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VSLVRVAPQVVADGVGNLARIGSSIGVANAAAAAATTTMVPAGGDEVSAAVADGQFQVLAEPVQTLGQAW LASPAGELLDPLVNAPFESLTGRELIGNGAAGVAGVDGGAGQAGGWLFGDGGPGAAATATSAAGRGGDAG LIGAGGAGGAGWANSGVAMMAGGAGGDGGLLLGDGGPGSPGAASFDPTVAGGAGGPGGDARGIGDGGRGG DGGPGATGAPGGRGSDGGPGGKGGNAGDYGTGGTGGTGGIGGAGGPGSPGGTPGAQGFRAGDAGNGGVGG IGGDGGHIKGHGGAGGIGGTGGAGVIGGDGVIGGDGQAGSAGEFPGDRGGSGGAGARGGNGGDGGAGGAG GHALAEGFHDGAAGTGGMGGDGGNGADGGDGHSGDPSWRSGGDGGNGGNGAYGGSGGQGGLNGDGATRAA HGVQGTMGDGGDGGDGGNGSTTSDQVDIDGGNGGYGGWGFNGGNGGNGGDGGTRPKGTLFFRSGGDGGFG GWGGNGYGGVGGGNGGAGGTAYTSGGVYAGGPVQPGTEGTGPSGDHGGFGGSGGIGGHGGQAP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_0391 | - | - | 100% (553) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_4381 | - | e-164 | 57.78% (540) | PE-PGRS family protein |
M. ulcerans Agy99 | MUL_0212 | - | e-114 | 44.77% (612) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1485c | PE_PGRS27 | 1e-119 | 46.60% (618) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 7e-99 | 47.56% (471) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | 1e-121 | 45.14% (627) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01556 | infB | 5e-10 | 41.90% (105) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_4284c | - | 3e-39 | 30.80% (487) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_4822 | - | 0.0 | 84.74% (629) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 1e-21 | 40.91% (176) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 8e-86 | 40.13% (613) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 4e-43 | 38.81% (335) | PUTATIVE - |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-100 | 47.38% (496) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MUL_0391|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4822|M.marinum_M -------------------------------------------------- Mb1485c|M.bovis_AF2122/97 -------------------------------------------------- Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MUL_0391|M.ulcerans_Agy99 ------------------MSLVRVAPQVVADGVGNLARIGSSIGVANAAA MMAR_4822|M.marinum_M ------------------MSLVRVAPQVVADGVGNLARIRSSIGVANAAA Mb1485c|M.bovis_AF2122/97 ------------------MSLVIVAPETVAAAALDVARIGSSIGVANSAA Rv1091|M.tuberculosis_H37Rv ------------------MSFVIAAPEALVAVASDLAGIGSALAEANAAA Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSA MAV_4827|M.avium_104 ------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEED MLBr_01556|M.leprae_Br4923 ------------------MAGKARVHELAKELGVTSKEVLARLNEQGEFV MUL_0391|M.ulcerans_Agy99 AAAT--------------------------------TTMVPAGGDEVS-- MMAR_4822|M.marinum_M AAAT--------------------------------TTMVPAGGDEVSVA Mb1485c|M.bovis_AF2122/97 AGST--------------------------------TSVLAAGADEVSAA Rv1091|M.tuberculosis_H37Rv LAPT--------------------------------TALLAAGADEVSAA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VSAAQVG------------------------------AVMPVVAESVASN MAV_4827|M.avium_104 AIDVTG----------------------------ADDAATASAPDRVISA MLBr_01556|M.leprae_Br4923 KSAS--------------------------------STVEAPVARRLRES MUL_0391|M.ulcerans_Agy99 ---------------------------------------------AAVAD MMAR_4822|M.marinum_M VVGLFRGLGQDYQLFGAQLEQFHQRFVQILDAARTAYLETETAAAAAVAD Mb1485c|M.bovis_AF2122/97 IATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLAT Rv1091|M.tuberculosis_H37Rv IAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAAEAANVSAAQS Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 