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IRDFTYESRPSRVVFAAGAVGLLQREVTRLAIRRLIVVCTPPQAGLAQAVTAPLGETVAAIHPHAVMHVP RAVADAAVAKTRSVDADGCLAIGGGSAIGLAKAVARETGIPIVAVPTTYAGSEMTTVWGVTDAERKSTGR DERVLPATVVYDPELTLPLPPATAVVSGFNAIAHSAEALYAPDCSPVTALVATESVRALIEALPRLVAEP DDLDARSEALYGAWLAGMTLGATTMSLHHQLCHILGGTFDLPHAETHTAVLPHALALNLTAAPHARAALQ RAVGADDPASRLFELARDLGPEMALKNLGMPEDGMETVVRQVLSAPYHNPVRVTEADLRGLLSNAFAGVI PRPATNPTLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6712 | - | - | 100% (361) | maleylacetate reductase |
| M. smegmatis MC2 155 | MSMEG_3006 | - | 2e-24 | 27.34% (395) | Fe-dependent alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6239 | - | 2e-20 | 28.28% (297) | 1,3-propanediol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1025 | - | 1e-14 | 25.25% (396) | iron-containing alcohol dehydrogenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4110 | - | 2e-24 | 27.27% (352) | aldehyde dehydrogenase |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3976 | - | 9e-25 | 26.74% (359) | bifunctional acetaldehyde-CoA/alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4405 | - | 2e-75 | 42.74% (351) | iron-containing alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6712|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4405|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
MUL_3976|M.ulcerans_Agy99 MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6712|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4405|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
MUL_3976|M.ulcerans_Agy99 VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6712|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4405|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
MUL_3976|M.ulcerans_Agy99 SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6712|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4405|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
MUL_3976|M.ulcerans_Agy99 LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6712|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4405|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
MUL_3976|M.ulcerans_Agy99 PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6712|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4405|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M LISKTFDSSVICPAEQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
MUL_3976|M.ulcerans_Agy99 LISKTFDSSVICPAKQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6712|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4405|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVLLAQLPSDLGELAAH
MUL_3976|M.ulcerans_Agy99 FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVPLAQLPSDLDELAAH
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6712|M.smegmatis_MC2_155 -----------------------------------------------MIR
Mvan_4405|M.vanbaalenii_PYR-1 -------------------------------------------------M
MMAR_4110|M.marinum_M PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
MUL_3976|M.ulcerans_Agy99 PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
Mflv_1025|M.gilvum_PYR-GCK -------------------------------------MASVMSCCHTGDG
MSMEG_6712|M.smegmatis_MC2_155 DFTYESRPSRVVFAAG-AVGLLQREVTRLA--------------------
Mvan_4405|M.vanbaalenii_PYR-1 GFVHEGHRQRVRFATGEATGQLAEEITALG--------------------
MMAR_4110|M.marinum_M AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
MUL_3976|M.ulcerans_Agy99 AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
Mflv_1025|M.gilvum_PYR-GCK DGAFTVDASRVTFGRG-CIAEVGDRARALG--------------------
*: . . . : *
MSMEG_6712|M.smegmatis_MC2_155 ---------IRR---------------------------------LIVVC
Mvan_4405|M.vanbaalenii_PYR-1 ---------VSR---------------------------------VMVIA
MMAR_4110|M.marinum_M YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
MUL_3976|M.ulcerans_Agy99 YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
Mflv_1025|M.gilvum_PYR-GCK ---------ITR-------------------------------AALFSDS
: * :. .
MSMEG_6712|M.smegmatis_MC2_155 TPPQAGLAQAVTAPLGETVAAIHP--HAVMHVPRAVADAAVAKTRSVDAD
Mvan_4405|M.vanbaalenii_PYR-1 ADEEADLAREIAGAL--PVAAWHH--DVAMHVPIEVAERARAVATGRHAD
MMAR_4110|M.marinum_M LTEERGVVEALRGKLRAQHVQVFS--EVTPEPDETTIRRGVALMQRVQPD
MUL_3976|M.ulcerans_Agy99 LTEERGVVEALRGKLRAQHVQVFS--EVTPEPDETTIRRGVALMQRVQPD
Mflv_1025|M.gilvum_PYR-GCK AVAQLEVFDAAQRSLRAAGIDVVDYIDVRVEPTDESFRSAAAFATEASPD
: : * .. . . * .*
MSMEG_6712|M.smegmatis_MC2_155 GCLAIGGGSAIGLAKAVARETGIP--------------------------
Mvan_4405|M.vanbaalenii_PYR-1 AVVSVGGGSTTGLAKAVALTTGVP--------------------------
MMAR_4110|M.marinum_M LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
MUL_3976|M.ulcerans_Agy99 LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
Mflv_1025|M.gilvum_PYR-GCK GYISVGGGSVIDTAKAANLYATHPADFLEYVNAPVG------AGAPVPGP
:::****. . .** *
MSMEG_6712|M.smegmatis_MC2_155 ---IVAVPTTY-AGSEMT--TVWGVTDAERKSTGRDERVLPATVVYDPEL
Mvan_4405|M.vanbaalenii_PYR-1 ---IVAVPTTY-AGSEAT--NVWGLTEGAKKTTGVDERVLPRAIIYDAAL
MMAR_4110|M.marinum_M RIQLVAVPTTSGTGSEVS--PAAVLTVGGKKETLVDYSLVPDLAIVDPVL
MUL_3976|M.ulcerans_Agy99 RIQLVAVPTTSGTGSEVS--PAAVLTVGGKKETLVDYSLVPDLAIVDPVL
Mflv_1025|M.gilvum_PYR-GCK LAPHIACPTTSGTGSEVTGIAIFDLLSMAAKTGIASPALRPTEALVDPDC
:* *** :*** : : * . : * : *.
