQTALTLLLAAIAVIVLVDWISER
MUL_3177|M.ulcerans_Agy99 ---------------------MSLQQLYLAMLIGGFVLLASIVGTRLATR
: :: :. *
Mb2309|M.bovis_AF2122/97 YRVGPPVLLILSGSLLG---LIPRFGDVQIDGEVVLLLFLPAILYWESMN
Rv2287|M.tuberculosis_H37Rv YRVGPPVLLILSGSLLG---LIPRFGDVQIDGEVVLLLFLPAILYWESMN
MMAR_3437|M.marinum_M YRVGPPVLLILLGALLG---LVPRFGDVQIDGEIVLLLFLPAILYWESLN
MAB_4246|M.abscessus_ATCC_1997 FGLATPLVLVVTGLAAT---AIPGLPSIEMDPDLVLFVILPPLLYTTALE
MSMEG_0764|M.smegmatis_MC2_155 FDVSAPLVLVVAGLAGS---TLPGFGDVALDPDLVLFVILPPLLWSAGME
Mflv_2583|M.gilvum_PYR-GCK RGLEPALVIVVVGIAVS---FIPGFEAPELDSHILLSVVLPPLLYSAALN
Mvan_4050|M.vanbaalenii_PYR-1 RGLEPALIIVVVGIAVS---FVPGFEAPELDSHILLSVVLPPLLYSAALD
MAV_3491|M.avium_104 TRLPSATLLVLVGIGQA---LLPG-PTIGLEPDVVMTCILPPLLYHAALE
MUL_3177|M.ulcerans_Agy99 VGFPSMLLFLLVGVIVGEDGFGLRFDDVELARNMG-TAALAVILVEGGLT
. . :::: * : .: *. :* .:
Mb2309|M.bovis_AF2122/97 TSFREIRWNLRVIVMFSIGLVIATAVAVSWT---ARALGMESHAAAVLGA
Rv2287|M.tuberculosis_H37Rv TSFREIRWNLRVIVMFSIGLVIATAVAVSWT---ARALGMESHAAAVLGA
MMAR_3437|M.marinum_M TSFRELRWNLRIVIMFSIGLVIATAVAVSWT---ARALGMESHAAAVLGA
MAB_4246|M.abscessus_ATCC_1997 SSYVNLRKNVRAVASLAVLLPLVTTVAVGFV-AFYAVPELPLAGAMVLGA
MSMEG_0764|M.smegmatis_MC2_155 SSYVALRRNMRSIGLLAVGLPLVTTFVVGIV-AYHTVPELTLAAALTLGA
Mflv_2583|M.gilvum_PYR-GCK FSFPTFLRNIKPILGLGVGLVVVTAFTVAMVSAWLVVVPLTFATALVLGA
Mvan_4050|M.vanbaalenii_PYR-1 FSFPTFLRNIKPILGLGVGLVVVTAFTVAAVSSWLVVVPLTFATALVLGA
MAV_3491|M.avium_104 SSLVGIRRNLRTVVSLSVVLVLLTAASVGVAFSLLVG-GATLAVGMVLGA
MUL_3177|M.ulcerans_Agy99 TRFSDIRKVLAPAATLATVGVMVSMVVTAVG--VHLVLGVSWQPALLLGA
: : :. : : .. . ***
Mb2309|M.bovis_AF2122/97 VLSPTDAAAVAGLAKR--LPRRALTVLRGESLINDGTALVLFAVTVAVAE
Rv2287|M.tuberculosis_H37Rv VLSPTDAAAVAGLAKR--LPRRALTVLRGESLINDGTALVLFAVTVAVAE
MMAR_3437|M.marinum_M VLSPTDAAAVAGLAKR--LPRRALTVLRGESLINDGTALVLFAVTVAVAE
MAB_4246|M.abscessus_ATCC_1997 IVAPPDAVSATAIGRRLGLPRNIMTLLGGESLLNDATALTAYRVAIAAAI
