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M. ulcerans Agy99 MUL_0391 (-)

annotation: PE-PGRS family protein
coordinates: 402249 - 403910
length: 553

VSLVRVAPQVVADGVGNLARIGSSIGVANAAAAAATTTMVPAGGDEVSAAVADGQFQVLAEPVQTLGQAW
LASPAGELLDPLVNAPFESLTGRELIGNGAAGVAGVDGGAGQAGGWLFGDGGPGAAATATSAAGRGGDAG
LIGAGGAGGAGWANSGVAMMAGGAGGDGGLLLGDGGPGSPGAASFDPTVAGGAGGPGGDARGIGDGGRGG
DGGPGATGAPGGRGSDGGPGGKGGNAGDYGTGGTGGTGGIGGAGGPGSPGGTPGAQGFRAGDAGNGGVGG
IGGDGGHIKGHGGAGGIGGTGGAGVIGGDGVIGGDGQAGSAGEFPGDRGGSGGAGARGGNGGDGGAGGAG
GHALAEGFHDGAAGTGGMGGDGGNGADGGDGHSGDPSWRSGGDGGNGGNGAYGGSGGQGGLNGDGATRAA
HGVQGTMGDGGDGGDGGNGSTTSDQVDIDGGNGGYGGWGFNGGNGGNGGDGGTRPKGTLFFRSGGDGGFG
GWGGNGYGGVGGGNGGAGGTAYTSGGVYAGGPVQPGTEGTGPSGDHGGFGGSGGIGGHGGQAP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_0391--100% (553)PE-PGRS family protein
M. ulcerans Agy99MUL_4381-e-16457.78% (540) PE-PGRS family protein
M. ulcerans Agy99MUL_0212-e-11444.77% (612) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1485cPE_PGRS271e-11946.60% (618) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-7e-9947.56% (471) triple helix repeat-containing collagen
M. tuberculosis H37RvRv1091PE_PGRS221e-12145.14% (627) PE-PGRS family protein
M. leprae Br4923MLBr_01556infB5e-1041.90% (105) translation initiation factor IF-2
M. abscessus ATCC 19977MAB_4284c-3e-3930.80% (487) hypothetical protein MAB_4284c
M. marinum MMMAR_4822-0.084.74% (629) PE-PGRS family protein
M. avium 104MAV_4827-1e-2140.91% (176) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-8e-8640.13% (613) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-4e-4338.81% (335) PUTATIVE -
M. vanbaalenii PYR-1Mvan_1264-1e-10047.38% (496) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


MUL_0391|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4822|M.marinum_M               --------------------------------------------------
Mb1485c|M.bovis_AF2122/97           --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MUL_0391|M.ulcerans_Agy99           ------------------MSLVRVAPQVVADGVGNLARIGSSIGVANAAA
MMAR_4822|M.marinum_M               ------------------MSLVRVAPQVVADGVGNLARIRSSIGVANAAA
Mb1485c|M.bovis_AF2122/97           ------------------MSLVIVAPETVAAAALDVARIGSSIGVANSAA
Rv1091|M.tuberculosis_H37Rv         ------------------MSFVIAAPEALVAVASDLAGIGSALAEANAAA
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSA
MAV_4827|M.avium_104                ------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEED
MLBr_01556|M.leprae_Br4923          ------------------MAGKARVHELAKELGVTSKEVLARLNEQGEFV
                                                                                      

MUL_0391|M.ulcerans_Agy99           AAAT--------------------------------TTMVPAGGDEVS--
MMAR_4822|M.marinum_M               AAAT--------------------------------TTMVPAGGDEVSVA
Mb1485c|M.bovis_AF2122/97           AGST--------------------------------TSVLAAGADEVSAA
Rv1091|M.tuberculosis_H37Rv         LAPT--------------------------------TALLAAGADEVSAA
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VSAAQVG------------------------------AVMPVVAESVASN
MAV_4827|M.avium_104                AIDVTG----------------------------ADDAATASAPDRVISA
MLBr_01556|M.leprae_Br4923          KSAS--------------------------------STVEAPVARRLRES
                                                                                      

MUL_0391|M.ulcerans_Agy99           ---------------------------------------------AAVAD
MMAR_4822|M.marinum_M               VVGLFRGLGQDYQLFGAQLEQFHQRFVQILDAARTAYLETETAAAAAVAD
Mb1485c|M.bovis_AF2122/97           IATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLAT
Rv1091|M.tuberculosis_H37Rv         IAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAAEAANVSAAQS
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      YG-------------YQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSP
MAV_4827|M.avium_104                ILG-------------------------TREGAADAGLQLSSIGVTWTDQ
MLBr_01556|M.leprae_Br4923          FGG------------------------IKPAADKGAEQVATKAQAKRLGE
                                                                                      

