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ESAPIAVPKAMPDPMPTRLLKFHAPEIVFGIDSMAEAAHAAVRLGGLRPLLVTDPGLIEAGWVDELLGHL REQCVTPQVWSAITPNPKDHEITAGHEFYRAHGCDVLIALGGGSVIDAAKGIAILSANGGDILDYAGVDK ATMPIPPLVVLPSTSGTGADVSQFCIVTDTTRNTKITILGRALVPDLTVIDPRLLTTMPEWLNAATGLDA LTHGIEAFVSLGHNQLTDHHALRSVVMVTENLVTTIERPKEMPARVLMAQAALEAGLAFTNAILGAAHAM SHQVGGLLDLPHGVINGVLLPHVVRFNAEADPAPFATIASYLGIADKRAPELESALALADRLQELARRVG VPRGLADLGVRAEDVPVLARNAMADACITTNPRPVDEAGLCALFRTAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6239 | - | - | 100% (399) | 1,3-propanediol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1392 | - | 2e-56 | 35.96% (356) | alcohol dehydrogenase, class IV |
| M. smegmatis MC2 155 | MSMEG_3006 | - | 5e-42 | 29.91% (351) | Fe-dependent alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1025 | - | 2e-32 | 27.43% (412) | iron-containing alcohol dehydrogenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4110 | - | 6e-50 | 36.29% (361) | aldehyde dehydrogenase |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3976 | - | 1e-48 | 35.73% (361) | bifunctional acetaldehyde-CoA/alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5476 | - | 1e-178 | 80.05% (381) | iron-containing alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6239|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
MUL_3976|M.ulcerans_Agy99 MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6239|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
MUL_3976|M.ulcerans_Agy99 VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6239|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
MUL_3976|M.ulcerans_Agy99 SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6239|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
MUL_3976|M.ulcerans_Agy99 LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6239|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
MUL_3976|M.ulcerans_Agy99 PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6239|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M LISKTFDSSVICPAEQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
MUL_3976|M.ulcerans_Agy99 LISKTFDSSVICPAKQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6239|M.smegmatis_MC2_155 ---------------------------------------------MES-A
Mvan_5476|M.vanbaalenii_PYR-1 ---------------------------------------------MGARY
MMAR_4110|M.marinum_M FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVLLAQLPSDLGELAAH
MUL_3976|M.ulcerans_Agy99 FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVPLAQLPSDLDELAAH
Mflv_1025|M.gilvum_PYR-GCK ---------------------------------------------MASVM
:
MSMEG_6239|M.smegmatis_MC2_155 PIAVPKAMPDPMPT--RLLKF---------------HAPEIVFGIDSMAE
Mvan_5476|M.vanbaalenii_PYR-1 PTLTPELDRGRAATTPRLLKF---------------HAPEIVFGIDSMVE
MMAR_4110|M.marinum_M PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
MUL_3976|M.ulcerans_Agy99 PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
Mflv_1025|M.gilvum_PYR-GCK SCCHTGDGDGAFTVD----------------------ASRVTFGRGCIAE
. . :. : . . : *
MSMEG_6239|M.smegmatis_MC2_155 AAHAAVRLG-----------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 AAHAAVRLG-----------------------------------------
MMAR_4110|M.marinum_M AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
MUL_3976|M.ulcerans_Agy99 AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
Mflv_1025|M.gilvum_PYR-GCK VGDRARALG-----------------------------------------
. * *
MSMEG_6239|M.smegmatis_MC2_155 ----------------------------------------GLRPLLVTDP
Mvan_5476|M.vanbaalenii_PYR-1 ----------------------------------------AQRPMLVTDP
MMAR_4110|M.marinum_M YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
MUL_3976|M.ulcerans_Agy99 YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
Mflv_1025|M.gilvum_PYR-GCK ----------------------------------------ITRAALFSDS
:.:*.
