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LWSQTFDVVVLGSGGAGLTAALSAAVAGATVAVFEKAPTVGGTTAVSGGIAWIPAHQRSPDRDLTVDDAL RYLRTQSLHSMDDALVETFVRTGAAMLDFVEKHSGVRFEIAAGFPDYRPELPGGQPAGGRSLGPAAFEPS RLGEWASRITSFPPDWSNVGFDAETRARLHAGVEESEDLCVAGTALVAGLLQGLLDVGVTPRTDAAAEEL VVEDGAVVGVRIAQSGRSISVRARRGVVLATGGFEWDPVLVRAFLRGPMHGAVSPPNNTGDGLRMAMARG AELANMGEAWWVPIVQIPNDTIDGKQRSRSVRLERTRPRSIIVNPAGQRFVNEACNYNSMAGAFHYLDPR GGYVNDHAWIVFDSAHLQRYGFLGIEPGQPVPDWFCESTDLTELATKTGIDADGLGRTIARWNHNVASGT DPDFGRGASAYDGYWGDDQATTLAGKTLGPIDSAPFYAVPIRVGAMGTKGGPRTDRDGRVRHVSGRSVPG LFTAGNAMAGVTGLAYGGAGGTIGPAMVFGYRAGRAVATGESADAP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_0349 | - | - | 100% (536) | dehydrogenase |
M. ulcerans Agy99 | MUL_4098 | - | 6e-84 | 38.00% (571) | 3-ketosteroid-delta-1-dehydrogenase |
M. ulcerans Agy99 | MUL_0346 | - | 1e-71 | 34.98% (566) | 3-ketosteroid-delta-1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3567 | - | 2e-84 | 37.32% (568) | 3-ketosteroid-delta-1-dehydrogenase |
M. gilvum PYR-GCK | Mflv_2398 | - | 0.0 | 72.32% (531) | fumarate reductase/succinate dehydrogenase flavoprotein |
M. tuberculosis H37Rv | Rv3537 | - | 2e-84 | 37.32% (568) | 3-ketosteroid-delta-1-dehydrogenase |
M. leprae Br4923 | MLBr_01226 | nadB | 9e-08 | 27.01% (311) | L-aspartate oxidase |
M. abscessus ATCC 19977 | MAB_0622c | - | 9e-85 | 36.97% (568) | 3-ketosteroid-delta-1-dehydrogenase |
M. marinum M | MMAR_4780 | - | 0.0 | 98.88% (536) | dehydrogenase |
M. avium 104 | MAV_0875 | - | 0.0 | 79.96% (534) | FAD binding domain-containing protein |
M. smegmatis MC2 155 | MSMEG_4870 | - | 0.0 | 72.74% (532) | FAD binding domain-containing protein |
M. thermoresistible (build 8) | TH_4085 | - | 0.0 | 71.93% (538) | PUTATIVE fumarate reductase/succinate dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_4248 | - | 0.0 | 72.23% (533) | fumarate reductase/succinate dehydrogenase flavoprotein |
