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TVGPWGDVDRMVDVLVVGSGGGGMTAALTAASSGLDTLVIEKSSCFGGSTALSGGGIWVPGDPAQRRAGY SPNPDDVVGYLRRITNGLVSEARIRQYVYSAPQMLEFLEGLSAWLEFVWKPGYADYYPELPGGSVLGSTI NVPPIDLRKLGDDQPRLLTPLALAPRGIWLGPKELRSFYRIRQSWAGKAVLLKLVTRMIRARVFGEQIAA IGQSLAARLRLAMKELGVALWLDAPLVELLTDAGGAVTGAVVQTEGGRERIGVRGGVILASGGFDHDLAW RKEHQPLVEQDWSFGNPAALGDGIRAGQRVGAAADLLDEAWWFPAIQWPDGRMQFMLNERMMPAQFIVNG AGKRFINEAAPYMDFGHAMIAGQKSGVTHIPCWLVTDHRSFNRYVVAGHLPIPKIPGAPVPTGRKIPTAW LESGVVKAATSWAELATKIGVPGGQLQATAERFNELAVYGHDDDFNRGDSVYDNYYGDPTLPNPNLYPLG DPPYYAFRIVLGDLGTSGGLRTDEYARVLRPDDTTVGGLYAVGNTSAPVMGRSYAGAGATIGPAMTFGFV AAKHLAARLDARRATPTTHFHGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0346 | - | - | 100% (584) | 3-ketosteroid-delta-1-dehydrogenase |
| M. ulcerans Agy99 | MUL_4098 | - | e-118 | 42.36% (569) | 3-ketosteroid-delta-1-dehydrogenase |
| M. ulcerans Agy99 | MUL_0349 | - | 1e-71 | 34.68% (571) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 1e-121 | 41.86% (571) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2403 | - | 0.0 | 72.28% (570) | 3-ketosteroid-delta-1-dehydrogenase |
| M. tuberculosis H37Rv | Rv3537 | - | 1e-121 | 41.86% (571) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0622c | - | 1e-123 | 42.68% (567) | 3-ketosteroid-delta-1-dehydrogenase |
| M. marinum M | MMAR_4775 | - | 0.0 | 98.80% (584) | dehydrogenase |
| M. avium 104 | MAV_0880 | - | 0.0 | 82.92% (568) | 3-ketosteroid-delta-1-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4864 | - | 0.0 | 75.49% (567) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_4337 | - | 0.0 | 74.96% (579) | PUTATIVE fumarate reductase/succinate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4243 | - | 0.0 | 74.04% (570) | 3-ketosteroid-delta-1-dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0346|M.ulcerans_Agy99 --MTVGPWGDVDRMVDVLVVGSGGGGMTAALTAASSGLDTLVIEKSSCFG
MMAR_4775|M.marinum_M --MTVGPWGDVDRMVDVLVVGSGGGGMTAALTAASSGLDTLVIEKSSCFG
MAV_0880|M.avium_104 -------MTDFDHLVDVLIVGSGGGGMTAALTAQAAGLDALIVEKSSHFG
Mflv_2403|M.gilvum_PYR-GCK MTERRSTVQSFDHVTDVLVVGSGGGGMTAALAADAAGLDTLVVEKSPRFG
Mvan_4243|M.vanbaalenii_PYR-1 MSS--VVGQTFEHFTDVLVIGSGGGGMTAALAADASGLDTLVVEKSPRFG
MSMEG_4864|M.smegmatis_MC2_155 MTSTNSPTDGFDHTVDLLVIGSGGGGMTAALAGDASGLDTLVVEKSPQFG
TH_4337|M.thermoresistible__bu -----MTVDTHDQTVDVLVVGSGGGGMTAALTADAAGLDTLLVEKSPQFG
Mb3567|M.bovis_AF2122/97 ---------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYG
