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LLSLIAISVVLAVWSLLSREMQRLRLTAPMVLVLTGMAISFTMKDHLGVTLNTDSAEHIAELILAVLLFV DATDVRGGFLGAQPKAALRMLFIAMPVGLALSVLLGLWLLPGLPWAVLLAVACIVVPIDFAPNSALLRDT RIPERVRGLLNVEAGYNDGIVSPVFIFALVLAADSEHASTPMEALGAAVPEAVKALIAGVVVGAGLALAA NAAERRDFMTAQAKRMILVAAPLLSFGASLAIGGNGFVAAFVCGIAFNYFRRSEQFHTELELVDDVGFLM TALMWFVFGLTAVLALGSGVPLGLVAFCLLALTVVRIVPVLLALLFSPVSWPERLLLGWLGPRGTTSIVF GLLAFNALDGVAESTVAMVLVVSVLGSVVLHGVGAPAAARAYQRQQTKLSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5825 | - | - | 100% (402) | Na+/H+ antiporter |
| M. smegmatis MC2 155 | MSMEG_0764 | - | 2e-13 | 25.18% (413) | Na+/H+ antiporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2309 | yjcE | 3e-07 | 21.60% (426) | integral membrane transport protein YjcE |
| M. gilvum PYR-GCK | Mflv_0160 | - | 7e-16 | 26.04% (361) | potassium/proton antiporter |
| M. tuberculosis H37Rv | Rv2287 | yjcE | 3e-07 | 21.60% (426) | integral membrane transport protein YjcE |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4717c | - | 7e-17 | 25.65% (382) | potassium/proton antiporter |
| M. marinum M | MMAR_0925 | nhaP | 8e-27 | 26.89% (383) | ion antiporter, NhaP |
| M. avium 104 | MAV_3491 | - | 2e-12 | 24.19% (339) | Na+/H+ antiporter |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0677 | nhaP | 2e-26 | 26.63% (383) | ion antiporter, NhaP |
| M. vanbaalenii PYR-1 | Mvan_0746 | - | 6e-18 | 25.00% (356) | potassium/proton antiporter |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0925|M.marinum_M -----------MSLVLAFG-VVLLISVSLSGVAARTVLSSALLFLVAGAL
MUL_0677|M.ulcerans_Agy99 -----------MSLVLAFG-VVLLISVSLSGVAARTVLSSALLFLVAGAL
Mflv_0160|M.gilvum_PYR-GCK ------MTLHQLYVALFLGGLVLLASIAATRLATGVGLPSLLLFLGVGVL
Mvan_0746|M.vanbaalenii_PYR-1 ------MTLHQLYVALMIGGVVLLASIAATRLATGIGLPSLLLFLGVGVL
MAB_4717c|M.abscessus_ATCC_199 ------MSLHQLYLDLLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVV
Mb2309|M.bovis_AF2122/97 MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSL
Rv2287|M.tuberculosis_H37Rv MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSL
MAV_3491|M.avium_104 ------MSSMGAQTALTLLLAAIAVIVLVDWISERTRLPSATLLVLVGIG
MSMEG_5825|M.smegmatis_MC2_155 -----------MLLSLIAISVVLAVWSLLSREMQRLRLTAPMVLVLTGMA
