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SPMMQFAAVPAGPDTGTPTDWHLQHLGSRAVAGAALVMVEATAVDPVGRSSHHDLGLWNDRQAQSFRRIT DFLKAQGTVPGIQIVHAGRKGSTGLPWADETQPPHQNWATVGPSAVPFGRLPAPSEMTTEEIARTVEAFA AAARRAADAGFQTLEIHGAHGYLIHQFLSPHSNHRDDRYGGPLEHRMRFALEVTEAVRAAWPDGLPLFFR VSATDWLGGDTDDARPGWTLADTVELAEHIKRIGVDLVDVSSGGSAPDAAIPVAPSYQVPFSTRIRKEVD VPTAAVGLITDAEQADSIIAEGEADAVFLARALLRDPAWIWRAAEQLGHQLPHPVRYARAFR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6486 | - | - | 100% (343) | oxidoreductase, FAD/FMN-binding |
| M. smegmatis MC2 155 | MSMEG_3338 | - | 2e-73 | 43.35% (346) | oxidoreductase, FAD/FMN-binding |
| M. smegmatis MC2 155 | MSMEG_2969 | - | 4e-29 | 30.86% (337) | NADH:flavin oxidoreductase/NADH oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1208c | fadH | 1e-25 | 27.48% (302) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 4e-28 | 33.23% (331) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv1175c | fadH | 6e-26 | 27.81% (302) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0485 | - | 2e-96 | 51.86% (349) | putative oxidoreductase |
| M. marinum M | MMAR_4276 | fadH | 2e-25 | 25.56% (313) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. avium 104 | MAV_4324 | - | 3e-23 | 28.49% (351) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. thermoresistible (build 8) | TH_3970 | - | 8e-28 | 31.68% (322) | PUTATIVE putative NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 1e-24 | 25.80% (314) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. vanbaalenii PYR-1 | Mvan_4790 | - | 2e-31 | 31.98% (344) | NADH:flavin oxidoreductase/NADH oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6486|M.smegmatis_MC2_155 --------------------------------MSPMMQFAAVPAGPDTGT
MAB_0485|M.abscessus_ATCC_1997 -----------MSLLFEPYRLR-DITVPNRIWMSPMCQYSAAPAGPLLGT
Mflv_1689|M.gilvum_PYR-GCK ----MTFTLSEQSALLKPIQVG-GTAAGNRLFMAPLTRSRADADG----T
Mvan_4790|M.vanbaalenii_PYR-1 ----MTKLIS------KPLELP-AFVTPNRVFMAPMTRMRAAQPGD---V
Mb1208c|M.bovis_AF2122/97 -------MTNPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRARH----
Rv1175c|M.tuberculosis_H37Rv -------MTNPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRARH----
MMAR_4276|M.marinum_M -------MTSPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRPKD----
MUL_1023|M.ulcerans_Agy99 -------MTSPYPNLLFPLDLG-FTTLRNRVVMGSMHTGLEDRPKD----
TH_3970|M.thermoresistible__bu MCGRRRDEMVPMTDLSAPLRFAHGPTWRNRLALAPLTNMQSNADGT----
MAV_4324|M.avium_104 --------MPTPPDVFSPAKLG-PITLRNRIIKSATFEARTPDALV----
..
MSMEG_6486|M.smegmatis_MC2_155 PTDWHLQHLGSRAVAGAALVMVEATAVDPVGRSSHHDL-GLWNDRQAQSF
MAB_0485|M.abscessus_ATCC_1997 PNDWHRTHLISRAIGGAGLVFTEATSVNAQGRLSPYDT-GLWNDTQEQAW
Mflv_1689|M.gilvum_PYR-GCK PSSLAAQYYAQR--ASAGLIISEATAVCEQANGAYLNTPGLYTDRQQDKW
Mvan_4790|M.vanbaalenii_PYR-1 PTDLMVDYYTQR--AGAGLIVTEGSQISPEGKG-YADTPGIHSDAQVAGW
Mb1208c|M.bovis_AF2122/97 -IDRLADYFAERARGGVGLIITGGYAPNRTGWLLPFAS-ELVTSAQARRH
Rv1175c|M.tuberculosis_H37Rv -IDRLADYFAERARGGVGLIITGGYAPNRTGWLLPFAS-ELVTSAQARRH
MMAR_4276|M.marinum_M -TDRLAEYFAERARGGVGMLITGGYAPNRTGWLYPFAS-ELVTPAEARRH
MUL_1023|M.ulcerans_Agy99 -TDRLAEYFAERARGGVGMLITGGYAPNRTGWLYPFAS-ELVTPAEARRH
TH_3970|M.thermoresistible__bu LHDDEHHWLVRRAEGGFAMVMTCAAHVSQAGQAFPGQL-GVWHDRHLPGL
MAV_4324|M.avium_104 -TDDLIEYHRLPAAGGVGMTTVAYCAVSPGGRTEGNGI--WMRPEAVPGF
. .. .: .