CLUSTAL 2.0.9 multiple sequence alignment Mb3567|M.bovis_AF2122/97 ---------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYG Rv3537|M.tuberculosis_H37Rv ---------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYG MAB_0622c|M.abscessus_ATCC_199 ---------MTEQEYDVVVVGSGGAGMVAALTAAHNGLSTVLIEKAPHFG MUL_0349|M.ulcerans_Agy99 ---------MWSQTFDVVVLGSGGAGLTAALSAAVAGATVAVFEKAPTVG MMAR_4780|M.marinum_M --------MLWSQTFDVVVLGSGGAGLTAALSAAVAGATVAVFEKAPTVG MAV_0875|M.avium_104 --------MSWDHEVDVVVLGSGGAGLTAALTAAVAGASVQVYEKAPTVG Mflv_2398|M.gilvum_PYR-GCK MTE-------WDHEVDVVVLGSGGAGLTAALAASVNGATVEVYEKAATVG Mvan_4248|M.vanbaalenii_PYR-1 MTD-------WDHEADVVVLGSGGAGLTAALTAAVNGATVEVYEKAETVG TH_4085|M.thermoresistible__bu VTE-------WDRETDVIVLGTGGAGLTAALTAVVDGAAVEVFEKAPTVG MSMEG_4870|M.smegmatis_MC2_155 MTDSNGLHDSFDDEVDVVVLGTGGAGLTAALTAAVNGASVAVYEKAATIG MLBr_01226|M.leprae_Br4923 ----MMAVPDWKHAADVVVIGTGVAGLAAALAAHRAGRNVVVLTKADQRR **:*:*:* **:.*** * * . : ** Mb3567|M.bovis_AF2122/97 GSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAY Rv3537|M.tuberculosis_H37Rv GSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAY MAB_0622c|M.abscessus_ATCC_199 GSTARSGGGVWIPNNEVLKKARQTDTPEAAREYLYSIIGDVVPREKIDTY MUL_0349|M.ulcerans_Agy99 GTTAVSGGIAWIPAHQRS--PDRDLTVDDALRYLRTQSLHSMDDALVETF MMAR_4780|M.marinum_M GTTAVSGGIAWIPAHQRS--PDRDLTVDDALRYLRAQSLHSMDDALVETF MAV_0875|M.avium_104 GTTAVSGGIVWIPAHNRC--PDGELTAADALKYLRAQSLGSMDDELVETF Mflv_2398|M.gilvum_PYR-GCK GTTAVSGGIVWIPAHDR---AEGELTADDAMAYLRAQSLGFMDEDLVETF Mvan_4248|M.vanbaalenii_PYR-1 GTTAVSGGIVWIPAHPRS--GDGELTAEDAMAYLRAQSLGYMDDELVETF TH_4085|M.thermoresistible__bu GTTAVSGGIAWIPAHDR---ASDELTVEDAMAYLRAQSLGYMDDDLVETF MSMEG_4870|M.smegmatis_MC2_155 GTTAVSGGIVWIPAHDR---AGEPLPVEDALAYLAAQSLGYMDTALVETF MLBr_01226|M.leprae_Br4923 GETATHYAQGGIAVVLP----GSDDSVDAHASDTLAAGAGMCNLDTVYSI * ** . *. . : : Mb3567|M.bovis_AF2122/97 LDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRP-GGRSIEPKPFNA Rv3537|M.tuberculosis_H37Rv LDRGPEMLSFVLKHTPLKMCWVPGYSDYYPEAPGGRP-GGRSIEPKPFNA MAB_0622c|M.abscessus_ATCC_199 LDRGPEMLSFVLANSPLKLDWVPNYSDYYPEAPGGRA-AGRSVEPKPFDA MUL_0349|M.ulcerans_Agy99 VRTGAAMLDFVEKHSGVRFEIAAGFPDYRPELPGGQPAGGRSLGPAAFEP MMAR_4780|M.marinum_M VRTGAAMLDFVEKHSGVRFEIAAGFPDYRPELPGGQPAGGRSLGPAAFEP MAV_0875|M.avium_104 VRTGPAMLDFIEAHSGLHFEIATGFPDYRPELPGGRPSGGRSLSAVPFDL Mflv_2398|M.gilvum_PYR-GCK VRTGARMLDFVEQHSDLVFEVAAGFPDYKPELPGGKPAGGRSLNAKPFDL Mvan_4248|M.vanbaalenii_PYR-1 VQSGAPMLDFLEAHSDLVFEVAAGFPDYKPELPGGKPGGGRSLHAGPFDL TH_4085|M.thermoresistible__bu VRTGPQMLDFVERHSELRFEVAEGFPDYKPELPGGRPGGGRSLHAAPYDL MSMEG_4870|M.smegmatis_MC2_155 VRTGPVMLDFVEAHSELRFAVAEGFPDYKPELPGGRPGGGRSLSAGPIDL MLBr_01226|M.leprae_Br4923 VAEGYHAVTELVGYG-------ARFDESIPGRWAVTCEGGHSRRRIVHAG : * : : : : * . .