* : . . .:: *
MMAR_0925|M.marinum_M LGPGILGLDNIGPNDPIVVALADVALFTVLFTDGQRANVRELRETWTLSG
MUL_0677|M.ulcerans_Agy99 LGPGILGLDNIGPNDPIVVALADVALFTVLFTDGQRANVRELRETWTLSG
Mflv_0160|M.gilvum_PYR-GCK VGEGGLGLQ--FDNAQLGQDLGTAALAVILVEGGLTTRFSDIRKVLAPAA
Mvan_0746|M.vanbaalenii_PYR-1 VGEDGLGLP--FDNAQLAQDLGTAALAVILVEGGLTTRFSDIRKVLAPAG
MAB_4717c|M.abscessus_ATCC_199 LGEDGLGLE--FDNVELARNVCTAALAVILVEGGLTTRFADIRKVLAPAG
Mb2309|M.bovis_AF2122/97 LG----LIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIV
Rv2287|M.tuberculosis_H37Rv LG----LIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIV
MAV_3491|M.avium_104 QA----LLPGP-TIGLEPDVVMTCILPPLLYHAALESSLVGIRRNLRTVV
MSMEG_5825|M.smegmatis_MC2_155 ISFTMKDHLGVTLNTDSAEHIAELILAVLLFVDATDVRGGFLGAQPKAAL
. : * :* . :
MMAR_0925|M.marinum_M RALGVGMPLTMIGIAVPAHFLTG-LNWPTAFLVGAILSPTDPVFAAAIVG
MUL_0677|M.ulcerans_Agy99 RALGVGMPLTMIGIAVPAHFLTG-LNWPTAFLVGAILSPTDPVFAAAIVG
Mflv_0160|M.gilvum_PYR-GCK VLATLGVAVSTLVTAAAVHWLLG-MNWQLALLLGAVISSTDAAAVFSVLR
Mvan_0746|M.vanbaalenii_PYR-1 VLATVGVAVSTAVTAAAVHWILG-MDWQLALLLGAVVSSTDAAAVFSVLR
MAB_4717c|M.abscessus_ATCC_199 ALATVGVVVSTVVTAFGAHVLLR-MDWQLALLLGAIVSSTDAAAVFSVLR
Mb2309|M.bovis_AF2122/97 MFSIGLVIATAVAV--SWTARALGMESHAAAVLGAVLSPTDAAAVAGLAK
Rv2287|M.tuberculosis_H37Rv MFSIGLVIATAVAV--SWTARALGMESHAAAVLGAVLSPTDAAAVAGLAK
MAV_3491|M.avium_104 SLSVVLVLLTAASVGVAFSLLVGGATLAVGMVLGAAVAPTDPVAALAVAR
MSMEG_5825|M.smegmatis_MC2_155 RMLFIAMPVGLALSVLLGLWLLPGLPWAVLLAVACIVVPIDFAPNSALLR
: :.. : . * . .:
MMAR_0925|M.marinum_M RSDIPERLRRLLNVESGLNDGLALPFVMIFLATAQ--------GAG--SD
MUL_0677|M.ulcerans_Agy99 RSDIPERLRRLLNVESGLNDGLALPFVMIFLATAQ--------GDG--SD
Mflv_0160|M.gilvum_PYR-GCK VVPLPRRLSGLLEAESGFNDAPAVILVMLFSVVPM--------ELNAVDI
Mvan_0746|M.vanbaalenii_PYR-1 VVPLPRRLSGLLEAESGFNDAPAVILVTLFSVVPL--------DLDPVTI
MAB_4717c|M.abscessus_ATCC_199 VLPLPRRLAGLLEAESGFNDAPAVILVLMFSIVPF--------VFEPKST
Mb2309|M.bovis_AF2122/97 R--LPRRALTVLRGESLINDGTALVLFAVTVAVAEG-----AAGIGPAAL
Rv2287|M.tuberculosis_H37Rv R--LPRRALTVLRGESLINDGTALVLFAVTVAVAEG-----AAGIGPAAL
MAV_3491|M.avium_104 KEGLPLNIVTLIEGEGLLNDATALTTLAVAVTVARG-----AAFSAPSAI
MSMEG_5825|M.smegmatis_MC2_155 DTRIPERVRGLLNVEAGYNDGIVSPVFIFALVLAADSEHASTPMEALGAA
:* . ::. *. **. . . . .
