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AADCYLTLDLPNVRLRALAWGPQDGPLVICGHGFPDSAHTWRLLGPRLGAEGWRVVAPFTRGYAPSEIPA DAEYGLGALMQDVLDIHTVLGGDERAIYIGHDWGALVGNALARSGRSPFARIVTMAVPPFEVLGSNMASI GPGGWPAVLARQLFMSWYTLFHQLPLLPEWLLPWLLRLYWRRWSPGYDARADLLYTGEAMLQKGNRRAVI GYYRANIRGALFPARKYWPTQRSLLDGARTPMLYLHGRNDGCMTYRLIDSARPDLPDRSVEIINGGGHFV HLECPDVVYELVREFLGPPTSKVE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4573c | - | - | 100% (305) | epoxide hydrolase EphC |
| M. abscessus ATCC 19977 | MAB_0679c | - | 2e-21 | 27.92% (283) | hydrolase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 3e-16 | 39.32% (117) | epoxide hydrolase EphA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1155 | ephC | 4e-69 | 45.86% (290) | epoxide hydrolase EphC |
| M. gilvum PYR-GCK | Mflv_0191 | - | 6e-61 | 44.41% (295) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1124 | ephC | 4e-69 | 45.86% (290) | epoxide hydrolase EphC |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-10 | 30.59% (170) | short chain dehydrogenase |
| M. marinum M | MMAR_4334 | ephC | 2e-65 | 45.17% (290) | epoxide hydrolase EphC |
| M. avium 104 | MAV_1256 | - | 4e-72 | 49.48% (289) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1998 | - | 4e-66 | 44.97% (298) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2114 | ephC | 5e-61 | 42.09% (297) | PROBABLE EPOXIDE HYDROLASE EPHC (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_0144 | ephC | 3e-65 | 45.17% (290) | epoxide hydrolase EphC |
| M. vanbaalenii PYR-1 | Mvan_0714 | - | 5e-59 | 42.67% (300) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1155|M.bovis_AF2122/97 MRAGRGERESTWRTTMAEPHWIDVKGPNGDLKALTWGPAG---APVALCL
Rv1124|M.tuberculosis_H37Rv MRAGRGERESTWRTTMAEPHWIDVKGPNGDLKALTWGPAG---APVALCL
MMAR_4334|M.marinum_M ---------------MPEPRWIDVPGPNGDLKALTWGRPE---APMALCL
MUL_0144|M.ulcerans_Agy99 --------MTTTRPVMPEPRWIDVPGPNGDLKALTWGRPE---APMALCL
MAV_1256|M.avium_104 -------------MKMAEPGWIDVTGPAGDLKALTWGPPD---GPLALCL
TH_2114|M.thermoresistible__bu -------------VTMTEPRWIDVRTPGADLRALVWEPAESDNAPIALCL
Mflv_0191|M.gilvum_PYR-GCK ---------------MTDPQTLTLTLPHLTVTALSWGPPD---GRLVLCL
Mvan_0714|M.vanbaalenii_PYR-1 ------------MAQVTAPQTLRLSLPHLDVAALSWGPPD---GRLVLCL
MSMEG_1998|M.smegmatis_MC2_155 ---------------MTAPERLTLDLPHLRFAALAWGPKD---GRLMLCL
MAB_4573c|M.abscessus_ATCC_199 ---------------MAADCYLTLDLPNVRLRALAWGPQD---GPLVICG
MLBr_00862|M.leprae_Br4923 --------MPATQSIHKVPHQFVESPDGVRLAIYQSGQPE---GPAIVLV
: . . :
Mb1155|M.bovis_AF2122/97 HGFPDTAYGWRKVAPRLAESGWHVVAPFMRGYAPSSIPA-DGSYHVGALM
Rv1124|M.tuberculosis_H37Rv HGFPDTAYGWRKVAPRLAESGWHVVAPFMRGYAPSSIPA-DGSYHVGALM
MMAR_4334|M.marinum_M HGFPDTAYGWRKLAPILVDSGWRVVAPFMRGYAPSAIPA-DGSYHVGALM
MUL_0144|M.ulcerans_Agy99 HGFPDTADGWRKLAPILVDSGWRVVAPFMRGYAPSAIPA-DGSYHVGALM
MAV_1256|M.avium_104 HGFPDTPYGWRKLAPRLADAGWRVVAPFMRGYAPSAIPS-DGSYHVGALM
TH_2114|M.thermoresistible__bu HGFPDTAHGWRKLAPLLADAGWRVVAPFNRGYAPSSPAH-DGSYHVGALM
Mflv_0191|M.gilvum_PYR-GCK HGFPDSAWGWRKFAPILAEHGFRVVAPFSRGYAPTGPAP-DGDYHIGALM
Mvan_0714|M.vanbaalenii_PYR-1 HGFPDSAWGWRKFAPLLAERGMRVVAPFSRGYAPTGPAP-DGDYHIGALM
MSMEG_1998|M.smegmatis_MC2_155 HGYPDSAWTWRHLGPHFAAQGFRVVAPFMRGYAPTELAR-DGDYGLGALM
MAB_4573c|M.abscessus_ATCC_199 HGFPDSAHTWRLLGPRLGAEGWRVVAPFTRGYAPSEIPA-DAEYGLGALM