MSMEG_0764|M.smegmatis_MC2_155 IVAPPDAVSATAVGRRLGLPRRTMTLLGGESLLNDATALTAYKVALAAAI
Mflv_2583|M.gilvum_PYR-GCK IVAPPDAVTAVAVGRKLGLPKRVMTILTGESLINDAAALALFSVAVAQVA
Mvan_4050|M.vanbaalenii_PYR-1 VVAPPDAVTAVAVGRKLGLPKRVMSILTGESLINDAAALALFSVAVAQVA
MAV_3491|M.avium_104 AVAPTDPVAALAVARKEGLPLNIVTLIEGEGLLNDATALTTLAVAVTVAR
MUL_3177|M.ulcerans_Agy99 IVSSTDAAAVFSVLRVLPLPRRVAGLLEAESGFNDAPAVILVLMFSEVPF
::..*..:. .: : ** . :: .*. :**..*: :
Mb2309|M.bovis_AF2122/97 GAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEG--AL
Rv2287|M.tuberculosis_H37Rv GAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEG--AL
MMAR_3437|M.marinum_M GSAQLGPAALAGRFVVSYLGGIVAGLLVGGLVTMLRRKIDAPLEEG--AL
MAB_4246|M.abscessus_ATCC_1997 GLGATVADGFR-IFALAAVGGVFVGFVIGKLVNIIRCKLDDPLSES--AI
MSMEG_0764|M.smegmatis_MC2_155 GAATSWGTALG-TFALAAVGGLVVGLVLGMLVHYVRTRLDDPLVES--AI
Mflv_2583|M.gilvum_PYR-GCK GSHTFIENPLL-LFTYSAVLGPLVGAALGYITLWIRRRLAHPALET--VQ
Mvan_4050|M.vanbaalenii_PYR-1 GSHTFIENPLL-LFAYSAVLGPLVGAALGYITLWIRRRLANPALET--VQ
MAV_3491|M.avium_104 GAAFSAPSAIR-EFVLAAVGGLVVGQVFAYARRLLRRWRHDVLTAN--AI
MUL_3177|M.ulcerans_Agy99 AFR---PAAALEALVFELLVGAAIGLAIGYLGAFTLRRIALPASGLYPIA
. :. : * * ..
Mb2309|M.bovis_AF2122/97 SLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVG-PTVIRARSRLQAHAF
Rv2287|M.tuberculosis_H37Rv SLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVG-PTVIRARSRLQAHAF
MMAR_3437|M.marinum_M SLLTPFAAFLLAQSMHCSGVVAVLISALVLTYTG-PRVIRARSRMQSYAF
MAB_4246|M.abscessus_ATCC_1997 GLVVPFFAYLLAEEIHGSGVIAVVVAGLMLGHRS--VHAGYATRLQDDAV
MSMEG_0764|M.smegmatis_MC2_155 GLVAPFSIYLIAEEAHGSGVIAVVVAALLLGQRE--TQASYATRLQDKAV
Mflv_2583|M.gilvum_PYR-GCK GLMVPFAAFILAEEMHASGVLAVVVAGFIVGSGT--VDAGYQTRLQERYV
Mvan_4050|M.vanbaalenii_PYR-1 GLMVPFAAFILAEEMHASGVLAVVVAGFVVGSGT--VDAGYQTRLQERFV
MAV_3491|M.avium_104 SLATPFLTYLVAEKLSASGVLAVVVCGLIVGHDSPRVESG-ASRLQTRAV
MUL_3177|M.ulcerans_Agy99 TFGLGLVAFAAAGESHASGFIAAYLAAVVLANTG------LPHRAATRSF
: : : * . **.:*. :...:: * .