MSMEG_6486|M.smegmatis_MC2_155 RRITDFLKAQGTVPGIQIVHAGRKGSTGLPWADETQPPHQN------WAT
MAB_0485|M.abscessus_ATCC_1997 AAIVDGIKHFGAVPAIQLGHAGRKASTVAPWDGHRSLEPTDPLS---WGT
Mflv_1689|M.gilvum_PYR-GCK SEIASAVHRAGGKMFVQLWHVGRMAHPEISG-FETVGPSPIAAD---LLT
Mvan_4790|M.vanbaalenii_PYR-1 RKVTDAVHAAGGRISLQLWHVGRLTHETLQGGQPGVSASAIDFDGTVTLK
Mb1208c|M.bovis_AF2122/97 RRINRAVHDSGAKILLQILHAGRYAYHPLAVSASPIKAPITPFR------
Rv1175c|M.tuberculosis_H37Rv RRITRAVHDSGAKILLQILHAGRYAYHPLAVSASPIKAPITPFR------
MMAR_4276|M.marinum_M RRITGAVHDADAKILLQVLHAGRYAYHPLSVSASSIKAPINPFR------
MUL_1023|M.ulcerans_Agy99 RRITGAVHDADAKILLQVLHAGRYAYHPLSVSASSIKAPINPFR------
TH_3970|M.thermoresistible__bu TRLAAGIRAAGAVATVQLHHGGRRAEARLTGLPVVAPWDDPDKG------
MAV_4324|M.avium_104 RRLTDAIHAEGAAVSAQIGHAGPVANARSNKAHALAPVRFFNPIG-----
: :: . *: * *
MSMEG_6486|M.smegmatis_MC2_155 VGPSAVPFGRLPAPSEMTTEEIARTVEAFAAAARRAADAGFQTLEIHGAH
MAB_0485|M.abscessus_ATCC_1997 VGPTDAPYGDFVPPVAATTADLTAIIEDYVSAAQRALRAGFQVLEVHAAH
Mflv_1689|M.gilvum_PYR-GCK HTPTG--KKPLPVPRALTTGEIAEIVGQFRAAARRAVDAGMDGVEIHSAN
Mvan_4790|M.vanbaalenii_PYR-1 HADGERYTAQSPTPRALEVSEIPRLIEDYRRATRNAREAGFDMVEIHAAN
Mb1208c|M.bovis_AF2122/97 -------------PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSE
Rv1175c|M.tuberculosis_H37Rv -------------PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSE
MMAR_4276|M.marinum_M -------------PRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSE
MUL_1023|M.ulcerans_Agy99 -------------SRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSE
TH_3970|M.thermoresistible__bu -------------VTALTTAQVEQVVQDFVDAAVRAEKAGFDGAEIHGAH
MAV_4324|M.avium_104 ----------MRFAKKATREDIDEVIAAHANAARLAIEAGFDAVEIHLGH
: : . .: * ** : *: ..