Rv3537|M.tuberculosis_H37Rv ---------MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYG
MAB_0622c|M.abscessus_ATCC_199 ---------MTEQEYDVVVVGSGGAGMVAALTAAHNGLSTVLIEKAPHFG
: *::::***..**.***.. **.::::**:. :*
MUL_0346|M.ulcerans_Agy99 GSTALSGGGIWVPGDPAQRRAGYSPNPDDVVGYLRRITNGLVSEARIRQY
MMAR_4775|M.marinum_M GSTALSGGGIWVPGAPAQRRAGYSPNPDDVVGYLRRITDGLVSEARIRQY
MAV_0880|M.avium_104 GSTALSGGGIWVPGAPAQRREGYSPSPEGVVEYLKNITDGLVSEARIRQY
Mflv_2403|M.gilvum_PYR-GCK GSTALSGGGIWVPGAPSQRREGHVVDPEQVFTYLKQITGGLVSDARLRKY
Mvan_4243|M.vanbaalenii_PYR-1 GSTALSGGGIWVPGAPSQRREGYVPDPDEVFTYLKEITGGLVSDARLRKY
MSMEG_4864|M.smegmatis_MC2_155 GSTALSGGGIWVPGAPAQRREGHVPSPDGVFEYLKQITGGLVSDARLRQY
TH_4337|M.thermoresistible__bu GSTALSGGGIWVPGAPAQRREGYSPDPDDVFEYLRQITGGLVSDARLRTY
Mb3567|M.bovis_AF2122/97 GSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAY
Rv3537|M.tuberculosis_H37Rv GSTARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAY
MAB_0622c|M.abscessus_ATCC_199 GSTARSGGGVWIPNNEVLKKARQTDTPEAAREYLYSIIGDVVPREKIDTY
**** ****:*:*. :: *: . ** * . :* :: *
MUL_0346|M.ulcerans_Agy99 VYSAPQMLEFLEGLSAWLEFVWKPGYADYYPELPGGSVLGSTINVPPIDL
MMAR_4775|M.marinum_M VYSAPQMLEFLEGLSAWLEFVWKPGYADYYPELPGGSVLGSTINVPPIDL
MAV_0880|M.avium_104 VETAPQMLAFLENLSGWFEFVWKPGYADYYPELPGGSELGSTINVPPIDL
Mflv_2403|M.gilvum_PYR-GCK VEAAPEMMEFLENLSPWLEFVWKPGYADYYPELPGGSALGSTINVPEIDL
Mvan_4243|M.vanbaalenii_PYR-1 VDAAPEMMEFLEKLSPWLEFVWKPGYADYYPELPGGSALGSTINVPEIDL
MSMEG_4864|M.smegmatis_MC2_155 VDSAPEMMDFLERTSNWMEFVWKPGYADYYPELPGGSALGSTINVPAIDL
TH_4337|M.thermoresistible__bu VDEAPKMMEFLEQLSPWCEFVWKPGYADYYPELPGGSPLGSTINVPAIDL
Mb3567|M.bovis_AF2122/97 LDRGPEMLSFVLKHTP-LKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNA
Rv3537|M.tuberculosis_H37Rv LDRGPEMLSFVLKHTP-LKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNA
MAB_0622c|M.abscessus_ATCC_199 LDRGPEMLSFVLANSP-LKLDWVPNYSDYYPEAPGGRAAGRSVEPKPFDA
: .*:*: *: : :: * *.*:***** *** * ::: ::
MUL_0346|M.ulcerans_Agy99 RKLGDDQPRLLTPLALAPRGIWLGPKELRSFYRIRQSWAGKAVLLKLVTR
MMAR_4775|M.marinum_M RKLGDDQPRLLTPLALAPRGIWLGPKELRSFYRIRQSWAGKAVLLKLVTR
MAV_0880|M.avium_104 RKLGPDEHKLLQPLALAPKGIWLGPKELRTFYRIRQSWAGKAVLLKLIAR
Mflv_2403|M.gilvum_PYR-GCK RTLGDEEQNLLTPLALAPKGIWFAPKDLRLFYQVRQSWKGKAVLVKLIWR
Mvan_4243|M.vanbaalenii_PYR-1 RVLGDEEQHLLAPLALAPRGIWFAPKDLRLFYQVRQSWRGKAVLLKLIWR
MSMEG_4864|M.smegmatis_MC2_155 RKLGDEERNLLTPLALAPKGIWFAPKDLRLFYQIRQNWRGKAVLLKLIWR
TH_4337|M.thermoresistible__bu RRLGDEEARLLQPLALAPRGIWFAPKDLRLFYQVRQNWRGKAVLVKLIWR
Mb3567|M.bovis_AF2122/97 RKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGAR
Rv3537|M.tuberculosis_H37Rv RKLGADMAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGVLRSMKVGAR
MAB_0622c|M.abscessus_ATCC_199 KKLGDELPNLEPPYGKVPLNVVVRQQDYVRLNQLKRHPRGVLRSLRVGVR
: ** : * . . .* .: . :: : :::: * ::: *
MUL_0346|M.ulcerans_Agy99 MIRARVFGEQIAAIGQSLAARLRLAMKELGVALWLDAPLVELLTDAGG--
MMAR_4775|M.marinum_M MIRARVFGEQIAAIGQSLAARLRLAMKELGVALWLDAPLVELLTDAGG--
MAV_0880|M.avium_104 MVRARVFGERMAAIGQSLAARMRLALRDRGVPLWLDSPMVRLLTDPQG--
Mflv_2403|M.gilvum_PYR-GCK MFRARVFGDRMAAIGQSLSARLRLAMKQQDIPLWLNSPMTELITDHDGPD
Mvan_4243|M.vanbaalenii_PYR-1 MFRARVFGDRMAAIGQSLSARLRLAMKQQNIPLWLNAPMTELITDTDGPE
MSMEG_4864|M.smegmatis_MC2_155 MFRARVFGDRMAAIGQSLAARLRLALKEQGIPLWLNSPMTELITADDG--
TH_4337|M.thermoresistible__bu MFRARVFGDRMAAIGQSLAARLRLAMRQQGVPLWLNAPMTELITDADG--
Mb3567|M.bovis_AF2122/97 TMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVS
Rv3537|M.tuberculosis_H37Rv TMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVELNTAFTDLFVENGVVS
MAB_0622c|M.abscessus_ATCC_199 TFWAQGTGKKLVGMGRALSAALRIGLRDAGVPVKLNTALTDLYIEDGTVR
. *: *..:..:*::* . :*:.:: .:.: *::.:. *
MUL_0346|M.ulcerans_Agy99 -AVTGAVVQTE-GGRERIGVRGGVILASGGFDHDLAWRKEHQPLVE----
MMAR_4775|M.marinum_M -AVTGAVVQTE-GGRERIGVRGGVILASGGFDHDLAWRKEHQPLVE----
MAV_0880|M.avium_104 -AVSGAVVERE-GKPQRIGARFGVILASGGFDHDLAWRKELLPEVE----
Mflv_2403|M.gilvum_PYR-GCK ARVIGAVVERD-GRTLRVRADRGVVLASGGFDHDMQWRLQHLPELARVRE
Mvan_4243|M.vanbaalenii_PYR-1 GRVVGAVIERD-GRPIRVRARGGVILASGGFDHDMQWRRQHLPELNRVDE
MSMEG_4864|M.smegmatis_MC2_155 -AVIGAVVERD-GTPMRIGARRGVILASGGFDHDMAWRRQYLPILE----
TH_4337|M.thermoresistible__bu -AVVGAVVEKD-GRAVRIRARHGVILAAGGFDHDMDRRREHLPLLE----
Mb3567|M.bovis_AF2122/97 GVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPIT---
Rv3537|M.tuberculosis_H37Rv GVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQMRIKYQRAPIT---
MAB_0622c|M.abscessus_ATCC_199 GVYVRETGAPEASEPTLIRGRRGVILASGGFEHNEQMRVKYQRAPIT---
: . : **:**.***:*: * :
MUL_0346|M.ulcerans_Agy99 -----QDWSFGNPAALGDGIRAGQRVGAAADLLDEAWWFPAIQWPDGRMQ
MMAR_4775|M.marinum_M -----QDWSFGNPAALGDGIRAGQRVGAAADLLDEAWWFPAIQWPDGRMQ
MAV_0880|M.avium_104 -----QDWSFGNPAAMGDGIRAGQNVGAATDLLDEAWWFPAIQWPDGRMQ
Mflv_2403|M.gilvum_PYR-GCK MAPEGKDWSFGNPAAMGDGIRAGEKVGGATELLDEAWWFPAICWPDGRLQ
Mvan_4243|M.vanbaalenii_PYR-1 LAGCGKDWSFGNPAATGDGIRAGEKVGAATDLLDEAWWFPAICWPDGRLQ
MSMEG_4864|M.smegmatis_MC2_155 -----KDWSFGNPAATGDGIRAGEKVGGATELLDEAWWFPAICWPDGRLQ
TH_4337|M.thermoresistible__bu -----KDWSFGNPAATGDGIRAGEKVGGATELLDEAWWFPAICWPDGRLQ