MSMEG_6712|M.smegmatis_MC2_155 TLPLPPATAVVSGFNAIAHSAEALYA------------------PDCSPV
Mvan_4405|M.vanbaalenii_PYR-1 TLSLPVDMSISSGLNALAHCIDSLWA------------------PNANPI
MMAR_4110|M.marinum_M TSSMPQKLTADTGIDALTHALEAIVS------------------IFASPY
MUL_3976|M.ulcerans_Agy99 TSSMPQKLTADIGIDALTHALEAIVS------------------IFASPY
Mflv_1025|M.gilvum_PYR-GCK TGTLPATVVACSGLDVLSHALESYTARPYTHRAAPARPTQRPMSQGANPW
* .:* *::.::*. :: : ..*
MSMEG_6712|M.smegmatis_MC2_155 TALVATESVRALIEALPRLVAEPDDLDARSEALYGAWLAGMTLGATTMSL
Mvan_4405|M.vanbaalenii_PYR-1 NSALAEAGIRALNAGLPQVAADALAIPGRELSLQGTYLSAAAFSAAGSGL
MMAR_4110|M.marinum_M TDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGT
MUL_3976|M.ulcerans_Agy99 TDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGT
Mflv_1025|M.gilvum_PYR-GCK SDLGCGEALRLLGTYLARAVADASDSEAREQVMWAATLAGIAFGNAGVHL
. . .:* : *.: :. .* .: *:. ::. :
MSMEG_6712|M.smegmatis_MC2_155 HHQLCHILG---GTFDLPHAETHTAVLPHALALNLTA-------------
Mvan_4405|M.vanbaalenii_PYR-1 HHKICHVLG---GMFNLAHAQTHAIVLPHVLAFNVSN-------------
MMAR_4110|M.marinum_M NHALAHAVG---AKFSVPHGRANGIFLPHVLRYNASLPTKFMPAPGYSAY
MUL_3976|M.ulcerans_Agy99 NHTLAHAVG---AKFSVPHGRANGIFLPHVLRYNASLPTKFMPAPGYSAY
Mflv_1025|M.gilvum_PYR-GCK PHAMAYAVAGQVRDFRPVGYPDSEPLVPHGMSVILNAPAAFRLTAHTDPA
* :.: :. * .:** : .
MSMEG_6712|M.smegmatis_MC2_155 -APHARAALQRAVGA----DDPASRLFE----LARDLGPEMALKNLGMPE
Mvan_4405|M.vanbaalenii_PYR-1 -AEEAQQRIARAFDS----ESAQTGLAN----LRRALDAPSALRDYGMPE
MMAR_4110|M.marinum_M IAPDKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDRLDMPRSLREFGVDE
MUL_3976|M.ulcerans_Agy99 IAPDKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDRLDMPRSLREFGVDE
Mflv_1025|M.gilvum_PYR-GCK RHLFAAARLGADTADAAP-EDAGTVLAEHLMTIMRQVGMPNGLAGVGYTD
: :.. * : :. .* * :
MSMEG_6712|M.smegmatis_MC2_155 DGMETVVRQVLS------APYHNPVRVTEADLRGLLSNAFAGVI--PRPA
Mvan_4405|M.vanbaalenii_PYR-1 SGLAEAVDAIVAV-----APASNPTPVTPEGIAALLRAAWEGDE--PQ--
MMAR_4110|M.marinum_M QEFLAALPTLAMTAFEDLSNRTNPRMPLVSEITDLLRLGYYGDTGVGEPA
MUL_3976|M.ulcerans_Agy99 QGFLVALPTLAMTAFEDLSNRTNPRMPLVSEITDLLRLGYYGDTGVGEPA
Mflv_1025|M.gilvum_PYR-GCK ADAAALADGAWPQ-------QRLLANAPIDVDKPLLANAFEQSMRYW---
** .:
MSMEG_6712|M.smegmatis_MC2_155 TNPTLR--------
Mvan_4405|M.vanbaalenii_PYR-1 --------------
MMAR_4110|M.marinum_M LAPIKPGDVDGRSV
MUL_3976|M.ulcerans_Agy99 LAPIKPGDVDGRSV
Mflv_1025|M.gilvum_PYR-GCK --------------