MSMEG_6239|M.smegmatis_MC2_155 GLIEAGWVDELLGHLREQCVTPQVWSAITPNPKDHEITAGHEFYRAHGCD
Mvan_5476|M.vanbaalenii_PYR-1 GLIEAGWSDEMVTHLAGMGVRAAIWSDLTPNPKDHEVAAGYQKYAEHGCD
MMAR_4110|M.marinum_M LTEERGVVEALRGKLRAQHV--QVFSEVTPEPDETTIRRGVALMQRVQPD
MUL_3976|M.ulcerans_Agy99 LTEERGVVEALRGKLRAQHV--QVFSEVTPEPDETTIRRGVALMQRVQPD
Mflv_1025|M.gilvum_PYR-GCK AVAQLEVFDAAQRSLRAAGIDVVDYIDVRVEPTDESFRSAAAFATEASPD
: : * : : : :* : . . *
MSMEG_6239|M.smegmatis_MC2_155 VLIALGGGSVIDAAKGIAILSANGGD-----ILDYAGVDKATMPIP----
Mvan_5476|M.vanbaalenii_PYR-1 VIVAVGGGSVIDAAKGVAILAANGGD-----ILDYEGVDKAQVPIP----
MMAR_4110|M.marinum_M LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
MUL_3976|M.ulcerans_Agy99 LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
Mflv_1025|M.gilvum_PYR-GCK GYISVGGGSVIDTAKAANLYATHPAD-----FLEYVN-APVGAGAPVPGP
:::*****:*:.*. : : . : : . *
MSMEG_6239|M.smegmatis_MC2_155 --PLVVLPSTSGTGADVSQFCIVTDTTRNTKITILGRALVPDLTVIDPRL
Mvan_5476|M.vanbaalenii_PYR-1 --PMVVVPSTSGTGADVSQFCIVTDTTRNTKITILGRALVPDITVIDPRL
MMAR_4110|M.marinum_M RIQLVAVPTTSGTGSEVSPAAVLTVGGK--KETLVDYSLVPDLAIVDPVL
MUL_3976|M.ulcerans_Agy99 RIQLVAVPTTSGTGSEVSPAAVLTVGGK--KETLVDYSLVPDLAIVDPVL
Mflv_1025|M.gilvum_PYR-GCK LAPHIACPTTSGTGSEVTGIAIFDLLSMAAKTGIASPALRPTEALVDPDC
:. *:*****::*: .:. * : . :* * :::**
MSMEG_6239|M.smegmatis_MC2_155 LTTMPEWLNAATGLDALTHGIEAFVS------------------LGHNQL
Mvan_5476|M.vanbaalenii_PYR-1 LTTMPEWLNAATGLDALTHGIEAFVS------------------LGHNQL
MMAR_4110|M.marinum_M TSSMPQKLTADTGIDALTHALEAIVS------------------IFASPY
MUL_3976|M.ulcerans_Agy99 TSSMPQKLTADIGIDALTHALEAIVS------------------IFASPY
Mflv_1025|M.gilvum_PYR-GCK TGTLPATVVACSGLDVLSHALESYTARPYTHRAAPARPTQRPMSQGANPW
::* : * *:*.*:*.:*: .: .
MSMEG_6239|M.smegmatis_MC2_155 TDHHALRSVVMVTENLVTTIERPKEMPARVLMAQAALEAGLAFTNAILGA
Mvan_5476|M.vanbaalenii_PYR-1 TDHHALRAVQMVTDNLVHTIDRPNEMPARVLMAQAALEAGLAFTNAILGA
MMAR_4110|M.marinum_M TDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGT
MUL_3976|M.ulcerans_Agy99 TDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGT
Mflv_1025|M.gilvum_PYR-GCK SDLGCGEALRLLGTYLARAVADASDSEAREQVMWAATLAGIAFGNAGVHL
:* . .:: :: * : ..: ** : ** **:** ** :
MSMEG_6239|M.smegmatis_MC2_155 AHAMSHQVGGLLD-------------LPHGVINGVLLPHVVRFNAEADPA
Mvan_5476|M.vanbaalenii_PYR-1 AHAMSHQVGGLLD-------------LPHGVINGVLLPHVIRFNAEADPE
MMAR_4110|M.marinum_M NHALAHAVGAKFS-------------VPHGRANGIFLPHVLRYNASLPTK
MUL_3976|M.ulcerans_Agy99 NHTLAHAVGAKFS-------------VPHGRANGIFLPHVLRYNASLPTK
Mflv_1025|M.gilvum_PYR-GCK PHAMAYAVAGQVRDFRPVGYPDSEPLVPHGMSVILNAPAAFRLTAHTDPA
*:::: *.. . :*** : * ..* .* .
MSMEG_6239|M.smegmatis_MC2_155 PFATIASYLGIADKRAPEL-----------ESALALADRLQELARRVGVP
Mvan_5476|M.vanbaalenii_PYR-1 PYQVIATSLGVTDPGAPAA-----------EAALALADRIDRLARDVGVP
MMAR_4110|M.marinum_M FMPAPGYSAYIAPDKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDRLDMP
MUL_3976|M.ulcerans_Agy99 FMPAPGYSAYIAPDKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDRLDMP
Mflv_1025|M.gilvum_PYR-GCK RHLFAAARLGADTADAAPE-----------DAGTVLAEHLMTIMRQVGMP
. . :: * : : :.:*
MSMEG_6239|M.smegmatis_MC2_155 RGLADLGVRAE----DVPVLARNAMADACITTNPRPVDEAGLCALFRTAL
Mvan_5476|M.vanbaalenii_PYR-1 RGLAELGVAED----DLPRLARTALQDACMSTNPRPADEAQMHALFRAAL
MMAR_4110|M.marinum_M RSLREFGVDEQEFLAALPTLAMTAFEDLSNRTNPRMPLVSEITDLLRLGY
MUL_3976|M.ulcerans_Agy99 RSLREFGVDEQGFLVALPTLAMTAFEDLSNRTNPRMPLVSEITDLLRLGY
Mflv_1025|M.gilvum_PYR-GCK NGLAGVGYTDAD---AAALADGAWPQQRLLANAPIDVDKPLLANAFEQSM
..* .* . : . * . : :. .
MSMEG_6239|M.smegmatis_MC2_155 ------------------------
Mvan_5476|M.vanbaalenii_PYR-1 ------------------------
MMAR_4110|M.marinum_M YGDTGVGEPALAPIKPGDVDGRSV
MUL_3976|M.ulcerans_Agy99 YGDTGVGEPALAPIKPGDVDGRSV
Mflv_1025|M.gilvum_PYR-GCK RYW---------------------