MUL_0391|M.ulcerans_Agy99           GQFQVL----------------AEPVQTLG--------QAWLAS------
MMAR_4822|M.marinum_M               GQFQVL----------------AEPVQTLG--------QAWLGS------
Mb1485c|M.bovis_AF2122/97           LEHNVLNA------------LNAPTQALLG--------RPLIGDGAAGAP
Rv1091|M.tuberculosis_H37Rv         TDQRLLDL------------INGPTQALLG--------RPLIGDGANGGP
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SLLSPRDN--------------------------------DFLSHNDTDF
MAV_4827|M.avium_104                LEAAALRD--------------------------------ALAARRIDNV
MLBr_01556|M.leprae_Br4923          SLDQTLDR---------------ALDKAVAGNGATTAAPVQVDHSAAVVP
                                                                                      

MUL_0391|M.ulcerans_Agy99           -------PAGELLDPLVNAPFESLTG--------RELIG-NGAAG---VA
MMAR_4822|M.marinum_M               -------PAGELLDPLVNAPFESLTG--------RELIG-NGAAG---VA
Mb1485c|M.bovis_AF2122/97           GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFG-TGGAGGAGGA
Rv1091|M.tuberculosis_H37Rv         --GQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAAGLIG-NGGAGGGGGA
Mflv_5091|M.gilvum_PYR-GCK          QN------GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG
Mvan_1264|M.vanbaalenii_PYR-1       QN------GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG
MSMEG_0868|M.smegmatis_MC2_155      DNPN-GGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA
TH_3810|M.thermoresistible__bu      -----------VDGDGGSGG-------------RTGLFS----------K
MAB_4284c|M.abscessus_ATCC_199      ASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAV
MAV_4827|M.avium_104                MLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDV
MLBr_01556|M.leprae_Br4923          IVAGEGPSTAHREELAPPAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTG
                                                                                      

MUL_0391|M.ulcerans_Agy99           GVDGGAGQAGG--WLFGDGGPGAAATATSAA-------------------
MMAR_4822|M.marinum_M               GVDGGAGQAGG--WLFGDGGPGAAATATSAA-------------------
Mb1485c|M.bovis_AF2122/97           GAAGGAGGSGG--WLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGVGGTG
Rv1091|M.tuberculosis_H37Rv         GAAGGNGGAGG--WLYGNGGAGGAGGTSVIPGVAG---------------
Mflv_5091|M.gilvum_PYR-GCK          GGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG-------------
Mvan_1264|M.vanbaalenii_PYR-1       SGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG-------------
MSMEG_0868|M.smegmatis_MC2_155      GLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGG-----------
TH_3810|M.thermoresistible__bu      LSRGGDGGDGG---LGGNGGHGGGTGIIS---------------------
MAB_4284c|M.abscessus_ATCC_199      AVGGSNSGPIAS----GQGSTAVNGDVRDSNIINADHG------------
MAV_4827|M.avium_104                YKQQIRAESYG--DAAGQLSAMVAGLEKLESLPGGLLLVG----------
MLBr_01556|M.leprae_Br4923          PHPGPAPKPGGRPPRVGNNPFSSAQSVARPIPRPPAPRPS----------
                                              .     *                                 

MUL_0391|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4822|M.marinum_M               --------------------------------------------------
Mb1485c|M.bovis_AF2122/97           GPGGPGGPGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGG
Rv1091|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------------APGV
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------------APGV
MSMEG_0868|M.smegmatis_MC2_155      ----------------------------------------------TGGT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MUL_0391|M.ulcerans_Agy99           -----GRGGDAGLIGAGG-----AGGAG-WANSGVAMMAG----------
MMAR_4822|M.marinum_M               -----GRGGDAGLIGAGG-----AGGAG-WANSGVAMMAG----------
Mb1485c|M.bovis_AF2122/97           VGGHGGVGGAAGLLGVGG-----HGGAGGHGAAGIAGAAGKGG-------
Rv1091|M.tuberculosis_H37Rv         --GNGGAGGSAGLWGTGG-----AGGDGGNGRSGPVNVAG----------
Mflv_5091|M.gilvum_PYR-GCK          AGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------
Mvan_1264|M.vanbaalenii_PYR-1       AGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------
MSMEG_0868|M.smegmatis_MC2_155      GGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYV
TH_3810|M.thermoresistible__bu      ---------LLSLAGNGG-----NGGNGYRTTDNNALDGG----------
MAB_4284c|M.abscessus_ATCC_199      ----SNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQ-------
MAV_4827|M.avium_104                -SGVDVAPLKQVLQTTTFLDVSVAEEPETALARGAALAAANAP-------
MLBr_01556|M.leprae_Br4923          ASPSSMSPRPGGAVGGGGPRPPRTGVPRPGGGRPGAPVGGRSD-------
                                                                       .              