*:* Mb3567|M.bovis_AF2122/97 RKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGAR Rv3537|M.tuberculosis_H37Rv RKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGAR MAB_0622c|M.abscessus_ATCC_199 KKLGDELPNLEPPYGKVPLNVVVRQQDYVRLNQLKRHPRGVLRSLRVGVR MUL_0349|M.ulcerans_Agy99 SRLG-EWASRITSFPPDWSNVGFDAETRARLHAGVEE------------- MMAR_4780|M.marinum_M SRLG-EWASRITSFPPDWSNVGFDAETRARLHAGVEE------------- MAV_0875|M.avium_104 ARLG-EWATRITSFPADWSNVGFDAETRARLHAAIDER------------ Mflv_2398|M.gilvum_PYR-GCK SLLG-DWGERISSFPADFSNVGIDAETRARIHAAVD-E------------ Mvan_4248|M.vanbaalenii_PYR-1 ARLG-DWRDRITSFPADFSNVGIDAETRARIHAAVDNE------------ TH_4085|M.thermoresistible__bu GRLG-GWREKITSFPPDFSNVGIDAETRARIHAAVEDT------------ MSMEG_4870|M.smegmatis_MC2_155 ARLG-EWRDRITSFPADFSNVGIDAETRARIHAAYDDP------------ MLBr_01226|M.leprae_Br4923 GDATGAEVQRALDHAADVLDIRTSHLALRVLHDGTVVN------------ . :: :: Mb3567|M.bovis_AF2122/97 TMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVS Rv3537|M.tuberculosis_H37Rv TMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVS MAB_0622c|M.abscessus_ATCC_199 TFWAQGTGKKLVGMGRALSAALRIGLRDAGVPVKLNTALTDLYIEDGTVR MUL_0349|M.ulcerans_Agy99 -------SEDLCVAGTALVAGLLQGLLDVGVTPRTDAAAEELVVEDGAVV MMAR_4780|M.marinum_M -------SEDLCVAGTALVAGLLQGLLDVGVTPRTDAAAEELVVEDGAVV MAV_0875|M.avium_104 -------TGHLCVAGTALIAGLLKGLLDLGVTPRVNARAEELVAEDGEIT Mflv_2398|M.gilvum_PYR-GCK -------AGDYCVAGTALIAGLLKGLLDRGVVPHTQARAVELTADPLGIT Mvan_4248|M.vanbaalenii_PYR-1 -------SGDYCVAGTALIAGLLRSLLDRGITPHTEARAVELIADPLGIT TH_4085|M.thermoresistible__bu -------DGDYCVAGTALIAGLLDALLRAGVAPHTNARALELIGDAGRIR MSMEG_4870|M.smegmatis_MC2_155 -------DADLCVAGTALVAGLLRGLLDRGVKPVTSARAVELLGSADGIT MLBr_01226|M.leprae_Br4923 --------------GVSVLNPNGWGIVSAPSVILASGGLGHLYGATTNPE * :: .: . .