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MASVMSCCHTGDGDGAFTVDASRVTFGRGCIAEVGDRARALGITRAALFSDSAVAQLEVFDAAQRSLRAA GIDVVDYIDVRVEPTDESFRSAAAFATEASPDGYISVGGGSVIDTAKAANLYATHPADFLEYVNAPVGAG APVPGPLAPHIACPTTSGTGSEVTGIAIFDLLSMAAKTGIASPALRPTEALVDPDCTGTLPATVVACSGL DVLSHALESYTARPYTHRAAPARPTQRPMSQGANPWSDLGCGEALRLLGTYLARAVADASDSEAREQVMW AATLAGIAFGNAGVHLPHAMAYAVAGQVRDFRPVGYPDSEPLVPHGMSVILNAPAAFRLTAHTDPARHLF AAARLGADTADAAPEDAGTVLAEHLMTIMRQVGMPNGLAGVGYTDADAAALADGAWPQQRLLANAPIDVD KPLLANAFEQSMRYW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1025 | - | - | 100% (435) | iron-containing alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4110 | - | 8e-33 | 31.90% (326) | aldehyde dehydrogenase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1392 | - | 3e-35 | 29.25% (359) | alcohol dehydrogenase, class IV |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3976 | - | 3e-32 | 31.60% (326) | bifunctional acetaldehyde-CoA/alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5811 | - | 0.0 | 81.76% (433) | iron-containing alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5811|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
MUL_3976|M.ulcerans_Agy99 MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5811|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
MUL_3976|M.ulcerans_Agy99 VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5811|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
MUL_3976|M.ulcerans_Agy99 SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5811|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
MUL_3976|M.ulcerans_Agy99 LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5811|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
MUL_3976|M.ulcerans_Agy99 PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5811|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M LISKTFDSSVICPAEQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
MUL_3976|M.ulcerans_Agy99 LISKTFDSSVICPAKQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK ---------------------------------MASVMSCCHTG--DGDG
Mvan_5811|M.vanbaalenii_PYR-1 -------------------------------------MSCCHHSGLDGDT
MMAR_4110|M.marinum_M FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVLLAQLPSDLGELAAH
MUL_3976|M.ulcerans_Agy99 FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVPLAQLPSDLDELAAH
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK AFTVDASRVTFGRG---------------------------------CIA
Mvan_5811|M.vanbaalenii_PYR-1 AFTVDASRVTFGRG---------------------------------CLA
MMAR_4110|M.marinum_M PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
MUL_3976|M.ulcerans_Agy99 PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
MSMEG_1392|M.smegmatis_MC2_155 -MVTNIALPRFAKIGAG---------------------------------
:. : :.
Mflv_1025|M.gilvum_PYR-GCK EVG-----------------------------------------------
Mvan_5811|M.vanbaalenii_PYR-1 EVG-----------------------------------------------
MMAR_4110|M.marinum_M AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
MUL_3976|M.ulcerans_Agy99 AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
MSMEG_1392|M.smegmatis_MC2_155 -----------------AADTLG---------------------------
Mflv_1025|M.gilvum_PYR-GCK ---------------------------------DRARALGITRAALFSDS
Mvan_5811|M.vanbaalenii_PYR-1 ---------------------------------DRAAALGIHRVALFSDP
MMAR_4110|M.marinum_M YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
MUL_3976|M.ulcerans_Agy99 YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
MSMEG_1392|M.smegmatis_MC2_155 ---------------------------------EVIADLGISRPVLVTDR
: *. .:.:*
Mflv_1025|M.gilvum_PYR-GCK AVAQLEVFDAAQRSLRAAGIDVVDYIDVRVEPTDESFRSAAAFATEASPD
Mvan_5811|M.vanbaalenii_PYR-1 TVATLEIFDTVQRSLREAGVEVVSYPDARVEPTDESFKQAAAFATDVNPD
MMAR_4110|M.marinum_M LTEERGVVEALRGKLRAQ--HVQVFSEVTPEPDETTIRRGVALMQRVQPD
MUL_3976|M.ulcerans_Agy99 LTEERGVVEALRGKLRAQ--HVQVFSEVTPEPDETTIRRGVALMQRVQPD
MSMEG_1392|M.smegmatis_MC2_155 YLVETGQAERLAKTLHAAGSTAAVFSDTVPDPTVESLSAGLELVRAHRAD
: .*: . : :. :* :: . : .*
Mflv_1025|M.gilvum_PYR-GCK GYISVGGGSVIDTAKAANLYATHPADFLEYVN------APVGAGAPVPGP
Mvan_5811|M.vanbaalenii_PYR-1 GYVSVGGGSVIDTAKAANLYASHPADFLEYVN------APVGAGAAVPGP
MMAR_4110|M.marinum_M LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
MUL_3976|M.ulcerans_Agy99 LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
MSMEG_1392|M.smegmatis_MC2_155 GIIGFGGGSPMDTAKALAVLSANGG-----------DIASYKAPSSYTGP
:..**** :*:.** : : * .