MUL_0391|M.ulcerans_Agy99           ---------------GAGGDGG---------LLLGDGGP-----------
MMAR_4822|M.marinum_M               ---------------GAGGDGG---------LVFGDGGP-----------
Mb1485c|M.bovis_AF2122/97           -------IFPDGSNGGAGGDAGDGGTGGRGGWLAGAGGAGGDGGIG----
Rv1091|M.tuberculosis_H37Rv         ---------SAGGNGGAGGAAG----------LFGDAGAGGNG-------
Mflv_5091|M.gilvum_PYR-GCK          -------AVGSAGAAGEAGETGTWG----NAGLPGKAGDAGGAG------
Mvan_1264|M.vanbaalenii_PYR-1       -------AVGSAGTAGSAGAPGVWG----NAGLPGAAGAAGGAG------
MSMEG_0868|M.smegmatis_MC2_155      LIAGPNVTVGSETRGGTGGAGGTGGQS--TAAGPGKGGGGGGGGGGAILI
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MUL_0391|M.ulcerans_Agy99           ------------GSPGAASFD--------------------PTVAGGAG-
MMAR_4822|M.marinum_M               ------------GSPGAASFD--------------------PTVAGGAG-
Mb1485c|M.bovis_AF2122/97           ----------GTGGAGGAGFSRALIVAGDNGGDGGNGGMGGAGGAGGPG-
Rv1091|M.tuberculosis_H37Rv         ----------GKGGAGGAAFS-INFTAGD-------------GGAGGAG-
Mflv_5091|M.gilvum_PYR-GCK          ----------AVGAAGAAG------TVGTA------------GATGGTG-
Mvan_1264|M.vanbaalenii_PYR-1       ----------AIGTAGVAG------AAGTA------------GATGGTG-
MSMEG_0868|M.smegmatis_MC2_155      GANGGTVDGHAIGGNGGNGGNGSTTAAGGN------------GGTGGTGR
TH_3810|M.thermoresistible__bu      --------------------------------------------HGGNG-
MAB_4284c|M.abscessus_ATCC_199      ----------RNTTNINDSFN--------------------TDRSTNIG-
MAV_4827|M.avium_104                ---------LFASSTAALAY----------------------AQDPGTG-
MLBr_01556|M.leprae_Br4923          ----------AGGGNYRGGG---------------------VGALPGGG-
                                                                                  . * 

MUL_0391|M.ulcerans_Agy99           ----------------GPGGDARGIGDGGRGGDG--------------GP
MMAR_4822|M.marinum_M               ----------------GPGGDARGIGDGGRGGDG--------------GP
Mb1485c|M.bovis_AF2122/97           ----------------GAGGLISLLGGQGAGGDG--------------GD
Rv1091|M.tuberculosis_H37Rv         ----------------GSGGHALLWGAGGAGGNG--------------GS
Mflv_5091|M.gilvum_PYR-GCK          --------------TGANGGAGGVGGVGGTGAAG--------------AA
Mvan_1264|M.vanbaalenii_PYR-1       --------------VGGNGGAGQAGGIGGTGAAG--------------AA
MSMEG_0868|M.smegmatis_MC2_155      VIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTAT
TH_3810|M.thermoresistible__bu      ----------------GNVGFFSLFNLGGAGGWG--------------GS
MAB_4284c|M.abscessus_ATCC_199      ----------------SGNTTNTEIGSHNQANIG--------------TS
MAV_4827|M.avium_104                -----------------AVDQYSLPDYLYVPVDP--------------EP
MLBr_01556|M.leprae_Br4923          -----------------SGGFRGRPGGGGHGGGG--------------RP
                                                             .                        

MUL_0391|M.ulcerans_Agy99           GATG------------------APGGRG----------------------
MMAR_4822|M.marinum_M               GATG------------------APGGRG----------------------
Mb1485c|M.bovis_AF2122/97           GGAGGVGGDRGAGANGNQAVNAGAGGAGGH--GGDPGAGGAGGTGGAGST
Rv1091|M.tuberculosis_H37Rv         GGTGGAGG-----------STAGAGGNG-----------GAGGGGGTGGL
Mflv_5091|M.gilvum_PYR-GCK          GGAGGLGETG---------TTGGAGGVGGQ--GTAGGTGGVGGIGGAGST
Mvan_1264|M.vanbaalenii_PYR-1       GQAGTAGETG---------VTGGVGGIGGQ--GTEGGTGGVGGVGGVGAT
MSMEG_0868|M.smegmatis_MC2_155      GGRGGDGIDG---------GTGGAGGMGEIYSGADGEATGISAGGDGGSA
TH_3810|M.thermoresistible__bu      GVDG----------------VDVVGGNP----------------------
MAB_4284c|M.abscessus_ATCC_199      TSAG------------------GSAAVG----------------------
MAV_4827|M.avium_104                GDDE-----------------LAYSAVGEE--------------------
MLBr_01556|M.leprae_Br4923          GQRG-----------------GAAGAFGRP--------------------
                                                            ..                        

