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NTPVVTAFQTGTHRTENSLGLGLLRQPGTVLFGPGQRRQLPRLVSSIGQRVLMITDSRMADSPEFAVITE GLTACGVAVEVYGGTEPDLPRRNVTEITGRFRREDVDVIVGIGGGSCMDLAKIASVVLAHGADVRDYYGE FLVPGPGCPVITVPTTGGTGAEVTCISVIYDEDKSMKVGVASPHLEATAAVIDPELTLTCPPGLTAAAGA DALSHLIESFTGRAKNPGPDDLATKLYAGKNLLADTYARTGLALLDTSLPAVASRPGDLQARSDTLFGAY CAGMAINTAGTAGAHAIQSPIGNLTHTPHGFGISALLPYVMRYNLPTRVPEFAEIGRIFGVASETDPQET QARKAIERIEEILATLGAPLDLRTLGLQPRDFDFVAEQAMLATRLTANNPRELTAETVRGILERGYDGDR SWWR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3006 | - | - | 100% (425) | Fe-dependent alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6239 | - | 5e-42 | 29.91% (351) | 1,3-propanediol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1392 | - | 3e-40 | 27.85% (395) | alcohol dehydrogenase, class IV |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1025 | - | 3e-32 | 26.92% (416) | iron-containing alcohol dehydrogenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4110 | - | 1e-26 | 25.71% (424) | aldehyde dehydrogenase |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3976 | - | 8e-26 | 25.18% (425) | bifunctional acetaldehyde-CoA/alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5476 | - | 1e-39 | 29.75% (353) | iron-containing alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4110|M.marinum_M MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
MUL_3976|M.ulcerans_Agy99 MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3006|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4110|M.marinum_M VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
MUL_3976|M.ulcerans_Agy99 VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3006|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4110|M.marinum_M SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
MUL_3976|M.ulcerans_Agy99 SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3006|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4110|M.marinum_M LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
MUL_3976|M.ulcerans_Agy99 LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3006|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4110|M.marinum_M PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
MUL_3976|M.ulcerans_Agy99 PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3006|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4110|M.marinum_M LISKTFDSSVICPAEQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
MUL_3976|M.ulcerans_Agy99 LISKTFDSSVICPAKQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3006|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4110|M.marinum_M FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVLLAQLPSDLGELAAH
MUL_3976|M.ulcerans_Agy99 FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVPLAQLPSDLDELAAH
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3006|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4110|M.marinum_M PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
MUL_3976|M.ulcerans_Agy99 PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3006|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4110|M.marinum_M AYGLAVRTGRILVNAPTAVGALGGVYNNLTP----TFSLGCGTWGGSSTT
MUL_3976|M.ulcerans_Agy99 AYGLAVRTGRILVNAPTAVGALGGVYNNLTP----TFSLGCGTWGGSSTT
Mvan_5476|M.vanbaalenii_PYR-1 ---------------------MGARYPTLTP----ELDR-----GRAATT
Mflv_1025|M.gilvum_PYR-GCK ---------------------MASVMSCCHTGDGD---------------
MSMEG_3006|M.smegmatis_MC2_155 ------------MNTPVVTAFQTGTHRTENSLG-----------------
. .
MMAR_4110|M.marinum_M ENVNYRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVV
MUL_3976|M.ulcerans_Agy99 ENVNYRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVV
Mvan_5476|M.vanbaalenii_PYR-1 P-----------RLLKFHAPEIVFGIDSMVEAAHAAVR----LGAQRPML
Mflv_1025|M.gilvum_PYR-GCK ------------GAFTVDASRVTFGRGCIAEVGDRARA----LGITRAAL
MSMEG_3006|M.smegmatis_MC2_155 ------------LGLLRQPGTVLFGPGQRRQLPRLVSS-----IGQRVLM
. * . :
MMAR_4110|M.marinum_M VTDALTEERGVVEALRGKLR--AQHVQVFSEVTPEPDETTIRRGVALMQR
MUL_3976|M.ulcerans_Agy99 VTDALTEERGVVEALRGKLR--AQHVQVFSEVTPEPDETTIRRGVALMQR
Mvan_5476|M.vanbaalenii_PYR-1 VTDPGLIEAGWSDEMVTHLAGMGVRAAIWSDLTPNPKDHEVAAGYQKYAE
Mflv_1025|M.gilvum_PYR-GCK FSDSAVAQLEVFDAAQRSLRAAGIDVVDYIDVRVEPTDESFRSAAAFATE
MSMEG_3006|M.smegmatis_MC2_155 ITDSRMADSPEFAVITEGLTACGVAVEVYGGTEPDLPRRNVTEITGRFRR
.:*. : * . . : : . .