MMAR_0925|M.marinum_M VLWVGVELVLGLALGVGVAAAVAFAWRAKILTAETHLQPLGPLAIAVVVY
MUL_0677|M.ulcerans_Agy99 VLWVGVELVLGLALGVGVAAAVAFAWRAKILTAETHLQPLGPLAIAVVAY
Mflv_0160|M.gilvum_PYR-GCK VGTLVYELGIGTVLGLGFGVLGAMTLRRIALPAAG-LYPLATFGLGMLAF
Mvan_0746|M.vanbaalenii_PYR-1 VGTLAYELAIGTVLGLAAGVLGAMALRRIALPATG-LYPLATFGLGMLAF
MAB_4717c|M.abscessus_ATCC_199 AVQIVYELLAGSAIGLLCGFLGAMALRRVALPASG-LYPIATFGIGLVAF
Mb2309|M.bovis_AF2122/97 VGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTP---FAAF
Rv2287|M.tuberculosis_H37Rv VGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTP---FAAF
MAV_3491|M.avium_104 R-EFVLAAVGGLVVGQVFAYARRLLRRWRHDVLTANAISLATP---FLTY
MSMEG_5825|M.smegmatis_MC2_155 VPEAVKALIAGVVVGAGLALAANAAERRDFMTAQAKRMILVAAP--LLSF
* * . * : . . :
MMAR_0925|M.marinum_M SACHLTHANPYLAAFAAGSTLATLD-----HVAAEQFQPFGDLLSEVTKF
MUL_0677|M.ulcerans_Agy99 SACHLTHANRYLAAFAVGSTLATLD-----HVAAEQFQPFGDLLSEVTKF
Mflv_0160|M.gilvum_PYR-GCK AAAGTAHGSGFLAAYLASVVLANSG-----LPHRSATRSFAEGAGWLAQI
Mvan_0746|M.vanbaalenii_PYR-1 AAAGSAHGSGFLAAYLAGVVLANSG-----LPHRSATRSFAEGAGWLAQI
MAB_4717c|M.abscessus_ATCC_199 AASGTVHASGFIAAYLAAVVLANSG-----LPHRSATRSFAEGLGWLAQI
Mb2309|M.bovis_AF2122/97 LLAQSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLING
Rv2287|M.tuberculosis_H37Rv LLAQSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLING
MAV_3491|M.avium_104 LVAEKLSASGVLAVVVCGLIVGHDSPRVESGASRLQTRAVWRLVNFLLEG
MSMEG_5825|M.smegmatis_MC2_155 GASLAIGGNGFVAAFVCGIAFNYFR----RSEQFHTELELVDDVGFLMTA
. . :*. . . . :
MMAR_0925|M.marinum_M AALIVFGALIT--------PDRLSGLSWRDWLLAVVVIAVIRPAAMLLSL
MUL_0677|M.ulcerans_Agy99 AALIVFGALIT--------PDRLSGLSWRDWLLAVVVIAVIRPAAMLLSL
Mflv_0160|M.gilvum_PYR-GCK GVFVILGLLVS--------PDQLLDEVVPAIVAGLALLLLARPISVFLSL
Mvan_0746|M.vanbaalenii_PYR-1 GVFVILGLLVS--------PDELLDEVVPAIVAGLVLLLLARPLSVVLSL
MAB_4717c|M.abscessus_ATCC_199 GLFVLLGLLVN--------PSELMDDLLPAILVGLVLLLVARPLSVVVSL
Mb2309|M.bovis_AF2122/97 SLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATRIAWVQATT
Rv2287|M.tuberculosis_H37Rv SLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATRIAWVQATT
MAV_3491|M.avium_104 VVFLLIGHQVPVILDELGG--YALSTILVAVGVTVAVVLLVRPLWLLLTQ
MSMEG_5825|M.smegmatis_MC2_155 LMWFVFGLTAV--------LALGSGVPLGLVAFCLLALTVVRIVPVLLAL
...* : * : :
MMAR_0925|M.marinum_M VR---------------------------TQLSRQERLTAAWFGPKGFAS
MUL_0677|M.ulcerans_Agy99 VR---------------------------TQLSRQERLTAAWFGPKGFAS
Mflv_0160|M.gilvum_PYR-GCK IG---------------------------FRVPWREKMFLSWAGLRGAVP
Mvan_0746|M.vanbaalenii_PYR-1 IG---------------------------FRVPWREQLFLSWAGLRGAVP
MAB_4717c|M.abscessus_ATCC_199 IG---------------------------FGVPWREQAFLSWAGLRGAVP
Mb2309|M.bovis_AF2122/97 VLGHTVDRVLK---------------KPTRHVGFRQRCVTSWAGFRGAVS
Rv2287|M.tuberculosis_H37Rv VLGHTVDRVLK---------------KPTRHVGFRQRCVTSWAGFRGAVS
MAV_3491|M.avium_104 ALPRSLHTRLGNVDDSATDDAEPRPERTRERLSGREIVVLSWAGTRGVVS
MSMEG_5825|M.smegmatis_MC2_155 LFS---------------------------PVSWPERLLLGWLGPRGTTS
: : .* * :* ..