* Mb3567|M.bovis_AF2122/97 GVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEW Rv3537|M.tuberculosis_H37Rv GVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPITTEW MAB_0622c|M.abscessus_ATCC_199 GVYVRETGAPEASEPTLIRGRRGVILASGGFEHNEQMRVKYQRAPITTEW MUL_0349|M.ulcerans_Agy99 GVRIAQSGR-----SISVRARRGVVLATGGFEWDPVLVRAFLRGPMHG-- MMAR_4780|M.marinum_M GVRIAQSGR-----SISVRARRGVVLATGGFEWDPVLVRAFLRGPMHG-- MAV_0875|M.avium_104 GVRIASAEG-----RIGVRARRGVILGTGGFEWDPVLVQAFLRGPMHG-- Mflv_2398|M.gilvum_PYR-GCK GVRIEQGSN-----DFRVRARKAVILGTGGFEWDQRLVEAYLRGPMRG-- Mvan_4248|M.vanbaalenii_PYR-1 GVRIEQGDS-----DFRVRAHRGVVLGTGGFEWDQRLVEAYLRGPMRG-- TH_4085|M.thermoresistible__bu GVRISRGDSGV-DQEMLVGARRGVVLATGGFEWDSRLVEAYLRGPMRG-- MSMEG_4870|M.smegmatis_MC2_155 GVRIRLDGT-----DIRVRARGGVVLATGGFEWDTTLVEAFLRGPMHG-- MLBr_01226|M.leprae_Br4923 GS---TGDG------IALALWAGVAVSDLEFIQFHPTMLFAAGTGTGGRR * : .* :. * Mb3567|M.bovis_AF2122/97 TVGASANTGDGILAAEKLGAALDL-MDDAWWGPTVPLVG-------KPWF Rv3537|M.tuberculosis_H37Rv TVGASANTGDGILAAEKLGAALDL-MDDAWWGPTVPLVG-------KPWF MAB_0622c|M.abscessus_ATCC_199 TVGAKANTGDGILAAEKLGAALEF-MEDSWWGPTVPLVG-------RPWF MUL_0349|M.ulcerans_Agy99 AVSPPNNTGDGLRMAMARGAELAN-MGEAWWVPIVQIPNDTIDGKQRSRS MMAR_4780|M.marinum_M AVSPPNNTGDGLRMAMARGAELAN-MGEAWWVPIVQIPNDTIDGKQRSRS MAV_0875|M.avium_104 AVSPPNNTGDGLRMAMAHGADLAN-MGEAWWVPIVQIPGDTIDGKPRSRS Mflv_2398|M.gilvum_PYR-GCK AVSPPNNTGDGLRMAMAHGADLAN-MGEAWWVPIVQIPGDTFEGRPRSRS Mvan_4248|M.vanbaalenii_PYR-1 AVSPPNNTGDGLRMAMAHGADLAN-MGEAWWVPIVQIPGDTFEGQPRSRS TH_4085|M.thermoresistible__bu AVSPPNNTGDGLRMAMAHGADLAN-MGEAWWVPIVQIPGDTFGGQPRSRS MSMEG_4870|M.smegmatis_MC2_155 PVSPPNNTGDGLRMAMAHGADLAN-MGEAWWVPVVQIPGDTIDGHPRSRS MLBr_01226|M.leprae_Br4923 PLVTEAIRGEGAILLDSKGNSVTSGVHPLGDLAPRDVVAAAIDARLKATG .: . *:* * : : . : :. Mb3567|M.bovis_AF2122/97 ALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPG-ENI Rv3537|M.tuberculosis_H37Rv ALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPG-ENI MAB_0622c|M.abscessus_ATCC_199 ALSERNSPGSIIVNSSGKRFMNESLPYVEATHRMYGGQYGQGPGPG-ENL MUL_0349|M.ulcerans_Agy99 VRLERTRPRSIIVNPAGQRFVNEACNYNS----MAGAFHYLDPRGGYVND MMAR_4780|M.marinum_M VRLERTRPRSIIVNPAGQRFVNEACDYNS----MAGAFHYLDPRGGYVND MAV_0875|M.avium_104 VRLERTRPRSIIVNAAGRRFVNEACDYNS----MAGAFHYLDPRGGYVND Mflv_2398|M.gilvum_PYR-GCK VRLERTRPRSIIVNRAGRRFLNEAGEYNS----MAGPFHFLDPKLGYAND Mvan_4248|M.vanbaalenii_PYR-1 VRLERTRPRSIIVNRAGRRFLNEAGEYNS----MAGPFHFLDPKLGYAND TH_4085|M.thermoresistible__bu