MSMEG_6486|M.smegmatis_MC2_155 GYLIHQFLSPHSNHRDDRYGGPLEHRMRFALEVTEAVRAAWP---DGLPL
MAB_0485|M.abscessus_ATCC_1997 GYIQHQFLSPASNTRTDEYGGSFSGRAKLTLDTVTAVRTVWP---EHLPL
Mflv_1689|M.gilvum_PYR-GCK GYLLHEFLSDVVNQRTDAYGGSPQNRARLAAEVVEAVVAEIG---PDR-V
Mvan_4790|M.vanbaalenii_PYR-1 GYLLQQFMSVSSNHRDDRYGGSLQNRARLPLEVVDALTDEWD---AAH-V
Mb1208c|M.bovis_AF2122/97 GYLLNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSRAAVG---SDFII
Rv1175c|M.tuberculosis_H37Rv GYLLNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSRAAVG---CDFII
MMAR_4276|M.marinum_M GYLLNQFLAPRTNKRTDSWGGTPAKRRRFPVEIVRRTRAAVG---PDFII
MUL_1023|M.ulcerans_Agy99 GYLLNQFLAPRTNQRTDSWGGTPAKRRRFPVEIVRRTRAAVG---PDFII
TH_3970|M.thermoresistible__bu GYLVAQFLDVRHNHRTDRYGGSPENRFRIVHEIIAGIRAATS---PDFQL
MAV_4324|M.avium_104 NYLASSFLSPLINRRNDEFGGSLQNRAKVARGMVMAVRRAVEKEGTPIAV
.*: .*: * * * :**. * :. :
MSMEG_6486|M.smegmatis_MC2_155 FFRVSATDWLG---GDTDDARPGWTLADTVELAEHIKRIGVDLVDVSSGG
MAB_0485|M.abscessus_ATCC_1997 FVRVSATDWLS---EEPGHEADSWTPDQTVELARMLQPRGVDLVDVSTGG
Mflv_1689|M.gilvum_PYR-GCK GLRISPGNSAG---DMREIDD----VSAYEALLCRIASLGIAYLHV----
Mvan_4790|M.vanbaalenii_PYR-1 GIRLSPMIKFG---GLDDADG----MEMGLYMAAALHERGVGYLH-----
Mb1208c|M.bovis_AF2122/97 CYRLSMADYVA---EGQSWDEIVALATEVEGAGATIINSGFGWHEAR---
Rv1175c|M.tuberculosis_H37Rv CYRLSMADYVA---EGQSWDEIVALATEVEGAGATIINSGFGWHEAR---
MMAR_4276|M.marinum_M CYRMSMADYVE---GGQSWDEIVALASELETAGATIINSGFGWHEAR---
MUL_1023|M.ulcerans_Agy99 CYRMSMADYVE---GGQSWDEIVALATELESAGATIINSGFGWHEAR---
TH_3970|M.thermoresistible__bu GLRLSPERYGI---VLD---------EARALAGEVLADGQLDYLDLSLWD
MAV_4324|M.avium_104 TAKLNMADGVRGGISTEESLTTAKWLESDGGLDAIELTAGSSLVNPMYLF
::. .
MSMEG_6486|M.smegmatis_MC2_155 SAPDAAIPVAPSYQVPFSTRIRKE-------------------------V
MAB_0485|M.abscessus_ATCC_1997 NVPHVHIPTGPGYQVRFARRIQTE-------------------------T
Mflv_1689|M.gilvum_PYR-GCK -LVEP---SAPAF-AAVRTQWEGT-------------------------L
Mvan_4790|M.vanbaalenii_PYR-1 -LCEPDWAEGPALDSAFRSGLRNA-------------------------F
Mb1208c|M.bovis_AF2122/97 -VPTIVTSVPGGAFVDISSAVAEH-------------------------V
Rv1175c|M.tuberculosis_H37Rv -VPTIVTSVPGGAFVDISSAVAEH-------------------------V
MMAR_4276|M.marinum_M -IPTIVTSVPSGAFVDISNAVAEQ-------------------------V
MUL_1023|M.ulcerans_Agy99 -IPTIVTSVPSGAFVEISNAVAEQ-------------------------V
TH_3970|M.thermoresistible__bu AFKEPYEEAHRGRRLIELFMDLPR-------------------------G
MAV_4324|M.avium_104 RGDAPLKEFAGAFKPPLRWGMRMTGKKFLREYPYREAYLLRDAKLFRAEL
.