YG-------------YQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSP MAV_4827|M.avium_104 ILG-------------------------TREGAADAGLQLSSIGVTWTDQ MLBr_01556|M.leprae_Br4923 FGG------------------------IKPAADKGAEQVATKAQAKRLGE MUL_0391|M.ulcerans_Agy99 GQFQVL----------------AEPVQTLG--------QAWLAS------ MMAR_4822|M.marinum_M GQFQVL----------------AEPVQTLG--------QAWLGS------ Mb1485c|M.bovis_AF2122/97 LEHNVLNA------------LNAPTQALLG--------RPLIGDGAAGAP Rv1091|M.tuberculosis_H37Rv TDQRLLDL------------INGPTQALLG--------RPLIGDGANGGP Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SLLSPRDN--------------------------------DFLSHNDTDF MAV_4827|M.avium_104 LEAAALRD--------------------------------ALAARRIDNV MLBr_01556|M.leprae_Br4923 SLDQTLDR---------------ALDKAVAGNGATTAAPVQVDHSAAVVP MUL_0391|M.ulcerans_Agy99 -------PAGELLDPLVNAPFESLTG--------RELIG-NGAAG---VA MMAR_4822|M.marinum_M -------PAGELLDPLVNAPFESLTG--------RELIG-NGAAG---VA Mb1485c|M.bovis_AF2122/97 GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFG-TGGAGGAGGA Rv1091|M.tuberculosis_H37Rv --GQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAAGLIG-NGGAGGGGGA Mflv_5091|M.gilvum_PYR-GCK QN------GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG Mvan_1264|M.vanbaalenii_PYR-1 QN------GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG MSMEG_0868|M.smegmatis_MC2_155 DNPN-GGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA TH_3810|M.thermoresistible__bu -----------VDGDGGSGG-------------RTGLFS----------K MAB_4284c|M.abscessus_ATCC_199 ASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAV MAV_4827|M.avium_104 MLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDV MLBr_01556|M.leprae_Br4923 IVAGEGPSTAHREELAPPAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTG MUL_0391|M.ulcerans_Agy99 GVDGGAGQAGG--WLFGDGGPGAAATATSAA------------------- MMAR_4822|M.marinum_M GVDGGAGQAGG--WLFGDGGPGAAATATSAA------------------- Mb1485c|M.bovis_AF2122/97 GAAGGAGGSGG--WLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGVGGTG Rv1091|M.tuberculosis_H37Rv GAAGGNGGAGG--WLYGNGGAGGAGGTSVIPGVAG--------------- Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG------------- Mvan_1264|M.vanbaalenii_PYR-1 SGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG------------- MSMEG_0868|M.smegmatis_MC2_155 GLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGG----------- TH_3810|M.thermoresistible__bu LSRGGDGGDGG---LGGNGGHGGGTGIIS--------------------- MAB_4284c|M.abscessus_ATCC_199 AVGGSNSGPIAS----GQGSTAVNGDVRDSNIINADHG------------ MAV_4827|M.avium_104 YKQQIRAESYG--DAAGQLSAMVAGLEKLESLPGGLLLVG---------- MLBr_01556|M.leprae_Br4923 PHPGPAPKPGGRPPRVGNNPFSSAQSVARPIPRPPAPRPS---------- . * MUL_0391|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4822|M.marinum_M -------------------------------------------------- Mb1485c|M.bovis_AF2122/97 GPGGPGGPGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGG Rv1091|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------------APGV Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------------APGV MSMEG_0868|M.smegmatis_MC2_155 ----------------------------------------------TGGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MUL_0391|M.ulcerans_Agy99 -----GRGGDAGLIGAGG-----AGGAG-WANSGVAMMAG---------- MMAR_4822|M.marinum_M -----GRGGDAGLIGAGG-----AGGAG-WANSGVAMMAG---------- Mb1485c|M.bovis_AF2122/97 VGGHGGVGGAAGLLGVGG-----HGGAGGHGAAGIAGAAGKGG------- Rv1091|M.tuberculosis_H37Rv --GNGGAGGSAGLWGTGG-----AGGDGGNGRSGPVNVAG---------- Mflv_5091|M.gilvum_PYR-GCK AGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------- Mvan_1264|M.vanbaalenii_PYR-1 AGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------- MSMEG_0868|M.smegmatis_MC2_155 GGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYV TH_3810|M.thermoresistible__bu ---------LLSLAGNGG-----NGGNGYRTTDNNALDGG---------- MAB_4284c|M.abscessus_ATCC_199 ----SNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQ------- MAV_4827|M.avium_104 -SGVDVAPLKQVLQTTTFLDVSVAEEPETALARGAALAAANAP------- MLBr_01556|M.leprae_Br4923 ASPSSMSPRPGGAVGGGGPRPPRTGVPRPGGGRPGAPVGGRSD------- . MUL_0391|M.ulcerans_Agy99 ---------------GAGGDGG---------LLLGDGGP----------- MMAR_4822|M.marinum_M ---------------GAGGDGG---------LVFGDGGP----------- Mb1485c|M.bovis_AF2122/97 -------IFPDGSNGGAGGDAGDGGTGGRGGWLAGAGGAGGDGGIG---- Rv1091|M.tuberculosis_H37Rv ---------SAGGNGGAGGAAG----------LFGDAGAGGNG------- Mflv_5091|M.gilvum_PYR-GCK -------AVGSAGAAGEAGETGTWG----NAGLPGKAGDAGGAG------ Mvan_1264|M.vanbaalenii_PYR-1 -------AVGSAGTAGSAGAPGVWG----NAGLPGAAGAAGGAG------ MSMEG_0868|M.smegmatis_MC2_155 LIAGPNVTVGSETRGGTGGAGGTGGQS--TAAGPGKGGGGGGGGGGAILI TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MUL_0391|M.ulcerans_Agy99 ------------GSPGAASFD--------------------PTVAGGAG- MMAR_4822|M.marinum_M ------------GSPGAASFD--------------------PTVAGGAG- Mb1485c|M.bovis_AF2122/97 ----------GTGGAGGAGFSRALIVAGDNGGDGGNGGMGGAGGAGGPG- Rv1091|M.tuberculosis_H37Rv ----------GKGGAGGAAFS-INFTAGD-------------GGAGGAG- Mflv_5091|M.gilvum_PYR-GCK ----------AVGAAGAAG------TVGTA------------GATGGTG- Mvan_1264|M.vanbaalenii_PYR-1 ----------AIGTAGVAG------AAGTA------------GATGGTG- MSMEG_0868|M.smegmatis_MC2_155 GANGGTVDGHAIGGNGGNGGNGSTTAAGGN------------GGTGGTGR TH_3810|M.thermoresistible__bu --------------------------------------------HGGNG- MAB_4284c|M.abscessus_ATCC_199 ----------RNTTNINDSFN--------------------TDRSTNIG- MAV_4827|M.avium_104 ---------LFASSTAALAY----------------------AQDPGTG- MLBr_01556|M.leprae_Br4923 ----------AGGGNYRGGG---------------------VGALPGGG- . * MUL_0391|M.ulcerans_Agy99 ----------------GPGGDARGIGDGGRGGDG--------------GP MMAR_4822|M.marinum_M ----------------GPGGDARGIGDGGRGGDG--------------GP Mb1485c|M.bovis_AF2122/97 ----------------GAGGLISLLGGQGAGGDG--------------GD Rv1091|M.tuberculosis_H37Rv ----------------GSGGHALLWGAGGAGGNG--------------GS Mflv_5091|M.gilvum_PYR-GCK --------------TGANGGAGGVGGVGGTGAAG--------------AA Mvan_1264|M.vanbaalenii_PYR-1 --------------VGGNGGAGQAGGIGGTGAAG--------------AA MSMEG_0868|M.smegmatis_MC2_155 VIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTAT TH_3810|M.thermoresistible__bu ----------------GNVGFFSLFNLGGAGGWG--------------GS MAB_4284c|M.abscessus_ATCC_199 ----------------SGNTTNTEIGSHNQANIG--------------TS MAV_4827|M.avium_104 -----------------AVDQYSLPDYLYVPVDP--------------EP MLBr_01556|M.leprae_Br4923 -----------------SGGFRGRPGGGGHGGGG--------------RP . MUL_0391|M.ulcerans_Agy99 GATG------------------APGGRG---------------------- MMAR_4822|M.marinum_M GATG------------------APGGRG---------------------- Mb1485c|M.bovis_AF2122/97 GGAGGVGGDRGAGANGNQAVNAGAGGAGGH--GGDPGAGGAGGTGGAGST Rv1091|M.tuberculosis_H37Rv GGTGGAGG-----------STAGAGGNG-----------GAGGGGGTGGL Mflv_5091|M.gilvum_PYR-GCK GGAGGLGETG---------TTGGAGGVGGQ--GTAGGTGGVGGIGGAGST Mvan_1264|M.vanbaalenii_PYR-1 GQAGTAGETG---------VTGGVGGIGGQ--GTEGGTGGVGGVGGVGAT MSMEG_0868|M.smegmatis_MC2_155 GGRGGDGIDG---------GTGGAGGMGEIYSGADGEATGISAGGDGGSA TH_3810|M.thermoresistible__bu