VRLERTRPRSIIVNRFGRRFVNEAGEYNS----MAGAFQYLDPRDGYVND MSMEG_4870|M.smegmatis_MC2_155 IRLERTRPRSVIVNRAGNRFVNEAGEYNS----MAGPFQYLDPKAGYAND MLBr_01226|M.leprae_Br4923 DSCVYLDARGIDGFASRFPTVTAACRTVG----IDPAREPIPVVPGAHYS . .: :. : : * Mb3567|M.bovis_AF2122/97 PAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGL Rv3537|M.tuberculosis_H37Rv PAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGL MAB_0622c|M.abscessus_ATCC_199 PAWLVFDQEYRNRYIFAGLQPGQKIPSKWIESGVIVKADTIEELAKKANL MUL_0349|M.ulcerans_Agy99 HAWIVFDSAHLQRYGFLGIEPGQPVPDWFCES------TDLTELATKTGI MMAR_4780|M.marinum_M HAWIVFDSAHLQRYGFLGIEPGQPVPDWFCES------TDLTELATKTGI MAV_0875|M.avium_104 RGWMVFDSVHLQRYGFLGVEPGQPVPDWFCES------ADLAELAAKTGI Mflv_2398|M.gilvum_PYR-GCK PAWIVFDSLHLKHYGFLGVDPDGPVPDWFCQS------RDLEELGEKTGI Mvan_4248|M.vanbaalenii_PYR-1 PAWIVFDSIHLKHYGFLGVDPDGPVPEWFCQS------ADLEELGEKTGI TH_4085|M.thermoresistible__bu PAWIVFDAGHLERYGFLGVAPGEPVPDWFNAS------DDLAELATRTGI MSMEG_4870|M.smegmatis_MC2_155 PAWIVFDSVHLQRYGFLGVEPGGQAPDWFCES------ADLDELSARTGI MLBr_01226|M.leprae_Br4923 CGGIVTDAYGQT--ELAGLFAAGEVARTGMHG-----ANRLASNSLLEGL . :* * : *: . . . : . . .: Mb3567|M.bovis_AF2122/97 PADELTATVQRFNAFA---RSGVDEDYHRGESAYDRYYGD--PSNKPNPN Rv3537|M.tuberculosis_H37Rv PADELTATVQRFNAFA---RSGVDEDYHRGESAYDRYYGD--PSNKPNPN MAB_0622c|M.abscessus_ATCC_199 PVEELRATIERFNGFA---RSGVDEDFGRGKSAYDRYYGD--PTNKPNPN MUL_0349|M.ulcerans_Agy99 DADGLGRTIARWNHNV---ASGTDPDFGRGASAYDGYWGDDQATTLAGKT MMAR_4780|M.marinum_M DADGLGRTIARWNHNV---ASGTDPDFGRGASAYDGYWGDDQATTLAGKT MAV_0875|M.avium_104 DADGLTRTVENWNRYV---AAGVDPDFGRGSSAYDGYWGDDSATTQAGKT Mflv_2398|M.gilvum_PYR-GCK DPAGLEATLSAWNTNV---AAEHDPDFGRGASAYDGYWGDTDAATTAGRT Mvan_4248|M.vanbaalenii_PYR-1 DPVGLGATLAAWNSNV---TQEHDPDFGRGASAYDGYWGDTTATTTAGQT TH_4085|M.thermoresistible__bu DPDGLQRTVDAWNKNV---ADGVDPDFGRGSSAYDGYWGDTGAPTPAART MSMEG_4870|M.smegmatis_MC2_155 DAAGLAATLRRWNDNVGRDTDPVDPDFGRGASAYDGYWGDTSADTPARQT MLBr_01226|M.leprae_Br4923 VVGGRAGRAAAAHAAAAG--RAYVSKLEPVTHHALKRRELQRVMSRDAAV : . . . Mb3567|M.bovis_AF2122/97 LGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV Rv3537|M.tuberculosis_H37Rv LGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNV MAB_0622c|M.abscessus_ATCC_199 