MLBr_00862|M.leprae_Br4923 HGFPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYTMTRFA
**:**: * . * : ::* ** . : . . * : :
Mb1155|M.bovis_AF2122/97 HDALRVRSAAGGTERDVIIGHDWGAIAATGLAAMP--DSPFAKAVIMSVP
Rv1124|M.tuberculosis_H37Rv HDALRVRSAAGGTERDVIIGHDWGAIAATGLAAMP--DSPFAKAVIMSVP
MMAR_4334|M.marinum_M DDALRVRSAAGATEGDVLIGHDWGAIAAAGLAAMP--DSPFSRAVIMSVP
MUL_0144|M.ulcerans_Agy99 DDALRVRSAAGATEGDVLIGHDWGAIAAAGLAAMP--DSPFSRAVIMSVP
MAV_1256|M.avium_104 DDALRVRAAAGGTENDVVIGHDWGAIAATGLAAMP--DSPFAKAVLMSVP
TH_2114|M.thermoresistible__bu DDALRVLDAAGRTGRDLLIGHDWGAIAGAGLAAMP--DSPFTRAVIMSVP
Mflv_0191|M.gilvum_PYR-GCK YDALAVHRELGAPDDAVLIGHDWGGFTAAGIAAYP--DSPFAEHITMAVA
Mvan_0714|M.vanbaalenii_PYR-1 YDALAVHRELGAPDDAVLIGHDWGAFTASAIAAYP--GSPFADHVSMAVP
MSMEG_1998|M.smegmatis_MC2_155 YDAVTLHEALGGTGDAVLVGHDWGGLASAGVAAYP--KNPFGTVVSMGVP
MAB_4573c|M.abscessus_ATCC_199 QDVLDIHTVLGGDERAIYIGHDWGALVGNALARSG--RSPFARIVTMAVP
MLBr_00862|M.leprae_Br4923 DDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGP
* : . :.****.. . . :. .
Mb1155|M.bovis_AF2122/97 PSAAF-RPLG---RVPERGRLLRELPHQLLRSWYILYFQLPWLP------
Rv1124|M.tuberculosis_H37Rv PSAAF-RPLG---RVPERGRLLRELPHQLLRSWYILYFQLPWLP------
MMAR_4334|M.marinum_M PAAAF-RPLG---RVPDRGRLARELPHQLLRSWYILYFQLPWLP------
MUL_0144|M.ulcerans_Agy99 PAAAF-RPLG---RVPDRGRLARELPHQLLRSWYILYFQLPWLP------
MAV_1256|M.avium_104 PSAAF-RRRGG--SAAERGRLAAHLARQVFRSWYIMYFQLPWLP------
TH_2114|M.thermoresistible__bu PAASF-RPLG---RVADPARLAARLPRQLLRSWYIMYFQLPWLP------
Mflv_0191|M.gilvum_PYR-GCK PIGAVNRTRG------PLTRQLALLPKQLRNSWYIMFFQLPELP------
Mvan_0714|M.vanbaalenii_PYR-1 PVGAINRTRG------SLARQLRMMPRQLRNSWYILFFQLPGLP------
MSMEG_1998|M.smegmatis_MC2_155 VVAGM-RDAG------NRRRLAPLLPVQMRMSWYILFQQIPWLS------
MAB_4573c|M.abscessus_ATCC_199 PFEVLGSNMA----SIGPGGWPAVLARQLFMSWYTLFHQLPLLP------
MLBr_00862|M.leprae_Br4923 SQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWI
. *: * : .:* *
Mb1155|M.bovis_AF2122/97 --------------------------------------------------
Rv1124|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4334|M.marinum_M --------------------------------------------------
MUL_0144|M.ulcerans_Agy99 --------------------------------------------------
MAV_1256|M.avium_104 --------------------------------------------------
TH_2114|M.thermoresistible__bu --------------------------------------------------
Mflv_0191|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0714|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1998|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4573c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 ALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRR
Mb1155|M.bovis_AF2122/97 ---------------------------ERSASWVVPLLWRRWSP-GYHAE
Rv1124|M.tuberculosis_H37Rv ---------------------------ERSASWVVPLLWRRWSP-GYHAE
MMAR_4334|M.marinum_M ---------------------------ERSASWVPRLLWRRWSP-TYYAE
MUL_0144|M.ulcerans_Agy99 ---------------------------ERWASWVPRLLWRRWSP-TYYAE
MAV_1256|M.avium_104 ---------------------------ERSASWVLPLLWRRWSP-GYRAE
TH_2114|M.thermoresistible__bu ---------------------------DRSSKWVVPALWRHWSP-DYPAD
Mflv_0191|M.gilvum_PYR-GCK ---------------------------ERLLPRVIPRLWRDWGPQGYDTG
Mvan_0714|M.vanbaalenii_PYR-1 ---------------------------ERLLPRVIPRLWQDWGPAGYDTA
MSMEG_1998|M.smegmatis_MC2_155 ---------------------------ERNLGRVIPKLWRDWCPPGYDAR