GVDG----------------VDVVGGNP---------------------- MAB_4284c|M.abscessus_ATCC_199 TSAG------------------GSAAVG---------------------- MAV_4827|M.avium_104 GDDE-----------------LAYSAVGEE-------------------- MLBr_01556|M.leprae_Br4923 GQRG-----------------GAAGAFGRP-------------------- .. MUL_0391|M.ulcerans_Agy99 ---------------------------------------------SDGGP MMAR_4822|M.marinum_M ---------------------------------------------SDGGP Mb1485c|M.bovis_AF2122/97 IGAHGAAGASPTSGGNGGAGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGA Rv1091|M.tuberculosis_H37Rv LFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGGAG------GDGGA Mflv_5091|M.gilvum_PYR-GCK GAVGGVGGKG----IQGGQG-------------LQGGKG------GDGGA Mvan_1264|M.vanbaalenii_PYR-1 GGAGGVGGKG----IQGGQG-------------LQGGQG------GDGGT MSMEG_0868|M.smegmatis_MC2_155 TGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKA------SDGGK TH_3810|M.thermoresistible__bu ----------------------------------------------DGGT MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------------GNAGL MAV_4827|M.avium_104 ----------------------------------------------DAES MLBr_01556|M.leprae_Br4923 -----------------------------------------------GGA . MUL_0391|M.ulcerans_Agy99 GGKGGNAG-------------------------DYGTGGTGGTG------ MMAR_4822|M.marinum_M GGKGGNAG-------------------------DYGNGGTGGTG------ Mb1485c|M.bovis_AF2122/97 GGAGGNGAPGAPPS---------------GGDPNGGGGGAGGAGGKGGDG Rv1091|M.tuberculosis_H37Rv GGAGGNAR-------------------------LWGVGGAGGAG------ Mflv_5091|M.gilvum_PYR-GCK GGKGGDADSMGS------------------AGATGGKGGNGGNGGRGGLF Mvan_1264|M.vanbaalenii_PYR-1 GGTGGDATSMGE------------------AGATGGKGGNGGNGGRGSLF MSMEG_0868|M.smegmatis_MC2_155 GGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIH TH_3810|M.thermoresistible__bu PGAHGESH-------------------------TPGVYTD---------- MAB_4284c|M.abscessus_ATCC_199 AGNAGLAG-------------------------NAGLAGNAGLAG----- MAV_4827|M.avium_104 PTVVIEKLFLPE-------------------DSEPRRRPVLLVG------ MLBr_01556|M.leprae_Br4923 PRRGRKSKRQKRQE-----------YDSMQAPVVGGVRLPHGNGE----- MUL_0391|M.ulcerans_Agy99 ---------------GIGGAGGPGSPGG------------------TPGA MMAR_4822|M.marinum_M ---------------GIGGAGGPGSPGG------------------TPGA Mb1485c|M.bovis_AF2122/97 GA-----------QAGDGGAGGAGGKGGNGG---NGATGATGLNGLGAGA Rv1091|M.tuberculosis_H37Rv ---------------GDGGAGGAGGKGG------------SGLSGNANGG Mflv_5091|M.gilvum_PYR-GCK G---------------KGGNAGNGAD----------------------GG Mvan_1264|M.vanbaalenii_PYR-1 G---------------RGGNAGNGGN----------------------GG MSMEG_0868|M.smegmatis_MC2_155 GSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------NAGLAGNAGLAG-------------------NAG MAV_4827|M.avium_104 -----------------SGLAVVGISAV------------------LALE MLBr_01556|M.leprae_Br4923 ----------------TIRLARGASLSDFAEKIDANPAALVQALFNLGEM MUL_0391|M.ulcerans_Agy99 QGFRAGDAGNGG-VGGIGGDGG-------------HIKGHGGAGGIGGTG MMAR_4822|M.marinum_M QGFRAGDAGNGG-VGGIGGDGG-------------HIKGHGGAGGIGGQG Mb1485c|M.bovis_AF2122/97 DGTDGGKGGNGG-AGGGGGAGGQGGKALA-ATHQDGSMGAGGAGGNGGAG Rv1091|M.tuberculosis_H37Rv AGGDSGRGGTGG-AGGEGGAAG-------------LLVGTGGHGGDGGAG Mflv_5091|M.gilvum_PYR-GCK TGGAGGAGGTGG-TGGAGGTGG-----------------TGGTGGIGGAG Mvan_1264|M.vanbaalenii_PYR-1 TGGNGGNGGTGG-TGGNGGTGG-----------------TGGTGGIGGAG MSMEG_0868|M.smegmatis_MC2_155 NGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDG TH_3810|M.thermoresistible__bu RQGEDGEDGTGTGIGGRGGNGG----------------SSSGTHPMAEDG MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAGLAGN-----------------AGLAGNAGLAG MAV_4827|M.avium_104 IALAIGIRTTGTVALQPTPNQHLIVP----------TEQAPAPPPVQASA MLBr_01556|M.leprae_Br4923 VTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLEPFDLTYGEDQGDE . MUL_0391|M.ulcerans_Agy99 ----------------------------------GAGVIGGDGV------ MMAR_4822|M.marinum_M ----------------------------------GAGGIGGD-------- Mb1485c|M.bovis_AF2122/97 GMGGDGGNGAKGTFDNGGDGVGGNGGNGGSRGIGGAGGIGGAGSTAGADG Rv1091|M.tuberculosis_H37Rv ------GAAVK----------GGDGGAAAGTGIAGAGGRGGAG------- Mflv_5091|M.gilvum_PYR-GCK ----------------------STGGTGGTGGTGGTGGTGGTG------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------STGGTGGTGGTGGTGGTGGTG------- MSMEG_0868|M.smegmatis_MC2_155 ----------------------GTFVNAGANGNGGAGGAGGVSE------ TH_3810|M.thermoresistible__bu ------------------------------EHVKALDGRPGLD------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------NAGLAGNAGLAG------ MAV_4827|M.avium_104 P-------------------------QPKISVPEPVAAPKPLSP------ MLBr_01556|M.leprae_Br4923 D---------------------ELQVRPPVVTVMGHVDHGKTRLLDTIR- MUL_0391|M.ulcerans_Agy99 --------------------------IGGDGQAGSAGEFPGDR------- MMAR_4822|M.marinum_M ------------------------------GQAGSAGEFPGDR------- Mb1485c|M.bovis_AF2122/97 ARGATPTSGGNGGTGGNGANATVAGGAGGAGGKGGNGGLVGNGGAGGKGG Rv1091|M.tuberculosis_H37Rv ---------GSGGSGGD----------GGGGAAGPAGWLFGDGGAGG--- Mflv_5091|M.gilvum_PYR-GCK ----------------------------GTGGTGGTGGTGGKGG------ Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------GTGGTGGTGGTGGKGG------ MSMEG_0868|M.smegmatis_MC2_155 ----------------------------GEGGTGGHGGDGGRGG------ TH_3810|M.thermoresistible__bu ------------------------------GGNGSHGGNGGHGG------ MAB_4284c|M.abscessus_ATCC_199 -----------------------------NAGLAGNAGLAGNAG------ MAV_4827|M.avium_104 ----------------------------PVAAPLPAAPPPAAPP------ MLBr_01556|M.leprae_Br4923 ---------------------------KANVREAEAGGITQHIG------ . MUL_0391|M.ulcerans_Agy99 -----------------------GGSGGAGARG----------------G MMAR_4822|M.marinum_M -----------------------GGSGGDGARG----------------G Mb1485c|M.bovis_AF2122/97 DGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGGTGGAGG Rv1091|M.tuberculosis_H37Rv ----------------------NGGAAAAGGAGGQAG---------GGGG Mflv_5091|M.gilvum_PYR-GCK ----------------------TGGTGGAGGTG-------------GDGG Mvan_1264|M.vanbaalenii_PYR-1 ----------------------TGGTGGDGGTG-------------GTGG MSMEG_0868|M.smegmatis_MC2_155 ----------------------DGALGGNGGTGGVGL---------GNGG TH_3810|M.thermoresistible__bu ----------------------RGGFLGIGGSG-------------GWGG MAB_4284c|M.abscessus_ATCC_199 ---------------------LAGNAGLAGNAG-----------LAGNAG MAV_4827|M.avium_104 ---------------------LPEAPPIPAAPPVVPVP-------VVVPP MLBr_01556|M.leprae_Br4923 --------------------AYQVGVDLDGSER-----------LITFID . MUL_0391|M.ulcerans_Agy99 NGGDGGAGG----------------------------------------- MMAR_4822|M.marinum_M NGGDGGAGG----------------------------------------- Mb1485c|M.bovis_AF2122/97 NGADGGAGGNGANGANATTPGAKGGDGGHGGPGAQGGNGGQGGPGGLAGN Rv1091|M.tuberculosis_H37Rv NGGNGGNGGNGGN------------------------------------- Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTG--------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGTG--------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 KGGNGGNGGNGGTYVDPS-------------------------------- TH_3810|M.thermoresistible__bu HGGNG--------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGN---------------------------------------- MAV_4827|M.avium_104 