Mb3567|M.bovis_AF2122/97 -----TEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLV-GKPW
Rv3537|M.tuberculosis_H37Rv -----TEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLV-GKPW
MAB_0622c|M.abscessus_ATCC_199 -----TEWTVGAKANTGDGILAAEKLGAALEFMEDSWWGPTVPLV-GRPW
:*:.* * **** *.:.:*.* ::::::** *:: *:
MUL_0346|M.ulcerans_Agy99 FMLNERMMPAQFIVNGAGKRFINEAAPYMDFGHAMIAGQKSG--------
MMAR_4775|M.marinum_M FMLNERMMPAQFIVNGAGKRFINEAAPYMDFGHAMIAGQKSG--------
MAV_0880|M.avium_104 FMLNERMMPAQFIVNGAGRRFINEAAPYMDFGHAMIEGQRSG--------
Mflv_2403|M.gilvum_PYR-GCK FMLNERMMPAQFIVNGAGKRFINEAAPYMDFAHAMIEGQRSG--------
Mvan_4243|M.vanbaalenii_PYR-1 FMLNERMMPSQFVVNGDGERFINEAAPYMDFAHAMIEGQRSG--------
MSMEG_4864|M.smegmatis_MC2_155 FMLNERMMPSQFVVNGEGKRFINEAAPYMDFAHAMIEGQQSG--------
TH_4337|M.thermoresistible__bu FMLNERMMPSQFIVNGAGRRFINEAAPYMDFAHAMIEGERAYRDSHGENG
Mb3567|M.bovis_AF2122/97 FALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGP-----G
Rv3537|M.tuberculosis_H37Rv FALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGP-----G
MAB_0622c|M.abscessus_ATCC_199 FALSERNSPGSIIVNSSGKRFMNESLPYVEATHRMYGGQYGQGP-----G
* *.** *..::** *.**:**: **:: * * *: .
MUL_0346|M.ulcerans_Agy99 -VTHIPCWLVTDHRSFNRYVVAGHLPIPKIPGAPVPTGRKIPTAWLESGV
MMAR_4775|M.marinum_M -VTHIPCWLVTDHRSFNRYVVAGHLPIPKIPGAPVPTGRKIPTAWLESGV
MAV_0880|M.avium_104 -VTHIPCWLITDHRSWNRYVIGGHLPLPKIPGAPVPTGRKIPPAWLESGV
Mflv_2403|M.gilvum_PYR-GCK -VTHIPCWLITDIRSFHRYVVGGHLPIPKVPFAPVPTGWKVPQAWLDSGV
Mvan_4243|M.vanbaalenii_PYR-1 -VTHIPCWLITDIRSFHRYVVAGHLPIPKVPFAPVPTGWKVPAAWLESGV
MSMEG_4864|M.smegmatis_MC2_155 -VTHIPCWLITDIDSFHRYVVAGHLPIPKIPFAPVPTGRKVPQAWLESGV
TH_4337|M.thermoresistible__bu TAQHIPCWLITDIRSFRRYVVAGHLPIPKIPFAPVPTGRKVPREWLESGV
Mb3567|M.bovis_AF2122/97 PGENIPAWLVFDQRYRDRYIFAG-----------LQPGQRIPSRWLDSGV
Rv3537|M.tuberculosis_H37Rv PGENIPAWLVFDQRYRDRYIFAG-----------LQPGQRIPSRWLDSGV
MAB_0622c|M.abscessus_ATCC_199 PGENLPAWLVFDQEYRNRYIFAG-----------LQPGQKIPSKWIESGV
::*.**: * **:..* : .* ::* *::***
MUL_0346|M.ulcerans_Agy99 VKAATSWAELATKIGVPGGQLQATAERFNELAVYGHDDDFNRGDSVYDNY
MMAR_4775|M.marinum_M VKAATSWAELATKVGVPGGQLQATAERFNELAVKGHDEDFNRGDSVYDNY
MAV_0880|M.avium_104 VKAAMTWDEMAAQIGVPAGELAETARRFNELARKGHDDDFNRGDSVYDNY
Mflv_2403|M.gilvum_PYR-GCK VKQGHTWEDLAREIGVPGTELRNTAERFNALAAKGHDDDFCRGDSAYDNY
Mvan_4243|M.vanbaalenii_PYR-1 VKTGSTWEELADQIGVPGTRLRGTAERFNALAAKGHDDDFNRGDSAYDNY
MSMEG_4864|M.smegmatis_MC2_155 VQEGRTMEELATKIGVPPQNLRATAERFDQLARAGHDDDFNRGDSAYDNY
TH_4337|M.thermoresistible__bu VHEGHSWEELAAKINVPADQLRATAERFNMLAAKGHDDDFNRGDSAYDNY