MSMEG_6486|M.smegmatis_MC2_155 DVPTAAVGLITDAEQADSIIAEGEADAVFLARALLRDPAWIWRAAEQLGH
MAB_0485|M.abscessus_ATCC_1997 PLPAAAVGMITEPHQAESILAAGDASAVLLGRELLRDPYWPRRAARELGA
Mflv_1689|M.gilvum_PYR-GCK VLNTPRT-VETDFATLENLADWGVISAAAVGRAFLANPDLIERLKLGAEL
Mvan_4790|M.vanbaalenii_PYR-1 SGIIIGA-GNYTVAKADEMIAEGFIDAAAFGRPFIANPDLPRRLFEELPL
Mb1208c|M.bovis_AF2122/97 TIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLKAQSNRVD
Rv1175c|M.tuberculosis_H37Rv TIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLKAQSNRVD
MMAR_4276|M.marinum_M SIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVLKAQSGRVD
MUL_1023|M.ulcerans_Agy99 SIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVLKAQSGRVD
TH_3970|M.thermoresistible__bu DTRVGVAGKITDAESARRCLDSG-ADFVLIGKAAIVHHDFARQVLADPAY
MAV_4324|M.avium_104 KMPLILLGGITNRETMDLAMAEG-FEFVAMARALLAEPDLINRIAADGAA
..: : . :
MSMEG_6486|M.smegmatis_MC2_155 QLP-----------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 DLSPA---------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK NEPDVATF-------------------------------------Y----
Mvan_4790|M.vanbaalenii_PYR-1 AEVDFDTV-------------------------------------YGSDV
Mb1208c|M.bovis_AF2122/97 EINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRRARSVAVV
Rv1175c|M.tuberculosis_H37Rv EINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRRARSVAVV
MMAR_4276|M.marinum_M EINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTLSPTQRARTVAVV
MUL_1023|M.ulcerans_Agy99 EINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTMSPTQRARTVAVV
TH_3970|M.thermoresistible__bu RAAPLPVS------------------------------------AEHLAA
MAV_4324|M.avium_104 HRVHSACTHCN---------------------------------------
MSMEG_6486|M.smegmatis_MC2_155 --HPVRYARAFR--------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --VPKQYARAF---------------------------------------
Mflv_1689|M.gilvum_PYR-GCK APGPDGYLDYPTLDEMVTPRSA----------------------------
Mvan_4790|M.vanbaalenii_PYR-1 AGYPQGYTDYPTAD------------------------------------
Mb1208c|M.bovis_AF2122/97 GAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGKEEFSETIR
Rv1175c|M.tuberculosis_H37Rv GAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGKEEFSETIR
MMAR_4276|M.marinum_M GAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKEEFNETIR
MUL_1023|M.ulcerans_Agy99 GAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKEEFNETIR
TH_3970|M.thermoresistible__bu EAVGPRFVDYLASNWDDFVSTG----------------------------
MAV_4324|M.avium_104 QCMPTIYSRTHCVVTGAPDRHTSAAT------------------------
MSMEG_6486|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 YFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAPRIPAIPGIDHPM
Rv1175c|M.tuberculosis_H37Rv YFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAPRIPAIPGIDHPM
MMAR_4276|M.marinum_M YFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAPRIPAIPGIAHAK
MUL_1023|M.ulcerans_Agy99 YFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAPRIPAIPGIAHAK
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MSMEG_6486|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 VLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVTDSSPTLNLKEWKAE
Rv1175c|M.tuberculosis_H37Rv VLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVTDSSPTLNLKEWKAE
MMAR_4276|M.marinum_M VLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTLNLKEWKAE
MUL_1023|M.ulcerans_Agy99 VLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTLNLKEWKAE
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MSMEG_6486|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 WGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKRLGKTTGWVHRAS
Rv1175c|M.tuberculosis_H37Rv WGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKRLGKTTGWVHRAS
MMAR_4276|M.marinum_M WGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKRLGKTSGWVHRAS
MUL_1023|M.ulcerans_Agy99 WGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKRLGKTSGWVHRAS
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MSMEG_6486|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 LKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVVVCAGQEPV
Rv1175c|M.tuberculosis_H37Rv LKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVVVCAGQEPV
MMAR_4276|M.marinum_M VKAKGVHQLSGVNYERISDDGLHISFGPERQRPQLLAVDSVVICAGQEPV
MUL_1023|M.ulcerans_Agy99 VKAKGVHQLSGVNYERISDDGLHISFGPDRQRPQLLAVDSVVICAGQEPV
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MSMEG_6486|M.smegmatis_MC2_155 ------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 ------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK ------------------------------------------
Mvan_4790|M.vanbaalenii_PYR-1 ------------------------------------------
Mb1208c|M.bovis_AF2122/97 RDLESELRRHGINPHISGGAAVAAELDAKRAIKQGTELAARL
Rv1175c|M.tuberculosis_H37Rv RDLESELRRHGINPHIIGGAAVAAELDAKRAIKQGTELAARL
MMAR_4276|M.marinum_M RDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL
MUL_1023|M.ulcerans_Agy99 RDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL
TH_3970|M.thermoresistible__bu ------------------------------------------
MAV_4324|M.avium_104 ------------------------------------------