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VTSTIEELLTAARRRRVFSAAGWSVGTATTTLCRGLLGTTAWDPPATAVTEDSRWDLASMTKPIVAIAVM SLIEDGVLTLDDTIAEHLPDYADTDKARIRVANLLTHTSGIPGRQPLYQWNRARDELLTAIRRLPLLGPP GAQVSYSSPGFILLGLIAESAAGMPLDQLVAERVTRPAGMVDAGFASPPTELAVATEDDPWRGHLVRGEV HDENAVVLGAPAGHAGMFATLVDMEALGRTLCAQGWGAHGRVLTPAGYAAMITPRTDHLPLRRTLGWQGV DAVDATAGDLIGPDGYGHTGFTGTSLWIDPDRGSYVVLLTNRIHPNRENTAISRVRRAVNNIGFALASL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6872 | - | - | 100% (349) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_6805 | - | 6e-34 | 31.59% (383) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3040 | - | 2e-16 | 26.50% (317) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1402c | - | 4e-19 | 31.41% (312) | hypothetical protein Mb1402c |
| M. gilvum PYR-GCK | Mflv_0495 | - | 3e-32 | 32.16% (342) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1367c | - | 3e-19 | 31.41% (312) | hypothetical protein Rv1367c |
| M. leprae Br4923 | MLBr_01782 | - | 2e-10 | 26.81% (276) | hypothetical protein MLBr_01782 |
| M. abscessus ATCC 19977 | MAB_4800 | - | 7e-29 | 29.79% (376) | putative beta-lactamase |
| M. marinum M | MMAR_3399 | - | 1e-34 | 32.75% (397) | hypothetical protein MMAR_3399 |
| M. avium 104 | MAV_3991 | - | 4e-28 | 29.06% (382) | beta-lactamase |
| M. thermoresistible (build 8) | TH_4016 | - | 4e-36 | 32.43% (370) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 1e-17 | 29.62% (314) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_5895 | - | 5e-29 | 30.40% (375) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4800|M.abscessus_ATCC_1997 MKVPGSHATRVCAVATVLLALAGIPSCGRPAQP---ITAP----------
TH_4016|M.thermoresistible__bu --------------------------------------------------
Mvan_5895|M.vanbaalenii_PYR-1 --MPGSRVARLCAAGSLLLTLATAPSCGQPGHP---TDPPPPSTGTPTAT
Mflv_0495|M.gilvum_PYR-GCK MTRSSTRLRRLGAAGAVVLALGACGDRPEPPGTSAVRPPATPTRVLPSPP
MMAR_3399|M.marinum_M -------MPAMDAAG-----------------------------------
MAV_3991|M.avium_104 -------MLTLVAASSTGRVVHTSPSEAPPASM------------TPHAS