MUL_0391|M.ulcerans_Agy99           ---------------------------------------------SDGGP
MMAR_4822|M.marinum_M               ---------------------------------------------SDGGP
Mb1485c|M.bovis_AF2122/97           IGAHGAAGASPTSGGNGGAGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGA
Rv1091|M.tuberculosis_H37Rv         LFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGGAG------GDGGA
Mflv_5091|M.gilvum_PYR-GCK          GAVGGVGGKG----IQGGQG-------------LQGGKG------GDGGA
Mvan_1264|M.vanbaalenii_PYR-1       GGAGGVGGKG----IQGGQG-------------LQGGQG------GDGGT
MSMEG_0868|M.smegmatis_MC2_155      TGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKA------SDGGK
TH_3810|M.thermoresistible__bu      ----------------------------------------------DGGT
MAB_4284c|M.abscessus_ATCC_199      ---------------------------------------------GNAGL
MAV_4827|M.avium_104                ----------------------------------------------DAES
MLBr_01556|M.leprae_Br4923          -----------------------------------------------GGA
                                                                                   .  

MUL_0391|M.ulcerans_Agy99           GGKGGNAG-------------------------DYGTGGTGGTG------
MMAR_4822|M.marinum_M               GGKGGNAG-------------------------DYGNGGTGGTG------
Mb1485c|M.bovis_AF2122/97           GGAGGNGAPGAPPS---------------GGDPNGGGGGAGGAGGKGGDG
Rv1091|M.tuberculosis_H37Rv         GGAGGNAR-------------------------LWGVGGAGGAG------
Mflv_5091|M.gilvum_PYR-GCK          GGKGGDADSMGS------------------AGATGGKGGNGGNGGRGGLF
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGDATSMGE------------------AGATGGKGGNGGNGGRGSLF
MSMEG_0868|M.smegmatis_MC2_155      GGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIH
TH_3810|M.thermoresistible__bu      PGAHGESH-------------------------TPGVYTD----------
MAB_4284c|M.abscessus_ATCC_199      AGNAGLAG-------------------------NAGLAGNAGLAG-----
MAV_4827|M.avium_104                PTVVIEKLFLPE-------------------DSEPRRRPVLLVG------
MLBr_01556|M.leprae_Br4923          PRRGRKSKRQKRQE-----------YDSMQAPVVGGVRLPHGNGE-----
                                                                                      

MUL_0391|M.ulcerans_Agy99           ---------------GIGGAGGPGSPGG------------------TPGA
MMAR_4822|M.marinum_M               ---------------GIGGAGGPGSPGG------------------TPGA
Mb1485c|M.bovis_AF2122/97           GA-----------QAGDGGAGGAGGKGGNGG---NGATGATGLNGLGAGA
Rv1091|M.tuberculosis_H37Rv         ---------------GDGGAGGAGGKGG------------SGLSGNANGG
Mflv_5091|M.gilvum_PYR-GCK          G---------------KGGNAGNGAD----------------------GG
Mvan_1264|M.vanbaalenii_PYR-1       G---------------RGGNAGNGGN----------------------GG
MSMEG_0868|M.smegmatis_MC2_155      GSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------NAGLAGNAGLAG-------------------NAG
MAV_4827|M.avium_104                -----------------SGLAVVGISAV------------------LALE
MLBr_01556|M.leprae_Br4923          ----------------TIRLARGASLSDFAEKIDANPAALVQALFNLGEM
                                                                                      

MUL_0391|M.ulcerans_Agy99           QGFRAGDAGNGG-VGGIGGDGG-------------HIKGHGGAGGIGGTG
MMAR_4822|M.marinum_M               QGFRAGDAGNGG-VGGIGGDGG-------------HIKGHGGAGGIGGQG
Mb1485c|M.bovis_AF2122/97           DGTDGGKGGNGG-AGGGGGAGGQGGKALA-ATHQDGSMGAGGAGGNGGAG
Rv1091|M.tuberculosis_H37Rv         AGGDSGRGGTGG-AGGEGGAAG-------------LLVGTGGHGGDGGAG
Mflv_5091|M.gilvum_PYR-GCK          TGGAGGAGGTGG-TGGAGGTGG-----------------TGGTGGIGGAG
Mvan_1264|M.vanbaalenii_PYR-1       TGGNGGNGGTGG-TGGNGGTGG-----------------TGGTGGIGGAG
MSMEG_0868|M.smegmatis_MC2_155      NGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDG
TH_3810|M.thermoresistible__bu      RQGEDGEDGTGTGIGGRGGNGG----------------SSSGTHPMAEDG
MAB_4284c|M.abscessus_ATCC_199      LAGNAGLAGNAGLAGNAGLAGN-----------------AGLAGNAGLAG
MAV_4827|M.avium_104                IALAIGIRTTGTVALQPTPNQHLIVP----------TEQAPAPPPVQASA
MLBr_01556|M.leprae_Br4923          VTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLEPFDLTYGEDQGDE
                                         .                                            