VPVPVPVRIP---------------------------------------- MLBr_01556|M.leprae_Br4923 TPGHEAFTAMR--------------------------------------- MUL_0391|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4822|M.marinum_M -------------------------------------------------- Mb1485c|M.bovis_AF2122/97 LFGQNGIQGVGGSGGKGGAGGLAGDGGNGANGNFAFGDGNGGHGGNGGNP Rv1091|M.tuberculosis_H37Rv -------------------------GGNGATGGWLYGNG----------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------------HT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- MUL_0391|M.ulcerans_Agy99 -AGGHALAEGFHD------------------GAAGTGG----MGG---DG MMAR_4822|M.marinum_M -AGGQALAEGFHD------------------GAAGTGG----VGGNGGDG Mb1485c|M.bovis_AF2122/97 GAGGQGGSGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGHSQVVGGNGGDG Rv1091|M.tuberculosis_H37Rv GAGGQGATAGAG----GAGANGVSSTNGG--GTGGNGG----IGGTGGSG Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGAG---------------DGTGGTGGTGG----TGGQGGQG Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGAG---------------DGLGGTGGTGG----TGGFGGQG MSMEG_0868|M.smegmatis_MC2_155 GAGGNGGNGGAGR----IRVNNGTATGTATGGNGGNGGNGDADGHRGGKG TH_3810|M.thermoresistible__bu --GDTDADGGNG-------------------GDGGNGG-------SAGRG MAB_4284c|M.abscessus_ATCC_199 -AAVAGNAAVAGN--------------AAVAGNAAVGG----VLNTGVSG MAV_4827|M.avium_104 VPDPVSPPQLLAP---------------PRLSVPQPVQPPVRVPQPPSPP MLBr_01556|M.leprae_Br4923 -ARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEG . MUL_0391|M.ulcerans_Agy99 GNGA-----------------DGG----DGHSG----------------- MMAR_4822|M.marinum_M GNGA-----------------DGG----DGHSG----------------- Mb1485c|M.bovis_AF2122/97 GNGG-----------------NGGSAGTGGNGGRGGDGAFGG-------- Rv1091|M.tuberculosis_H37Rv GAGG-----------------NAGLLGVGGAGG----------------- Mflv_5091|M.gilvum_PYR-GCK GQGG-----------------TGGTGGQGG-LGGGGGTG----------- Mvan_1264|M.vanbaalenii_PYR-1 GQGG-----------------TGGTGGQGG-LGGVGGTG----------- MSMEG_0868|M.smegmatis_MC2_155 GDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVV TH_3810|M.thermoresistible__bu GTGG---------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AIGG--------------------SSHVGGAIN----------------- MAV_4827|M.avium_104 QVGG---------------------------------------------- MLBr_01556|M.leprae_Br4923 ADPAKIR----------------GQLTEYGLVAEDFGGDTMFIDISAKVG . MUL_0391|M.ulcerans_Agy99 --------------DPSWRSGGDGGNGGNGAYGGSG--------GQGGLN MMAR_4822|M.marinum_M --------------DPSWRSGGDGGNGGNGAYGGNG--------GQGGLS Mb1485c|M.bovis_AF2122/97 MSANATNPGENGPNGNPGGNGGAGGAGGAGLNGGNG--------GAGGNG Rv1091|M.tuberculosis_H37Rv -------------HGASGGAGDRGGAGGTGFISSDG--------GAGGDG Mflv_5091|M.gilvum_PYR-GCK ------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAG Mvan_1264|M.vanbaalenii_PYR-1 ------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAG MSMEG_0868|M.smegmatis_MC2_155 QANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNG TH_3810|M.thermoresistible__bu ---------------LRGVFGINGGNGRAGLGGRGX--------XXXG-- MAB_4284c|M.abscessus_ATCC_199 --------------ESLGGSGSVGGSTAVGGGAHTG--------VGGGVS MAV_4827|M.avium_104 -----------TVPQSPPQHQTPPGEGTPPKPDGPG--------NYGGGH MLBr_01556|M.leprae_Br4923 TNIEALLEAVLLTADAALDLRANSGMEAQGVAIEAHLDR-----GRGPVA * MUL_0391|M.ulcerans_Agy99 -------------------------------GDGATRAAHGVQG----TM MMAR_4822|M.marinum_M -------------------------------GDGATRAAHGVQG----TM Mb1485c|M.bovis_AF2122/97 GLGGFGGNGAAGANGVAVGAPGQPGGAGGHGGAGGNGGAGGNGGQGVVSD