MSMEG_6872|M.smegmatis_MC2_155 --------------------------------------------------
Mb1402c|M.bovis_AF2122/97 --------------------------------------------------
Rv1367c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1772|M.ulcerans_Agy99 --------------------MGVARPRWRGPRAAWFAGARKPSDGRRLTR
MLBr_01782|M.leprae_Br4923 --------------------------------------------------
MAB_4800|M.abscessus_ATCC_1997 ----SIVPTGPFAPITTLVNDAVAAPRLPGAVVEIGHAGKIVFRQAFGWR
TH_4016|M.thermoresistible__bu --------------VIGQVDDAVAVRRLPGAVVQIGHAGEVVFRQAFGSR
Mvan_5895|M.vanbaalenii_PYR-1 ATATATDPVADFAAVSQLMHDAIAAHRLPGAVVQIGHAGKIVFRQAFGSR
Mflv_0495|M.gilvum_PYR-GCK PPVPEVTPTGDFSAVARLVEDAIAARRLPGAVVQVGHAGKVVFRRAFGVR
MMAR_3399|M.marinum_M --------LAAFAPVSRLINDAIAAERLPGAVVVVGHGGKIVFHQAYGSR
MAV_3991|M.avium_104 LVPESTSPAEDFTTISKLVNDAIAARGLPGAVVMVGHGGKVVFHQAYGSR
MSMEG_6872|M.smegmatis_MC2_155 ----------MTSTIEELLTAARRRRVFSAAGWSVGTATTTLCRGLLG--
Mb1402c|M.bovis_AF2122/97 ---------------------------------MVWQREKLLQVNEIGYR
Rv1367c|M.tuberculosis_H37Rv ---------------------------------MVWQREKLLQVNEIGYR
MUL_1772|M.ulcerans_Agy99 RPPAANLNPVNLDANQADIREVCDAGLLSGAVTVVWQHGEVLQVNEIGYR
MLBr_01782|M.leprae_Br4923 ---------------MVALDALDDWPVPTTAAAVVGPTG-----------
:
MAB_4800|M.abscessus_ATCC_1997 KLPDEPGLNGSPAPAEPMTDDTIFDIASLTKPLATSVAVLQLYEGGRVHI
TH_4016|M.thermoresistible__bu KLAGEPGPTGEPTPAEPMTEDTMFDLASLTKSLATTVAVLQLAEQGRLRV
Mvan_5895|M.vanbaalenii_PYR-1 KLAGEPGLDGSPAPAEPMTEDTIFDLASLSKSLATAPAFLQLYERGLVRI
Mflv_0495|M.gilvum_PYR-GCK KLESEPGLDGAPAPAEPMTEDTVFDIASLTKSLATATAVMQLHEQGRVRI
MMAR_3399|M.marinum_M KLAGEQGLDGVSAPAEAMTEDTIFDIASLTKCLATATAIMQLYEQGKVGF
MAV_3991|M.avium_104 KLAGEPGLDGAPAPAEPMTEDTIFDLASLTKCLATAVAVMQLYEQGKVAF
MSMEG_6872|M.smegmatis_MC2_155 -------TTAWDPPATAVTEDSRWDLASMTKPIV-AIAVMSLIEDGVLTL
Mb1402c|M.bovis_AF2122/97 ----------DIDAGVPMQRDTLFRIASMTKPVT-VAAAMSLVDEGKLAL
Rv1367c|M.tuberculosis_H37Rv ----------DIDAGVPMQRDTLFRIASMTKPVT-VAAAMSLVDEGKLAL
MUL_1772|M.ulcerans_Agy99 ----------DVEAGLPMQRDTLFRIASMTKPVT-VAAAMSMVDEGKIAL
MLBr_01782|M.leprae_Br4923 ------------VLAARGDTEQVFPLASVTKPLV-ARAVQIAIEEGVVDL
. : : :**::* :. * : * : .
