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TTTRPVMPEPRWIDVPGPNGDLKALTWGRPEAPMALCLHGFPDTADGWRKLAPILVDSGWRVVAPFMRGY APSAIPADGSYHVGALMDDALRVRSAAGATEGDVLIGHDWGAIAAAGLAAMPDSPFSRAVIMSVPPAAAF RPLGRVPDRGRLARELPHQLLRSWYILYFQLPWLPERWASWVPRLLWRRWSPTYYAEEDLRHVDAAIGTA EGWRAALGPYRATIRNTRPPARYAELNRWWTEAPQLPVLYLHGRDDGCAAVAFTHWTERVLPPGSEVAVV EQAGHFLQLEQPEAVAKLILPFIAPPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0144 | ephC | - | 100% (308) | epoxide hydrolase EphC |
| M. ulcerans Agy99 | MUL_4193 | ephA | 8e-19 | 25.53% (333) | epoxide hydrolase EphA |
| M. ulcerans Agy99 | MUL_4244 | ephE | 9e-13 | 30.14% (282) | epoxide hydrolase EphE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1155 | ephC | 1e-151 | 82.08% (307) | epoxide hydrolase EphC |
| M. gilvum PYR-GCK | Mflv_0191 | - | 1e-73 | 46.18% (301) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1124 | ephC | 1e-151 | 82.08% (307) | epoxide hydrolase EphC |
| M. leprae Br4923 | MLBr_02297 | - | 6e-11 | 28.72% (282) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4573c | - | 4e-65 | 45.17% (290) | epoxide hydrolase EphC |
| M. marinum M | MMAR_4334 | ephC | 0.0 | 99.00% (301) | epoxide hydrolase EphC |
| M. avium 104 | MAV_1256 | - | 1e-138 | 76.82% (302) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1998 | - | 4e-63 | 45.30% (298) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2114 | ephC | 1e-123 | 70.23% (299) | PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE HYDRATASE) |
| M. vanbaalenii PYR-1 | Mvan_0714 | - | 3e-73 | 46.98% (298) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0191|M.gilvum_PYR-GCK ---------------MTDP---------QTLTLTLPHLTVTALSWGPPD-
Mvan_0714|M.vanbaalenii_PYR-1 ------------MAQVTAP---------QTLRLSLPHLDVAALSWGPPD-
MSMEG_1998|M.smegmatis_MC2_155 ---------------MTAP---------ERLTLDLPHLRFAALAWGPKD-
MUL_0144|M.ulcerans_Agy99 --------MTTTRPVMPEP---------RWIDVPGPNGDLKALTWGRPE-
MMAR_4334|M.marinum_M ---------------MPEP---------RWIDVPGPNGDLKALTWGRPE-
Mb1155|M.bovis_AF2122/97 MRAGRGERESTWRTTMAEP---------HWIDVKGPNGDLKALTWGPAG-
Rv1124|M.tuberculosis_H37Rv MRAGRGERESTWRTTMAEP---------HWIDVKGPNGDLKALTWGPAG-
MAV_1256|M.avium_104 -------------MKMAEP---------GWIDVTGPAGDLKALTWGPPD-
TH_2114|M.thermoresistible__bu -------------VTMTEP---------RWIDVRTPGADLRALVWEPAES
MAB_4573c|M.abscessus_ATCC_199 ---------------MAAD---------CYLTLDLPNVRLRALAWGPQD-
MLBr_02297|M.leprae_Br4923 -------------MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQP
:. : : . .:
Mflv_0191|M.gilvum_PYR-GCK -----------GRLVLCLHGFPDSAWGWRKFAPILAEHGFRVVAPFSRGY
Mvan_0714|M.vanbaalenii_PYR-1 -----------GRLVLCLHGFPDSAWGWRKFAPLLAERGMRVVAPFSRGY
MSMEG_1998|M.smegmatis_MC2_155 -----------GRLMLCLHGYPDSAWTWRHLGPHFAAQGFRVVAPFMRGY