Rv1091|M.tuberculosis_H37Rv -------------------------------GDGGNGGAGGTGG---LLF Mflv_5091|M.gilvum_PYR-GCK GDGGLGG----------------------LGGFGGSGGTGGQGGLGGPGG Mvan_1264|M.vanbaalenii_PYR-1 GDGGLGG----------------------LGGFGGVGGTGGQGGQGGPGG MSMEG_0868|M.smegmatis_MC2_155 GDGIDGG----------------------LGGNGGDGVVNTTANAANPGS TH_3810|M.thermoresistible__bu ---------------------------------GGVGAAVRSGN------ MAB_4284c|M.abscessus_ATCC_199 ---------------------------------TGVGVGSHVGG--GISE MAV_4827|M.avium_104 VP------------------------------TPGAGGSGGSGGGHVPTP MLBr_01556|M.leprae_Br4923 TVLVQRG----------------------TLRIGDSVVAGDAYGRVRRMV . MUL_0391|M.ulcerans_Agy99 GDGGDGGDGG--NGSTTSDQ------------VDIDGGNGGYGGWGFNGG MMAR_4822|M.marinum_M GDGGDGGDGG--NGSTTSDQ------------PDIDGGNGGYGGWGFNGG Mb1485c|M.bovis_AF2122/97 GAGGAGGAGG--DGGAPGDGANGGNGQGAGAFAGGGGGRGGDGGNAGNAG Rv1091|M.tuberculosis_H37Rv GAGGNGGPGG--SGGAADIGGNGG--------AGNGGGTDGNGGNGGSGG Mflv_5091|M.gilvum_PYR-GCK STGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGA Mvan_1264|M.vanbaalenii_PYR-1 STGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGA MSMEG_0868|M.smegmatis_MC2_155 ATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGG TH_3810|M.thermoresistible__bu --GVFSGGGG-----------------------TPSAGFGVPTTIQFPAG MAB_4284c|M.abscessus_ATCC_199 SLGGSGSVGG---STAVGGGAHTG----------VGGGVSTGVGVGSHVG MAV_4827|M.avium_104 GAGGSGGSGG---------------------GHVPTPGTGGPGGTGGSGG MLBr_01556|M.leprae_Br4923 DEHGVDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSAR . MUL_0391|M.ulcerans_Agy99 NGGNGGDG-------------------GTRPKGTLFFRSGGDGGFGGWGG MMAR_4822|M.marinum_M NGGNGGDG-------------------GTRPKGTVFFRSGGDGGFGGWGG Mb1485c|M.bovis_AF2122/97 AGGPGGTGSTAGKAGPAGSILHDGGNGGHGGHGAASGGNGGPGGHGGNGG Rv1091|M.tuberculosis_H37Rv GAGSGGDG------------------GGAGGNGAWLFGNGGAGGGGGKGG Mflv_5091|M.gilvum_PYR-GCK QGATGAQGATG----------------AQGATG-ATGAAGKAGATGAAGA Mvan_1264|M.vanbaalenii_PYR-1 QGATGAQGATG----------------AQGATG-ATGASGAQGSAGSAGS MSMEG_0868|M.smegmatis_MC2_155 EASNGGVAGNGGNALV----------MAAGTTGVATGNTATGGDGGAATT TH_3810|M.thermoresistible__bu SCTSRAVS-------------------REGIMPSSRAASARAGAACASST MAB_4284c|M.abscessus_ATCC_199 GGISESLG-------------------GSGSVGGSTAVGGGAHTGVGGGV MAV_4827|M.avium_104 GHVPTPGAG------------------TPGGSGGGHLPFPGAGSTPGGSG MLBr_01556|M.leprae_Br4923 KRNALAARSRKRISLEDLDS-------ALKETSQLNLILKGDNAGTVEAL MUL_0391|M.ulcerans_Agy99 NGYG-------GVGG--------------------------GNGGAGG-- MMAR_4822|M.marinum_M NGYG-------GVGGDGGNGGWGGNGVNRYGVLNPGWGGDGGNGGAGG-- Mb1485c|M.bovis_AF2122/97 NGGTGANGGNGGIGGTGGAGSTGAKGVLGTNEGDGGDGGRGGNGGRGGNG Rv1091|M.tuberculosis_H37Rv NGAG------GGLGG-------GSFGLPGLN-GSGGDGGDGGNGAPGG-- Mflv_5091|M.gilvum_PYR-GCK AGAAG------SAG-----------TTGAQGSAGTNGA-NGANGSQGAAG Mvan_1264|M.vanbaalenii_PYR-1 AGVAG------SAG-----------TTGAQGSAGTNGA-NGANGSQGAAG MSMEG_0868|M.smegmatis_MC2_155 AGATG------GAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADG TH_3810|M.thermoresistible__bu SRSRR------------------------------------SFCCSRA-- MAB_4284c|M.abscessus_ATCC_199 NTGVG----------------------VGSHVGGGISESLGGSGSVGG-- MAV_4827|M.avium_104 GGHLP----------------------------------TPGAGTPGG-- MLBr_01556|M.leprae_Br4923 EEALMGIQVDDEVALRVIDRGVGGITETNVNLASASDAIIIGFNVRAEGK . MUL_0391|M.ulcerans_Agy99 -------------------TAYTSGGVYA--------------------- MMAR_4822|M.marinum_M -------------------TAYTSGGVYA--------------------- Mb1485c|M.bovis_AF2122/97 