MMAR_0925|M.marinum_M VVYGLLALQSG-----LASKELVFDIVAVTIALSIVLHSSTDVPIAKVLQ
MUL_0677|M.ulcerans_Agy99 VVYGLLALQSG-----LASKELVFDIVAVTIALSIVLHSSTDVPIAKVLQ
Mflv_0160|M.gilvum_PYR-GCK IVLCTYPIVAG-----VPDSWRLLHIVFILVVLYTAIQGPSLRRVAEWLN
Mvan_0746|M.vanbaalenii_PYR-1 IVLCTYPIVAG-----VPDSWRLLNIVFILVVLFTVIQGPSLRPVAEWLH
MAB_4717c|M.abscessus_ATCC_199 VVLATFPIVAG-----VPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLG
Mb2309|M.bovis_AF2122/97 LAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTVLVQGTSLPTVVRWAR
Rv2287|M.tuberculosis_H37Rv LAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTVLVQGTSLPTVVRWAR
MAV_3491|M.avium_104 LAAIFAVPVLTEGNAPFPDRDLLLFCTLVVVLVTLIGQGVTFGPLVRALG
MSMEG_5825|M.smegmatis_MC2_155 IVFGLLAFNALDG----VAESTVAMVLVVSVLGSVVLHGVGAPAAARAYQ
:. : : : :. ..
MMAR_0925|M.marinum_M VEPPDDLPGCREPADADEEATAEV--------------------------
MUL_0677|M.ulcerans_Agy99 VEPPDDLPGCREPADADEEATAEV--------------------------
Mflv_0160|M.gilvum_PYR-GCK LIPRDTTREIQVDAAPLDVLGAELLTMTVLPGSRLHNVT--------VLE
Mvan_0746|M.vanbaalenii_PYR-1 LIPRDTTREIQVDAAPLDVLGAELLTMTVSPGSRLHNVT--------VLE
MAB_4717c|M.abscessus_ATCC_199 LITREATREIQVEAAPLDVLDAELLTMKVQPASRLRNVT--------ILE
Mb2309|M.bovis_AF2122/97 MPEDVAHANELQ-LARTRSAQAALDALPTVADELGVAPD-----LVKHLE
Rv2287|M.tuberculosis_H37Rv MPEDVAHANELQ-LARTRSAQAALDALPTVADELGVAPD-----LVKHLE
MAV_3491|M.avium_104 LRAKTTDELRLRNRARAAALRAALDRLDSLDPEDGADVDPRVIDVVRQQL
MSMEG_5825|M.smegmatis_MC2_155 RQQTKLSS------------------------------------------
MMAR_0925|M.marinum_M --------------------------------------------------
MUL_0677|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0160|M.gilvum_PYR-GCK LRLPDPSVITLIIRDGQSFVPQPVTRLQIGDELLIVTTSVTRDQAERRLR
Mvan_0746|M.vanbaalenii_PYR-1 LRLPDPSVITLIIRAGQPFVPQPVTRLRVGDELLIVTTSVTRDLAERRLR
MAB_4717c|M.abscessus_ATCC_199 LRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTSKTRALTESRLR
Mb2309|M.bovis_AF2122/97 KEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQ
Rv2287|M.tuberculosis_H37Rv KEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQ
MAV_3491|M.avium_104 SAQLERYEHRLTLLSDVDELPAAPAYEAAVGLRRVAIDAQRDELVRWRDA
MSMEG_5825|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0925|M.marinum_M -----------------------------
MUL_0677|M.ulcerans_Agy99 -----------------------------
Mflv_0160|M.gilvum_PYR-GCK AVSRRGKLAYWFDEYGDPA----------
Mvan_0746|M.vanbaalenii_PYR-1 AVSRRGKLAYWFDEYGDQA----------
MAB_4717c|M.abscessus_ATCC_199 AVSRRGKLAYWFDEYGDVG----------
Mb2309|M.bovis_AF2122/97 NLIDDIVLRELQAAMDLEEVQLLDPADAE
Rv2287|M.tuberculosis_H37Rv NLIDDIVLRELQAAMDLEEVQLLDPADAE
MAV_3491|M.avium_104 GMLPDQSLRAIERELDHEESMLPMG----
MSMEG_5825|M.smegmatis_MC2_155 -----------------------------