MUL_0144|M.ulcerans_Agy99 -----------APMALCLHGFPDTADGWRKLAPILVDSGWRVVAPFMRGY
MMAR_4334|M.marinum_M -----------APMALCLHGFPDTAYGWRKLAPILVDSGWRVVAPFMRGY
Mb1155|M.bovis_AF2122/97 -----------APVALCLHGFPDTAYGWRKVAPRLAESGWHVVAPFMRGY
Rv1124|M.tuberculosis_H37Rv -----------APVALCLHGFPDTAYGWRKVAPRLAESGWHVVAPFMRGY
MAV_1256|M.avium_104 -----------GPLALCLHGFPDTPYGWRKLAPRLADAGWRVVAPFMRGY
TH_2114|M.thermoresistible__bu D---------NAPIALCLHGFPDTAHGWRKLAPLLADAGWRVVAPFNRGY
MAB_4573c|M.abscessus_ATCC_199 -----------GPLVICGHGFPDSAHTWRLLGPRLGAEGWRVVAPFTRGY
MLBr_02297|M.leprae_Br4923 AGQDCAPSATARPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGY
: : **: . ** : ::** ***
Mflv_0191|M.gilvum_PYR-GCK APTGPAPDGDYHIGALMYDALAVHRELGAPDDAVLIGHDWGGFTAAGIAA
Mvan_0714|M.vanbaalenii_PYR-1 APTGPAPDGDYHIGALMYDALAVHRELGAPDDAVLIGHDWGAFTASAIAA
MSMEG_1998|M.smegmatis_MC2_155 APTELARDGDYGLGALMYDAVTLHEALGGTGDAVLVGHDWGGLASAGVAA
MUL_0144|M.ulcerans_Agy99 APSAIPADGSYHVGALMDDALRVRSAAGATEGDVLIGHDWGAIAAAGLAA
MMAR_4334|M.marinum_M APSAIPADGSYHVGALMDDALRVRSAAGATEGDVLIGHDWGAIAAAGLAA
Mb1155|M.bovis_AF2122/97 APSSIPADGSYHVGALMHDALRVRSAAGGTERDVIIGHDWGAIAATGLAA
Rv1124|M.tuberculosis_H37Rv APSSIPADGSYHVGALMHDALRVRSAAGGTERDVIIGHDWGAIAATGLAA
MAV_1256|M.avium_104 APSAIPSDGSYHVGALMDDALRVRAAAGGTENDVVIGHDWGAIAATGLAA
TH_2114|M.thermoresistible__bu APSSPAHDGSYHVGALMDDALRVLDAAGRTGRDLLIGHDWGAIAGAGLAA
MAB_4573c|M.abscessus_ATCC_199 APSEIPADAEYGLGALMQDVLDIHTVLGGDERAIYIGHDWGALVGNALAR
MLBr_02297|M.leprae_Br4923 GGSDKPPRG-YDGWTLAGDTAGLIRALG-HSSATLVGHAEGGLACWATAL
. : . . * :* *. : * :** *.:. . *
Mflv_0191|M.gilvum_PYR-GCK YPDSPFAEHITMAVAP---IGAVNRTRGPLT--RQLALLPKQLRNSWYIM
Mvan_0714|M.vanbaalenii_PYR-1 YPGSPFADHVSMAVPP---VGAINRTRGSLA--RQLRMMPRQLRNSWYIL
MSMEG_1998|M.smegmatis_MC2_155 YPKNPFGTVVSMGVPV---VAGM-RDAGNRR--RLAPLLPVQMRMSWYIL
MUL_0144|M.ulcerans_Agy99 MPDSPFSRAVIMSVPPAAAFRPLG-RVPDRG--RLARELPHQLLRSWYIL
MMAR_4334|M.marinum_M MPDSPFSRAVIMSVPPAAAFRPLG-RVPDRG--RLARELPHQLLRSWYIL
Mb1155|M.bovis_AF2122/97 MPDSPFAKAVIMSVPPSAAFRPLG-RVPERG--RLLRELPHQLLRSWYIL
Rv1124|M.tuberculosis_H37Rv MPDSPFAKAVIMSVPPSAAFRPLG-RVPERG--RLLRELPHQLLRSWYIL
MAV_1256|M.avium_104 MPDSPFAKAVLMSVPPSAAFRRRGGSAAERG--RLAAHLARQVFRSWYIM
TH_2114|M.thermoresistible__bu MPDSPFTRAVIMSVPPAASFRPLG-RVADPA--RLAARLPRQLLRSWYIM
MAB_4573c|M.abscessus_ATCC_199 SGRSPFARIVTMAVPP---FEVLGSNMASIGPGGWPAVLARQLFMSWYTL
MLBr_02297|M.leprae_Br4923 LHPRLVRAIALINSPHPAALRRSMLTHRNQG----YALLPTLLR---YQL
. : . . :. : * :
Mflv_0191|M.gilvum_PYR-GCK FFQLPELPERLLPRVIPRLWRDWGPQGYDTGAELA----DALAALPSPAH
Mvan_0714|M.vanbaalenii_PYR-1 FFQLPGLPERLLPRVIPRLWQDWGPAGYDTAAELD----DALAALPSPAH
MSMEG_1998|M.smegmatis_MC2_155 FQQIPWLSERNLGRVIPKLWRDWCPPGYDAREDLA----HLWEALPDTRR
MUL_0144|M.ulcerans_Agy99 YFQLPWLPERWASWVPRLLWRRWSP-TYYAEEDLR----HVDAAIGTAEG