Mb3567|M.bovis_AF2122/97 IVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRY
Rv3537|M.tuberculosis_H37Rv IVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRY
MAB_0622c|M.abscessus_ATCC_199 IVKADTIEELAKKANLPVEELRATIERFNGFARSGVDEDFGRGKSAYDRY
: . : ::* : .:* .* * .**: :* * *:*: **.*.**.*
MUL_0346|M.ulcerans_Agy99 YGDPT-LPNPNLYPLGDPPYYAFRIVLGDLGTSGGLRTDEYARVLRPDDT
MMAR_4775|M.marinum_M YGDPT-LPNPNLYPLGDPPYYAFRIVLGDLGTSGGLRTDEYARVLRPDDT
MAV_0880|M.avium_104 YGDPT-LPNPNLYPLGDPPYYAFRIVLGDLGTSGGLRTDEHARVLRADDT
Mflv_2403|M.gilvum_PYR-GCK YGDQT-LPNPNLYPLGKPPYYAFQIILGDLGTSGGLRTDEFARVLRSDDS
Mvan_4243|M.vanbaalenii_PYR-1 YGDPT-LPNPNLHPLGAPPYFAFQIILGDLGTSGGLRTDEHARVLRGDDS
MSMEG_4864|M.smegmatis_MC2_155 YGDPT-LPNPNLRPLGKPPYYAFQIILGDLGTSGGLRTDEFARVLRSDET
TH_4337|M.thermoresistible__bu YGDPT-LPNPNLHPLGRPPYYAFQIILGDLGTSGGLRTDEHARVLRVDDS
Mb3567|M.bovis_AF2122/97 YGDPSNKPNPNLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGS
Rv3537|M.tuberculosis_H37Rv YGDPSNKPNPNLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGRALRDDGS
MAB_0622c|M.abscessus_ATCC_199 YGDPTNKPNPNLGALTKAPFYAAKMVPGDLGTKGGVRTDVKGRVLRDDNS
*** : ***** : .*::. ::: *****.**:*** .*.** * :
MUL_0346|M.ulcerans_Agy99 TVGGLYAVGNTSAPVMGRSYAGAGATIGPAMTFGFVAAKHLAARLDARRA
MMAR_4775|M.marinum_M TVGGLYAVGNTSAPVMGRSYAGAGATIGPAMTFGFVAAKHLAAQLDARRA
MAV_0880|M.avium_104 VVPGLYAVGNTSAPVMGRSYAGAGATIGPAMTFGYVAAKHVAAQVANRAA
Mflv_2403|M.gilvum_PYR-GCK AIPGLYAVGNASSAVMGRSYAGAGATIGPAMAFGYVAARHIAETETLTAL
Mvan_4243|M.vanbaalenii_PYR-1 VIGGLYAVGNASAAVMGRSYAGAGATIGPAMTFGYVAARHIADSAGGTT-
MSMEG_4864|M.smegmatis_MC2_155 VVSGLYAVGNASGAVMGRSYAGAGATIGPAMTFGYVAARHAAAGESAVPN
TH_4337|M.thermoresistible__bu VVPGLYAVGNNSAAVMGRSYAGAGATIGPAMTFGYVAARHIAERAAPATT
Mb3567|M.bovis_AF2122/97 IIDGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR--
Rv3537|M.tuberculosis_H37Rv IIDGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR--
MAB_0622c|M.abscessus_ATCC_199 VIEGLYAAGNVSTPVMGHTYAGPGATIGPAMTWGYLAALDIAGK------
: ****.** * .***::*.*.*.******::*::** . *
MUL_0346|M.ulcerans_Agy99 TPTTHFHGR-------
MMAR_4775|M.marinum_M TPTTHLHGR-------
MAV_0880|M.avium_104 N--THRR---------
Mflv_2403|M.gilvum_PYR-GCK DDQSLQAPDLQGGNQ-
Mvan_4243|M.vanbaalenii_PYR-1 -DRTTTSTESPGSSRR
MSMEG_4864|M.smegmatis_MC2_155 PDNALQHRIS------
TH_4337|M.thermoresistible__bu SSPTRPSTSKSNVS--
Mb3567|M.bovis_AF2122/97 ----------------
Rv3537|M.tuberculosis_H37Rv ----------------
MAB_0622c|M.abscessus_ATCC_199 ----------------