GQGLTGAGGNGGT-----GGTPGNGGNGGNGASGDLVTSPGDGGGGGRGG Rv1091|M.tuberculosis_H37Rv -------------------VLYGNGGAGGQGSS----------------- Mflv_5091|M.gilvum_PYR-GCK KAGATGTTGATG--------AAGEDGDAGSGGSG---------------- Mvan_1264|M.vanbaalenii_PYR-1 KAGATGTTGATG--------AAGDAGDPGSEAVD---------------- MSMEG_0868|M.smegmatis_MC2_155 WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGG--------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------STAVGGGAHTSAIN----------------- MAV_4827|M.avium_104 -------------------GLGGFGGGHAPAPG----------------- MLBr_01556|M.leprae_Br4923 ATELASREGVEIRYYLVIYQAIDDIEKALRGMLKP--------------- MUL_0391|M.ulcerans_Agy99 ----------GGPVQPG------------------TEGTGPSGDHG---- MMAR_4822|M.marinum_M ----------GGPVQPG------------------TEGTGPSGDHG---- Mb1485c|M.bovis_AF2122/97 DAGRGGDAGLGGSSGPGGTPG--------DWGTGGTGGTGGTGGQGANGG Rv1091|M.tuberculosis_H37Rv ----------GGIGGPG-----------------ATGGAGGKGGDGGDAQ Mflv_5091|M.gilvum_PYR-GCK --------INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE-- Mvan_1264|M.vanbaalenii_PYR-1 --------INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE-- MSMEG_0868|M.smegmatis_MC2_155 --------ASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------DALGGSGSVGG---------------STAVGGGAHTSAINESM MAV_4827|M.avium_104 ----------GGLGGGGG---------------HAPAPGGGLGGFG---- MLBr_01556|M.leprae_Br4923 ------IYEENQLGRAEIRALFRSSKVGIIAGCIISSGVVRRNAKVRLLR MUL_0391|M.ulcerans_Agy99 -------GFGGSGGIGGHGGQAP--------------------------- MMAR_4822|M.marinum_M -------GFGGSGGIGGHGGQAP--------------------------- Mb1485c|M.bovis_AF2122/97 LTGGR-GGTGGNGGAGGTGGTGHNGSQPGMGGNGGAGGFGGNGFAGVGGR Rv1091|M.tuberculosis_H37Rv LIGD--GGNGGNGGAGGTGGT------PGPGGPGGSGGLGG--------- Mflv_5091|M.gilvum_PYR-GCK ------GGAGGGGGAGGSGAGGAG----GAGGSGGSGGSGG--------- Mvan_1264|M.vanbaalenii_PYR-1 ------GGAGGSGGAGGSGTGGAG----GAGGSGGSGGSGG--------- MSMEG_0868|M.smegmatis_MC2_155 PGGNGAGGAGGNGGTGGTTAGGSGN--GGNGGNGGNGGADG--------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHAS--------- MAV_4827|M.avium_104 -------GGHSGGGLGGLGGGHK--------------------------- MLBr_01556|M.leprae_Br4923 DNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGD------- MUL_0391|M.ulcerans_Agy99 -------------------------------------------------- MMAR_4822|M.marinum_M -------------------------------------------------- Mb1485c|M.bovis_AF2122/97 GGMGGSGGTGGTGDAGPFGTGTGGTGGHGGQGGGGGFSILLGLGGLGGLG Rv1091|M.tuberculosis_H37Rv --------------------------------------LLFGQTGTAGVS Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------SGGSGGAAGDS Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------AGGSGGAAGDS MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------TPGTAGTTGAN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------ETAHTTLPGAE MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ---------------------------------------VIESYELVEKQ MUL_0391|M.ulcerans_Agy99 ---------------------------- MMAR_4822|M.marinum_M ---------------------------- Mb1485c|M.bovis_AF2122/97 SPGSIATGTAGGAGGGGGFGGLGGGEFV Rv1091|M.tuberculosis_H37Rv P--------------------------- Mflv_5091|M.gilvum_PYR-GCK DD-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 D--------------------------- MSMEG_0868|M.smegmatis_MC2_155 NP-------------------------- TH_3810|M.thermoresistible__bu ---------------------------- MAB_4284c|M.abscessus_ATCC_199 HH-------------------------- MAV_4827|M.avium_104 ---------------------------- MLBr_01556|M.leprae_Br4923 RA--------------------------