MUL_0391|M.ulcerans_Agy99           ----------------------------------GAGVIGGDGV------
MMAR_4822|M.marinum_M               ----------------------------------GAGGIGGD--------
Mb1485c|M.bovis_AF2122/97           GMGGDGGNGAKGTFDNGGDGVGGNGGNGGSRGIGGAGGIGGAGSTAGADG
Rv1091|M.tuberculosis_H37Rv         ------GAAVK----------GGDGGAAAGTGIAGAGGRGGAG-------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------STGGTGGTGGTGGTGGTGGTG-------
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------STGGTGGTGGTGGTGGTGGTG-------
MSMEG_0868|M.smegmatis_MC2_155      ----------------------GTFVNAGANGNGGAGGAGGVSE------
TH_3810|M.thermoresistible__bu      ------------------------------EHVKALDGRPGLD-------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------NAGLAGNAGLAG------
MAV_4827|M.avium_104                P-------------------------QPKISVPEPVAAPKPLSP------
MLBr_01556|M.leprae_Br4923          D---------------------ELQVRPPVVTVMGHVDHGKTRLLDTIR-
                                                                                      

MUL_0391|M.ulcerans_Agy99           --------------------------IGGDGQAGSAGEFPGDR-------
MMAR_4822|M.marinum_M               ------------------------------GQAGSAGEFPGDR-------
Mb1485c|M.bovis_AF2122/97           ARGATPTSGGNGGTGGNGANATVAGGAGGAGGKGGNGGLVGNGGAGGKGG
Rv1091|M.tuberculosis_H37Rv         ---------GSGGSGGD----------GGGGAAGPAGWLFGDGGAGG---
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------GTGGTGGTGGTGGKGG------
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------GTGGTGGTGGTGGKGG------
MSMEG_0868|M.smegmatis_MC2_155      ----------------------------GEGGTGGHGGDGGRGG------
TH_3810|M.thermoresistible__bu      ------------------------------GGNGSHGGNGGHGG------
MAB_4284c|M.abscessus_ATCC_199      -----------------------------NAGLAGNAGLAGNAG------
MAV_4827|M.avium_104                ----------------------------PVAAPLPAAPPPAAPP------
MLBr_01556|M.leprae_Br4923          ---------------------------KANVREAEAGGITQHIG------
                                                                        .             

MUL_0391|M.ulcerans_Agy99           -----------------------GGSGGAGARG----------------G
MMAR_4822|M.marinum_M               -----------------------GGSGGDGARG----------------G
Mb1485c|M.bovis_AF2122/97           DGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGGTGGAGG
Rv1091|M.tuberculosis_H37Rv         ----------------------NGGAAAAGGAGGQAG---------GGGG
Mflv_5091|M.gilvum_PYR-GCK          ----------------------TGGTGGAGGTG-------------GDGG
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------TGGTGGDGGTG-------------GTGG
MSMEG_0868|M.smegmatis_MC2_155      ----------------------DGALGGNGGTGGVGL---------GNGG
TH_3810|M.thermoresistible__bu      ----------------------RGGFLGIGGSG-------------GWGG
MAB_4284c|M.abscessus_ATCC_199      ---------------------LAGNAGLAGNAG-----------LAGNAG
MAV_4827|M.avium_104                ---------------------LPEAPPIPAAPPVVPVP-------VVVPP
MLBr_01556|M.leprae_Br4923          --------------------AYQVGVDLDGSER-----------LITFID
                                                                 .                    

MUL_0391|M.ulcerans_Agy99           NGGDGGAGG-----------------------------------------
MMAR_4822|M.marinum_M               NGGDGGAGG-----------------------------------------
Mb1485c|M.bovis_AF2122/97           NGADGGAGGNGANGANATTPGAKGGDGGHGGPGAQGGNGGQGGPGGLAGN
Rv1091|M.tuberculosis_H37Rv         NGGNGGNGGNGGN-------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          TGGTGGTGGTG---------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       TGGTGGTGGTG---------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      KGGNGGNGGNGGTYVDPS--------------------------------
TH_3810|M.thermoresistible__bu      HGGNG---------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LAGNAGLAGN----------------------------------------
MAV_4827|M.avium_104                VPVPVPVRIP----------------------------------------
MLBr_01556|M.leprae_Br4923          TPGHEAFTAMR---------------------------------------
                                                                                      

MUL_0391|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4822|M.marinum_M               --------------------------------------------------
Mb1485c|M.bovis_AF2122/97           LFGQNGIQGVGGSGGKGGAGGLAGDGGNGANGNFAFGDGNGGHGGNGGNP
Rv1091|M.tuberculosis_H37Rv         -------------------------GGNGATGGWLYGNG-----------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      ------------------------------------------------HT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          --------------------------------------------------
                                                                                      