MAB_4800|M.abscessus_ATCC_1997 DEPVQAYLPDFN------------PTNDPRRDQVTLRMLLTHTSGIGGDL
TH_4016|M.thermoresistible__bu DDPVQSHLPEFN------------PQHDPRRARVTLRMLLTHTSGIAGDL
Mvan_5895|M.vanbaalenii_PYR-1 DEPVQTYLPEFN------------PAGDPRRAQVTLRMLLTHTSGLAGDL
Mflv_0495|M.gilvum_PYR-GCK DEPVQTYLPGFN------------PAGDPRRAAVTVRMLLTHTSGIAGDL
MMAR_3399|M.marinum_M DDPVQNHLPGFN------------PASDPQRAQVTVRMLLTQTSGEPVDV
MAV_3991|M.avium_104 DDPVQKYLPAFN------------TTNDPQRAKVTIRMLLTNTSGEGIDV
MSMEG_6872|M.smegmatis_MC2_155 DDTIAEHLPDY---------------ADTDKARIRVANLLTHTSGIPGRQ
Mb1402c|M.bovis_AF2122/97 RDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAYGF
Rv1367c|M.tuberculosis_H37Rv RDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAYGF
MUL_1772|M.ulcerans_Agy99 RDPITRWAPELRDIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAYSF
MLBr_01782|M.leprae_Br4923 DTVAG-------------------------PPGSTIRHLLAHASGLAMH-
: **:::**
MAB_4800|M.abscessus_ATCC_1997 SHQGPWGLKQADKADG------IHRALTTPLAFDPGTTFHYSDINFIILG
TH_4016|M.thermoresistible__bu SLDGPWGLDRPDKAEG------VRRALGAWVVHEPGRLFHYSDIGFILLG
Mvan_5895|M.vanbaalenii_PYR-1 SLDGPWGLDKPDKADG------IRRALAAWVVFDPGEIFHYSDINFILVG
Mflv_0495|M.gilvum_PYR-GCK SLDGPWGLAGPDKADG------VRRALGAWVVSDPGEGFHYSDINFIILG
MMAR_3399|M.marinum_M GLQDVWGLDGADRVEG------IHRALSTPLQSPPGREFRYSDINYILLG
MAV_3991|M.avium_104 SLRDPWGLAGPDKAEG------IHRALTTPLQSAPAGEFRYSDINYLLLG
MSMEG_6872|M.smegmatis_MC2_155 PLY-QWNRARDELLTA------IRRLP---LLGPPGAQVSYSSPGFILLG
Mb1402c|M.bovis_AF2122/97 SVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYS-HAIDVLG
Rv1367c|M.tuberculosis_H37Rv SVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYS-HAIDVLG
MUL_1772|M.ulcerans_Agy99 SVSGDISRAYMRLPFGHGSDAWLAELAALPLVHQPGERVTYS-HAIDLLG
MLBr_01782|M.leprae_Br4923 ---------------------------SKYVMAPPGTRRIYSNYGFRVLA
: *. ** ::.
MAB_4800|M.abscessus_ATCC_1997 ALVEKVTGQTLDIYVQDNIFAPLGMNETRYLPAAKACGPHHIVGTAITLE
TH_4016|M.thermoresistible__bu AIVEKLTGEPLDVYVTENVFAPLGMADTRYLPVSKACGPIRMVGNAVVED
Mvan_5895|M.vanbaalenii_PYR-1 AIIEKLTGEQLDSYVRDRVFAPLGMTDTRYLPAAKTCGPHEIRGTTVALG
Mflv_0495|M.gilvum_PYR-GCK ALVEKITGEPEDSYVDRNVFAPLKMSETRYLPVTKVCGPHRVRGTAIAAD
MMAR_3399|M.marinum_M ALLEKIAGEAEDGYVAQHVFAPIGMQDSDFLPAAKACGPHSVRGAAIGWA
MAV_3991|M.avium_104 ALLEKITGEDEDDYVQHHVFGPLGMHDTRYLPPAKACGPHIIRGAAIAWA
MSMEG_6872|M.smegmatis_MC2_155 LIAESAAGMPLDQLVAERVTRPAGMVDAGFASPPTELAVATED-------
Mb1402c|M.bovis_AF2122/97 VIVSRIEDAPLYQVIDERVLGPAGMTDTGFYVSADAQRRAATMYR-----
Rv1367c|M.tuberculosis_H37Rv VIVSRIEDAPLYQIIDERVLGPAGMTDTGFYVSADAQRRAATMYR-----
MUL_1772|M.ulcerans_Agy99 VIMSRIDDKPFYQVLDERILGPAGMTDTGFFVSTQAQRRAATMYR-----
MLBr_01782|M.leprae_Br4923 ETVQREAGIGFSRYLTEAVLEPLAMTATKLEDGTWAAG------------
. . : : * * : .