MAB_4573c|M.abscessus_ATCC_199 ---------------------------EWLLPWLLRLYWRRWSP-GYDAR
MLBr_00862|M.leprae_Br4923 GKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPM
: : : . : .
Mb1155|M.bovis_AF2122/97 EDLRHVDAAIGTPEGRRAALGPYRATMR----------------------
Rv1124|M.tuberculosis_H37Rv EDLRHVDAAIGTPEGRRAALGPYRATMR----------------------
MMAR_4334|M.marinum_M EDLRHVDAAIGTAEGWRAALGPYRATIR----------------------
MUL_0144|M.ulcerans_Agy99 EDLRHVDAAIGTAEGWRAALGPYRATIR----------------------
MAV_1256|M.avium_104 EDLRHVDAAIGAPESWRAALGPYRATIR----------------------
TH_2114|M.thermoresistible__bu EDIELVRDAIGAPERWRAALGYYRATIR----------------------
Mflv_0191|M.gilvum_PYR-GCK AELADALAALPSPAHRRAAVAYYRAMVR----------------------
Mvan_0714|M.vanbaalenii_PYR-1 AELDDALAALPSPAHRRAAVSYYRAMVR----------------------
MSMEG_1998|M.smegmatis_MC2_155 EDLAHLWEALPDTRRRTAALAYYRAALR----------------------
MAB_4573c|M.abscessus_ATCC_199 ADLLYTGEAMLQKGNRRAVIGYYRANIRG---------------------
MLBr_00862|M.leprae_Br4923 SHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGS
. *: ** :*
Mb1155|M.bovis_AF2122/97 --------------------------------------------------
Rv1124|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4334|M.marinum_M --------------------------------------------------
MUL_0144|M.ulcerans_Agy99 --------------------------------------------------
MAV_1256|M.avium_104 --------------------------------------------------
TH_2114|M.thermoresistible__bu --------------------------------------------------
Mflv_0191|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0714|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1998|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4573c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSD
Mb1155|M.bovis_AF2122/97 --------------------------------------------------
Rv1124|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4334|M.marinum_M --------------------------------------------------
MUL_0144|M.ulcerans_Agy99 --------------------------------------------------
MAV_1256|M.avium_104 --------------------------------------------------
TH_2114|M.thermoresistible__bu --------------------------------------------------
Mflv_0191|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0714|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1998|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4573c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLG
Mb1155|M.bovis_AF2122/97 -----------------------NTRAPADYADLNRLWTEA-PKLPVLYL
Rv1124|M.tuberculosis_H37Rv -----------------------NTRAPADYADLNRLWTEA-PKLPVLYL
MMAR_4334|M.marinum_M -----------------------NTRPPARYAELNRWWTEA-PQLPVLYL
MUL_0144|M.ulcerans_Agy99 -----------------------NTRPPARYAELNRWWTEA-PQLPVLYL
MAV_1256|M.avium_104 -----------------------NTAPPAQYATLHRLWTEE-PVLPCLYL
TH_2114|M.thermoresistible__bu -----------------------NTRPPHRYAELHQHWLSA-PRIPTLYL
Mflv_0191|M.gilvum_PYR-GCK -----------------------PSEPSGRYADLHRWCFDV-PRVPILHL
Mvan_0714|M.vanbaalenii_PYR-1 -----------------------PSRPGRMYADLHKWCFEL-PRAPILHV
MSMEG_1998|M.smegmatis_MC2_155 -----------------------PWRRGS-HAELDRYAMTQNPISPMLVL
MAB_4573c|M.abscessus_ATCC_199 -----------------------ALFPARKYWPTQRSLLDG-ARTPMLYL
MLBr_00862|M.leprae_Br4923 GVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMF
: . . . .