MUL_0391|M.ulcerans_Agy99           -AGGHALAEGFHD------------------GAAGTGG----MGG---DG
MMAR_4822|M.marinum_M               -AGGQALAEGFHD------------------GAAGTGG----VGGNGGDG
Mb1485c|M.bovis_AF2122/97           GAGGQGGSGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGHSQVVGGNGGDG
Rv1091|M.tuberculosis_H37Rv         GAGGQGATAGAG----GAGANGVSSTNGG--GTGGNGG----IGGTGGSG
Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGTGGAG---------------DGTGGTGGTGG----TGGQGGQG
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGTGGAG---------------DGLGGTGGTGG----TGGFGGQG
MSMEG_0868|M.smegmatis_MC2_155      GAGGNGGNGGAGR----IRVNNGTATGTATGGNGGNGGNGDADGHRGGKG
TH_3810|M.thermoresistible__bu      --GDTDADGGNG-------------------GDGGNGG-------SAGRG
MAB_4284c|M.abscessus_ATCC_199      -AAVAGNAAVAGN--------------AAVAGNAAVGG----VLNTGVSG
MAV_4827|M.avium_104                VPDPVSPPQLLAP---------------PRLSVPQPVQPPVRVPQPPSPP
MLBr_01556|M.leprae_Br4923          -ARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEG
                                                                   .                  

MUL_0391|M.ulcerans_Agy99           GNGA-----------------DGG----DGHSG-----------------
MMAR_4822|M.marinum_M               GNGA-----------------DGG----DGHSG-----------------
Mb1485c|M.bovis_AF2122/97           GNGG-----------------NGGSAGTGGNGGRGGDGAFGG--------
Rv1091|M.tuberculosis_H37Rv         GAGG-----------------NAGLLGVGGAGG-----------------
Mflv_5091|M.gilvum_PYR-GCK          GQGG-----------------TGGTGGQGG-LGGGGGTG-----------
Mvan_1264|M.vanbaalenii_PYR-1       GQGG-----------------TGGTGGQGG-LGGVGGTG-----------
MSMEG_0868|M.smegmatis_MC2_155      GDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVV
TH_3810|M.thermoresistible__bu      GTGG----------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AIGG--------------------SSHVGGAIN-----------------
MAV_4827|M.avium_104                QVGG----------------------------------------------
MLBr_01556|M.leprae_Br4923          ADPAKIR----------------GQLTEYGLVAEDFGGDTMFIDISAKVG
                                       .                                              

MUL_0391|M.ulcerans_Agy99           --------------DPSWRSGGDGGNGGNGAYGGSG--------GQGGLN
MMAR_4822|M.marinum_M               --------------DPSWRSGGDGGNGGNGAYGGNG--------GQGGLS
Mb1485c|M.bovis_AF2122/97           MSANATNPGENGPNGNPGGNGGAGGAGGAGLNGGNG--------GAGGNG
Rv1091|M.tuberculosis_H37Rv         -------------HGASGGAGDRGGAGGTGFISSDG--------GAGGDG
Mflv_5091|M.gilvum_PYR-GCK          ------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAG
Mvan_1264|M.vanbaalenii_PYR-1       ------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAG
MSMEG_0868|M.smegmatis_MC2_155      QANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNG
TH_3810|M.thermoresistible__bu      ---------------LRGVFGINGGNGRAGLGGRGX--------XXXG--
MAB_4284c|M.abscessus_ATCC_199      --------------ESLGGSGSVGGSTAVGGGAHTG--------VGGGVS
MAV_4827|M.avium_104                -----------TVPQSPPQHQTPPGEGTPPKPDGPG--------NYGGGH
MLBr_01556|M.leprae_Br4923          TNIEALLEAVLLTADAALDLRANSGMEAQGVAIEAHLDR-----GRGPVA
                                                            *                         

MUL_0391|M.ulcerans_Agy99           -------------------------------GDGATRAAHGVQG----TM
MMAR_4822|M.marinum_M               -------------------------------GDGATRAAHGVQG----TM
Mb1485c|M.bovis_AF2122/97           GLGGFGGNGAAGANGVAVGAPGQPGGAGGHGGAGGNGGAGGNGGQGVVSD
Rv1091|M.tuberculosis_H37Rv         -------------------------------GDGGNGGAGGTGG---LLF
Mflv_5091|M.gilvum_PYR-GCK          GDGGLGG----------------------LGGFGGSGGTGGQGGLGGPGG
Mvan_1264|M.vanbaalenii_PYR-1       GDGGLGG----------------------LGGFGGVGGTGGQGGQGGPGG
MSMEG_0868|M.smegmatis_MC2_155      GDGIDGG----------------------LGGNGGDGVVNTTANAANPGS
TH_3810|M.thermoresistible__bu      ---------------------------------GGVGAAVRSGN------
MAB_4284c|M.abscessus_ATCC_199      ---------------------------------TGVGVGSHVGG--GISE
MAV_4827|M.avium_104                VP------------------------------TPGAGGSGGSGGGHVPTP
MLBr_01556|M.leprae_Br4923          TVLVQRG----------------------TLRIGDSVVAGDAYGRVRRMV
                                                                               .      