MAB_4800|M.abscessus_ATCC_1997 EG--PRAAPDCATGAWSTALLTRIAPTAHDEDT---PGINPHYGRLIRGT
TH_4016|M.thermoresistible__bu ES--AEPTP-CGEDRWSTSLRARIAPTSCDGDT---PDLNPHRGRLLRGT
Mvan_5895|M.vanbaalenii_PYR-1 HY--PPWIGQCPAGTWSTALLPRIAPTARDGDT---PGLNPDYGHLLRGT
Mflv_0495|M.gilvum_PYR-GCK PH--GQAVDNCPDGTWNIDLLERIAPTALDEDT---PGLNPDYGYPLRGT
MMAR_3399|M.marinum_M PAPAGRPRAPCPAGTWDTALLSHIAPTALDEESGADPSRNPNFNRLLRGT
MAV_3991|M.avium_104 PN--GEPMTECPEWTWRTTLLPRIAPTARDEESRDDPSKNPDYYALLRGT
MSMEG_6872|M.smegmatis_MC2_155 ---------------------------------------DPWRGHLVRGE
Mb1402c|M.bovis_AF2122/97 ---------------------------------------LDEQDRLRHDV
Rv1367c|M.tuberculosis_H37Rv ---------------------------------------LDEQDRLRHDV
MUL_1772|M.ulcerans_Agy99 ---------------------------------------LDELDQLRHDV
MLBr_01782|M.leprae_Br4923 --------------------------------------------------
MAB_4800|M.abscessus_ATCC_1997 VHDPTARRMGGVAGSAGVFSTAGDVGRYCQALLDRLAGRPSTFPLKRATL
TH_4016|M.thermoresistible__bu VHDPTARRMGGVSGSAGVFSTAADVGSYAQALLDRLAGRPSRFPLRRSTL
Mvan_5895|M.vanbaalenii_PYR-1 VHDPTARRMGGVTGSAGVFSTVGDVGRFAQALLDGLAGRPSAFPLTRSTL
Mflv_0495|M.gilvum_PYR-GCK VHDPTARRMGGVAGSAGVFTTVHDMGRFAQALLDRVAGRPSPFPLSQAGA
MMAR_3399|M.marinum_M VHDPTARRMGGVAGHAGVFSTAHDVSSFAQALLDRLAGRPSTFPLTQATC
MAV_3991|M.avium_104 VHDPTARRMGGVAGNAGVFSTAHDVGVYAQALLDRLAGRPSDFPLQQGTV
MSMEG_6872|M.smegmatis_MC2_155 VHDENAVVLGAPAGHAGMFATLVDMEALGRTLCAQGWG-AHGRVLTPAGY
Mb1402c|M.bovis_AF2122/97 MGPPHVTPPSFCNAGGGLWSTADDYLRFVRMLLG-DGTVDGVRVLSPESV
Rv1367c|M.tuberculosis_H37Rv MGPPHVTPPSFCNAGGGLWSTADDYLRFVRMLLG-DGTVDGVRVLSPESV
MUL_1772|M.ulcerans_Agy99 MGPPHVRPPSFCNAGGGLWSTADDYLRFVRLLLG-DGTIDGVRVLSPESV
MLBr_01782|M.leprae_Br4923 ---------------FGATSTVADLAAFANDLLRPATVSAQIHAEATSVQ
* :* * . *
MAB_4800|M.abscessus_ATCC_1997 ELMTSPAQPGHNDGQLKAANDAARLAIEKTSNSTDPLLAPGYPAIAGQNL
TH_4016|M.thermoresistible__bu QMMTSPQQPGHAPGQLDVANKAAREAVLSASD--DPLLAPDYPAVPGRDL
Mvan_5895|M.vanbaalenii_PYR-1 EMMTTPQQPGHTPGQLEAANDAIRTATENDPD----STARNYPAVPGQDL
Mflv_0495|M.gilvum_PYR-GCK RMMTTPQQP-----------------------------------APGRDL
MMAR_3399|M.marinum_M ELMTTPQQPGHDMAQLDAANAAAREALAHRPNRTDPMLAPRYPAISGQTL
MAV_3991|M.avium_104 ELMTTPQQPGHDPRQLEAANRAARSG------------TPNYPAIKGQNL