Mflv_1025|M.gilvum_PYR-GCK LAPHIACPTTSGTGSEVTGIAIFDLLSMAAKTGIASPALRPTEALVDPDC
Mvan_5811|M.vanbaalenii_PYR-1 LRPHIACPTTSGTGSEVTGIAIFDLLAMAAKTGIASPALRPTEALVDPDC
MMAR_4110|M.marinum_M RIQLVAVPTTSGTGSEVSPAAVLTVGGKKETLVD--YSLVPDLAIVDPVL
MUL_3976|M.ulcerans_Agy99 RIQLVAVPTTSGTGSEVSPAAVLTVGGKKETLVD--YSLVPDLAIVDPVL
MSMEG_1392|M.smegmatis_MC2_155 ALPIVAVPTTAGSGSEATQFTVITDGETDEKMLCPGLSFLPIAIVVDYEL
:* ***:*:***.: ::: . :: * :**
Mflv_1025|M.gilvum_PYR-GCK TGTLPATVVACSGLDVLSHALESYTARPYTHRAAPARPTQRPMSQGANPW
Mvan_5811|M.vanbaalenii_PYR-1 TDTLPASVVACSGLDVLSHALESYTARPYRRRAVTGRPSRRPMSQGANPW
MMAR_4110|M.marinum_M TSSMPQKLTADTGIDALTHALEAIVS------------------IFASPY
MUL_3976|M.ulcerans_Agy99 TSSMPQKLTADIGIDALTHALEAIVS------------------IFASPY
MSMEG_1392|M.smegmatis_MC2_155 TVSMPARLTADTGVDALTHAIEAYVS------------------RRAGGF
* ::* :.* *:*.*:**:*: .: *. :
Mflv_1025|M.gilvum_PYR-GCK SDLGCGEALRLLGTYLARAVADASDSEAREQVMWAATLAGIAFGNAGVHL
Mvan_5811|M.vanbaalenii_PYR-1 SDLGSLEALRLLGRYLERAVTDAADREAREQVMWAATLAGIAFGNAGVHI
MMAR_4110|M.marinum_M TDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGT
MUL_3976|M.ulcerans_Agy99 TDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGT
MSMEG_1392|M.smegmatis_MC2_155 SDALALAAMQSISKHLRRAYVDGDDREAREAMMLASTQAGMAFSNSSVAL
:* . *:: : * ** * * .** : *:* **:**.*: *
Mflv_1025|M.gilvum_PYR-GCK PHAMAYAVAGQVRDFRPVGYPDSEPLVPHGMSVILNAPAAFRLTAHTDPA
Mvan_5811|M.vanbaalenii_PYR-1 PHAMAYAVAGQVHDFHPPEYPGDEPMVPHGMSVVLNAPAAFRLTAPTDPV
MMAR_4110|M.marinum_M NHALAHAVGAKFS-------------VPHGRANGIFLPHVLRYNASLPTK
MUL_3976|M.ulcerans_Agy99 NHTLAHAVGAKFS-------------VPHGRANGIFLPHVLRYNASLPTK
MSMEG_1392|M.smegmatis_MC2_155 VHGMSRPIGGHFH-------------VAHGLSNAMLLPAVTRFSVESAIG
* :: .:..:. *.** : : * . * ..
Mflv_1025|M.gilvum_PYR-GCK RHLFAAARLGADTADAAPE-----------DAGTVLAEHLMTIMRQVGMP
Mvan_5811|M.vanbaalenii_PYR-1 RHLEAARQLGADAADAGPE-----------DAGTVLAEHLIRIMRAVGMP
MMAR_4110|M.marinum_M FMPAPGYSAYIAPDKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDRLDMP
MUL_3976|M.ulcerans_Agy99 FMPAPGYSAYIAPDKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDRLDMP
MSMEG_1392|M.smegmatis_MC2_155 RYADCARAMGIVGAAVADR-----------DAASELVTELERLCADVEVP
. . *: * : : : :*
Mflv_1025|M.gilvum_PYR-GCK NGLAGVGYTDADAAALADGAWPQQRLLANAPIDVDKPLLANAFEQSMRYW
Mvan_5811|M.vanbaalenii_PYR-1 NGLAGVGYSETDAAALADGAWPQQRLLNNAPIDVDKAWLADTFRRALNYW
MMAR_4110|M.marinum_M RSLREFGVDEQEFLAALP-TLAMTAFEDLSNRTNPRMPLVSEITDLLRLG
MUL_3976|M.ulcerans_Agy99 RSLREFGVDEQGFLVALP-TLAMTAFEDLSNRTNPRMPLVSEITDLLRLG
MSMEG_1392|M.smegmatis_MC2_155 -TPRSYGIDEKDWEARLP-TMAEQALASGSPQNNPRVPTHDEIVALYREI
* : . : . : : : . : .
Mflv_1025|M.gilvum_PYR-GCK -------------------------
Mvan_5811|M.vanbaalenii_PYR-1 -------------------------
MMAR_4110|M.marinum_M YYGDTGVGEPALAPIKPGDVDGRSV
MUL_3976|M.ulcerans_Agy99 YYGDTGVGEPALAPIKPGDVDGRSV
MSMEG_1392|M.smegmatis_MC2_155 Y------------------------