Mb2309|M.bovis_AF2122/97 WDIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIA
Rv2287|M.tuberculosis_H37Rv WDIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIA
MMAR_3437|M.marinum_M WDITTFLINGSLWVFVGVQIPGAIDHISNVDGGLRRATFIALAVTGVIIA
MAB_4246|M.abscessus_ATCC_1997 WKAVQLLLESFAFLLIGLQLPKVVAGLRG--LSFNTIVLSSVAVLTTVIV
MSMEG_0764|M.smegmatis_MC2_155 WKALQLVLESFAFLLIGLQLPAVVGELAG--ISAATLAISSAAVLAAVIG
Mflv_2583|M.gilvum_PYR-GCK WNSVDVLLEAFVFAYIGLHLRFVLEDLRDAHESLVQVAVASVVVLLIVLV
Mvan_4050|M.vanbaalenii_PYR-1 WNSVDVLLEVFVFAYIGLHLRFVLEDLQQAHESLTQVAVASAVVLLIVLV
MAV_3491|M.avium_104 WRLVNFLLEGVVFLLIGHQVPVILDELGG--YALSTILVAVGVTVAVVLL
MUL_3177|M.ulcerans_Agy99 AEGVGWLAQIGLFVLLGLLVEPIE--------VIHDLIAAIVVGLLLLLV
: : : :* : . ::
Mb2309|M.bovis_AF2122/97 TRIAWVQATTVLGHTVDRVLKKP---------------------------
Rv2287|M.tuberculosis_H37Rv TRIAWVQATTVLGHTVDRVLKKP---------------------------
MMAR_3437|M.marinum_M TRIVWVEVTTVLGVALDRFLKKD---------------------------
MAB_4246|M.abscessus_ATCC_1997 VRIVFVFAFAYL-RPPGQR-------------------------------
MSMEG_0764|M.smegmatis_MC2_155 VRIVWVYGCTYL-GRLFTKNHE----------------------------
Mflv_2583|M.gilvum_PYR-GCK IRPLSVFAMFGR-RKLANQVEKRLSVPVPERG-RGALGARRRDPDRPRRR
Mvan_4050|M.vanbaalenii_PYR-1 IRPLSVFAMFGR-GVLARQVERRLSVPIPEGGGRGALGVRRQSQPPAKWR
MAV_3491|M.avium_104 VRPLWLLLTQALPRSLHTRLGN----------------VDDSATDDAEPR
MUL_3177|M.ulcerans_Agy99 ARPLSVVLSLSG--------------------------------------
* :
Mb2309|M.bovis_AF2122/97 ----TRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLII
Rv2287|M.tuberculosis_H37Rv ----TRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLII
MMAR_3437|M.marinum_M ----TRHVGFRQRCITSWAGFRGAVSLAAALAVPMTTHSGAPFPDRNLII
MAB_4246|M.abscessus_ATCC_1997 -------PSARGVFVVAWAGMRGVVSLAMAFAVPLSTVTGEPLPGHPHIV
MSMEG_0764|M.smegmatis_MC2_155 -----PPPSHAQVFILSWAGMRGVVSLAAAFGIPLITLSGEQFPGRAQLC
Mflv_2583|M.gilvum_PYR-GCK FGSDNRTLSWQENVVVSWTGMRGVVTLAAAAAIPATTAAGEPFPERATIQ
Mvan_4050|M.vanbaalenii_PYR-1 SRIDNRALSWQENVVVSWTGMRGVVTLAAAAAIPATTAAGAPFPERATIQ
MAV_3491|M.avium_104 PERTRERLSGREIVVLSWAGTRGVVSLAAIFAVPVLTEGNAPFPDRDLLL
MUL_3177|M.ulcerans_Agy99 -----FRIPWRDQVFLSWAGLRGAVPIVLATFPIVAG-----VPDSYRLL
. :*:* **.*.:. .* :
Mb2309|M.bovis_AF2122/97 FVVSVVILVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRS--AQAA
Rv2287|M.tuberculosis_H37Rv FVVSVVILVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRS--AQAA
MMAR_3437|M.marinum_M FVVSVVILVTVLVQGSSLPAVVRWARVPGDVAHADEVQLARTRS--AEAA
MAB_4246|M.abscessus_ATCC_1997 FLTFVVVVGTLLLHGLTLPWVIRVLGVQSDDERKDALAEAAAQDKAARAA
MSMEG_0764|M.smegmatis_MC2_155 FLTFVVVVGTLLLHGLTLPWFIRVLGAEGDEAHSDAIATAAAQDKAARAA
Mflv_2583|M.gilvum_PYR-GCK AISFVVAVATLLLQGWTLPLLIRRLKVSAEADRAYTVAETEKAELVVHEA
Mvan_4050|M.vanbaalenii_PYR-1 AIAFVVSVGTLLLQGWTLPLLIRRLKLSADADQAYTSAETQKAEQVVHAA
MAV_3491|M.avium_104 FCTLVVVLVTLIGQGVTFGPLVRALGLRAKTTDELRLRN-RARAAALRAA
MUL_3177|M.ulcerans_Agy99 NIVFMLVVVFTLVQGPSLRPIAHLLGLISREATREIQVEAAPLD-----V
:: : : :* :: . : .