MMAR_4110|M.marinum_M VQPDLLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYP
MUL_3976|M.ulcerans_Agy99 VQPDLLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYP
Mvan_5476|M.vanbaalenii_PYR-1 HGCDVIVAVGGGSVIDAAKGVAILAANGGDILDYEGVDKAQVP-------
Mflv_1025|M.gilvum_PYR-GCK ASPDGYISVGGGSVIDTAKAANLYATHPADFLEYVNAPVGAGAPVPG---
MSMEG_3006|M.smegmatis_MC2_155 EDVDVIVGIGGGSCMDLAKIASVVLAHGADVRDYYGEFLVPGPG------
* :.:**** :* .* : : . :
MMAR_4110|M.marinum_M TDRHRIQLVAVPTTSGTGSEVSPAAVLTVGGK--KETLVDYSLVPDLAIV
MUL_3976|M.ulcerans_Agy99 TDRHRIQLVAVPTTSGTGSEVSPAAVLTVGGK--KETLVDYSLVPDLAIV
Mvan_5476|M.vanbaalenii_PYR-1 ----IPPMVVVPSTSGTGADVSQFCIVTDTTRNTKITILGRALVPDITVI
Mflv_1025|M.gilvum_PYR-GCK ---PLAPHIACPTTSGTGSEVTGIAIFDLLSMAAKTGIASPALRPTEALV
MSMEG_3006|M.smegmatis_MC2_155 -----CPVITVPTTGGTGAEVTCISVIYDEDKSMKVGVASPHLEATAAVI
:. *:*.***::*: .:. * : . * . :::
MMAR_4110|M.marinum_M DPVLTSSMPQKLTADTGIDALTHALEAIVS------------------IF
MUL_3976|M.ulcerans_Agy99 DPVLTSSMPQKLTADIGIDALTHALEAIVS------------------IF
Mvan_5476|M.vanbaalenii_PYR-1 DPRLLTTMPEWLNAATGLDALTHGIEAFVS------------------LG
Mflv_1025|M.gilvum_PYR-GCK DPDCTGTLPATVVACSGLDVLSHALESYTARPYTHRAAPARPTQRPMSQG
MSMEG_3006|M.smegmatis_MC2_155 DPELTLTCPPGLTAAAGADALSHLIESFTG---RAKNPGPDDLATKLYAG
** : * : * * *.*:* :*: ..
MMAR_4110|M.marinum_M ASPYTDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNA
MUL_3976|M.ulcerans_Agy99 ASPYTDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNA
Mvan_5476|M.vanbaalenii_PYR-1 HNQLTDHHALRAVQMVTDNLVHTIDRPNEMPARVLMAQAALEAGLAFTNA
Mflv_1025|M.gilvum_PYR-GCK ANPWSDLGCGEALRLLGTYLARAVADASDSEAREQVMWAATLAGIAFGNA
MSMEG_3006|M.smegmatis_MC2_155 KNLLADTYARTGLALLDTSLPAVASRPGDLQARSDTLFGAYCAGMAINTA
. :* . .: :: * . ..: ** .* **:*: .*
MMAR_4110|M.marinum_M FVGTNHALAHAVGAKFS-------------VPHGRANGIFLPHVLRYNAS
MUL_3976|M.ulcerans_Agy99 FVGTNHTLAHAVGAKFS-------------VPHGRANGIFLPHVLRYNAS
Mvan_5476|M.vanbaalenii_PYR-1 ILGAAHAMSHQVGGLLD-------------LPHGVINGVLLPHVIRFNAE
Mflv_1025|M.gilvum_PYR-GCK GVHLPHAMAYAVAGQVRDFRPVGYPDSEPLVPHGMSVILNAPAAFRLTAH
MSMEG_3006|M.smegmatis_MC2_155 GTAGAHAIQSPIGNLTH-------------TPHGFGISALLPYVMRYNLP
*:: :. *** * .:* .
MMAR_4110|M.marinum_M LPTKFMPAPGYSAYIAPDKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDR
MUL_3976|M.ulcerans_Agy99 LPTKFMPAPGYSAYIAPDKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDR
Mvan_5476|M.vanbaalenii_PYR-1 ADPEPYQVIATSLGVTDP-----------GAPAAEAALALADRIDRLARD
Mflv_1025|M.gilvum_PYR-GCK TDPARHLFAAARLGADTA-----------DAAPEDAGTVLAEHLMTIMRQ
MSMEG_3006|M.smegmatis_MC2_155 TRVPEFAEIGRIFGVASET-----------DPQETQARKAIERIEEILAT
. : :
MMAR_4110|M.marinum_M LDMPRSLREFGVDEQEFLAALPTLAMTAFEDLSNRTNPRMPLVSEITDLL
MUL_3976|M.ulcerans_Agy99 LDMPRSLREFGVDEQGFLVALPTLAMTAFEDLSNRTNPRMPLVSEITDLL
Mvan_5476|M.vanbaalenii_PYR-1 VGVPRGLAELGVAED----DLPRLARTALQDACMSTNPRPADEAQMHALF
Mflv_1025|M.gilvum_PYR-GCK VGMPNGLAGVGYTDA----DAAALADGAWPQQRLLANAPIDVDKPLLANA
MSMEG_3006|M.smegmatis_MC2_155 LGAPLDLRTLGLQPR----DFDFVAEQAMLATRLTANNPRELTAETVRGI
:. * .* .* :* * :*
MMAR_4110|M.marinum_M RLGYYGDTGVGEPALAPIKPGDVDGRSV
MUL_3976|M.ulcerans_Agy99 RLGYYGDTGVGEPALAPIKPGDVDGRSV
Mvan_5476|M.vanbaalenii_PYR-1 RAAL------------------------
Mflv_1025|M.gilvum_PYR-GCK FEQSMRYW--------------------
MSMEG_3006|M.smegmatis_MC2_155 LERGYDGDRSWWR---------------