MMAR_4334|M.marinum_M YFQLPWLPERSASWVPRLLWRRWSP-TYYAEEDLR----HVDAAIGTAEG
Mb1155|M.bovis_AF2122/97 YFQLPWLPERSASWVVPLLWRRWSP-GYHAEEDLR----HVDAAIGTPEG
Rv1124|M.tuberculosis_H37Rv YFQLPWLPERSASWVVPLLWRRWSP-GYHAEEDLR----HVDAAIGTPEG
MAV_1256|M.avium_104 YFQLPWLPERSASWVLPLLWRRWSP-GYRAEEDLR----HVDAAIGAPES
TH_2114|M.thermoresistible__bu YFQLPWLPDRSSKWVVPALWRHWSP-DYPADEDIE----LVRDAIGAPER
MAB_4573c|M.abscessus_ATCC_199 FHQLPLLPEWLLPWLLRLYWRRWSP-GYDARADLL----YTGEAMLQKGN
MLBr_02297|M.leprae_Br4923 PIWPERLLTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAA
* : . : : :: *:
Mflv_0191|M.gilvum_PYR-GCK RRAAVAYYRAMVRPSEPSGR-YADLHRWCFDV-PRVPILHLQGELDGAME
Mvan_0714|M.vanbaalenii_PYR-1 RRAAVSYYRAMVRPSRPGRM-YADLHKWCFEL-PRAPILHVQGKQDGAMQ
MSMEG_1998|M.smegmatis_MC2_155 RTAALAYYRAALRPWRRGS--HAELDRYAMTQNPISPMLVLHGRLDGAID
MUL_0144|M.ulcerans_Agy99 WRAALGPYRATIRNTRPPAR-YAELNRWWTEA-PQLPVLYLHGRDDGCAA
MMAR_4334|M.marinum_M WRAALGPYRATIRNTRPPAR-YAELNRWWTEA-PQLPVLYLHGRDDGCAA
Mb1155|M.bovis_AF2122/97 RRAALGPYRATMRNTRAPAD-YADLNRLWTEA-PKLPVLYLHGHDDGCAT
Rv1124|M.tuberculosis_H37Rv RRAALGPYRATMRNTRAPAD-YADLNRLWTEA-PKLPVLYLHGHDDGCAT
MAV_1256|M.avium_104 WRAALGPYRATIRNTAPPAQ-YATLHRLWTEE-PVLPCLYLHGRDDGCMT
TH_2114|M.thermoresistible__bu WRAALGYYRATIRNTRPPHR-YAELHQHWLSA-PRIPTLYLHGADDGCAT
MAB_4573c|M.abscessus_ATCC_199 RRAVIGYYRANIRGALFPARKYWPTQRSLLDG-ARTPMLYLHGRNDGCMT
MLBr_02297|M.leprae_Br4923 AHCALEYQRWAVRSQLRNEG--RKFMKSMSRP-FSVPLLHVRGDADPYLL
..: * :* : * * ::* *
Mflv_0191|M.gilvum_PYR-GCK AEYAAPIATALPAGSRVRIIDEAGHFLQIERPQVTADTVLDYLGDRRGPR
Mvan_0714|M.vanbaalenii_PYR-1 AGYAEPIGAVLPPGSRVVTIPAAGHFLQIERPAETAAAVLQYLGDRSGPR
MSMEG_1998|M.smegmatis_MC2_155 VRIGTLSASVLVPGSRHEVIDGAGHFMHLDRPDEVHALIADYANL-----
MUL_0144|M.ulcerans_Agy99 VAFTHWTERVLPPGSEVAVVEQAGHFLQLEQPEAVAKLILPFIAPPG---
MMAR_4334|M.marinum_M VAFTHWTERVLPPGSEVAVVEQAGHFLQLEQPETVAKLILPFIAPPG---
Mb1155|M.bovis_AF2122/97 SAFTHWTARVLPAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG---
Rv1124|M.tuberculosis_H37Rv SAFTHWTARVLPAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG---
MAV_1256|M.avium_104 SAFAHQVEKVLPPGSEVDIVEHAGHFLQLEQPDKVAGLVLGFIGSPG---
TH_2114|M.thermoresistible__bu PDYARWVEPVLPVGSAVAILDRAGHFLQLDRPDAVADHILRFAG------
MAB_4573c|M.abscessus_ATCC_199 YRLIDSARPDLPDRS-VEIINGGGHFVHLECPDVVYELVREFLGPPTSKV
MLBr_02297|M.leprae_Br4923 ADSVDRTRRYAPHGRYVSVSD-AGHFSHEEAPEEINRYLTRFLKQVHGPR
.*** : : * : :
Mflv_0191|M.gilvum_PYR-GCK --
Mvan_0714|M.vanbaalenii_PYR-1 --
MSMEG_1998|M.smegmatis_MC2_155 --
MUL_0144|M.ulcerans_Agy99 --
MMAR_4334|M.marinum_M --
Mb1155|M.bovis_AF2122/97 --
Rv1124|M.tuberculosis_H37Rv --
MAV_1256|M.avium_104 --
TH_2114|M.thermoresistible__bu --
MAB_4573c|M.abscessus_ATCC_199 E-
MLBr_02297|M.leprae_Br4923 LS