LGALTKAPFYAAKMVPGDLGTKGGVRTDVKGRVLRDDNSVIEGLYAAGNV MUL_0349|M.ulcerans_Agy99 LGPIDSAPFYAVPIRVGAMGTKGGPRTDRDGRVRHVSGRSVPGLFTAGNA MMAR_4780|M.marinum_M LGPIDSAPFYAVPIRVGAMGTKGGPRTDRDGRVRHVSGGSVPGLFAAGNA MAV_0875|M.avium_104 LGPIDTAPYYAVPVSIGAMGTKGGPRTDRDARVLHVGGEPIPGLFAAGNA Mflv_2398|M.gilvum_PYR-GCK LGPIDTAPYYAVPVSVGAMGTKGGPRTDRDGRVLHVNGTAITGLFAAGNA Mvan_4248|M.vanbaalenii_PYR-1 LGPIDTAPYFAVPVSIGAMGTKGGPRTDRDGRVLHVSGTAITGLFAAGNA TH_4085|M.thermoresistible__bu LGPLDAAPYFAVPVRIGAMGTKGGPRTDRDGRVLHVSGAPIVGLYAAGNA MSMEG_4870|M.smegmatis_MC2_155 LGPLDTAPFYAVPVKVGAMGTKGGPRTDRDGRVLHVNGSPIPGLYAAGNA MLBr_01226|M.leprae_Br4923 MRNAAGLQRLSDTLAEAPIRHVTGRRDFEDVALTLTARAVAAAALARNES : . : . : * * . . : .: Mb3567|M.bovis_AF2122/97 SAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR------------- Rv3537|M.tuberculosis_H37Rv SAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR------------- MAB_0622c|M.abscessus_ATCC_199 STPVMGHTYAGPGATIGPAMTWGYLAALDIAGK----------------- MUL_0349|M.ulcerans_Agy99 MAGVTGLAYGGAGGTIGPAMVFGYRAGRAVATGESADAP----------- MMAR_4780|M.marinum_M MAGVTGRAYGGAGGTIGPAMVFGYRAGRAAATGESADAP----------- MAV_0875|M.avium_104 MGGVTGRAYGGAGGTLGPAMVFGYRAGHAAATGKSVDLQ----------- Mflv_2398|M.gilvum_PYR-GCK MAGATGKAYGGAGGTIGPAMVFGYRAGHAAATGTSLS------------- Mvan_4248|M.vanbaalenii_PYR-1 MAGATGKAYGGAGGTLGPAMVFGYRAGYTAATGKSAP------------- TH_4085|M.thermoresistible__bu MAGVTGKAYGGAGGTLGPALVFGFRAGHHAATGGSVDXXXRLTRCRWALP MSMEG_4870|M.smegmatis_MC2_155 MAGVTGKAYGGAGGTLGPALVFGYRSGYAAATGKSVD------------- MLBr_01226|M.leprae_Br4923 RGCHHCTEYPDTAPEHARSTVIRLADDQNLVRAEALATVG---------- * ... . : . . Mb3567|M.bovis_AF2122/97 ---------------------------- Rv3537|M.tuberculosis_H37Rv ---------------------------- MAB_0622c|M.abscessus_ATCC_199 ---------------------------- MUL_0349|M.ulcerans_Agy99 ---------------------------- MMAR_4780|M.marinum_M ---------------------------- MAV_0875|M.avium_104 ---------------------------- Mflv_2398|M.gilvum_PYR-GCK ---------------------------- Mvan_4248|M.vanbaalenii_PYR-1 ---------------------------- TH_4085|M.thermoresistible__bu SASRASSPADVTPGSSVNGANGSVTKPR MSMEG_4870|M.smegmatis_MC2_155 ---------------------------- MLBr_01226|M.leprae_Br4923 ----------------------------