MSMEG_6872|M.smegmatis_MC2_155 AAMITPRTDHLPLR------------------------------------
Mb1402c|M.bovis_AF2122/97 RLMRTDRLTDEQKR-------------------------HSFLGAPFWVG
Rv1367c|M.tuberculosis_H37Rv RLMRTDRLTDEQKR-------------------------HSFLGAPFWVG
MUL_1772|M.ulcerans_Agy99 RLMRTDRLSDEHKR-------------------------HNFLGAPFWVG
MLBr_01782|M.leprae_Br4923 FPDLDGVLPGHGVQ--------------------------------RPND
MAB_4800|M.abscessus_ATCC_1997 RGLGWDIDTELSKPRGM-LFPIGSFGHSGFTGVT-LWLDPGSDTYVVVLA
TH_4016|M.thermoresistible__bu RGFGWDIDTNQSRPRGS-VFPVGSFGHTGFTGVT-LWIDPGSDTYVVVLA
Mvan_5895|M.vanbaalenii_PYR-1 RGFGWDIDTAHSRPRGT-LFPVGSFGHAGFTGVT-LWMDPGSDTYVVVLA
Mflv_0495|M.gilvum_PYR-GCK RGFGWDIDTAHSGPRGS-VFPVGSFGHTGFTGVS-VWLDPESDTYVVILG
MMAR_3399|M.marinum_M FGFGWDIDTPYSAPRGV-VFPIGSFGGTGFTGTS-LWIDPGSDSYVVLLS
MAV_3991|M.avium_104 FGFGWDIDTGYSRPRGR-VFPIGSFGNTGFTGTT-LWMDPGSDTYVILLS
MSMEG_6872|M.smegmatis_MC2_155 RTLGWQGVDAVDATAGD-LIGPDGYGHTGFTGTS-LWIDPDRGSYVVLLT
Mb1402c|M.bovis_AF2122/97 RGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLY
Rv1367c|M.tuberculosis_H37Rv RGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLY
MUL_1772|M.ulcerans_Agy99 RGFGLNLSVVTDPVQSTPLFGPGGLGTFSWPGAYGTWWQADPGADLILLY
MLBr_01782|M.leprae_Br4923 WGLGYEIKNSKLPHWTGTLNSARTYGHFGQSGGF-IWADPEAELALVVLT
:* : : * . .* * :. :::*
MAB_4800|M.abscessus_ATCC_1997 NVIHQ-----------RGGPPIVRLSGHIATVAARMLDLYRN---
TH_4016|M.thermoresistible__bu NVIHQ-----------PGGPPVAPLSGRVATLAARALHLYGT---
Mvan_5895|M.vanbaalenii_PYR-1 NVIHQ-----------PGGPPIVNLSGEVATATAQALGLYR----
Mflv_0495|M.gilvum_PYR-GCK NVIHQ-----------RGGPPITPLSGAVATEAARALHLYGS---
MMAR_3399|M.marinum_M NAIHL-----------RGSTPISDLRGQVATAAALALGL------
MAV_3991|M.avium_104 NSIHL-----------RGSPPISNLRGDVATAAARALHLYGAAPP
MSMEG_6872|M.smegmatis_MC2_155 NRIHPN----------RENTAISRVRRAVNNIGFALASL------
Mb1402c|M.bovis_AF2122/97 LIQHCPDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL---
Rv1367c|M.tuberculosis_H37Rv LIQHCPDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL---
MUL_1772|M.ulcerans_Agy99 LIQHCPDLSVNAAAAVAGNPGLAKLRTAQPRFVRRTYRALGL---
MLBr_01782|M.leprae_Br4923 DRDFG--------------EWALQLWPAISDAVISEYAR------
. :