MUL_0391|M.ulcerans_Agy99           GDGGDGGDGG--NGSTTSDQ------------VDIDGGNGGYGGWGFNGG
MMAR_4822|M.marinum_M               GDGGDGGDGG--NGSTTSDQ------------PDIDGGNGGYGGWGFNGG
Mb1485c|M.bovis_AF2122/97           GAGGAGGAGG--DGGAPGDGANGGNGQGAGAFAGGGGGRGGDGGNAGNAG
Rv1091|M.tuberculosis_H37Rv         GAGGNGGPGG--SGGAADIGGNGG--------AGNGGGTDGNGGNGGSGG
Mflv_5091|M.gilvum_PYR-GCK          STGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGA
Mvan_1264|M.vanbaalenii_PYR-1       STGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGA
MSMEG_0868|M.smegmatis_MC2_155      ATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGG
TH_3810|M.thermoresistible__bu      --GVFSGGGG-----------------------TPSAGFGVPTTIQFPAG
MAB_4284c|M.abscessus_ATCC_199      SLGGSGSVGG---STAVGGGAHTG----------VGGGVSTGVGVGSHVG
MAV_4827|M.avium_104                GAGGSGGSGG---------------------GHVPTPGTGGPGGTGGSGG
MLBr_01556|M.leprae_Br4923          DEHGVDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSAR
                                             .                                        

MUL_0391|M.ulcerans_Agy99           NGGNGGDG-------------------GTRPKGTLFFRSGGDGGFGGWGG
MMAR_4822|M.marinum_M               NGGNGGDG-------------------GTRPKGTVFFRSGGDGGFGGWGG
Mb1485c|M.bovis_AF2122/97           AGGPGGTGSTAGKAGPAGSILHDGGNGGHGGHGAASGGNGGPGGHGGNGG
Rv1091|M.tuberculosis_H37Rv         GAGSGGDG------------------GGAGGNGAWLFGNGGAGGGGGKGG
Mflv_5091|M.gilvum_PYR-GCK          QGATGAQGATG----------------AQGATG-ATGAAGKAGATGAAGA
Mvan_1264|M.vanbaalenii_PYR-1       QGATGAQGATG----------------AQGATG-ATGASGAQGSAGSAGS
MSMEG_0868|M.smegmatis_MC2_155      EASNGGVAGNGGNALV----------MAAGTTGVATGNTATGGDGGAATT
TH_3810|M.thermoresistible__bu      SCTSRAVS-------------------REGIMPSSRAASARAGAACASST
MAB_4284c|M.abscessus_ATCC_199      GGISESLG-------------------GSGSVGGSTAVGGGAHTGVGGGV
MAV_4827|M.avium_104                GHVPTPGAG------------------TPGGSGGGHLPFPGAGSTPGGSG
MLBr_01556|M.leprae_Br4923          KRNALAARSRKRISLEDLDS-------ALKETSQLNLILKGDNAGTVEAL
                                                                                      

MUL_0391|M.ulcerans_Agy99           NGYG-------GVGG--------------------------GNGGAGG--
MMAR_4822|M.marinum_M               NGYG-------GVGGDGGNGGWGGNGVNRYGVLNPGWGGDGGNGGAGG--
Mb1485c|M.bovis_AF2122/97           NGGTGANGGNGGIGGTGGAGSTGAKGVLGTNEGDGGDGGRGGNGGRGGNG
Rv1091|M.tuberculosis_H37Rv         NGAG------GGLGG-------GSFGLPGLN-GSGGDGGDGGNGAPGG--
Mflv_5091|M.gilvum_PYR-GCK          AGAAG------SAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
Mvan_1264|M.vanbaalenii_PYR-1       AGVAG------SAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
MSMEG_0868|M.smegmatis_MC2_155      AGATG------GAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADG
TH_3810|M.thermoresistible__bu      SRSRR------------------------------------SFCCSRA--
MAB_4284c|M.abscessus_ATCC_199      NTGVG----------------------VGSHVGGGISESLGGSGSVGG--
MAV_4827|M.avium_104                GGHLP----------------------------------TPGAGTPGG--
MLBr_01556|M.leprae_Br4923          EEALMGIQVDDEVALRVIDRGVGGITETNVNLASASDAIIIGFNVRAEGK
                                                                             .        