Mb1155|M.bovis_AF2122/97 HGHD---------------DGCATSAFTHWTARVLPAGSEVAVVEHAGHF
Rv1124|M.tuberculosis_H37Rv HGHD---------------DGCATSAFTHWTARVLPAGSEVAVVEHAGHF
MMAR_4334|M.marinum_M HGRD---------------DGCAAVAFTHWTERVLPPGSEVAVVEQAGHF
MUL_0144|M.ulcerans_Agy99 HGRD---------------DGCAAVAFTHWTERVLPPGSEVAVVEQAGHF
MAV_1256|M.avium_104 HGRD---------------DGCMTSAFAHQVEKVLPPGSEVDIVEHAGHF
TH_2114|M.thermoresistible__bu HGAD---------------DGCATPDYARWVEPVLPVGSAVAILDRAGHF
Mflv_0191|M.gilvum_PYR-GCK QGEL---------------DGAMEAEYAAPIATALPAGSRVRIIDEAGHF
Mvan_0714|M.vanbaalenii_PYR-1 QGKQ---------------DGAMQAGYAEPIGAVLPPGSRVVTIPAAGHF
MSMEG_1998|M.smegmatis_MC2_155 HGRL---------------DGAIDVRIGTLSASVLVPGSRHEVIDGAGHF
MAB_4573c|M.abscessus_ATCC_199 HGRN---------------DGCMTYRLIDSARPDLPDRS-VEIINGGGHF
MLBr_00862|M.leprae_Br4923 SDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQL
. * . *::
Mb1155|M.bovis_AF2122/97 LQLE-----QPDKIAELIVAFIGSPG------------------------
Rv1124|M.tuberculosis_H37Rv LQLE-----QPDKIAELIVAFIGSPG------------------------
MMAR_4334|M.marinum_M LQLE-----QPETVAKLILPFIAPPG------------------------
MUL_0144|M.ulcerans_Agy99 LQLE-----QPEAVAKLILPFIAPPG------------------------
MAV_1256|M.avium_104 LQLE-----QPDKVAGLVLGFIGSPG------------------------
TH_2114|M.thermoresistible__bu LQLD-----RPDAVADHILRFAG---------------------------
Mflv_0191|M.gilvum_PYR-GCK LQIE-----RPQVTADTVLDYLGDRRGPR---------------------
Mvan_0714|M.vanbaalenii_PYR-1 LQIE-----RPAETAAAVLQYLGDRSGPR---------------------
MSMEG_1998|M.smegmatis_MC2_155 MHLD-----RPDEVHALIADYANL--------------------------
MAB_4573c|M.abscessus_ATCC_199 VHLE-----CPDVVYELVREFLGPPTSKVE--------------------
MLBr_00862|M.leprae_Br4923 DMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLR
: * :
Mb1155|M.bovis_AF2122/97 --------
Rv1124|M.tuberculosis_H37Rv --------
MMAR_4334|M.marinum_M --------
MUL_0144|M.ulcerans_Agy99 --------
MAV_1256|M.avium_104 --------
TH_2114|M.thermoresistible__bu --------
Mflv_0191|M.gilvum_PYR-GCK --------
Mvan_0714|M.vanbaalenii_PYR-1 --------
MSMEG_1998|M.smegmatis_MC2_155 --------
MAB_4573c|M.abscessus_ATCC_199 --------
MLBr_00862|M.leprae_Br4923 STARIRVI