Mb2309|M.bovis_AF2122/97 LDALPTVADELG------VAPDLVKHLEKEYEERAVLVMADGADS---AT
Rv2287|M.tuberculosis_H37Rv LDALPTVADELG------VAPDLVKHLEKEYEERAVLVMADGADS---AT
MMAR_3437|M.marinum_M LEVLPDVASELG------VSPDLLKRLTKEYEERATIIRENGDDS---AP
MAB_4246|M.abscessus_ATCC_1997 ADRLEELLDDNDGIEDTNVRSRAAEILRHWNTRRRNAAWERLGRS---DE
MSMEG_0764|M.smegmatis_MC2_155 AERLDALLAEQP--ASAEVSHRAADVLRAWNTRRRNAAWERLGRD---EE
Mflv_2583|M.gilvum_PYR-GCK ADEVFEVFRANP---PQGLDPRTLAEIRGIVERHSQDADEMP------DP
Mvan_4050|M.vanbaalenii_PYR-1 ADEVLAEFRANP---PDGLDPRVLAEIGGIVARHSQDADEMP------DP
MAV_3491|M.avium_104 LDRLDSLDPEDG----ADVDPRVIDVVRQQLSAQLERYEHRLTLLSDVDE
MUL_3177|M.ulcerans_Agy99 LDAELVTMTVQP--------PSRLHNVTMLELRLPDPAVITLIIR-----
: :
Mb2309|M.bovis_AF2122/97 SDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEE
Rv2287|M.tuberculosis_H37Rv SDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEE
MMAR_3437|M.marinum_M SDLAQRTDLVRRVRLGVLEHQRHAITALRNQNLIDDIVLREVQADMDLEE
MAB_4246|M.abscessus_ATCC_1997 DAGESPMAAFRNLRLEMLETERAVFIAERDAGNIDDEVLRTVLRGLDLEE
MSMEG_0764|M.smegmatis_MC2_155 DIGESPTSAFRRLRLEMLAAERETFIAERDAGHIDDEVLRTVLHGLDLEE
Mflv_2583|M.gilvum_PYR-GCK EGRTRRAEVFGQLYRDVLAAQRAALIGERDAGRIDDEAVRAMLERLDLQE
Mvan_4050|M.vanbaalenii_PYR-1 EAPTLRAEVFGQLYRDVLAAQRVALIGERDAGRIDEEAVRAMLVRLDLQE
MAV_3491|M.avium_104 LPAAPAYEAAVGLRRVAIDAQRDELVRWRDAGMLPDQSLRAIERELDHEE
MUL_3177|M.ulcerans_Agy99 ----KGHTFVPMPDTRIQRGDELLIVTTSTTRAAAESRLRAVSRRGKLAY
:. . : :* : .
Mb2309|M.bovis_AF2122/97 VQLLDPADAE-
Rv2287|M.tuberculosis_H37Rv VQLLDPADAE-
MMAR_3437|M.marinum_M VQLLDPVEHD-
MAB_4246|M.abscessus_ATCC_1997 ATMNQADR---
MSMEG_0764|M.smegmatis_MC2_155 ATLNRD-----
Mflv_2583|M.gilvum_PYR-GCK AGVSARLESRL
Mvan_4050|M.vanbaalenii_PYR-1 AGVSARLESRF
MAV_3491|M.avium_104 SMLPMG-----
MUL_3177|M.ulcerans_Agy99 WFDEYGEPD--