MUL_0391|M.ulcerans_Agy99           -------------------TAYTSGGVYA---------------------
MMAR_4822|M.marinum_M               -------------------TAYTSGGVYA---------------------
Mb1485c|M.bovis_AF2122/97           GQGLTGAGGNGGT-----GGTPGNGGNGGNGASGDLVTSPGDGGGGGRGG
Rv1091|M.tuberculosis_H37Rv         -------------------VLYGNGGAGGQGSS-----------------
Mflv_5091|M.gilvum_PYR-GCK          KAGATGTTGATG--------AAGEDGDAGSGGSG----------------
Mvan_1264|M.vanbaalenii_PYR-1       KAGATGTTGATG--------AAGDAGDPGSEAVD----------------
MSMEG_0868|M.smegmatis_MC2_155      WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGG---------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------STAVGGGAHTSAIN-----------------
MAV_4827|M.avium_104                -------------------GLGGFGGGHAPAPG-----------------
MLBr_01556|M.leprae_Br4923          ATELASREGVEIRYYLVIYQAIDDIEKALRGMLKP---------------
                                                                                      

MUL_0391|M.ulcerans_Agy99           ----------GGPVQPG------------------TEGTGPSGDHG----
MMAR_4822|M.marinum_M               ----------GGPVQPG------------------TEGTGPSGDHG----
Mb1485c|M.bovis_AF2122/97           DAGRGGDAGLGGSSGPGGTPG--------DWGTGGTGGTGGTGGQGANGG
Rv1091|M.tuberculosis_H37Rv         ----------GGIGGPG-----------------ATGGAGGKGGDGGDAQ
Mflv_5091|M.gilvum_PYR-GCK          --------INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE--
Mvan_1264|M.vanbaalenii_PYR-1       --------INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE--
MSMEG_0868|M.smegmatis_MC2_155      --------ASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------DALGGSGSVGG---------------STAVGGGAHTSAINESM
MAV_4827|M.avium_104                ----------GGLGGGGG---------------HAPAPGGGLGGFG----
MLBr_01556|M.leprae_Br4923          ------IYEENQLGRAEIRALFRSSKVGIIAGCIISSGVVRRNAKVRLLR
                                                                                      

MUL_0391|M.ulcerans_Agy99           -------GFGGSGGIGGHGGQAP---------------------------
MMAR_4822|M.marinum_M               -------GFGGSGGIGGHGGQAP---------------------------
Mb1485c|M.bovis_AF2122/97           LTGGR-GGTGGNGGAGGTGGTGHNGSQPGMGGNGGAGGFGGNGFAGVGGR
Rv1091|M.tuberculosis_H37Rv         LIGD--GGNGGNGGAGGTGGT------PGPGGPGGSGGLGG---------
Mflv_5091|M.gilvum_PYR-GCK          ------GGAGGGGGAGGSGAGGAG----GAGGSGGSGGSGG---------
Mvan_1264|M.vanbaalenii_PYR-1       ------GGAGGSGGAGGSGTGGAG----GAGGSGGSGGSGG---------
MSMEG_0868|M.smegmatis_MC2_155      PGGNGAGGAGGNGGTGGTTAGGSGN--GGNGGNGGNGGADG---------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      NSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHAS---------
MAV_4827|M.avium_104                -------GGHSGGGLGGLGGGHK---------------------------
MLBr_01556|M.leprae_Br4923          DNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGD-------
                                                                                      

MUL_0391|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4822|M.marinum_M               --------------------------------------------------
Mb1485c|M.bovis_AF2122/97           GGMGGSGGTGGTGDAGPFGTGTGGTGGHGGQGGGGGFSILLGLGGLGGLG
Rv1091|M.tuberculosis_H37Rv         --------------------------------------LLFGQTGTAGVS
Mflv_5091|M.gilvum_PYR-GCK          ---------------------------------------SGGSGGAAGDS
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------------------------AGGSGGAAGDS
MSMEG_0868|M.smegmatis_MC2_155      ---------------------------------------TPGTAGTTGAN
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------------------------------ETAHTTLPGAE
MAV_4827|M.avium_104                --------------------------------------------------
MLBr_01556|M.leprae_Br4923          ---------------------------------------VIESYELVEKQ
                                                                                      

MUL_0391|M.ulcerans_Agy99           ----------------------------
MMAR_4822|M.marinum_M               ----------------------------
Mb1485c|M.bovis_AF2122/97           SPGSIATGTAGGAGGGGGFGGLGGGEFV
Rv1091|M.tuberculosis_H37Rv         P---------------------------
Mflv_5091|M.gilvum_PYR-GCK          DD--------------------------
Mvan_1264|M.vanbaalenii_PYR-1       D---------------------------
MSMEG_0868|M.smegmatis_MC2_155      NP--------------------------
TH_3810|M.thermoresistible__bu      ----------------------------
MAB_4284c|M.abscessus_ATCC_199      HH--------------------------
MAV_4827|M.avium_104                ----------------------------
MLBr_01556|M.leprae_Br4923          RA--------------------------